| scholarly article | Q13442814 |
| P819 | ADS bibcode | 2009PLoSO...4.7983L |
| P356 | DOI | 10.1371/JOURNAL.PONE.0007983 |
| P932 | PMC publication ID | 2776992 |
| P698 | PubMed publication ID | 19956695 |
| P5875 | ResearchGate publication ID | 40443777 |
| P50 | author | Orian S Shirihai | Q37837313 |
| P2093 | author name string | Chong Wee Liew | |
| Rohit N Kulkarni | |||
| E Dale Abel | |||
| Jamie Soto | |||
| Siming Liu | |||
| Heiko Bugger | |||
| Anke Assmann | |||
| Terumasa Okada | |||
| P2860 | cites work | Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes. | Q54104864 |
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| Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes. | Q38299277 | ||
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| Glucose-dependent increase in mitochondrial membrane potential, but not cytoplasmic calcium, correlates with insulin secretion in single islet cells | Q39729108 | ||
| Transcriptional co-activator peroxisome proliferator-activated receptor (PPAR)gamma co-activator-1beta is involved in the regulation of glucose-stimulated insulin secretion in INS-1E cells. | Q39905162 | ||
| Bad is a BH3 domain-containing protein that forms an inactivating dimer with Bcl-XL. | Q40024055 | ||
| The essential role of the death domain kinase receptor-interacting protein in insulin growth factor-I-induced c-Jun N-terminal kinase activation | Q40263696 | ||
| Role of peroxisome proliferator-activated receptor-gamma coactivator-1alpha in the transcriptional regulation of the human uncoupling protein 2 gene in INS-1E cells. | Q40352391 | ||
| Ceramide induces mitochondrial abnormalities in insulin-secreting INS-1 cells: potential mechanisms underlying ceramide-mediated metabolic dysfunction of the beta cell | Q40379415 | ||
| Exposure to chronic high glucose induces beta-cell apoptosis through decreased interaction of glucokinase with mitochondria: downregulation of glucokinase in pancreatic beta-cells | Q40381260 | ||
| Glucose effects on beta-cell growth and survival require activation of insulin receptors and insulin receptor substrate 2. | Q41870014 | ||
| Modulation by insulin-like growth factor I of the phosphatase PTEN in astrocytes | Q42522221 | ||
| beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass | Q43940568 | ||
| Impact of genetic background on development of hyperinsulinemia and diabetes in insulin receptor/insulin receptor substrate-1 double heterozygous mice | Q44453030 | ||
| Reduced β-cell mass and altered glucose sensing impair insulin-secretory function in βIRKO mice | Q44602874 | ||
| Mitochondrial dysfunction: glucokinase downregulation lowers interaction of glucokinase with mitochondria, resulting in apoptosis of pancreatic beta-cells | Q44976126 | ||
| Rescue purification maximizes the use of human islet preparations for transplantation | Q45214551 | ||
| Functional and morphological alterations of mitochondria in pancreatic beta cells from type 2 diabetic patients. | Q45227245 | ||
| Changes in mitochondrial membrane potential and mitochondrial mass occur independent of the activation of caspase-8 and caspase-3 during CD95-mediated apoptosis in peripheral blood T cells | Q46923947 | ||
| Rsk1 mediates a MEK-MAP kinase cell survival signal | Q22253213 | ||
| Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein | Q22253357 | ||
| 14-3-3 inhibits Bad-induced cell death through interaction with serine-136 | Q24291932 | ||
| Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1 | Q24679555 | ||
| Minireview: implication of mitochondria in insulin secretion and action | Q27863915 | ||
| Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms | Q28137802 | ||
| Cell death: critical control points | Q28240722 | ||
| Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes | Q28345343 | ||
| The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins | Q28507365 | ||
| Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis | Q28509136 | ||
| Dual role of proapoptotic BAD in insulin secretion and beta cell survival | Q28586275 | ||
| p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD | Q28592766 | ||
| BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis | Q28594183 | ||
| Cellular survival: a play in three Akts | Q29547806 | ||
| Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic beta-cell function | Q33412998 | ||
| Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines | Q33903502 | ||
| Insulin-like growth factor-1 enhances inflammatory responses in endothelial cells: role of Gab1 and MEKK3 in TNF-alpha-induced c-Jun and NF-kappaB activation and adhesion molecule expression | Q34133390 | ||
| Sab (SH3BP5), a novel mitochondria-localized JNK-interacting protein. | Q34362136 | ||
| Banting Lecture 1995. A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm | Q34370210 | ||
| Signalling through IGF-I and insulin receptors: where is the specificity? | Q34783548 | ||
| Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance | Q35829169 | ||
| A conserved role for phosphatidylinositol 3-kinase but not Akt signaling in mitochondrial adaptations that accompany physiological cardiac hypertrophy. | Q36156412 | ||
| Myocardial insulin resistance and cardiac complications of diabetes. | Q36223473 | ||
| New insights into the roles of insulin/IGF-I in the development and maintenance of beta-cell mass | Q36253113 | ||
| The network of glucokinase-expressing cells in glucose homeostasis and the potential of glucokinase activators for diabetes therapy | Q36354621 | ||
| The where's and when's of kinase anchoring | Q36475672 | ||
| P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P433 | issue | 11 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | preproinsulin | Q7240673 |
| P304 | page(s) | e7983 | |
| P577 | publication date | 2009-11-24 | |
| P1433 | published in | PLOS One | Q564954 |
| P1476 | title | Insulin signaling regulates mitochondrial function in pancreatic beta-cells | |
| P478 | volume | 4 |
| Q33855651 | A phospho-BAD BH3 helix activates glucokinase by a mechanism distinct from that of allosteric activators |
| Q34528162 | Alteration in mitochondrial Ca(2+) uptake disrupts insulin signaling in hypertrophic cardiomyocytes. |
| Q34091221 | Altered insulin receptor signalling and β-cell cycle dynamics in type 2 diabetes mellitus |
| Q33558360 | An islet in distress: β cell failure in type 2 diabetes |
| Q42477072 | Basal α-Cell Up-Regulation in Obese Insulin-Resistant Adolescents |
| Q34295303 | Basolateral P2X₄channels stimulate ENaC activity in Xenopus cortical collecting duct A6 cells |
| Q42800055 | Brain energy metabolism parameters in an animal model of diabetes |
| Q51529869 | Characterization of a nanogland for the autotransplantation of human pancreatic islets. |
| Q37078025 | Class IA phosphatidylinositol 3-kinase in pancreatic β cells controls insulin secretion by multiple mechanisms |
| Q93205455 | Contribution of Oxidative Stress and Impaired Biogenesis of Pancreatic β-Cells to Type 2 Diabetes |
| Q39985807 | Defects in beta cell Ca²+ signalling, glucose metabolism and insulin secretion in a murine model of K(ATP) channel-induced neonatal diabetes mellitus |
| Q36067828 | Excessive Cellular Proliferation Negatively Impacts Reprogramming Efficiency of Human Fibroblasts |
| Q38773675 | GLP-1 signalling compensates for impaired insulin signalling in regulating beta cell proliferation in βIRKO mice. |
| Q35893382 | Glucokinase activation repairs defective bioenergetics of islets of Langerhans isolated from type 2 diabetics |
| Q33961250 | Glucose sensing in the pancreatic beta cell: a computational systems analysis |
| Q38836995 | Glycogen phosphorylase inhibition improves beta cell function. |
| Q34507235 | Insulin infusion during normoglycemia modulates insulin secretion according to whole-body insulin sensitivity |
| Q33730511 | Insulin regulates carboxypeptidase E by modulating translation initiation scaffolding protein eIF4G1 in pancreatic β cells |
| Q37715179 | Insulin signaling meets mitochondria in metabolism |
| Q58781043 | Links Between Obesity-Induced Brain Insulin Resistance, Brain Mitochondrial Dysfunction, and Dementia |
| Q33609715 | Mitochondrial metabolism and diabetes |
| Q37189580 | Phospho-BAD BH3 mimicry protects β cells and restores functional β cell mass in diabetes |
| Q27021930 | Redox homeostasis in pancreatic β cells |
| Q38369733 | Regulation of mitochondrial nutrient and energy metabolism by BCL-2 family proteins |
| Q36635942 | SUMOylation of pancreatic glucokinase regulates its cellular stability and activity |
| Q55306046 | Sweet Mitochondria: A Shortcut to Alzheimer's Disease. |
| Q38211528 | The regulation of pre- and post-maturational plasticity of mammalian islet cell mass. |
| Q42835430 | α-Lipoic acid protects 3T3-L1 adipocytes from NYGGF4 (PID1) overexpression-induced insulin resistance through increasing phosphorylation of IRS-1 and Akt. |
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