Preferential binding of human topoisomerase I to superhelical DNA.

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Preferential binding of human topoisomerase I to superhelical DNA. is …
instance of (P31):
scholarly articleQ13442814

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P932PMC publication ID394649
P698PubMed publication ID7489729

P2093author name stringL Stewart
J J Champoux
K R Madden
P2860cites workMitotic recombination in the rDNA of S. cerevisiae is suppressed by the combined action of DNA topoisomerases I and II.Q27933954
Function of DNA topoisomerases as replication swivels in Saccharomyces cerevisiaeQ27939978
DNA topoisomerasesQ28264119
Association of DNA topoisomerase I and RNA polymerase I: a possible role for topoisomerase I in ribosomal gene transcriptionQ28570763
Selective extraction of polyoma DNA from infected mouse cell culturesQ29547500
Supercoiling of the DNA template during transcriptionQ29617503
Involvement of DNA topoisomerase I in transcription of human ribosomal RNA genes.Q33552740
cDNA cloning of human DNA topoisomerase I: catalytic activity of a 67.7-kDa carboxyl-terminal fragmentQ33566923
Regulation of the function of eukaryotic DNA topoisomerase I: topological conditions for inactivityQ33852312
Peptide sequencing and site-directed mutagenesis identify tyrosine-727 as the active site tyrosine of Saccharomyces cerevisiae DNA topoisomerase I.Q33856425
Eukaryotic topoisomerases recognize nucleic acid topology by preferentially interacting with DNA crossoversQ33923932
Roles of DNA topoisomerases in simian virus 40 DNA replication in vitroQ34595603
Regulation of the function of eukaryotic DNA topoisomerase I: analysis of the binding step and of the catalytic constants of topoisomerization as a function of DNA topologyQ68490254
Quantitation of eukaryotic topoisomerase I reactivity with DNA. Preferential cleavage of supercoiled DNAQ70078680
DNA topoisomerasesQ70095180
Bacterial DNA topoisomerase I can relax positively supercoiled DNA containing a single-stranded loopQ70106552
High titers of autoantibodies to topoisomerase I (Scl-70) in sera from scleroderma patientsQ70124748
Identification of Saccharomyces cerevisiae mutants deficient in DNA topoisomerase I activityQ70185349
DNA tridimensional context affects the reactivity of eukaryotic DNA topoisomerase IQ70461112
Preferential binding of histone H1 to four-way helical junction DNAQ70500424
DNA structural features that lead to strand breakage by eukaryotic type-I topoisomeraseQ72413032
DNA is linked to the rat liver DNA nicking-closing enzyme by a phosphodiester bond to tyrosineQ72891179
Homologous pairing and topological linkage of DNA molecules by combined action of E. coli recA protein and topoisomerase IQ72894009
The effect of salt on the binding of the eucaryotic DNA nicking-closing enzyme to DNA and chromatinQ72901424
Eukaryotic topoisomerase I-mediated cleavage requires bipartite DNA interaction. Cleavage of DNA substrates containing strand interruptions implicates a role for topoisomerase I in illegitimate recombinationQ72969281
An activity from mammalian cells that untwists superhelical DNA--a possible swivel for DNA replication (polyoma-ethidium bromide-mouse-embryo cells-dye binding assay).Q34767494
DNA topoisomerases: why so many?Q34781117
Induction of cleavage in topoisomerase I c-DNA by topoisomerase I enzymes from calf thymus and wheat germ in the presence and absence of camptothecinQ35020099
Evidence for an intermediate with a single-strand break in the reaction catalyzed by the DNA untwisting enzymeQ35030024
Strand breakage by the DNA untwisting enzyme results in covalent attachment of the enzyme to DNAQ35050115
Topoisomerase I is preferentially associated with normal SV40 replicative intermediates, but is associated with both replicating and nonreplicating SV40 DNAs which are deficient in histonesQ35072982
Nucleotide sequence preference at rat liver and wheat germ type 1 DNA topoisomerase breakage sites in duplex SV40 DNAQ35273563
Eukaryotic DNA topoisomerases: two forms of type I DNA topoisomerases from HeLa cell nucleiQ35376336
The binding of gyrase to DNA: analysis by retention by nitrocellulose filtersQ35719264
Eukaryotic topoisomerase I-DNA interaction is stabilized by helix curvatureQ35918001
Interaction of topoisomerase 1 with the transcribed region of the Drosophila HSP 70 heat shock geneQ35952935
The basis for camptothecin enhancement of DNA breakage by eukaryotic topoisomerase I.Q35952975
Transcription-driven site-specific DNA recombination in vitroQ36198124
The rRNA-encoding DNA array has an altered structure in topoisomerase I mutants of Saccharomyces cerevisiaeQ36481716
Camptothecin, a specific inhibitor of type I DNA topoisomerase, induces DNA breakage at replication forksQ36792502
Topoisomerase inhibitors can selectively interfere with different stages of simian virus 40 DNA replicationQ36901211
Conformational fluctuations of DNA helixQ37458627
Action of nicking-closing enzyme on supercoiled and nonsupercoiled closed circular DNA: formation of a Boltzmann distribution of topological isomersQ37458662
Determination of the number of superhelical turns in simian virus 40 DNA by gel electrophoresisQ37464394
Drosophila DNA topoisomerase I is associated with transcriptionally active regions of the genomeQ37576691
Vaccinia DNA topoisomerase I: single-turnover and steady-state kinetic analysis of the DNA strand cleavage and ligation reactionsQ38312184
Unusual DNA structuresQ39625578
Priming of superhelical SV40 DNA by Escherichia coli RNA polymerase for in vitro DNA synthesisQ39923185
Purification and characterization of the DNA untwisting enzyme from rat liverQ40018568
Mechanism of the reaction catalyzed by the DNA untwisting enzyme: Attachment of the enzyme to 3′-terminus of the nicked DNAQ40136209
Recognition sites of eukaryotic DNA topoisomerase I: DNA nucleotide sequencing analysis of topo I cleavage sites on SV40 DNA.Q40464254
Experimental analysis of chromatin function in transcription control.Q40516092
In vitro preferential topoisomerization of bent DNA.Q40538560
Eukaryotic DNA topoisomerase I reaction is topology dependentQ40554083
Analysis of the biased distribution of topoisomerase I break sites on replicating simian virus 40 DNA.Q41554257
The twist, writhe and overall shape of supercoiled DNA change during counterion-induced transition from a loosely to a tightly interwound superhelix. Possible implications for DNA structure in vivoQ41634869
DNA topoisomerase I is involved in both repression and activation of transcriptionQ42508509
Structure of plectonemically supercoiled DNA.Q46337596
Interaction between DNA and an Escherichia coli protein omegaQ47757460
Lac repressor-operator interaction. I. Equilibrium studiesQ47770743
A high affinity topoisomerase I binding sequence is clustered at DNAase I hypersensitive sites in Tetrahymena R-chromatin.Q52457341
Topoisomerase I interacts with transcribed regions in Drosophila cells.Q52457534
The role of DNA topoisomerases in recombination and genome stability: a double-edged sword?Q54710073
Transcription generates positively and negatively supercoiled domains in the template.Q54748648
Need for DNA topoisomerase activity as a swivel for DNA replication for transcription of ribosomal RNAQ59078548
Conformational and thermodynamic properties of supercoiled DNAQ67580936
Overexpression of human topoisomerase I in baby hamster kidney cells: hypersensitivity of clonal isolates to camptothecinQ67841296
The conformation of constitutive DNA interaction sites for eukaryotic DNA topoisomerase I on intrinsically curved DNAsQ68267668
P433issue21
P407language of work or nameEnglishQ1860
P304page(s)5399-5409
P577publication date1995-11-01
P1433published inThe EMBO JournalQ1278554
P1476titlePreferential binding of human topoisomerase I to superhelical DNA.
P478volume14

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cites work (P2860)
Q33421561A functional type I topoisomerase from Pseudomonas aeruginosa
Q35476141A robust assay to measure DNA topology-dependent protein binding affinity.
Q36568115Accessibility to topoisomerases I and II regulates the replication efficiency of simian virus 40 minichromosomes
Q37406087Adaptation of topoisomerase I paralogs to nuclear and mitochondrial DNA.
Q35154537All tangled up: how cells direct, manage and exploit topoisomerase function
Q33773596Assays for the preferential binding of human topoisomerase I to supercoiled DNA.
Q36900710Bullied no more: when and how DNA shoves proteins around
Q36794626Collaborating functions of BLM and DNA topoisomerase I in regulating human rDNA transcription
Q27662183Crystal Structure of a Bacterial Topoisomerase IB in Complex with DNA Reveals a Secondary DNA Binding Site
Q36912561Doxorubicin induced heart failure: Phenotype and molecular mechanisms.
Q28070190Effects of DNA supercoiling on chromatin architecture
Q39051657Effects of DNA supercoiling on chromatin architecture.
Q36097816Human DNA topoisomerase I: relaxation, roles, and damage control
Q40566471Importance of disentanglement and entanglement during DNA replication and segregation: Comment on: "Disentangling DNA molecules" by Alexander Vologodskii
Q41980937Intramolecular synapsis of duplex DNA by vaccinia topoisomerase
Q35024291Mutational analysis of the preferential binding of human topoisomerase I to supercoiled DNA.
Q41813525Plasmid r1 conjugative DNA processing is regulated at the coupling protein interface.
Q25256778Poly(ADP-RIBOSE) polymerase-1 (Parp-1) antagonizes topoisomerase I-dependent recombination stimulation by P53
Q42573475Recruitment timing and dynamics of transcription factors at the Hsp70 loci in living cells
Q34044496Simulations of DNA topoisomerase 1B bound to supercoiled DNA reveal changes in the flexibility pattern of the enzyme and a secondary protein-DNA binding site
Q30673594Single-Molecule Supercoil Relaxation Assay as a Screening Tool to Determine the Mechanism and Efficacy of Human Topoisomerase IB Inhibitors
Q33775078Targeting to transcriptionally active loci by the hydrophilic N-terminal domain of Drosophila DNA topoisomerase I.
Q34669395The C-terminal domain but not the tyrosine 723 of human DNA topoisomerase I active site contributes to kinase activity
Q51273340The Dynamic Interplay Between DNA Topoisomerases and DNA Topology.
Q89719919The Functional Consequences of Eukaryotic Topoisomerase 1 Interaction with G-Quadruplex DNA
Q36465041The cap region of topoisomerase I binds to sites near both ends of simian virus 40 T antigen
Q33639806The dynamic interplay between DNA topoisomerases and DNA topology
Q40028536Topoisomerase I inhibitors and drug resistance
Q41374297Topoisomerase IB-DNA interactions: X marks the spot
Q36764406Type II diabetes increases mitochondrial DNA mutations in the left ventricle of the Goto-Kakizaki diabetic rat.