Pathogenesis of insulin resistance in skeletal muscle

scientific article

Pathogenesis of insulin resistance in skeletal muscle is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1155/2010/476279
P932PMC publication ID2860140
P698PubMed publication ID20445742
P5875ResearchGate publication ID44576285

P50authorRalph A. DeFronzoQ58689309
P2093author name stringMuhammad A Abdul-Ghani
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Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetesQ33853693
Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) ratsQ33857313
Signalling through the insulin receptorQ33860499
Characterization of cellular defects of insulin action in type 2 (non-insulin-dependent) diabetes mellitusQ33889791
Regulation of phosphatidylinositol 3-kinase activity in liver and muscle of animal models of insulin-resistant and insulin-deficient diabetes mellitusQ33904740
Signaling pathways in insulin action: molecular targets of insulin resistanceQ33973814
Insulin resistance in morbid obesity: reversal with intramyocellular fat depletionQ34106543
Transmembrane glucose transport in skeletal muscle of patients with non-insulin-dependent diabetesQ34114343
Nomenclature of the GLUT/SLC2A family of sugar/polyol transport facilitators.Q34117304
Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents.Q34126257
Studies on the mechanism of insulin resistance in the liver from humans with noninsulin-dependent diabetes. Insulin action and binding in isolated hepatocytes, insulin receptor structure, and kinase activityQ34182065
Intracellular glucose oxidation and glycogen synthase activity are reduced in non-insulin-dependent (type II) diabetes independent of impaired glucose uptakeQ34243161
Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approachQ34294997
Molecular and linkage analysis of type-1 protein phosphatase catalytic beta-subunit gene: lack of evidence for its major role in insulin resistance in Pima IndiansQ34314399
Impaired mitochondrial substrate oxidation in muscle of insulin-resistant offspring of type 2 diabetic patientsQ34370850
GSK3 takes centre stage more than 20 years after its discoveryQ34374129
Demonstration of insulin resistance in untreated adult onset diabetic subjects with fasting hyperglycemiaQ34474718
Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitusQ34541876
Diabetes trends in the U.S.: 1990-1998.Q44590624
Discordant effects of a chronic physiological increase in plasma FFA on insulin signaling in healthy subjects with or without a family history of type 2 diabetesQ44883028
Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport and increased sarcolemmal FAT/CD36.Q44888045
Regulation of plasma long-chain fatty acid oxidation in relation to uptake in human skeletal muscle during exerciseQ44928887
Intracellular defects in glucose metabolism in obese patients with NIDDM.Q45156124
Glucose Intolerance and Aging: Evidence for Tissue Insensitivity to InsulinQ45186876
Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetesQ45199109
Additive effects of insulin and muscle contraction on fatty acid transport and fatty acid transporters, FAT/CD36, FABPpm, FATP1, 4 and 6.Q45968554
Role of human skeletal muscle insulin receptor kinase in the in vivo insulin resistance of noninsulin-dependent diabetes mellitus and obesity.Q46017837
Prospective investigation of metabolic characteristics in relation to weight gain in older adults: the Hoorn StudyQ46131438
Dose-response effect of elevated plasma free fatty acid on insulin signalingQ46513253
Measurement of plasma glucose, free fatty acid, lactate, and insulin for 24 h in patients with NIDDM.Q46624327
Insulin sensitivity in African-American children with and without family history of type 2 diabetesQ46674629
Effect of a sustained reduction in plasma free fatty acid concentration on intramuscular long-chain fatty Acyl-CoAs and insulin action in type 2 diabetic patientsQ46774705
Development of hyperinsulinemia and insulin resistance during the early stage of weight gainQ46825836
Impact of exercise training on insulin sensitivity, physical fitness, and muscle oxidative capacity in first-degree relatives of type 2 diabetic patientsQ46849852
Increased lipid availability impairs insulin-stimulated ATP synthesis in human skeletal muscleQ46870183
Decreased non-insulin-dependent glucose clearance contributes to the rise in fasting plasma glucose in the nondiabetic rangeQ46901912
Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetesQ46915798
Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight lossQ47251032
Changes induced by physical activity and weight loss in the morphology of intermyofibrillar mitochondria in obese men and womenQ47338109
Effects of weight loss and physical activity on skeletal muscle mitochondrial function in obesityQ47398932
Genetic variants in promoters and coding regions of the muscle glycogen synthase and the insulin-responsive GLUT4 genes in NIDDM.Q48080300
An electrophoretic study of the distribution and properties of human hexokinasesQ48426127
Overnight lowering of free fatty acids with Acipimox improves insulin resistance and glucose tolerance in obese diabetic and nondiabetic subjects.Q51561168
A null mutation in murine CD36 reveals an important role in fatty acid and lipoprotein metabolism.Q51562671
Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study.Q51565080
Insulin resistance in chronic heart failure: relation to severity and etiology of heart failure.Q51574264
Metabolic defects in lean nondiabetic offspring of NIDDM parents: a cross-sectional study.Q51575337
Skeletal muscle triglyceride levels are inversely related to insulin action.Q51575343
Insulin resistance and coronary artery disease.Q51578743
Insulin action on glucose transport and plasma membrane GLUT4 content in skeletal muscle from patients with NIDDM.Q51579259
Intramuscular triglyceride and muscle insulin sensitivity: evidence for a relationship in nondiabetic subjects.Q51580403
Elevation of serum insulin concentration during euglycemic hyperinsulinemic clamp studies leads to similar activation of insulin receptor kinase in skeletal muscle of subjects with and without NIDDM.Q51584932
Tissue oxidative capacity, fuel stores and skeletal muscle fatty acid composition in obesity-prone and obesity-resistant rats.Q51586048
The metabolic profile of NIDDM is fully established in glucose-tolerant offspring of two Mexican-American NIDDM parentsQ51603248
Effect of insulin on oxidative and nonoxidative pathways of free fatty acid metabolism in human obesity.Q51604953
Skeletal muscle glycogen synthase activity in subjects with non-insulin-dependent diabetes mellitus after glyburide therapy.Q51613792
Oxidative and non-oxidative glucose metabolism in non-obese type 2 (non-insulin-dependent) diabetic patients.Q51624905
Human Forearm Muscle Metabolism during Exercise II Uptake, release and oxidation of individual FFA and glycerolQ53023760
Insulin action and insulin resistance: diseases involving defects in insulin receptors, signal transduction, and the glucose transport effector system.Q54117527
Reversal of chronic alterations of skeletal muscle protein kinase C from fat-fed rats by BRL-49653.Q54151747
Polymorphisms of the human hexokinase II gene: lack of association with NIDDM and insulin resistance.Q54174859
Insulin resistance in type 2 (non-insulin-dependent) diabetic patients and their relatives is not associated with a defect in the expression of the insulin-responsive glucose transporter (GLUT-4) gene in human skeletal muscleQ54276480
Impaired expression of glycogen synthase mRNA in skeletal muscle of NIDDM patients.Q54284119
Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylationQ37580452
Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular diseaseQ37742798
Modest PGC-1alpha overexpression in muscle in vivo is sufficient to increase insulin sensitivity and palmitate oxidation in subsarcolemmal, not intermyofibrillar, mitochondriaQ38295319
Metabolism of Free Fatty Acids and Ketone Bodies During Exercise in Normal and Diabetic ManQ39644506
Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM.Q39648063
Adaptations of skeletal muscle to endurance exercise and their metabolic consequencesQ40178125
Mitochondrial dysfunction induces aberrant insulin signalling and glucose utilisation in murine C2C12 myotube cellsQ40273568
Insulin secretion, insulin action, and hepatic glucose production in identical twins discordant for non-insulin-dependent diabetes mellitusQ40342100
Effect of the antilipolytic nicotinic acid analogue acipimox on whole-body and skeletal muscle glucose metabolism in patients with non-insulin-dependent diabetes mellitusQ40342372
Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications.Q40452210
Arachidonic acid and free fatty acids as second messengers and the role of protein kinase CQ40475595
Decreased insulin activation of glycogen synthase in skeletal muscles in young nonobese Caucasian first-degree relatives of patients with non-insulin-dependent diabetes mellitusQ41019246
The role of free fatty acid metabolism in the pathogenesis of insulin resistance in obesity and noninsulin-dependent diabetes mellitusQ41176971
Analysis of the signaling pathway involved in the regulation of hexokinase II gene transcription by insulinQ41185163
Evidence against altered expression of GLUT1 or GLUT4 in skeletal muscle of patients with obesity or NIDDM.Q41232527
Mitogen-activated protein kinase kinase inhibition does not block the stimulation of glucose utilization by insulinQ41302003
Carbohydrate and lipid metabolism of skeletal muscle in type 2 diabetic patientsQ41357348
The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated proteQ41437636
Troglitazone prevents glucose-induced insulin resistance of insulin receptor in rat-1 fibroblastsQ41486246
Insulin binding in diabetes. Relationships with plasma insulin levels and insulin sensitivityQ41964676
Lower intrinsic ADP-stimulated mitochondrial respiration underlies in vivo mitochondrial dysfunction in muscle of male type 2 diabetic patientsQ42439774
Insulin Binding and Responsiveness in Fat Cells from Patients with Reduced Glucose Tolerance and Type II DiabetesQ42454831
Expression and function of IRS-1 in insulin signal transmission.Q42455127
Sustained reduction in plasma free fatty acid concentration improves insulin action without altering plasma adipocytokine levels in subjects with strong family history of type 2 diabetesQ42467298
Chronic kidney disease causes defects in signaling through the insulin receptor substrate/phosphatidylinositol 3-kinase/Akt pathway: implications for muscle atrophyQ42493294
Glucose uptake and metabolism by cultured human skeletal muscle cells: rate-limiting stepsQ42505768
Adipocyte glycogen synthase and pyruvate dehydrogenase in obese and type II diabetic subjectsQ42511444
Association of the glycogen synthase locus on 19q13 with NIDDM in Pima IndiansQ42520400
Does impaired mitochondrial function affect insulin signaling and action in cultured human skeletal muscle cells?Q42520636
Differential effect of chronic treatment with two beta-blocking agents on insulin sensitivity: the carvedilol-metoprolol studyQ42554675
Human hexokinase II mRNA and gene structureQ42691343
Localization of adipocyte long-chain fatty acyl-CoA synthetase at the plasma membrane.Q42816411
Insulin stimulation of glycogen synthesis and glycogen synthase activity is blocked by wortmannin and rapamycin in 3T3-L1 adipocytes: evidence for the involvement of phosphoinositide 3-kinase and p70 ribosomal protein-S6 kinaseQ42823635
Hyperinsulinemia in nonobese women reporting a moderate weight gain at the beginning of menopause: a useful early measure of susceptibility to insulin resistanceQ43278211
Large energetic adaptations of elderly muscle to resistance and endurance trainingQ43572818
Regulation by insulin of gene expression in human skeletal muscle and adipose tissue. Evidence for specific defects in type 2 diabetes.Q43596031
Increased fatty acid uptake and altered fatty acid metabolism in insulin-resistant muscle of obese Zucker ratsQ43618939
Effects of acute changes of plasma free fatty acids on intramyocellular fat content and insulin resistance in healthy subjectsQ43651825
Interactions of impaired glucose transport and phosphorylation in skeletal muscle insulin resistance: a dose-response assessment using positron emission tomographyQ43719966
Skeletal muscle insulin resistance in normoglycemic subjects with a strong family history of type 2 diabetes is associated with decreased insulin-stimulated insulin receptor substrate-1 tyrosine phosphorylationQ43778798
Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetesQ43833528
The effect of concurrent endurance and strength training on quantitative estimates of subsarcolemmal and intermyofibrillar mitochondriaQ43843917
Normalization of plasma glucose concentration by insulin therapy improves insulin-stimulated glycogen synthesis in type 2 diabetesQ43867562
Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscleQ43990155
Evaluation of insulin resistance and metabolic syndrome in patients with polycystic ovary syndrome.Q44002285
Force generation, but not myosin ATPase activity, declines with age in rat muscle fibersQ44021411
Leptin increases FA oxidation in lean but not obese human skeletal muscle: evidence of peripheral leptin resistanceQ44030261
Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alphaQ44043178
Free fatty acid-induced hepatic insulin resistance: a potential role for protein kinase C-deltaQ44129305
Contribution of abnormal muscle and liver glucose metabolism to postprandial hyperglycemia in NIDDM.Q44216727
Skeletal muscle lipid metabolism with obesityQ44355154
Abnormal cardiac and skeletal muscle energy metabolism in patients with type 2 diabetesQ44480693
Impact of aerobic exercise training on age-related changes in insulin sensitivity and muscle oxidative capacityQ44527020
Enhanced fat oxidation through physical activity is associated with improvements in insulin sensitivity in obesityQ44563999
Decreased kinase activity of insulin receptors from adipocytes of non-insulin-dependent diabetic subjectsQ34556125
Insulin receptor kinase in human skeletal muscle from obese subjects with and without noninsulin dependent diabetesQ34570368
Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. Evidence for multiple sites of insulin resistanceQ34577169
Relationship between obesity and maximal insulin-stimulated glucose uptake in vivo and in vitro in Pima IndiansQ34605902
Decreased muscle glucose transport/phosphorylation is an early defect in the pathogenesis of non-insulin-dependent diabetes mellitusQ34669998
Influence of dietary fat composition on development of insulin resistance in rats. Relationship to muscle triglyceride and omega-3 fatty acids in muscle phospholipidQ35013075
Metabolic and molecular basis of insulin resistanceQ35148800
Energy translocation across cell membranes and membrane modelsQ35178592
Regulation of glycogen synthase and phosphorylase activities by glucose and insulin in human skeletal muscleQ35575530
Effects of insulin infusion on human skeletal muscle pyruvate dehydrogenase, phosphofructokinase, and glycogen synthase. Evidence for their role in oxidative and nonoxidative glucose metabolismQ35578164
Role of glucose transporters in the cellular insulin resistance of type II non-insulin-dependent diabetes mellitusQ35588279
Reversibility of defective adipocyte insulin receptor kinase activity in non-insulin-dependent diabetes mellitus. Effect of weight lossQ35591970
Glycogen synthase and phosphofructokinase protein and mRNA levels in skeletal muscle from insulin-resistant patients with non-insulin-dependent diabetes mellitus.Q35609877
Patients with type 2 diabetes have normal mitochondrial function in skeletal muscleQ35676919
The role of lipid accumulation in liver and muscle for insulin resistance and type 2 diabetes mellitus in humansQ35711963
Effects of fat on glucose uptake and utilization in patients with non-insulin-dependent diabetesQ35762624
Studies of plasma membrane fatty acid-binding protein and other lipid-binding proteins in human skeletal muscleQ35855930
Pathogenesis of type 2 diabetes mellitusQ35861736
Metabolic fluxes in skeletal muscle in relation to obesity and insulin resistanceQ36252474
Muscle triglycerides and mitochondrial function: possible mechanisms for the development of type 2 diabetesQ36356864
Diabetes and mitochondrial function: role of hyperglycemia and oxidative stress.Q36401757
Lipodystrophy: lessons in lipid and energy metabolismQ36419149
Etiology of insulin resistanceQ36431215
Pathways leading to muscle insulin resistance--the muscle--fat connectionQ36576544
Isolation and Characterization of the Human Muscle Glycogen Synthase GeneQ36692469
Muscle-specific IRS-1 Ser->Ala transgenic mice are protected from fat-induced insulin resistance in skeletal muscleQ36906334
Insulin signaling and glucose transport in insulin resistant human skeletal muscleQ36914873
In vitro insulin resistance of human adipocytes isolated from subjects with noninsulin-dependent diabetes mellitusQ36991208
An in vivo and in vitro study of the mechanism of prednisone-induced insulin resistance in healthy subjectsQ36992538
Insulin Binding to Monocytes and Insulin Action in Human Obesity, Starvation, and RefeedingQ37030221
Insulin Sensitivity and Insulin Binding to Monocytes in Maturity-Onset DiabetesQ37038173
Molecular mechanisms of skeletal muscle insulin resistance in type 2 diabetes.Q37065529
Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitusQ37141727
Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscleQ37175187
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P921main subjectpathogenesisQ372016
human musculoskeletal systemQ726543
tissueQ40397
insulin resistanceQ1053470
preproinsulinQ7240673
physiological phenomenonQ66615932
P304page(s)476279
P577publication date2010-04-26
P1433published inJournal of Biomedicine and BiotechnologyQ15752146
P1476titlePathogenesis of insulin resistance in skeletal muscle
P478volume2010

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Q33814873Genetic-epigenetic interactions in cis: a major focus in the post-GWAS era
Q28567664Genomic and metabolic responses to methionine-restricted and methionine-restricted, cysteine-supplemented diets in Fischer 344 rat inguinal adipose tissue, liver and quadriceps muscle
Q47821534Gestational Protein Restriction Impairs Glucose Disposal in the Gastrocnemius Muscles of Female Rats.
Q47890264Gestational Protein Restriction in Wistar Rats; Effect of Taurine Supplementation on Properties of Newborn Skeletal Muscle.
Q33901226Gestational protein restriction impairs insulin-regulated glucose transport mechanisms in gastrocnemius muscles of adult male offspring
Q90570276Glucose Uptake and Insulin Response in Tissue-engineered Human Skeletal Muscle
Q37368731Glucose-6-phosphate dehydrogenase contributes to the regulation of glucose uptake in skeletal muscle.
Q58114787Glucose-Mediated Glucose Disposal at Baseline Insulin is Impaired in IFG
Q34604686Guava leaf extracts promote glucose metabolism in SHRSP.Z-Leprfa/Izm rats by improving insulin resistance in skeletal muscle
Q33831849Gut microbiota, probiotics and diabetes.
Q58762736High Fat With High Sucrose Diet Leads to Obesity and Induces Myodegeneration
Q34871681High-fat diet feeding alters metabolic response to fasting/non fasting conditions. Effect on caveolin expression and insulin signalling.
Q26773988Hyperglycemic Stress and Carbon Stress in Diabetic Glucotoxicity
Q36628044Impaired glucose metabolism and exercise capacity with muscle-specific glycogen synthase 1 (gys1) deletion in adult mice
Q36279150Increased adipose protein carbonylation in human obesity
Q51103206Increased body fat mass and tissue lipotoxicity associated with ovariectomy or high-fat diet differentially affects bone and skeletal muscle metabolism in rats.
Q33646768Increased interaction with insulin receptor substrate 1, a novel abnormality in insulin resistance and type 2 diabetes.
Q41469912Insulin Control of Blood Glucose and GLUT4 Expression in the Skeletal Muscle of Septic Rats
Q48056892Insulin action in the brain: Roles in energy and glucose homeostasis
Q83452752Insulin resistance
Q42580599Insulin-dependent H2O2 production is higher in muscle fibers of mice fed with a high-fat diet
Q35620997Irisin and Myonectin Regulation in the Insulin Resistant Muscle: Implications to Adipose Tissue: Muscle Crosstalk
Q47755876Is It Time to Change the Type 2 Diabetes Treatment Paradigm? Yes! GLP-1 RAs Should Replace Metformin in the Type 2 Diabetes Algorithm.
Q38205763Knockout mouse models of insulin signaling: Relevance past and future
Q48246662Lipopolysaccharide inhibits hepatic gluconeogenesis in rats: The role of immune cells
Q41690998Liver Adiposity and Metabolic Profile in Individuals with Chronic Spinal Cord Injury.
Q34168368Liver and muscle in morbid obesity: the interplay of fatty liver and insulin resistance.
Q35927659Long-term high-fat-diet feeding induces skeletal muscle mitochondrial biogenesis in rats in a sex-dependent and muscle-type specific manner.
Q92854127Maternal Selenium Deficiency in Mice Alters Offspring Glucose Metabolism and Thyroid Status in a Sexually Dimorphic Manner
Q36184050Maternal moderate physical training during pregnancy attenuates the effects of a low-protein diet on the impaired secretion of insulin in rats: potential role for compensation of insulin resistance and preventing gestational diabetes mellitus
Q35744922Mechanisms Linking Inflammation to Insulin Resistance
Q28731457Metabolic control by S6 kinases depends on dietary lipids
Q26830631Metabolic disturbance in PCOS: clinical and molecular effects on skeletal muscle tissue
Q47235131Microbial Regulation of Glucose Metabolism and Insulin Resistance
Q39739679Mild Hyperbaric Oxygen Improves Decreased Oxidative Capacity of Spinal Motoneurons Innervating the Soleus Muscle of Rats with Type 2 Diabetes
Q41180449Mild Hyperbaric Oxygen Inhibits Growth-related Decrease in Muscle Oxidative Capacity of Rats with Metabolic Syndrome
Q38171425Mitochondria in metabolic disease: getting clues from proteomic studies.
Q96953430Mitochondrial Utilization of Competing Fuels Is Altered in Insulin Resistant Skeletal Muscle of Non-obese Rats (Goto-Kakizaki)
Q36320932Mitochondrial antioxidative capacity regulates muscle glucose uptake in the conscious mouse: effect of exercise and diet
Q35543642Mitochondrial dysfunction and insulin resistance from the outside in: extracellular matrix, the cytoskeleton, and mitochondria
Q36294297Molecular targets related to inflammation and insulin resistance and potential interventions
Q34878940Multiple implications of 3-phosphoinositide-dependent protein kinase 1 in human cancer.
Q36021653Muscular dystrophies at different ages: metabolic and endocrine alterations
Q42534113MyomiRs as Markers of Insulin Resistance and Decreased Myogenesis in Skeletal Muscle of Diet-Induced Obese Mice.
Q30008893Next-generation sequencing methylation profiling of subjects with obesity identifies novel gene changes
Q89624036Non-alcoholic fatty liver disease in lean individuals
Q64098845Overexpression of Long-Chain Acyl-CoA Synthetase 5 Increases Fatty Acid Oxidation and Free Radical Formation While Attenuating Insulin Signaling in Primary Human Skeletal Myotubes
Q37992232PTP1B and TCPTP--nonredundant phosphatases in insulin signaling and glucose homeostasis
Q35864829Pathobiochemical changes in diabetic skeletal muscle as revealed by mass-spectrometry-based proteomics
Q33849720Pathogenesis of chronic hyperglycemia: from reductive stress to oxidative stress
Q37845220Peripheral effects of the endocannabinoid system in energy homeostasis: adipose tissue, liver and skeletal muscle
Q36297299Phenolic compounds isolated from fermented blueberry juice decrease hepatocellular glucose output and enhance muscle glucose uptake in cultured murine and human cells
Q49117467Plasma carnosine, but not muscle carnosine, attenuates high-fat diet-induced metabolic stress
Q52745102Potential epigenetic biomarkers of obesity-related insulin resistance in human whole-blood.
Q48199112Potential of rooibos, its major C-glucosyl flavonoids, and Z-2-(β-D-glucopyranosyloxy)-3-phenylpropenoic acid in prevention of metabolic syndrome
Q34766541Pre- and early-postnatal nutrition modify gene and protein expressions of muscle energy metabolism markers and phospholipid Fatty Acid composition in a muscle type specific manner in sheep
Q37106937Prediabetes as a toxic environment for the initiation of microvascular and macrovascular complications
Q34718215Progesterone increases skeletal muscle mitochondrial H2O2 emission in nonmenopausal women
Q35653805Protein phosphatase 1 regulatory subunit 12A and catalytic subunit δ, new members in the phosphatidylinositide 3 kinase insulin-signaling pathway
Q34122700Proteomic analysis of gastrocnemius muscle in rats with streptozotocin-induced diabetes and chronically exposed to fluoride
Q34551875Proteomic analysis of skeletal muscle in insulin-resistant mice: response to 6-week aerobic exercise
Q36007826Proteomic analysis reveals cellular pathways regulating carbohydrate metabolism that are modulated in primary human skeletal muscle culture due to treatment with bioactives from Artemisia dracunculus L.
Q38980335Quantitative phosphoproteomics reveals novel phosphorylation events in insulin signaling regulated by protein phosphatase 1 regulatory subunit 12A.
Q54979343Rac1 muscle knockout exacerbates the detrimental effect of high-fat diet on insulin-stimulated muscle glucose uptake independently of Akt.
Q34110159Reduction in inflammatory gene expression in skeletal muscle from Roux-en-Y gastric bypass patients randomized to omentectomy
Q89983362Resveratrol alleviates obesity-induced skeletal muscle inflammation via decreasing M1 macrophage polarization and increasing the regulatory T cell population
Q49723467Revisiting the metabolic syndrome: the emerging role of aquaglyceroporins.
Q37724096Risk of postprandial insulin resistance: the liver/vagus rapport
Q38998401Role of AMP-Activated Protein Kinase for Regulating Post-exercise Insulin Sensitivity.
Q91121470Role of Complement and Complement-Related Adipokines in Regulation of Energy Metabolism and Fat Storage
Q24610857Role of nuclear receptor corepressor RIP140 in metabolic syndrome
Q27013026Roles of interstitial fluid pH in diabetes mellitus: Glycolysis and mitochondrial function
Q37163006SCD1 activity in muscle increases triglyceride PUFA content, exercise capacity, and PPARδ expression in mice
Q64059121SELENON (SEPN1) protects skeletal muscle from saturated fatty acid-induced ER stress and insulin resistance
Q47599401Sarcopenia is associated with an increased risk of advanced colorectal neoplasia
Q92662966Sarcopenic Obesity, Insulin Resistance, and Their Implications in Cardiovascular and Metabolic Consequences
Q38025166Second generation CB1 receptor blockers and other inhibitors of peripheral endocannabinoid overactivity and the rationale of their use against metabolic disorders
Q38436848Skeletal Muscle Vascular Function: A Counterbalance of Insulin Action.
Q102328552Skeletal muscle atrophy in heart failure with diabetes: from molecular mechanisms to clinical evidence
Q38261195Skeletal muscle glucose metabolism and inflammation in the development of the metabolic syndrome.
Q35128702Skeletal muscle proteomics: current approaches, technical challenges and emerging techniques
Q35088530Stem cells for skeletal muscle repair
Q28388533Sunflower oil supplementation has proinflammatory effects and does not reverse insulin resistance in obesity induced by high-fat diet in C57BL/6 mice
Q64903345Targeting ER stress/ER stress response in myopathies.
Q64255905Targeting the Zinc Transporter ZIP7 in the Treatment of Insulin Resistance and Type 2 Diabetes
Q92854149The Effects of Poncirus fructus on Insulin Resistance and the Macrophage-Mediated Inflammatory Response in High Fat Diet-Induced Obese Mice
Q89901290The Endothelial Barrier Is not Rate-limiting to Insulin Action in the Myocardium of Male Mice
Q45988896The FGF21 response to fructose predicts metabolic health and persists after bariatric surgery in obese humans.
Q29247855The Impact of Shiftwork on Skeletal Muscle Health
Q57810299The Proposal of Molecular Mechanisms of Weak Organic Acids Intake-Induced Improvement of Insulin Resistance in Diabetes Mellitus via Elevation of Interstitial Fluid pH
Q42803551The fatty acid-rich fraction of Eruca sativa (rocket salad) leaf extract exerts antidiabetic effects in cultured skeletal muscle, adipocytes and liver cells
Q33600053The nature, significance, and glucagon-like peptide-1 analog treatment of brain insulin resistance in Alzheimer's disease
Q38328228The proteomic signature of insulin-resistant human skeletal muscle reveals increased glycolytic and decreased mitochondrial enzymes.
Q38040181The role of the endocannabinoid system in skeletal muscle and metabolic adaptations to exercise: potential implications for the treatment of obesity
Q40997556To explain the variation of OGTT dynamics by biological mechanisms: a novel approach based on principal components analysis in women with history of GDM.
Q38879146Toona Sinensis ameliorates insulin resistance via AMPK and PPARγ pathways
Q34504189Trace elements in glucometabolic disorders: an update
Q28395286Translating the basic knowledge of mitochondrial functions to metabolic therapy: role of L-carnitine
Q26783350Treatment of prediabetes
Q47913074VLDL and apolipoprotein CIII induce ER stress and inflammation and attenuate insulin signalling via Toll-like receptor 2 in mouse skeletal muscle cells.
Q89036802Voluntary exercise opposes insulin resistance of skeletal muscle glucose transport during liquid fructose ingestion in rats
Q38241464What are the pharmacotherapy options for treating prediabetes?
Q48159058Zinc stimulates glucose oxidation and glycemic control by modulating the insulin signaling pathway in human and mouse skeletal muscle cell lines
Q47127733Zinc transporters and insulin resistance: therapeutic implications for type 2 diabetes and metabolic disease.
Q35753755iTRAQ-based quantitative proteomic analysis of longissimus muscle from growing pigs with dietary supplementation of non-starch polysaccharide enzymes

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