Chronic Hyperinsulinemia Causes Selective Insulin Resistance and Down-regulates Uncoupling Protein 3 (UCP3) through the Activation of Sterol Regulatory Element-binding Protein (SREBP)-1 Transcription Factor in the Mouse Heart

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Chronic Hyperinsulinemia Causes Selective Insulin Resistance and Down-regulates Uncoupling Protein 3 (UCP3) through the Activation of Sterol Regulatory Element-binding Protein (SREBP)-1 Transcription Factor in the Mouse Heart is …
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scholarly articleQ13442814

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P356DOI10.1074/JBC.M115.673988
P932PMC publication ID4692222
P698PubMed publication ID26555260

P50authorRomain HarmanceyQ86663961
P2093author name stringHeinrich Taegtmeyer
Derek L Haight
Kayla A Watts
P2860cites workUncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expressionQ24309291
UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissueQ24312228
SREBP-1c and Sp1 interact to regulate transcription of the gene for phosphoenolpyruvate carboxykinase (GTP) in the liverQ28240899
Increased mitochondrial uncoupling proteins, respiratory uncoupling and decreased efficiency in the chronically infarcted rat heartQ28570211
Identification of conserved cis-elements and transcription factors required for sterol-regulated transcription of stearoyl-CoA desaturase 1 and 2Q28646392
Insulin-resistant heart exhibits a mitochondrial biogenic response driven by the peroxisome proliferator-activated receptor-alpha/PGC-1alpha gene regulatory pathway.Q30359509
A new role for sterol regulatory element binding protein 1 transcription factors in the regulation of muscle mass and muscle cell differentiationQ33648820
Decreased long-chain fatty acid oxidation impairs postischemic recovery of the insulin-resistant rat heartQ33713702
Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) ratsQ33857313
The regulation and turnover of mitochondrial uncoupling proteins.Q33936374
Genetic deletion in uncoupling protein 3 augments 18F-fluorodeoxyglucose cardiac uptake in the ischemic heartQ34021788
SREBP-1 interacts with hepatocyte nuclear factor-4 alpha and interferes with PGC-1 recruitment to suppress hepatic gluconeogenic genes.Q34289658
Western diet changes cardiac acyl-CoA composition in obese rats: a potential role for hepatic lipogenesisQ34559873
Adaptation and maladaptation of the heart in diabetes: Part I: general conceptsQ34592521
Gene expression profiling in human skeletal muscle during recovery from eccentric exerciseQ34758964
A novel SP1/SP3 dependent intronic enhancer governing transcription of the UCP3 gene in brown adipocytesQ35082470
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Metabolic stress-induced activation of FoxO1 triggers diabetic cardiomyopathy in miceQ35780290
Carbohydrate responsive element binding protein (ChREBP) and sterol regulatory element binding protein-1c (SREBP-1c): two key regulators of glucose metabolism and lipid synthesis in liverQ36055803
UCP3 regulates cardiac efficiency and mitochondrial coupling in high fat-fed mice but not in leptin-deficient mice.Q36410680
Hyperinsulinemia as an independent risk factor for ischemic heart disease.Q51581884
Differential expression of cardiac uncoupling proteins 2 and 3 in response to myocardial ischemia-reperfusion in rats.Q54227505
Angiographic Findings and Outcome in Diabetic Patients Treated With Thrombolytic Therapy for Acute Myocardial Infarction: The GUSTO-I ExperienceQ56945225
Myocardial steatosis, cardiac remodelling and fitness in insulin-sensitive and insulin-resistant obese womenQ56981574
Functional Relationship between MyoD and Peroxisome Proliferator-Activated Receptor-Dependent Regulatory Pathways in the Control of the Human Uncoupling Protein-3 Gene TranscriptionQ60636891
The plasma free fatty acid rebound induced by nicotinic acidQ72252881
Early postoperative outcome and medium-term survival in 540 diabetic and 2239 nondiabetic patients undergoing coronary artery bypass graftingQ74805086
Streptozotocin treatment upregulates uncoupling protein 3 expression in the rat heartQ77766014
Activation of a novel long-chain free fatty acid generation and export system in mitochondria of diabetic rat heartsQ79949239
Cardiac steatosis in diabetes mellitus: a 1H-magnetic resonance spectroscopy studyQ80795946
Mitochondrial uncoupling: a key contributor to reduced cardiac efficiency in diabetes.Q36547048
ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiationQ36694542
Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetesQ36698641
Bioinformatic profiling of the transcriptional response of adult rat cardiomyocytes to distinct fatty acidsQ36727375
Role of uncoupling protein 3 in ischemia-reperfusion injury, arrhythmias, and preconditioningQ36837997
Myocardial AKT: the omnipresent nexusQ36908289
Type 1 diabetic akita mouse hearts are insulin sensitive but manifest structurally abnormal mitochondria that remain coupled despite increased uncoupling protein 3.Q36943690
Genetic deletion of uncoupling protein 3 exaggerates apoptotic cell death in the ischemic heart leading to heart failure.Q36974257
Molecular mechanisms for myocardial mitochondrial dysfunction in the metabolic syndromeQ37053844
Selective versus total insulin resistance: a pathogenic paradoxQ37076798
Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscleQ37175187
Susceptibility to myocardial ischemia reperfusion injury at early stage of type 1 diabetes in ratsQ37357405
Myocardial lipid accumulation in patients with pressure-overloaded heart and metabolic syndromeQ37382176
Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.Q37382401
Myocardial fatty acid metabolism in health and diseaseQ37677921
Lipid metabolism and toxicity in the heartQ38017379
Microarray analyses of SREBP-1a and SREBP-1c target genes identify new regulatory pathways in muscleQ38289985
Transcriptional effects of chronic Akt activation in the heart.Q38290130
Physiological increases in uncoupling protein 3 augment fatty acid oxidation and decrease reactive oxygen species production without uncoupling respiration in muscle cells.Q40392941
Insulin regulation of sterol regulatory element-binding protein-1 expression in L-6 muscle cells and 3T3 L1 adipocytesQ40547543
Up-regulation of uncoupling protein 3 gene expression by fatty acids and agonists for PPARs in L6 myotubes.Q40779525
A novel intronic peroxisome proliferator-activated receptor gamma enhancer in the uncoupling protein (UCP) 3 gene as a regulator of both UCP2 and -3 expression in adipocytesQ40812851
Uncoupling protein 3 (UCP3) stimulates glucose uptake in muscle cells through a phosphoinositide 3-kinase-dependent mechanism.Q40816499
Uncoupling protein 3 mediates H₂O₂ preconditioning-afforded cardioprotection through the inhibition of MPTP openingQ41682803
A high fat diet increases mitochondrial fatty acid oxidation and uncoupling to decrease efficiency in rat heartQ41814555
Lack of UCP3 does not affect skeletal muscle mitochondrial function under lipid-challenged conditions, but leads to sudden cardiac deathQ41845774
Effects of insulin replacements, inhibitors of angiotensin, and PKCbeta's actions to normalize cardiac gene expression and fuel metabolism in diabetic ratsQ42509701
Regulation of sterol regulatory-element binding protein 1 gene expression in liver: role of insulin and protein kinase B/cAktQ42996869
Involvement of GSK-3β in attenuation of the cardioprotective effect of ischemic preconditioning in diabetic rat heart.Q43050253
Effect of experimental hyperinsulinemia on insulin binding and glucose transport in isolated rat adipocytesQ43431397
Uncoupling protein 3 transcription is regulated by peroxisome proliferator-activated receptor (alpha) in the adult rodent heartQ43548122
Uncoupling protein 3 content is decreased in skeletal muscle of patients with type 2 diabetes.Q43808977
Human obesity and type 2 diabetes are associated with alterations in SREBP1 isoform expression that are reproduced ex vivo by tumor necrosis factor-alphaQ43935429
Diabetes mellitus, myocardial reperfusion, and outcome in patients with acute ST-elevation myocardial infarction treated with primary angioplasty (from HORIZONS AMI).Q43986424
Sterol regulatory element binding protein-1c expression and action in rat muscles: insulin-like effects on the control of glycolytic and lipogenic enzymes and UCP3 gene expressionQ44007196
Diabetes mellitus increases short-term mortality and morbidity in patients undergoing coronary artery bypass graft surgeryQ44079557
Relationship between obesity, insulin resistance, and coronary heart disease riskQ44133524
Cholesteryl ester transfer protein expression is down-regulated in hyperinsulinemic transgenic miceQ44516295
Coronary artery bypass grafting in type II diabetic patients: a comparison between insulin-dependent and non-insulin-dependent patients at short- and mid-term follow-upQ44927558
Diurnal variations in the responsiveness of cardiac and skeletal muscle to fatty acidsQ45005728
Plasma free fatty acids and peroxisome proliferator-activated receptor alpha in the control of myocardial uncoupling protein levelsQ46818642
Transcription of the human uncoupling protein 3 gene is governed by a complex interplay between the promoter and intronic sequencesQ47727759
The mitochondrial uncoupling-protein homologuesQ50308475
Intramyocardial lipid accumulation in the failing human heart resembles the lipotoxic rat heart.Q50782443
Acute starvation in C57BL/6J mice increases myocardial UCP2 and UCP3 protein expression levels and decreases mitochondrial bio-energetic function.Q51389528
P4510describes a project that usesImageJQ1659584
P433issue52
P407language of work or nameEnglishQ1860
P921main subjectinsulin resistanceQ1053470
P304page(s)30947-30961
P577publication date2015-11-10
P1433published inJournal of Biological ChemistryQ867727
P1476titleChronic Hyperinsulinemia Causes Selective Insulin Resistance and Down-regulates Uncoupling Protein 3 (UCP3) through the Activation of Sterol Regulatory Element-binding Protein (SREBP)-1 Transcription Factor in the Mouse Heart
P478volume290

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cites work (P2860)
Q54978476Deficiency of PRKD2 triggers hyperinsulinemia and metabolic disorders.
Q48166254Glucose regulates the intrinsic inflammatory response of the heart to surgically induced hypothermic ischemic arrest and reperfusion
Q64264371Important Trends in UCP3 Investigation
Q39159635Insulin and β Adrenergic Receptor Signaling: Crosstalk in Heart
Q47722955Mitochondrial uncoupling proteins: subtle regulators of cellular redox signaling
Q89944024Modulation of Fatty Acid-Related Genes in the Response of H9c2 Cardiac Cells to Palmitate and n-3 Polyunsaturated Fatty Acids
Q50057684Temporal partitioning of adaptive responses of the murine heart to fasting
Q58100959Uncoupling protein 3 deficiency impairs myocardial fatty acid oxidation and contractile recovery following ischemia/reperfusion

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