The absence of insulin signaling in the heart induces changes in potassium channel expression and ventricular repolarization (scientific article published on 27 December 2013)

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Targeted deletion of Kv4.2 eliminates I(to,f) and results in electrical and molecular remodeling, with no evidence of ventricular hypertrophy or myocardial dysfunction

Q81492019

Diabetic cardiomyopathy

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Cardiac hypertrophy with preserved contractile function after selective deletion of GLUT4 from the heart

Q24562618

Regulation of KChIP2 potassium channel beta subunit gene expression underlies the gradient of transient outward current in canine and human ventricle

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Transmural expression of transient outward potassium current subunits in normal and failing canine and human hearts

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The molecular physiology of the cardiac transient outward potassium current (I(to)) in normal and diseased myocardium

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Augmentation of Kv4.2-encoded currents by accessory dipeptidyl peptidase 6 and 10 subunits reflects selective cell surface Kv4.2 protein stabilization

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Molecular determinants of cardiac transient outward potassium current (I(to)) expression and regulation

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Diabetic cardiomyopathy, causes and effects

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Co-assembly of Kv4 {alpha} subunits with K+ channel-interacting protein 2 stabilizes protein expression and promotes surface retention of channel complexes

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Knockout of insulin receptors in cardiomyocytes attenuates coronary arterial dysfunction induced by pressure overload

Q34502029

Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression

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Transient outward potassium current, 'Ito', phenotypes in the mammalian left ventricle: underlying molecular, cellular and biophysical mechanisms

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Molecular physiology of cardiac repolarization

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Four kinetically distinct depolarization-activated K+ currents in adult mouse ventricular myocytes

Q36420431

Molecular and metabolic mechanisms of cardiac dysfunction in diabetes.

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Contribution of impaired myocardial insulin signaling to mitochondrial dysfunction and oxidative stress in the heart.

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Gender-dependent attenuation of cardiac potassium currents in type 2 diabetic db/db mice

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Optical mapping of propagation changes induced by elevated extracellular potassium ion concentration in genetically altered mouse hearts

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Heterogeneous expression of repolarizing, voltage-gated K+ currents in adult mouse ventricles

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Molecular basis of transient outward K+ current diversity in mouse ventricular myocytes.

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Improvement of the metabolic status recovers cardiac potassium channel synthesis in experimental diabetes.

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Effects of insulin on potassium currents of rat ventricular myocytes in streptozotocin diabetes

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Short-term diabetes alters K+ currents in rat ventricular myocytes

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Effects of diabetic cardiomyopathy on regional electrophysiologic characteristics of rat ventricle

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Potassium currents in ventricular myocytes from genetically diabetic rats

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Functional consequences of elimination of i(to,f) and i(to,s): early afterdepolarizations, atrioventricular block, and ventricular arrhythmias in mice lacking Kv1.4 and expressing a dominant-negative Kv4 alpha subunit

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Type I and II models of diabetes produce different modifications of K+ currents in rat heart: role of insulin

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Diabetes mellitus attenuates the repolarization reserve in mammalian heart

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Ionic mechanisms underlying abnormal QT prolongation and the associated arrhythmias in diabetic rabbits: a role of rapid delayed rectifier K+ current

Q80314928

P433

issue

P921

main subject

preproinsulin

Q7240673

P304

page(s)

H747-54

P577

publication date

2013-12-27

P1433

published in

American Journal of Physiology Heart and Circulatory Physiology

Q3193662

P1476

title

The absence of insulin signaling in the heart induces changes in potassium channel expression and ventricular repolarization

P478

volume

306

Reverse relations

cites work (P2860)

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Q33166935	Insight into specific pro-arrhythmic triggers in Brugada and early repolarization syndromes: results of long-term follow-up.
Q91625356	Insulin Resistance is Associated with Longitudinal Changes of Cardiac Repolarization Heterogeneity in Apparently Healthy Subjects
Q37439581	Macrophage-dependent IL-1β production induces cardiac arrhythmias in diabetic mice.
Q28068153	Molecular and Electrophysiological Mechanisms Underlying Cardiac Arrhythmogenesis in Diabetes Mellitus
Q46034115	Myocyte membrane and microdomain modifications in diabetes: determinants of ischemic tolerance and cardioprotection.
Q26752678	New Molecular Insights of Insulin in Diabetic Cardiomyopathy
Q36714022	Reduction in Kv Current Enhances the Temporal Dispersion of the Action Potential in Diabetic Myocytes: Insights From a Novel Repolarization Algorithm
Q64100814	The Association Between Diabetes Mellitus and Atrial Fibrillation: Clinical and Mechanistic Insights
Q89529373	The Pathogenic Role of Very Low Density Lipoprotein on Atrial Remodeling in the Metabolic Syndrome