Mitochondrial energy dissipation by fatty acids. Mechanisms and implications for cell death

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Mitochondrial energy dissipation by fatty acids. Mechanisms and implications for cell death is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/S0083-6729(02)65061-7
P698PubMed publication ID12481544

P50authorPaolo BernardiQ16199016
Lech WojtczakQ65028336
P2093author name stringDaniele Penzo
P2860cites workMolecular characterization of mitochondrial apoptosis-inducing factorQ22001452
UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cellsQ22008783
Effects of palmitoyl CoA and palmitoyl carnitine on the membrane potential and Mg2+ content of rat heart mitochondriaQ52477253
Interactions of cyclophilin with the mitochondrial inner membrane and regulation of the permeability transition pore, and cyclosporin A-sensitive channel.Q52518634
Ceramide induces hepatocyte cell death through disruption of mitochondrial function in the rat.Q52524724
Ca2+ depletion prevents anoxic death of hepatocytes by inhibiting mitochondrial permeability transition.Q52541141
Modulation of the mitochondrial permeability transition pore by pyridine nucleotides and dithiol oxidation at two separate sites.Q52547831
Involvement of the dicarboxylate carrier in the protonophoric action of long-chain fatty acids in mitochondria.Q52552924
Perturbations in the control of cellular arachidonic acid levels block cell growth and induce apoptosis in HL-60 cells.Q53423505
Long-chain fatty acids promote opening of the reconstituted mitochondrial permeability transition pore.Q53902212
Mitochondrial function as a determinant of recovery or death in cell response to injury.Q53945860
Fatty acid-induced uncoupling of oxidative phosphorylation is partly due to opening of the mitochondrial permeability transition pore.Q53957729
Early migratory rat neural crest cells express functional gap junctions: evidence that neural crest cell survival requires gap junction functionQ74267386
The overexpression of Bax produces cell death upon induction of the mitochondrial permeability transitionQ74358996
Superoxide in apoptosis. Mitochondrial generation triggered by cytochrome c lossQ74495012
Formation and disappearance of an endogenous uncoupling factor during swelling and contraction of mitochondriaQ76423884
INDUCTION OF SWELLING OF LIVER MITOCHONDRIA BY FATTY ACIDS OF VARIOUS CHAIN LENGTHQ76626154
Protonophoric activity of fatty acid analogs and derivatives in the inner mitochondrial membrane: a further argument for the fatty acid cycling modelQ77165003
Structure and function of the uncoupling protein from brown adipose tissueQ77796455
Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome cQ24309066
Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expressionQ24309291
Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptorsQ24310559
Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosisQ24310597
The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCPQ24531899
Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosisQ24533270
PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acidQ24568285
Movement of Bax from the cytosol to mitochondria during apoptosisQ24677881
Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibitionQ28115131
Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteinsQ28117928
Fatty acid import into mitochondriaQ28138465
Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosisQ28139061
Endonuclease G is an apoptotic DNase when released from mitochondriaQ28206238
The Ca2+-induced membrane transition in mitochondria. III. Transitional Ca2+ releaseQ28211160
Mechanism and evolution of the uncoupling protein of brown adipose tissueQ28237840
The Ca2+-induced membrane transition in mitochondria. I. The protective mechanismsQ28305411
Propagation of the apoptotic signal by mitochondrial wavesQ28345086
Arachidonic acid as a bioactive moleculeQ28366329
Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas deathQ28586301
Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2)Q28586461
On the mechanism of fatty acid-induced proton transport by mitochondrial uncoupling proteinQ28646366
Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membraneQ28647586
The mitochondrial permeability transition pore may comprise VDAC moleculesQ29397664
Isolation and structure of a brain constituent that binds to the cannabinoid receptorQ29547476
The mitochondrial permeability transition pore and its role in cell deathQ29614183
Mitochondrial control of cell deathQ29617739
Formation and inactivation of endogenous cannabinoid anandamide in central neuronsQ29620558
Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomasQ29620630
Role of BAX in the apoptotic response to anticancer agentsQ31523620
Opening of the mitochondrial permeability transition pore causes depletion of mitochondrial and cytosolic NAD+ and is a causative event in the death of myocytes in postischemic reperfusion of the heart.Q31552541
Natural and azido fatty acids inhibit phosphate transport and activate fatty acid anion uniport mediated by the mitochondrial phosphate carrierQ31583143
The mitochondrial permeability transition, release of cytochrome c and cell death. Correlation with the duration of pore openings in situQ31779663
Physiological regulation of the transport activity in the uncoupling proteins UCP1 and UCP2.Q32139124
Oligomeric C-terminal truncated Bax preferentially releases cytochrome c but not adenylate kinase from mitochondria, outer membrane vesicles and proteoliposomesQ43750514
Anion permeation limits the uncoupling activity of fatty acids in mitochondriaQ43856760
Palmitate induces apoptosis via a direct effect on mitochondria.Q44666621
Does the function of adenine nucleotide translocase in fatty acid uncoupling depend on the type of mitochondria?Q44792395
Effect of metal cations on the inhibition of adenine nucleotide translocation by acyl-CoAQ45173595
Anadamide, an endogenous cannabinoid receptor agonist inhibits lymphocyte proliferation and induces apoptosisQ46850762
Fatty acid cycling mechanism and mitochondrial uncoupling proteinsQ47729445
Oxidative phosphorylation, Ca(2+) transport, and fatty acid-induced uncoupling in malaria parasites mitochondriaQ47862400
A plant cold-induced uncoupling proteinQ48045241
Complexes between kinases, mitochondrial porin and adenylate translocator in rat brain resemble the permeability transition poreQ48864569
Photoactivated azido fatty acid irreversibly inhibits anion and proton transport through the mitochondrial uncoupling proteinQ50336022
Commitment to apoptosis by GD3 ganglioside depends on opening of the mitochondrial permeability transition pore.Q51088828
The relationship between plasma free fatty acids and liver mitochondrial function in vivo.Q51613509
Fatty acid uncoupling of oxidative phosphorylation in rat liver mitochondria.Q51810665
On the mechanism of the so-called uncoupling effect of medium- and short-chain fatty acids.Q52460525
Cardiac fatty acid metabolism and the induction of apoptosisQ33688823
Formation of N-acyl-phosphatidylethanolamine and N-acylethanolamine (including anandamide) during glutamate-induced neurotoxicityQ33695254
Mitochondria and cell death. Mechanistic aspects and methodological issuesQ33734610
Mitochondrial transport of cations: channels, exchangers, and permeability transition.Q33744633
The mitochondrial uncoupling protein-2: current statusQ33800673
The role of cyclooxygenases in inflammation, cancer, and developmentQ33814331
Uncoupling protein--a useful energy dissipatorQ33827384
Anion carriers in fatty acid-mediated physiological uncouplingQ33827388
The mechanisms of fatty acid-induced proton permeability of the inner mitochondrial membrane.Q33827393
Fatty acid interaction with mitochondrial uncoupling proteinsQ33827398
Progress on the mitochondrial permeability transition pore: regulation by complex I and ubiquinone analogs.Q33832698
The internal structure of mitochondriaQ33953227
The movement of N-arachidonoylethanolamine (anandamide) across cellular membranesQ34098988
N-Acylethanolamines and precursor phospholipids - relation to cell injuryQ34098995
A mitochondrial perspective on cell deathQ34134640
Pathophysiological relevance of mitochondria in NAD(+) metabolism.Q34180523
Aspirin use and reduced risk of fatal colon cancerQ34567474
Regulation of the mitochondrial permeability transition pore by ubiquinone analogs. A progress reportQ34690048
Fatty acid circuit as a physiological mechanism of uncoupling of oxidative phosphorylationQ36849270
Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2.Q37366851
Solute carriers involved in energy transfer of mitochondria form a homologous protein familyQ39506741
Coordinate control of intermediary metabolism in rat liver by the insulin/glucagon ratio during starvation and after glucose refeeding. Regulatory significance of long-chain acyl-CoA and cyclic AMP.Q40109949
Transient and long-lasting openings of the mitochondrial permeability transition pore can be monitored directly in intact cells by changes in mitochondrial calcein fluorescenceQ40137371
Thermogenic mechanisms in brown fatQ40140016
The mitochondrial permeability transition.Q40462729
Recent progress on regulation of the mitochondrial permeability transition pore; a cyclosporin-sensitive pore in the inner mitochondrial membraneQ40615810
Effect of fatty acids on energy coupling processes in mitochondriaQ40859214
Regulation of the activity of caspases by L-carnitine and palmitoylcarnitineQ40865200
Phospholipase A2 is necessary for tumor necrosis factor alpha-induced ceramide generation in L929 cellsQ41100173
Inhibition of carnitine palmitoyltransferase I augments sphingolipid synthesis and palmitate-induced apoptosisQ41128299
Uncoupling effect of fatty acids on heart muscle mitochondria and submitochondrial particlesQ41146078
Cytosolic phospholipase A2 (PLA2), but not secretory PLA2, potentiates hydrogen peroxide cytotoxicity in kidney epithelial cellsQ41173304
Relationship between arachidonate--phospholipid remodeling and apoptosisQ41184105
Cyclooxygenase and lipoxygenase inhibitors in cancer therapyQ41306132
Partial inhibition by cyclosporin A of the swelling of liver mitochondria in vivo and in vitro induced by sub-micromolar [Ca2+], but not by butyrate. Evidence for two distinct swelling mechanismsQ42140765
N-Oleoylethanolamine inhibits glucosylation of natural ceramides in CHP-100 neuroepithelioma cells: possible implications for apoptosis.Q42468460
Identification and characterization of a protozoan uncoupling protein in Acanthamoeba castellaniiQ42475935
Regulation of the permeability transition pore in skeletal muscle mitochondria. Modulation By electron flow through the respiratory chain complex i.Q42677114
Fatty acid oxidation by liver and muscle preparations of exhaustively exercised ratsQ42869112
Three classes of ubiquinone analogs regulate the mitochondrial permeability transition pore through a common siteQ43504935
Calcium and pyridine nucleotide interaction in mitochondrial membranesQ43507689
Arachidonic acid causes cell death through the mitochondrial permeability transition. Implications for tumor necrosis factor-alpha aopototic signalingQ43514127
Induction of apoptosis through B-cell receptor cross-linking occurs via de novo generated C16-ceramide and involves mitochondriaQ43559569
Palmitate-induced apoptosis can occur through a ceramide-independent pathwayQ43559742
Alkylsulfonates as probes of uncoupling protein transport mechanism. Ion pair transport demonstrates that direct H(+) translocation by UCP1 is not necessary for uncoupling.Q43684813
Fatty acid-promoted mitochondrial permeability transition by membrane depolarization and binding to the ADP/ATP carrier.Q53959848
On the voltage dependence of the mitochondrial permeability transition pore. A critical appraisal.Q53969386
Opening of the mitochondrial permeability transition pore by uncoupling or inorganic phosphate in the presence of Ca2+ is dependent on mitochondrial-generated reactive oxygen species.Q53992783
Inhibition of the mitochondrial permeability transition by cyclosporin A during long time frame experiments: relationship between pore opening and the activity of mitochondrial phospholipases.Q53998526
On the effects of paraquat on isolated mitochondria. Evidence that paraquat causes opening of the cyclosporin A-sensitive permeability transition pore synergistically with nitric oxide.Q54009695
The ATP/ADP-antiporter is involved in the uncoupling effect of fatty acids on mitochondria.Q54350597
Influence of fatty acids on energy metabolism. 1. Stimulation of oxygen consumption, ketogenesis and CO2 production following addition of octanoate and oleate in perfused rat liver.Q54679543
The Ca2+-induced membrane transition in mitochondriaQ57309821
Palmitate-mediated Alterations in the Fatty Acid Metabolism of Rat Neonatal Cardiac MyocytesQ57635890
A Ubiquinone-binding Site Regulates the Mitochondrial Permeability Transition PoreQ58454362
Regulation of the permeability transition pore, a voltage-dependent mitochondrial channel inhibited by cyclosporin AQ58454400
Coenzyme Q is an obligatory cofactor for uncoupling protein functionQ59059866
PUMPing plantsQ60074375
Fatty acids induced uncoupling of Saccharomyces cerevisiae mitochondria requires an intact ADP/ATP carrier.Q64975626
N-acylethanolamine accumulation in infarcted myocardiumQ66970879
Toxicity of free fatty acids for cultured rat heart muscle and endothelioid cells. I. Saturated long-chain fatty acidsQ67412259
Toxicity of free fatty acids for cultured rat heart muscle and endothelioid cells. II. Unsaturated long-chain fatty acidsQ67412261
Effect of oleate on the apparent Km of monoamine oxidase and the amount of membrane-bound hexokinase in isolated rat hepatocytes: further evidence for the controlling role of the surface charge in hexokinase bindingQ68376075
The inhibition of translocation of adenine nucleotides through mitochondrial membranes by oleateQ68398986
Adenine nucleotide translocation of mitochondria. Identification of carrier sitesQ68462131
Long-chain fatty acids act as protonophoric uncouplers of oxidative phosphorylation in rat liver mitochondriaQ69360691
An appraisal of the functional significance of the inhibitory effect of long chain acyl-CoAs on mitochondrial transportsQ70049692
Photomodification of mitochondrial proteins by azido fatty acids and its effect on mitochondrial energetics. Further evidence for the role of the ADP/ATP carrier in fatty-acid-mediated uncouplingQ71614972
The inhibition of adenine nucleotide translocase activity by oleoyl CoA and its reversal in rat liver mitochondriaQ71804769
Prospective study of plasma fatty acids and risk of prostate cancerQ72365231
A metabolic role for mitochondria in palmitate-induced cardiac myocyte apoptosisQ73112699
De novo-synthesized ceramide signals apoptosis in astrocytes via extracellular signal-regulated kinaseQ73127880
Anandamide and 2-arachidonoylglycerol inhibit fatty acid amide hydrolase by activating the lipoxygenase pathway of the arachidonate cascadeQ73235467
Involvement of aspartate/glutamate antiporter in fatty acid-induced uncoupling of liver mitochondriaQ73296939
Inactive fatty acids are unable to flip-flop across the lipid bilayerQ73425115
A structure-activity study of fatty acid interaction with mitochondrial uncoupling proteinQ73425119
First evidence and characterization of an uncoupling protein in fungi kingdom: CpUCP of Candida parapsilosisQ73450411
Interaction of mitochondrial phosphate carrier with fatty acids and hydrophobic phosphate analogsQ73591280
Long-chain fatty acid-promoted swelling of mitochondria: further evidence for the protonophoric effect of fatty acids in the inner mitochondrial membraneQ73666085
Overexpression of cyclooxygenase-2 is sufficient to induce tumorigenesis in transgenic miceQ73693790
Anandamide induces apoptosis of PC-12 cells: involvement of superoxide and caspase-3Q73713217
Reconstituted plant uncoupling mitochondrial protein allows for proton translocation via fatty acid cycling mechanismQ73717932
Antagonism of arachidonic acid is linked to the antitumorigenic effect of dietary eicosapentaenoic acid in Apc(Min/+) miceQ73763480
Palmitate-induced apoptosis in cardiomyocytes is mediated through alterations in mitochondria: prevention by cyclosporin AQ73764620
Thyroid hormone-induced expression of the ADP/ATP carrier and its effect on fatty acid-induced uncoupling of oxidative phosphorylationQ73879374
Determination of the phospholipid precursor of anandamide and other N-acylethanolamine phospholipids before and after sodium azide-induced toxicity in cultured neocortical neuronsQ74016123
Regulation of constitutive cyclooxygenase-2 expression in colon carcinoma cellsQ74127393
Mitochondria uncoupling by a long chain fatty acyl analogueQ74167592
P921main subjectcell deathQ2383867
fatty acidQ61476
P304page(s)97-126
P577publication date2002-01-01
P1433published inVitamins and HormonesQ15753296
P1476titleMitochondrial energy dissipation by fatty acids. Mechanisms and implications for cell death
P478volume65

Reverse relations

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