| scholarly article | Q13442814 |
| P2093 | author name string | J G Edwards | |
| S Hicks | |||
| B Piteo | |||
| D Laurent | |||
| S A Gupte | |||
| J E Mathew | |||
| N Labinskyy | |||
| P2860 | cites work | Exercise training enhanced myocardial endothelial nitric oxide synthase (eNOS) function in diabetic Goto-Kakizaki (GK) rats | Q21246036 |
| Phosphorylation of DNA topoisomerase I by the c-Abl tyrosine kinase confers camptothecin sensitivity | Q24305397 | ||
| Protein kinase C delta activates topoisomerase IIalpha to induce apoptotic cell death in response to DNA damage | Q24317273 | ||
| Respiratory complex III is required to maintain complex I in mammalian mitochondria | Q24322645 | ||
| Myocardial cell death in human diabetes | Q73281473 | ||
| Association of prolonged hyperglycemia with glomerular hypertrophy and renal basement membrane thickening in the Goto Kakizaki model of non-insulin-dependent diabetes mellitus | Q73396325 | ||
| Multiple hepatic mitochondrial DNA deletions suggest premature oxidative aging in alcoholic patients | Q73574806 | ||
| Elevated atrial natriuretic peptides and early renal failure in type 2 diabetic Goto-Kakizaki rats | Q77919772 | ||
| Detection of mitochondrial DNA mutations by temporal temperature gradient gel electrophoresis | Q78077754 | ||
| The effect of insulin on oxidative phosphorylation in normal and diabetic mitochondria | Q78756401 | ||
| Mitochondrial and nucleocytoplasmic targeting of O-linked GlcNAc transferase | Q78827061 | ||
| Early adaptations to training: upregulation of alpha-myosin heavy chain gene expression | Q79547039 | ||
| Glucose-6-phosphate dehydrogenase-derived NADPH fuels superoxide production in the failing heart | Q79861960 | ||
| Dysregulation of mitochondrial biogenesis in vascular endothelial and smooth muscle cells of aged rats | Q80837041 | ||
| Overexpression of mitochondrial transcription factor a ameliorates mitochondrial deficiencies and cardiac failure after myocardial infarction | Q80932637 | ||
| Mitochondrial DNA mutations activate programmed cell survival in the mouse heart | Q81667251 | ||
| Neuroprotective effect of ginger on anti-oxidant enzymes in streptozotocin-induced diabetic rats | Q83027360 | ||
| Inhibition of NADPH oxidase alleviates experimental diabetes-induced myocardial contractile dysfunction | Q83310697 | ||
| Mitochondrial DNA damage triggers mitochondrial-superoxide generation and apoptosis | Q46852259 | ||
| Enhanced mitochondrial superoxide in hyperglycemic endothelial cells: direct measurements and formation of hydrogen peroxide and peroxynitrite | Q46974160 | ||
| Mitochondrial transcription factor A regulates mtDNA copy number in mammals | Q47963219 | ||
| Decreased mitochondrial DNA content in peripheral blood precedes the development of non-insulin-dependent diabetes mellitus | Q50536954 | ||
| Type 1 diabetes affects topoisomerase I activity and GlcNAcylation in rat organs: kidney, liver and pancreas. | Q51367931 | ||
| Left ventricle structural remodelling in the prediabetic Goto-Kakizaki rat. | Q51372745 | ||
| Effects of diabetes on cardiac glycogen metabolism in rats. | Q51602799 | ||
| Hydrogen peroxide dose dependent induction of cell death or hypertrophy in cardiomyocytes. | Q52537534 | ||
| Random point mutations with major effects on protein-coding genes are the driving force behind premature aging in mtDNA mutator mice. | Q53379421 | ||
| Mitochondrial energetics in the heart in obesity-related diabetes: direct evidence for increased uncoupled respiration and activation of uncoupling proteins. | Q53541654 | ||
| Palmitate induced mitochondrial deoxyribonucleic acid damage and apoptosis in l6 rat skeletal muscle cells. | Q53595198 | ||
| Accumulation of somatic mutation in mitochondrial DNA and atherosclerosis in diabetic patients. | Q54718897 | ||
| Enhancement of the antitumor effect of glucose oxidase by combined administration of hydrogen peroxide decomposition inhibitors together with an oxygenated fluorocarbon. | Q55006265 | ||
| Short-term exercise worsens cardiac oxidative stress and fibrosis in 8-month-olddb/dbmice by depleting cardiac glutathione | Q63513877 | ||
| Thickening of glomerular basement membrane in spontaneously diabetic rats | Q67403951 | ||
| Topoisomerases and yeast rRNA transcription: negative supercoiling stimulates initiation and topoisomerase activity is required for elongation | Q67491941 | ||
| Diabetic control and the renin-angiotensin system, catecholamines, and blood pressure | Q69975118 | ||
| Peripheral neuropathy in selectively-inbred spontaneously diabetic rats: electrophysiological, morphometrical and freeze-replica studies | Q70528875 | ||
| Thyroid hormone influences beta myosin heavy chain (beta MHC) expression | Q72340101 | ||
| Construction of transgenic mice with tissue-specific acceleration of mitochondrial DNA mutagenesis | Q73076403 | ||
| Dual localization of human DNA topoisomerase IIIalpha to mitochondria and nucleus | Q24535778 | ||
| Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases | Q28253777 | ||
| Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality | Q28292632 | ||
| Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice | Q28474793 | ||
| Impact of the mitochondrial genetic background in complex III deficiency | Q28475526 | ||
| Subcellular localization of Nox4 and regulation in diabetes | Q28566200 | ||
| Increased enzymatic O-GlcNAcylation of mitochondrial proteins impairs mitochondrial function in cardiac myocytes exposed to high glucose | Q28573520 | ||
| Synergistic activation of glucose-6-phosphate dehydrogenase and NAD(P)H oxidase by Src kinase elevates superoxide in type 2 diabetic, Zucker fa/fa, rat liver | Q28573824 | ||
| Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging | Q29616056 | ||
| Mitochondrial dysfunction in the elderly: possible role in insulin resistance | Q29618783 | ||
| S-glutathionylation: from molecular mechanisms to health outcomes | Q30398587 | ||
| Superoxide flashes: early mitochondrial signals for oxidative stress-induced apoptosis | Q30503211 | ||
| Mitochondrial DNA deletion mutations colocalize with segmental electron transport system abnormalities, muscle fiber atrophy, fiber splitting, and oxidative damage in sarcopenia | Q30649164 | ||
| Molecular analyses of mtDNA deletion mutations in microdissected skeletal muscle fibers from aged rhesus monkeys. | Q31114075 | ||
| Endothelial dysfunction and salt-sensitive hypertension in spontaneously diabetic Goto-Kakizaki rats | Q32071205 | ||
| Superoxide production by mitochondria of insulin-sensitive tissues: mechanistic differences and effect of early diabetes | Q33618562 | ||
| Role of NAD(P)H Oxidase in Superoxide Generation and Endothelial Dysfunction in Goto-Kakizaki (GK) Rats as a Model of Nonobese NIDDM | Q33644486 | ||
| Drosophila topo IIIalpha is required for the maintenance of mitochondrial genome and male germ-line stem cells | Q33778982 | ||
| NF-kappaB-induced oxidative stress contributes to mitochondrial and cardiac dysfunction in type II diabetes. | Q33814830 | ||
| Downstream targets and intracellular compartmentalization in Nox signaling | Q33818148 | ||
| Peptide sequencing and site-directed mutagenesis identify tyrosine-727 as the active site tyrosine of Saccharomyces cerevisiae DNA topoisomerase I. | Q33856425 | ||
| Therapeutic targeting of mitochondrial superoxide in hypertension | Q33981734 | ||
| Hyperglycemia activates p53 and p53-regulated genes leading to myocyte cell death. | Q34092744 | ||
| Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents. | Q34126257 | ||
| Use of antioxidant vitamins for the prevention of cardiovascular disease: meta-analysis of randomised trials | Q34206974 | ||
| Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production | Q34212784 | ||
| How crowded is the cytoplasm? | Q34268384 | ||
| Randomized trials of vitamin E in the treatment and prevention of cardiovascular disease | Q34336191 | ||
| Impaired complex I assembly in a Leigh syndrome patient with a novel missense mutation in the ND6 gene | Q34543018 | ||
| NADPH oxidase 4 is an oncoprotein localized to mitochondria | Q34581756 | ||
| Chronically elevated glucose compromises myocardial mitochondrial DNA integrity by alteration of mitochondrial topoisomerase function | Q34597594 | ||
| NADPH oxidases in cardiovascular disease: insights from in vivo models and clinical studies. | Q35145985 | ||
| Activation of topoisomerase II-mediated excision of chromosomal DNA loops during oxidative stress. | Q35199859 | ||
| Mitochondrial superoxide and coenzyme Q in insulin-deficient rats: increased electron leak | Q35601557 | ||
| Hypertension superimposed on type II diabetes in Goto Kakizaki rats induces progressive nephropathy. | Q44445081 | ||
| H(2)O(2) regulates cardiac myocyte phenotype via concentration-dependent activation of distinct kinase pathways | Q44466694 | ||
| AT1 blockade prevents glucose-induced cardiac dysfunction in ventricular myocytes: role of the AT1 receptor and NADPH oxidase | Q44504103 | ||
| A truncated form of DNA topoisomerase IIβ associates with the mtDNA genome in mammalian mitochondria | Q44602456 | ||
| Cardiac dysfunction in the Goto-Kakizaki rat. A model of type II diabetes mellitus | Q44764548 | ||
| Antioxidant treatment attenuates hyperglycemia-induced cardiomyocyte death in rats | Q45135925 | ||
| Impact of altered substrate utilization on cardiac function in isolated hearts from Zucker diabetic fatty rats | Q45199020 | ||
| Modelling the effects of age-related mtDNA mutation accumulation; Complex I deficiency, superoxide and cell death | Q46005725 | ||
| Angiotensin II receptor blockage prevents diabetes-induced oxidative damage in rat heart. | Q46010011 | ||
| Prolonged ethanol administration depletes mitochondrial DNA in MnSOD-overexpressing transgenic mice, but not in their wild type littermates | Q46209870 | ||
| Cardiomyocyte apoptosis induced by short-term diabetes requires mitochondrial GSH depletion | Q46417518 | ||
| Glutathione redox state regulates mitochondrial reactive oxygen production | Q46481374 | ||
| Rosiglitazone improves myocardial glucose uptake in patients with type 2 diabetes and coronary artery disease: a 16-week randomized, double-blind, placebo-controlled study | Q46670150 | ||
| A case of CPT deficiency, homoplasmic mtDNA mutation and ragged red fibers at muscle biopsy | Q46707830 | ||
| A novel peroxisome proliferator-activated receptor alpha/gamma agonist, BPR1H0101, inhibits topoisomerase II catalytic activity in human cancer cells | Q46822396 | ||
| Perfused hearts from Type 2 diabetic (db/db) mice show metabolic responsiveness to insulin | Q46835029 | ||
| Prevention of mitochondrial oxidative damage as a therapeutic strategy in diabetes | Q35641719 | ||
| Increased mitochondrial biogenesis in muscle improves aging phenotypes in the mtDNA mutator mouse | Q35909435 | ||
| Hepatic mitochondrial alterations and increased oxidative stress in nutritional diabetes-prone Psammomys obesus model | Q35996583 | ||
| Damaged mitochondrial DNA replication system and the development of diabetic retinopathy | Q36001839 | ||
| Fatty acid metabolism is enhanced in type 2 diabetic hearts | Q36132785 | ||
| Mitochondria as a target for early detection and diagnosis of cancer | Q36359505 | ||
| Diabetic cardiomyopathy: the search for a unifying hypothesis | Q36423632 | ||
| Wolfram/DIDMOAD syndrome, a heterogenic and molecularly complex neurodegenerative disease. | Q36460403 | ||
| Mitochondrial topoisomerases and alternative splicing of the human TOP1mt gene | Q36680245 | ||
| A compensatory mechanism protects retinal mitochondria from initial insult in diabetic retinopathy | Q36783430 | ||
| Superoxide flashes in single mitochondria | Q36900957 | ||
| Cardiac energy metabolism in obesity | Q36912047 | ||
| Casein kinase I delta/epsilon phosphorylates topoisomerase IIalpha at serine-1106 and modulates DNA cleavage activity | Q37077394 | ||
| Superoxide production by NAD(P)H oxidase and mitochondria is increased in genetically obese and hyperglycemic rat heart and aorta before the development of cardiac dysfunction. The role of glucose-6-phosphate dehydrogenase-derived NADPH. | Q37264479 | ||
| Nox4-derived reactive oxygen species mediate cardiomyocyte injury in early type 1 diabetes | Q37270928 | ||
| Compartmentalization of redox signaling through NADPH oxidase-derived ROS. | Q37322476 | ||
| Hyperphosphorylation of RNA polymerase II in response to topoisomerase I cleavage complexes and its association with transcription- and BRCA1-dependent degradation of topoisomerase I. | Q37369481 | ||
| Angiotensin II and the development of insulin resistance: implications for diabetes | Q37371106 | ||
| Adaptation of topoisomerase I paralogs to nuclear and mitochondrial DNA. | Q37406087 | ||
| A repressor region in the human beta-myosin heavy chain gene that has a partial position dependency | Q38324243 | ||
| Quantification of mitochondrial DNA (mtDNA) damage and error rates by real-time QPCR. | Q38357918 | ||
| Hydrogen peroxide induces cell cycle arrest in cardiomyoblast H9c2 cells, which is related to hypertrophy | Q39564020 | ||
| Activities of hepatic enzymes in spontaneous diabetes rats produced by selective breeding of normal Wistar rats | Q39865038 | ||
| N-acetylcysteine prevents glucose/glucose oxidase-induced oxidative stress, mitochondrial damage and apoptosis in H9c2 cells | Q39892479 | ||
| Mitochondrial DNA background modulates the assembly kinetics of OXPHOS complexes in a cellular model of mitochondrial disease. | Q39937507 | ||
| Functional coupling of angiotensin II type 1 receptor with insulin resistance of energy substrate uptakes in immortalized cardiomyocytes (HL-1 cells). | Q40056615 | ||
| Altered phosphorylation of topoisomerase I following overexpression in an ovarian cancer cell line | Q40319756 | ||
| Hyperglycemia-induced apoptosis in mouse myocardium: mitochondrial cytochrome C-mediated caspase-3 activation pathway | Q40729629 | ||
| Preferential binding of human topoisomerase I to superhelical DNA. | Q40789846 | ||
| Increase of mitochondria and mitochondrial DNA in response to oxidative stress in human cells | Q40879108 | ||
| Bcl-2 and mitochondrial oxygen radicals. New approaches with reactive oxygen species-sensitive probes. | Q40924370 | ||
| Production of spontaneous diabetic rats by repetition of selective breeding | Q41059786 | ||
| Methods for detection of point mutations: performance and quality assessment. IFCC Scientific Division, Committee on Molecular Biology Techniques | Q41525225 | ||
| Evolution of glomerular lesions in rats with spontaneous diabetes | Q41592805 | ||
| Cardiomyocyte H9c2 Cells Exhibit Differential Sensitivity to Intracellular Reactive Oxygen Species Generation with Regard to Their Hypertrophic vs Death Responses to Exogenously Added Hydrogen Peroxide | Q42606224 | ||
| Differential responses to blood pressure and oxidative stress in streptozotocin-induced diabetic Wistar-Kyoto rats and spontaneously hypertensive rats: effects of antioxidant (honey) treatment | Q42751405 | ||
| N-acetylcysteine impairs survival of luteal cells through mitochondrial dysfunction | Q43164210 | ||
| Overexpression of manganese superoxide dismutase prevents alcohol-induced liver injury in the rat. | Q43690442 | ||
| A novel nonsense mutation (Q352X) in the mitochondrial cytochrome b gene associated with a combined deficiency of complexes I and III. | Q43814295 | ||
| Accumulation of 8-hydroxy-2'-deoxyguanosine and mitochondrial DNA deletion in kidney of diabetic rats | Q43972574 | ||
| Abnormality in fibre type distribution of soleus and plantaris muscles in non-obese diabetic Goto-Kakizaki rats | Q44169307 | ||
| Impaired glucose tolerance and insulinopenia in the GK-rat causes peripheral neuropathy | Q44240871 | ||
| Age-dependent changes in metabolism, contractile function, and ischemic sensitivity in hearts from db/db mice | Q44286385 | ||
| P433 | issue | 7 | |
| P921 | main subject | type 2 diabetes | Q3025883 |
| mitochondrial DNA | Q27075 | ||
| P304 | page(s) | H903-15 | |
| P577 | publication date | 2013-02-01 | |
| P1433 | published in | American Journal of Physiology Heart and Circulatory Physiology | Q3193662 |
| P1476 | title | Type II diabetes increases mitochondrial DNA mutations in the left ventricle of the Goto-Kakizaki diabetic rat. | |
| P478 | volume | 304 |
| Q33767807 | Chronic ethanol consumption increases myocardial mitochondrial DNA mutations: a potential contribution by mitochondrial topoisomerases |
| Q39826187 | G9a histone methyltransferase inhibitor BIX01294 promotes expansion of adult cardiac progenitor cells without changing their phenotype or differentiation potential |
| Q64386241 | Mitochondria and cardiovascular diseases-from pathophysiology to treatment |
| Q91982108 | Mitochondrial Dysfunction and Diabetes: Is Mitochondrial Transfer a Friend or Foe? |
| Q39340874 | Myocardial Mitochondria at the Intersection of Health and Disease |
| Q39418956 | Oxidative Stress and Cardiovascular Risk: Obesity, Diabetes, Smoking, and Pollution: Part 3 of a 3-Part Series |
| Q37612026 | Suppression of Excessive Histone Deacetylases Activity in Diabetic Hearts Attenuates Myocardial Ischemia/Reperfusion Injury via Mitochondria Apoptosis Pathway. |
| Q34412057 | Targeting mitochondrial alterations to prevent type 2 diabetes--evidence from studies of dietary redox-active compounds |
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