Deleterious action of FA metabolites on ATP synthesis: possible link between lipotoxicity, mitochondrial dysfunction, and insulin resistance

scientific article published in July 2008

Deleterious action of FA metabolites on ATP synthesis: possible link between lipotoxicity, mitochondrial dysfunction, and insulin resistance is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1152/AJPENDO.90287.2008
P698PubMed publication ID18593850

P50authorFlorian MullerQ43107131
Ralph A. DeFronzoQ58689309
Holly Van RemmenQ78838825
P2093author name stringYuhong Liu
Muhammad A Abdul-Ghani
Devjit Tripathy
Rucha Jani
Franco Folli
Pengou Zuo
Alberto O Chavez
Marjorie Molina-Carrion
Zhi Chang
Bogdan Balas
Adriana Monroy
P2860cites workInhibitory effect of palmitate on the mitochondrial NADH:ubiquinone oxidoreductase (complex I) as related to the active-de-active enzyme transitionQ39373439
Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM.Q39648063
The role of free fatty acid metabolism in the pathogenesis of insulin resistance in obesity and noninsulin-dependent diabetes mellitusQ41176971
Sustained reduction in plasma free fatty acid concentration improves insulin action without altering plasma adipocytokine levels in subjects with strong family history of type 2 diabetesQ42467298
Palmitic acid opens a novel cyclosporin A-insensitive pore in the inner mitochondrial membraneQ43613403
Free fatty acid effects on mitochondrial permeability: an overviewQ43613406
Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetesQ43833528
Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscleQ43990155
Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alphaQ44043178
Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men.Q44055110
Effect of weight loss on insulin sensitivity and intramuscular long-chain fatty acyl-CoAs in morbidly obese subjectsQ44155508
Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistanceQ44760628
Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetesQ45199109
Dose-response effect of elevated plasma free fatty acid on insulin signalingQ46513253
Effect of a sustained reduction in plasma free fatty acid concentration on intramuscular long-chain fatty Acyl-CoAs and insulin action in type 2 diabetic patientsQ46774705
Reduced mitochondrial coupling in vivo alters cellular energetics in aged mouse skeletal muscleQ46778032
Long-chain acyl-CoA esters as indicators of lipid metabolism and insulin sensitivity in rat and human muscle.Q51554321
Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study.Q51565080
Skeletal muscle triglyceride levels are inversely related to insulin action.Q51575343
Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents.Q55033199
Lipid Infusion Decreases the Expression of Nuclear Encoded Mitochondrial Genes and Increases the Expression of Extracellular Matrix Genes in Human Skeletal MuscleQ58451168
Biochemical and Osmotic Properties of Skeletal Muscle MitochondriaQ59097012
Role of long-chain fatty acyl-CoA esters in the regulation of metabolism and in cell signallingQ24530119
Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistanceQ24629603
The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitusQ28190307
Complex III releases superoxide to both sides of the inner mitochondrial membraneQ28509539
Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetesQ29614548
Mitochondrial dysfunction and type 2 diabetesQ29617913
Mitochondrial dysfunction in the elderly: possible role in insulin resistanceQ29618783
Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents.Q34126257
Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophyQ34129374
Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. Evidence for multiple sites of insulin resistanceQ34577169
Mitochondrial energy dissipation by fatty acids. Mechanisms and implications for cell deathQ35025248
Burning fat: the structural basis of fatty acid beta-oxidationQ35035239
Metabolic and molecular basis of insulin resistanceQ35148800
Mild mitochondrial uncoupling impacts cellular aging in human muscles in vivoQ35578499
Impaired free fatty acid utilization by skeletal muscle in non-insulin-dependent diabetes mellitusQ35824553
Pathogenesis of type 2 diabetes mellitusQ35861736
Muscle triglycerides and mitochondrial function: possible mechanisms for the development of type 2 diabetesQ36356864
Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscleQ37175187
P433issue3
P921main subjectinsulin resistanceQ1053470
preproinsulinQ7240673
P304page(s)E678-85
P577publication date2008-07-01
P1433published inAmerican Journal of Physiology - Endocrinology and MetabolismQ15765671
P1476titleDeleterious action of FA metabolites on ATP synthesis: possible link between lipotoxicity, mitochondrial dysfunction, and insulin resistance
P478volume295

Reverse relations

cites work (P2860)
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Q46355683What Is Lipotoxicity?

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