scholarly article | Q13442814 |
P356 | DOI | 10.1172/JCI25151 |
P8608 | Fatcat ID | release_kaxzt4w27zffde7d6avdesj26a |
P932 | PMC publication ID | 1280967 |
P698 | PubMed publication ID | 16284649 |
P50 | author | Stefan Bilz | Q51092222 |
Gerald I. Shulman | Q52509909 | ||
Katsutaro Morino | Q57020116 | ||
Kitt Falk Petersen | Q65055037 | ||
Sylvie Dufour | Q109941922 | ||
Douglas Befroy | Q114424629 | ||
Susanne Neschen | Q114429537 | ||
Saki Sono | Q114735233 | ||
Marc Pypaert | Q114735255 | ||
P2093 | author name string | Morris F White | |
Jared Frattini | |||
Nadine Shatzkes | |||
P2860 | cites work | AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation | Q24541475 |
Multiple environmental and genetic factors influence skeletal muscle PGC-1alpha and PGC-1beta gene expression in twins | Q24561604 | ||
Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance | Q24629603 | ||
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1 | Q24679555 | ||
Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action | Q28199220 | ||
Prevention of fat-induced insulin resistance by salicylate | Q28345600 | ||
Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes | Q28369463 | ||
Mechanisms of fatty acid-induced inhibition of glucose uptake | Q28369732 | ||
PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes | Q29547229 | ||
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity | Q29614241 | ||
Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes | Q29614548 | ||
Cellular mechanisms of insulin resistance | Q29619549 | ||
A central role for JNK in obesity and insulin resistance | Q29619778 | ||
Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity | Q33834971 | ||
The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes | Q34370790 | ||
Development of muscle insulin resistance after liver insulin resistance in high-fat-fed rats | Q34975588 | ||
Effect of insulin on human skeletal muscle mitochondrial ATP production, protein synthesis, and mRNA transcripts | Q35147530 | ||
The effect of non-insulin-dependent diabetes mellitus and obesity on glucose transport and phosphorylation in skeletal muscle | Q36804318 | ||
Protein kinase C modulation of insulin receptor substrate-1 tyrosine phosphorylation requires serine 612. | Q38342426 | ||
Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes | Q42441787 | ||
Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease. | Q42462295 | ||
Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle | Q43990155 | ||
Gene expression profile in skeletal muscle of type 2 diabetes and the effect of insulin treatment | Q44007240 | ||
Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha | Q44043178 | ||
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A short questionnaire for the measurement of habitual physical activity in epidemiological studies | Q70501617 | ||
A microfluorometric method for the determination of free fatty acids in plasma | Q71689514 | ||
Glucose metabolism during the menstrual cycle. Assessment with the euglycemic, hyperinsulinemic clamp | Q72831976 | ||
Phosphorylation of insulin receptor substrate-1 (IRS-1) by protein kinase B positively regulates IRS-1 function | Q73019421 | ||
Measurement of intracellular triglyceride stores by H spectroscopy: validation in vivo | Q77755584 | ||
Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade | Q77795070 | ||
P433 | issue | 12 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | mitochondrion | Q39572 |
phosphorylation | Q242736 | ||
insulin resistance | Q1053470 | ||
preproinsulin | Q7240673 | ||
P304 | page(s) | 3587-3593 | |
P577 | publication date | 2005-11-10 | |
P1433 | published in | Journal of Clinical Investigation | Q3186904 |
P1476 | title | Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents | |
P478 | volume | 115 |
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Q38104693 | Perspectives and potential applications of mitochondria-targeted antioxidants in cardiometabolic diseases and type 2 diabetes |
Q37638746 | Phloretin exerts hypoglycemic effect in streptozotocin-induced diabetic rats and improves insulin resistance in vitro |
Q41886295 | Phosphatidylinositol 3,4,5-Trisphosphate Phosphatase SKIP Links Endoplasmic Reticulum Stress in Skeletal Muscle to Insulin Resistance |
Q24337301 | Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1 |
Q37736477 | Physiological insights gained from gene expression analysis in obesity and diabetes |
Q37271487 | Plasma acylcarnitine profiles suggest incomplete long-chain fatty acid beta-oxidation and altered tricarboxylic acid cycle activity in type 2 diabetic African-American women. |
Q33668158 | Plasma lactate and diabetes risk in 8045 participants of the atherosclerosis risk in communities study |
Q28476486 | Plasma metabolomic profiles reflective of glucose homeostasis in non-diabetic and type 2 diabetic obese African-American women |
Q50988205 | Pleiotropic effects of thiazolidinediones: implications for the treatment of patients with type 2 diabetes mellitus. |
Q37143194 | Potential mechanisms of muscle mitochondrial dysfunction in aging and obesity and cellular consequences |
Q54503216 | Progression of type 2 diabetes in GK rats affects muscle and liver mitochondria differently: pronounced reduction of complex II flux is observed in liver only. |
Q36886235 | Proteome-wide alterations on adipose tissue from obese patients as age-, diabetes- and gender-specific hallmarks |
Q38155079 | Pulmonary arterial hypertension: challenges in translational research and a vision for change |
Q37389002 | Quantitative proteomic and functional analysis of liver mitochondria from high fat diet (HFD) diabetic mice |
Q36942945 | Race differences in the association of oxidative stress with insulin sensitivity in African- and European-American women |
Q34468071 | Racial differences in peripheral insulin sensitivity and mitochondrial capacity in the absence of obesity |
Q39832067 | Raptor binds the SAIN (Shc and IRS-1 NPXY binding) domain of insulin receptor substrate-1 (IRS-1) and regulates the phosphorylation of IRS-1 at Ser-636/639 by mTOR |
Q34489640 | Rats bred for low aerobic capacity become promptly fatigued and have slow metabolic recovery after stimulated, maximal muscle contractions |
Q53704324 | Reduced Skeletal Muscle Phosphocreatine Concentration in Type 2 Diabetic Patients: A Quantitative Image-Based Phosphorus-31 MR Spectroscopy Study. |
Q58722516 | Reduced expression of Twist 1 is protective against insulin resistance of adipocytes and involves mitochondrial dysfunction |
Q37824851 | Regulation of endothelial function by mitochondrial reactive oxygen species |
Q37716524 | Regulation of hepatic pyruvate dehydrogenase phosphorylation in offspring glucose intolerance induced by intrauterine hyperglycemia |
Q28272571 | Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2 |
Q34119796 | Regulation of mitochondrial biogenesis |
Q39389656 | Regulation of mitochondrial biogenesis by lipoprotein lipase in muscle of insulin-resistant offspring of parents with type 2 diabetes |
Q34113727 | Regulation of skeletal muscle oxidative capacity and insulin signaling by the mitochondrial rhomboid protease PARL. |
Q37599302 | Relation of mitochondrial oxygen consumption in peripheral blood mononuclear cells to vascular function in type 2 diabetes mellitus |
Q36089550 | Relationship of oxidative stress in skeletal muscle with obesity and obesity-associated hyperinsulinemia in horses. |
Q35837809 | Resistance Training in Type II Diabetes Mellitus: Impact on Areas of Metabolic Dysfunction in Skeletal Muscle and Potential Impact on Bone |
Q47649709 | Respiromics - An integrative analysis linking mitochondrial bioenergetics to molecular signatures |
Q47700908 | Resveratrol attenuates type 2 diabetes mellitus by mediating mitochondrial biogenesis and lipid metabolism via Sirtuin type 1. |
Q55379110 | Resveratrol improves ex vivo mitochondrial function but does not affect insulin sensitivity or brown adipose tissue in first degree relatives of patients with type 2 diabetes. |
Q35450836 | Retinoid X receptor α overexpression alleviates mitochondrial dysfunction-induced insulin resistance through transcriptional regulation of insulin receptor substrate 1 |
Q35991365 | Reversal of muscle insulin resistance by weight reduction in young, lean, insulin-resistant offspring of parents with type 2 diabetes |
Q41999664 | Role of Neu-p11/luzindole in the regulation of insulin signaling pathways and insulin resistance |
Q27028142 | Role of mitochondria in nonalcoholic fatty liver disease |
Q37097807 | Role of mitochondrial dysfunction in insulin resistance |
Q33924199 | Role of skeletal muscle mitochondrial density on exercise-stimulated lipid oxidation |
Q41136392 | Roles of Fatty Acid oversupply and impaired oxidation in lipid accumulation in tissues of obese rats |
Q48088509 | Rosmarinic Acid Mediates Mitochondrial Biogenesis in Insulin Resistant Skeletal Muscle Through Activation of AMPK. |
Q33750699 | SIRT1 mRNA expression may be associated with energy expenditure and insulin sensitivity |
Q48002642 | SIRT6 regulates metabolic homeostasis in skeletal muscle through activation of AMPK. |
Q92354662 | Sarcopenia and type 2 diabetes mellitus: a bidirectional relationship |
Q92703384 | Serine Phosphorylation of IRS1 Correlates with Aβ-Unrelated Memory Deficits and Elevation in Aβ Level Prior to the Onset of Memory Decline in AD |
Q80080511 | Short-term activation of peroxysome proliferator-activated receptor beta/delta increases fatty acid oxidation but does not restore insulin action in muscle cells from type 2 diabetic patients |
Q37193670 | Short-term exercise training does not stimulate skeletal muscle ATP synthesis in relatives of humans with type 2 diabetes |
Q54289083 | Similar changes in muscle lipid metabolism are induced by chronic high-fructose feeding and high-fat feeding in C57BL/J6 mice. |
Q64111476 | Sirtuins and Type 2 Diabetes: Role in Inflammation, Oxidative Stress, and Mitochondrial Function |
Q26772781 | Skeletal Muscle Mitochondrial Bioenergetics and Morphology in High Fat Diet Induced Obesity and Insulin Resistance: Focus on Dietary Fat Source |
Q47215940 | Skeletal Muscle-Specific Deletion of MKP-1 Reveals a p38 MAPK/JNK/Akt Signaling Node that Regulates Obesity-Induced Insulin Resistance. |
Q45071737 | Skeletal muscle autophagy and mitophagy in endurance-trained runners before and after a high-fat meal. |
Q36901521 | Skeletal muscle insulin resistance is fundamental to the cardiometabolic syndrome |
Q37624257 | Skeletal muscle insulin resistance is the primary defect in type 2 diabetes |
Q36965630 | Skeletal muscle insulin resistance: roles of fatty acid metabolism and exercise |
Q37463518 | Skeletal muscle insulin resistance: the interplay of local lipid excess and mitochondrial dysfunction. |
Q51820293 | Stage of perinatal development regulates skeletal muscle mitochondrial biogenesis and myogenic regulatory factor genes with little impact of growth restriction or cross-fostering. |
Q35086757 | Standard magnetic resonance-based measurements of the Pi→ATP rate do not index the rate of oxidative phosphorylation in cardiac and skeletal muscles |
Q42825276 | Synergistic effects of metformin, resveratrol, and hydroxymethylbutyrate on insulin sensitivity |
Q37798716 | Systemic effects of white adipose tissue dysregulation and obesity-related inflammation |
Q34454336 | Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance. |
Q36956731 | Targeting PGC-1 alpha to control energy homeostasis |
Q51740135 | Targeting mitochondria as therapeutic strategy for metabolic disorders. |
Q42555610 | The 6th Annual World Congress on the insulin resistance syndrome |
Q55176253 | The Essential Element Manganese, Oxidative Stress, and Metabolic Diseases: Links and Interactions. |
Q40300384 | The Genetic Basis of Type 2 Diabetes. |
Q42686318 | The H19/let-7 double-negative feedback loop contributes to glucose metabolism in muscle cells. |
Q52663276 | The Mitochondrial tRNALeu(UUR) A3302G Mutation may be Associated With Insulin Resistance in Woman With Polycystic Ovary Syndrome. |
Q47138434 | The Role of Insulin Receptor Isoforms in Diabetes and Its Metabolic and Vascular Complications. |
Q94553871 | The Role of Overexpressed Apolipoprotein AV in Insulin-Resistant Hepatocytes |
Q49971616 | The Role of Skeletal Muscle Estrogen Receptors in Metabolic Homeostasis and Insulin Sensitivity |
Q54355769 | The activation of hepatic and muscle polyamine catabolism improves glucose homeostasis. |
Q37055585 | The association of plasma lactate with incident cardiovascular outcomes: the ARIC Study |
Q36433751 | The coordination of nuclear and mitochondrial communication during aging and calorie restriction |
Q89397680 | The impact of immobilisation and inflammation on the regulation of muscle mass and insulin resistance: different routes to similar end-points |
Q36430696 | The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux |
Q38845636 | The potential of endurance exercise-derived exosomes to treat metabolic diseases. |
Q36482349 | The role of AMP-activated protein kinase in mitochondrial biogenesis |
Q49906238 | The role of DNA-PK in aging and energy metabolism |
Q36864744 | The role of estrogens in control of energy balance and glucose homeostasis |
Q37606811 | The role of mitochondria in health and disease |
Q37930956 | The role of mitochondria in insulin resistance and type 2 diabetes mellitus |
Q36003367 | The role of mitochondria in the pathogenesis of type 2 diabetes |
Q33779662 | The role of mitochondria in the pathophysiology of skeletal muscle insulin resistance |
Q37061247 | The role of muscle insulin resistance in the pathogenesis of atherogenic dyslipidemia and nonalcoholic fatty liver disease associated with the metabolic syndrome. |
Q33942082 | The role of oxidative stress in the pathogenesis of type 2 diabetes: from molecular mechanism to clinical implication. |
Q35642128 | The role of skeletal muscle glycogen breakdown for regulation of insulin sensitivity by exercise |
Q38121600 | Therapeutic potential of resveratrol in obesity and type 2 diabetes: new avenues for health benefits? |
Q30429437 | Total Skeletal Muscle PGC-1 Deficiency Uncouples Mitochondrial Derangements from Fiber Type Determination and Insulin Sensitivity |
Q37335290 | Training Does Not Alter Muscle Ceramide and Diacylglycerol in Offsprings of Type 2 Diabetic Patients Despite Improved Insulin Sensitivity |
Q55162907 | Transcriptional Metabolic Inflexibility in Skeletal Muscle Among Individuals With Increasing Insulin Resistance |
Q46489599 | Troxerutin attenuates diet-induced oxidative stress, impairment of mitochondrial biogenesis and respiratory chain complexes in mice heart |
Q58447602 | Type 2 diabetes mellitus |
Q36764406 | Type II diabetes increases mitochondrial DNA mutations in the left ventricle of the Goto-Kakizaki diabetic rat. |
Q40675125 | Unacylated ghrelin restores insulin and autophagic signaling in skeletal muscle of diabetic mice |
Q39612792 | Unique cellular and mitochondrial defects mediate FK506-induced islet β-cell dysfunction. |
Q36144595 | Uteroplacental insufficiency leads to hypertension, but not glucose intolerance or impaired skeletal muscle mitochondrial biogenesis, in 12-month-old rats |
Q50320399 | Wushenziye Formula Improves Skeletal Muscle Insulin Resistance in Type 2 Diabetes Mellitus via PTP1B-IRS1-Akt-GLUT4 Signaling Pathway. |
Q59072672 | Zingiber officinale (Ginger): A Future Outlook on Its Potential in Prevention and Treatment of Diabetes and Prediabetic States |
Q33646200 | miR-24-mediated knockdown of H2AX damages mitochondria and the insulin signaling pathway |
Q36339596 | ³¹P-magnetization transfer magnetic resonance spectroscopy measurements of in vivo metabolism |
Q37810522 | β-Arrestins: multifunctional signaling adaptors in type 2 diabetes |
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