Markers of skeletal muscle mitochondrial function and lipid accumulation are moderately associated with the homeostasis model assessment index of insulin resistance in obese men

scientific article (publication date: 2013)

Markers of skeletal muscle mitochondrial function and lipid accumulation are moderately associated with the homeostasis model assessment index of insulin resistance in obese men is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2013PLoSO...866322S
P356DOI10.1371/JOURNAL.PONE.0066322
P3181OpenCitations bibliographic resource ID3259039
P932PMC publication ID3680409
P698PubMed publication ID23776659
P5875ResearchGate publication ID239942434

P50authorAdeel SafdarQ30505500
Mazen J. HamadehQ30506420
Sandeep RahaQ42893231
Jonathan P. LittleQ51093621
Mark A TarnopolskyQ89229965
Imtiaz A SamjooQ90682341
Alexander GloverQ99210151
P2093author name stringJose Santana
Gregory R Steinberg
Nicholas J Mocellin
P2860cites workProtein measurement with the Folin phenol reagentQ20900776
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Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunctionQ24632414
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1Q24679555
Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in manQ26776977
PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetesQ29547229
Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetesQ29614548
Dysfunction of mitochondria in human skeletal muscle in type 2 diabetesQ29616567
Mitochondrial dysfunction and type 2 diabetesQ29617913
Cellular mechanisms of insulin resistanceQ29619549
Increased basal level of Akt-dependent insulin signaling may be responsible for the development of insulin resistanceQ30434586
Deficiency of electron transport chain in human skeletal muscle mitochondria in type 2 diabetes mellitus and obesityQ33589062
Aberrant mitochondrial homeostasis in the skeletal muscle of sedentary older adultsQ33592857
Integration of microRNA changes in vivo identifies novel molecular features of muscle insulin resistance in type 2 diabetesQ33762245
Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activityQ33834971
Lipid partitioning, incomplete fatty acid oxidation, and insulin signal transduction in primary human muscle cells: effects of severe obesity, fatty acid incubation, and fatty acid translocase/CD36 overexpressionQ34086699
Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents.Q34126257
Low-volume interval training improves muscle oxidative capacity in sedentary adultsQ34174192
Skeletal muscle mitochondria in insulin resistance: differences in intermyofibrillar versus subsarcolemmal subpopulations and relationship to metabolic flexibility.Q34622538
Muscle triglyceride and insulin resistanceQ34676006
Exercise increases mitochondrial PGC-1alpha content and promotes nuclear-mitochondrial cross-talk to coordinate mitochondrial biogenesis.Q34695923
Skeletal muscle mitochondrial capacity and insulin resistance in type 2 diabetesQ34758533
Patients with type 2 diabetes have normal mitochondrial function in skeletal muscleQ35676919
The role of exercise and PGC1alpha in inflammation and chronic diseaseQ36984669
Lipid and insulin infusion-induced skeletal muscle insulin resistance is likely due to metabolic feedback and not changes in IRS-1, Akt, or AS160 phosphorylationQ37264198
Skeletal muscle "mitochondrial deficiency" does not mediate insulin resistanceQ37341270
Intramuscular lipid content is increased in obesity and decreased by weight lossQ39535127
Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator.Q40122836
Effect of exercise training on insulin sensitivity and glucose metabolism in lean, obese, and diabetic menQ41898194
Early or advanced stage type 2 diabetes is not accompanied by in vivo skeletal muscle mitochondrial dysfunctionQ42165355
Ceramide content is increased in skeletal muscle from obese insulin-resistant humansQ42454790
Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletesQ43819832
Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscleQ43990155
Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alphaQ44043178
Impact of aerobic exercise training on age-related changes in insulin sensitivity and muscle oxidative capacityQ44527020
Disassociation of muscle triglyceride content and insulin sensitivity after exercise training in patients with Type 2 diabetes.Q44691839
Effects of weight loss and physical activity on muscle lipid content and droplet sizeQ44912977
Effect of exercise training on muscle glucose transporter 4 protein and intramuscular lipid content in elderly men with impaired glucose toleranceQ45103931
Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetesQ45199109
Mitochondrial function in skeletal muscle is normal and unrelated to insulin action in young men born with low birth weightQ46482859
Endurance training without weight loss lowers systemic, but not muscle, oxidative stress with no effect on inflammation in lean and obese womenQ46576470
Human skeletal muscle ceramide content is not a major factor in muscle insulin sensitivity.Q46610480
Asian Indians have enhanced skeletal muscle mitochondrial capacity to produce ATP in association with severe insulin resistance.Q46745043
Endurance training in obese humans improves glucose tolerance and mitochondrial fatty acid oxidation and alters muscle lipid contentQ46933158
Muscle fiber type is associated with obesity and weight lossQ47186050
Reduction in obesity and related comorbid conditions after diet-induced weight loss or exercise-induced weight loss in men. A randomized, controlled trialQ47234529
Markers of capacity to utilize fatty acids in human skeletal muscle: relation to insulin resistance and obesity and effects of weight lossQ47254568
CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK.Q48588727
Intramyocellular lipid content in type 2 diabetes patients compared with overweight sedentary men and highly trained endurance athletes.Q49165135
Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study.Q51565080
Skeletal muscle triglyceride levels are inversely related to insulin action.Q51575343
Influences of endurance training on the ultrastructural composition of the different muscle fiber types in humans.Q54158947
Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents.Q55033199
Influence of endurance exercise training and sex on intramyocellular lipid and mitochondrial ultrastructure, substrate use, and mitochondrial enzyme activity.Q55042692
Increased subsarcolemmal lipids in type 2 diabetes: effect of training on localization of lipids, mitochondria, and glycogen in sedentary human skeletal muscleQ58456043
Skeletal muscle glycolytic and oxidative enzyme capacities are determinants of insulin sensitivity and muscle composition in obese womenQ61696377
Progressive effect of endurance training on metabolic adaptations in working skeletal muscleQ71464249
Seven days of exercise increase GLUT-4 protein content in human skeletal muscleQ71628304
Exercise induces rapid increases in GLUT4 expression, glucose transport capacity, and insulin-stimulated glycogen storage in muscleQ72417351
Altered glycolytic and oxidative capacities of skeletal muscle contribute to insulin resistance in NIDDMQ73497254
Homeostasis model assessment as a clinical index of insulin resistance in type 2 diabetic patients treated with sulfonylureasQ77761950
Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascadeQ77795070
Short-term manipulation of plasma free fatty acids does not change skeletal muscle concentrations of ceramide and glucosylceramide in lean and overweight subjectsQ79691407
Mitochondrial function: use it or lose itQ79721968
Increased skeletal muscle ceramide level in men at risk of developing type 2 diabetesQ80854696
IMCL area density, but not IMCL utilization, is higher in women during moderate-intensity endurance exercise, compared with menQ81391350
Expression profiling following local muscle inactivity in humans provides new perspective on diabetes-related genesQ81570494
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectobesityQ12174
insulin resistanceQ1053470
P304page(s)e66322
P577publication date2013-01-01
P1433published inPLOS OneQ564954
P1476titleMarkers of skeletal muscle mitochondrial function and lipid accumulation are moderately associated with the homeostasis model assessment index of insulin resistance in obese men
P478volume8

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