Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents.

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Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1172/JCI25151
P8608Fatcat IDrelease_kaxzt4w27zffde7d6avdesj26a
P932PMC publication ID1280967
P698PubMed publication ID16284649

P50authorStefan BilzQ51092222
Gerald I. ShulmanQ52509909
Katsutaro MorinoQ57020116
Kitt Falk PetersenQ65055037
Sylvie DufourQ109941922
Douglas BefroyQ114424629
Susanne NeschenQ114429537
Saki SonoQ114735233
Marc PypaertQ114735255
P2093author name stringMorris F White
Jared Frattini
Nadine Shatzkes
P2860cites workAMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivationQ24541475
Multiple environmental and genetic factors influence skeletal muscle PGC-1alpha and PGC-1beta gene expression in twinsQ24561604
Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistanceQ24629603
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1Q24679555
Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin actionQ28199220
Prevention of fat-induced insulin resistance by salicylateQ28345600
Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetesQ28369463
Mechanisms of fatty acid-induced inhibition of glucose uptakeQ28369732
PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetesQ29547229
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivityQ29614241
Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetesQ29614548
Cellular mechanisms of insulin resistanceQ29619549
A central role for JNK in obesity and insulin resistanceQ29619778
Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activityQ33834971
The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetesQ34370790
Development of muscle insulin resistance after liver insulin resistance in high-fat-fed ratsQ34975588
Effect of insulin on human skeletal muscle mitochondrial ATP production, protein synthesis, and mRNA transcriptsQ35147530
The effect of non-insulin-dependent diabetes mellitus and obesity on glucose transport and phosphorylation in skeletal muscleQ36804318
Protein kinase C modulation of insulin receptor substrate-1 tyrosine phosphorylation requires serine 612.Q38342426
Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetesQ42441787
Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease.Q42462295
Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscleQ43990155
Gene expression profile in skeletal muscle of type 2 diabetes and the effect of insulin treatmentQ44007240
Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alphaQ44043178
Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetesQ45199109
Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp.Q51561183
Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study.Q51565080
Metabolic effects of troglitazone monotherapy in type 2 diabetes mellitus. A randomized, double-blind, placebo-controlled trial.Q51571877
Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents.Q55033199
Quantitative analysis of total mitochondrial DNA: Competitive polymerase chain reaction versus real-time polymerase chain reactionQ61794052
A short questionnaire for the measurement of habitual physical activity in epidemiological studiesQ70501617
A microfluorometric method for the determination of free fatty acids in plasmaQ71689514
Glucose metabolism during the menstrual cycle. Assessment with the euglycemic, hyperinsulinemic clampQ72831976
Phosphorylation of insulin receptor substrate-1 (IRS-1) by protein kinase B positively regulates IRS-1 functionQ73019421
Measurement of intracellular triglyceride stores by H spectroscopy: validation in vivoQ77755584
Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascadeQ77795070
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectmitochondrionQ39572
phosphorylationQ242736
insulin resistanceQ1053470
preproinsulinQ7240673
P304page(s)3587-3593
P577publication date2005-11-10
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleReduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents
P478volume115

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Q58722516Reduced expression of Twist 1 is protective against insulin resistance of adipocytes and involves mitochondrial dysfunction
Q37824851Regulation of endothelial function by mitochondrial reactive oxygen species
Q37716524Regulation of hepatic pyruvate dehydrogenase phosphorylation in offspring glucose intolerance induced by intrauterine hyperglycemia
Q28272571Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2
Q34119796Regulation of mitochondrial biogenesis
Q39389656Regulation of mitochondrial biogenesis by lipoprotein lipase in muscle of insulin-resistant offspring of parents with type 2 diabetes
Q34113727Regulation of skeletal muscle oxidative capacity and insulin signaling by the mitochondrial rhomboid protease PARL.
Q37599302Relation of mitochondrial oxygen consumption in peripheral blood mononuclear cells to vascular function in type 2 diabetes mellitus
Q36089550Relationship of oxidative stress in skeletal muscle with obesity and obesity-associated hyperinsulinemia in horses.
Q35837809Resistance Training in Type II Diabetes Mellitus: Impact on Areas of Metabolic Dysfunction in Skeletal Muscle and Potential Impact on Bone
Q47649709Respiromics - An integrative analysis linking mitochondrial bioenergetics to molecular signatures
Q47700908Resveratrol attenuates type 2 diabetes mellitus by mediating mitochondrial biogenesis and lipid metabolism via Sirtuin type 1.
Q55379110Resveratrol improves ex vivo mitochondrial function but does not affect insulin sensitivity or brown adipose tissue in first degree relatives of patients with type 2 diabetes.
Q35450836Retinoid X receptor α overexpression alleviates mitochondrial dysfunction-induced insulin resistance through transcriptional regulation of insulin receptor substrate 1
Q35991365Reversal of muscle insulin resistance by weight reduction in young, lean, insulin-resistant offspring of parents with type 2 diabetes
Q41999664Role of Neu-p11/luzindole in the regulation of insulin signaling pathways and insulin resistance
Q27028142Role of mitochondria in nonalcoholic fatty liver disease
Q37097807Role of mitochondrial dysfunction in insulin resistance
Q33924199Role of skeletal muscle mitochondrial density on exercise-stimulated lipid oxidation
Q41136392Roles of Fatty Acid oversupply and impaired oxidation in lipid accumulation in tissues of obese rats
Q48088509Rosmarinic Acid Mediates Mitochondrial Biogenesis in Insulin Resistant Skeletal Muscle Through Activation of AMPK.
Q33750699SIRT1 mRNA expression may be associated with energy expenditure and insulin sensitivity
Q48002642SIRT6 regulates metabolic homeostasis in skeletal muscle through activation of AMPK.
Q92354662Sarcopenia and type 2 diabetes mellitus: a bidirectional relationship
Q92703384Serine Phosphorylation of IRS1 Correlates with Aβ-Unrelated Memory Deficits and Elevation in Aβ Level Prior to the Onset of Memory Decline in AD
Q80080511Short-term activation of peroxysome proliferator-activated receptor beta/delta increases fatty acid oxidation but does not restore insulin action in muscle cells from type 2 diabetic patients
Q37193670Short-term exercise training does not stimulate skeletal muscle ATP synthesis in relatives of humans with type 2 diabetes
Q54289083Similar changes in muscle lipid metabolism are induced by chronic high-fructose feeding and high-fat feeding in C57BL/J6 mice.
Q64111476Sirtuins and Type 2 Diabetes: Role in Inflammation, Oxidative Stress, and Mitochondrial Function
Q26772781Skeletal Muscle Mitochondrial Bioenergetics and Morphology in High Fat Diet Induced Obesity and Insulin Resistance: Focus on Dietary Fat Source
Q47215940Skeletal Muscle-Specific Deletion of MKP-1 Reveals a p38 MAPK/JNK/Akt Signaling Node that Regulates Obesity-Induced Insulin Resistance.
Q45071737Skeletal muscle autophagy and mitophagy in endurance-trained runners before and after a high-fat meal.
Q36901521Skeletal muscle insulin resistance is fundamental to the cardiometabolic syndrome
Q37624257Skeletal muscle insulin resistance is the primary defect in type 2 diabetes
Q36965630Skeletal muscle insulin resistance: roles of fatty acid metabolism and exercise
Q37463518Skeletal muscle insulin resistance: the interplay of local lipid excess and mitochondrial dysfunction.
Q51820293Stage of perinatal development regulates skeletal muscle mitochondrial biogenesis and myogenic regulatory factor genes with little impact of growth restriction or cross-fostering.
Q35086757Standard magnetic resonance-based measurements of the Pi→ATP rate do not index the rate of oxidative phosphorylation in cardiac and skeletal muscles
Q42825276Synergistic effects of metformin, resveratrol, and hydroxymethylbutyrate on insulin sensitivity
Q37798716Systemic effects of white adipose tissue dysregulation and obesity-related inflammation
Q34454336Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance.
Q36956731Targeting PGC-1 alpha to control energy homeostasis
Q51740135Targeting mitochondria as therapeutic strategy for metabolic disorders.
Q42555610The 6th Annual World Congress on the insulin resistance syndrome
Q55176253The Essential Element Manganese, Oxidative Stress, and Metabolic Diseases: Links and Interactions.
Q40300384The Genetic Basis of Type 2 Diabetes.
Q42686318The H19/let-7 double-negative feedback loop contributes to glucose metabolism in muscle cells.
Q52663276The Mitochondrial tRNALeu(UUR) A3302G Mutation may be Associated With Insulin Resistance in Woman With Polycystic Ovary Syndrome.
Q47138434The Role of Insulin Receptor Isoforms in Diabetes and Its Metabolic and Vascular Complications.
Q94553871The Role of Overexpressed Apolipoprotein AV in Insulin-Resistant Hepatocytes
Q49971616The Role of Skeletal Muscle Estrogen Receptors in Metabolic Homeostasis and Insulin Sensitivity
Q54355769The activation of hepatic and muscle polyamine catabolism improves glucose homeostasis.
Q37055585The association of plasma lactate with incident cardiovascular outcomes: the ARIC Study
Q36433751The coordination of nuclear and mitochondrial communication during aging and calorie restriction
Q89397680The impact of immobilisation and inflammation on the regulation of muscle mass and insulin resistance: different routes to similar end-points
Q36430696The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux
Q38845636The potential of endurance exercise-derived exosomes to treat metabolic diseases.
Q36482349The role of AMP-activated protein kinase in mitochondrial biogenesis
Q49906238The role of DNA-PK in aging and energy metabolism
Q36864744The role of estrogens in control of energy balance and glucose homeostasis
Q37606811The role of mitochondria in health and disease
Q37930956The role of mitochondria in insulin resistance and type 2 diabetes mellitus
Q36003367The role of mitochondria in the pathogenesis of type 2 diabetes
Q33779662The role of mitochondria in the pathophysiology of skeletal muscle insulin resistance
Q37061247The role of muscle insulin resistance in the pathogenesis of atherogenic dyslipidemia and nonalcoholic fatty liver disease associated with the metabolic syndrome.
Q33942082The role of oxidative stress in the pathogenesis of type 2 diabetes: from molecular mechanism to clinical implication.
Q35642128The role of skeletal muscle glycogen breakdown for regulation of insulin sensitivity by exercise
Q38121600Therapeutic potential of resveratrol in obesity and type 2 diabetes: new avenues for health benefits?
Q30429437Total Skeletal Muscle PGC-1 Deficiency Uncouples Mitochondrial Derangements from Fiber Type Determination and Insulin Sensitivity
Q37335290Training Does Not Alter Muscle Ceramide and Diacylglycerol in Offsprings of Type 2 Diabetic Patients Despite Improved Insulin Sensitivity
Q55162907Transcriptional Metabolic Inflexibility in Skeletal Muscle Among Individuals With Increasing Insulin Resistance
Q46489599Troxerutin attenuates diet-induced oxidative stress, impairment of mitochondrial biogenesis and respiratory chain complexes in mice heart
Q58447602Type 2 diabetes mellitus
Q36764406Type II diabetes increases mitochondrial DNA mutations in the left ventricle of the Goto-Kakizaki diabetic rat.
Q40675125Unacylated ghrelin restores insulin and autophagic signaling in skeletal muscle of diabetic mice
Q39612792Unique cellular and mitochondrial defects mediate FK506-induced islet β-cell dysfunction.
Q36144595Uteroplacental insufficiency leads to hypertension, but not glucose intolerance or impaired skeletal muscle mitochondrial biogenesis, in 12-month-old rats
Q50320399Wushenziye Formula Improves Skeletal Muscle Insulin Resistance in Type 2 Diabetes Mellitus via PTP1B-IRS1-Akt-GLUT4 Signaling Pathway.
Q59072672Zingiber officinale (Ginger): A Future Outlook on Its Potential in Prevention and Treatment of Diabetes and Prediabetic States
Q33646200miR-24-mediated knockdown of H2AX damages mitochondria and the insulin signaling pathway
Q36339596³¹P-magnetization transfer magnetic resonance spectroscopy measurements of in vivo metabolism
Q37810522β-Arrestins: multifunctional signaling adaptors in type 2 diabetes

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