Salidroside improves endothelial function and alleviates atherosclerosis by activating a mitochondria-related AMPK/PI3K/Akt/eNOS pathway

scientific article published on 14 July 2015

Salidroside improves endothelial function and alleviates atherosclerosis by activating a mitochondria-related AMPK/PI3K/Akt/eNOS pathway is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.VPH.2015.07.004
P698PubMed publication ID26187353

P50authorTao ZhengQ57012305
P2093author name stringYong-Hui Zhang
Dan Wu
Wen-Jing Li
Fang Bian
Yong-Sheng Li
Si Jin
You-Zhi Zhang
Xiao-Yan Yang
Guang-Jie Wu
Xiang-Li Bai
Cun-Tai Zhang
Jiang-Yang Chi
Sha-Sha Xing
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LKB1 is the upstream kinase in the AMP-activated protein kinase cascadeQ28610414
Inflammation in atherosclerosisQ29547428
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Activation of cardiac AMP-activated protein kinase by LKB1 expression or chemical hypoxia is blunted by increased Akt activityQ64378088
AMP-activated protein kinase phosphorylation of endothelial NO synthaseQ74456171
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Impaired fibrillin-1 function promotes features of plaque instability in apolipoprotein E-deficient miceQ84965072
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Phosphorylation of Thr(495) regulates Ca(2+)/calmodulin-dependent endothelial nitric oxide synthase activity.Q33950554
Rejuvenating activity of salidroside (SDS): dietary intake of SDS enhances the immune response of aged ratsQ34172820
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Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cellsQ35218922
The role of chemokines in atherosclerosis: recent evidence from experimental models and population geneticsQ35689477
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Activation and signaling by the AMP-activated protein kinase in endothelial cellsQ37553770
Binding to WGR domain by salidroside activates PARP1 and protects hematopoietic stem cells from oxidative stressQ37667497
Leptin-stimulated endothelial nitric-oxide synthase via an adenosine 5'-monophosphate-activated protein kinase/Akt signaling pathway is attenuated by interaction with C-reactive protein.Q39862194
Apurinic/apyrimidinic endonuclease1/redox factor-1 inhibits monocyte adhesion in endothelial cellsQ40344445
The effect of salidroside on cell damage induced by glutamate and intracellular free calcium in PC12 cellsQ42496435
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Thrombin and histamine stimulate endothelial nitric-oxide synthase phosphorylation at Ser1177 via an AMPK mediated pathway independent of PI3K-AktQ45029420
Mechanism of thrombin mediated eNOS phosphorylation in endothelial cells is dependent on ATP levels after stimulationQ46440444
Insulin antagonizes ischemia-induced Thr172 phosphorylation of AMP-activated protein kinase alpha-subunits in heart via hierarchical phosphorylation of Ser485/491.Q46844438
Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthaseQ46917092
AMP-activated protein kinase (AMPK) signaling in endothelial cells is essential for angiogenesis in response to hypoxic stressQ47858200
Reduced endothelial nitric oxide synthase expression and production in human atherosclerosisQ47870932
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Agonist-modulated regulation of AMP-activated protein kinase (AMPK) in endothelial cells. Evidence for an AMPK -> Rac1 -> Akt -> endothelial nitric-oxide synthase pathway.Q53551231
Protection of curcumin against fructose-induced hyperuricaemia and renal endothelial dysfunction involves NO-mediated JAK-STAT signalling in rats.Q54447363
Induction of nitric oxide by erythropoietin is mediated by the {beta} common receptor and requires interaction with VEGF receptor 2.Q54451413
Salidroside protects human erythrocytes against hydrogen peroxide-induced apoptosisQ57098977
Endothelial FunctionQ61704068
P921main subjectendotheliumQ111140
P304page(s)141-152
P577publication date2015-07-14
P1433published inVascular PharmacologyQ7916446
P1476titleSalidroside improves endothelial function and alleviates atherosclerosis by activating a mitochondria-related AMPK/PI3K/Akt/eNOS pathway
P478volume72

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cites work (P2860)
Q37437241A novel TRPV4-specific agonist inhibits monocyte adhesion and atherosclerosis
Q50006173Asperosaponin VI promotes angiogenesis and accelerates wound healing in rats via up-regulating HIF-1α/VEGF signaling
Q47111436Cavin-1 regulates caveolae-mediated LDL transcytosis: crosstalk in an AMPK/eNOS/ NF-κB/Sp1 loop
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Q64279578Matrine attenuates high-fat diet-induced in vivo and ox-LDL-induced in vitro vascular injury by regulating the PKCα/eNOS and PI3K/Akt/eNOS pathways
Q48348864Monotropein promotes angiogenesis and inhibits oxidative stress-induced autophagy in endothelial progenitor cells to accelerate wound healing.
Q55044611Pharmacological activities, mechanisms of action, and safety of salidroside in the central nervous system.
Q47920712Rhodiola crenulata Attenuates High Glucose Induced Endothelial Dysfunction in Human Umbilical Vein Endothelial Cells
Q47422236Rhynchophylla total alkaloid rescues autophagy, decreases oxidative stress and improves endothelial vasodilation in spontaneous hypertensive rats
Q41147225Role of free fatty acids in endothelial dysfunction
Q89795286Salidroside Decreases Atherosclerosis Plaque Formation via Inhibiting Endothelial Cell Pyroptosis
Q52573088Salidroside Protects Against Advanced Glycation End Products-Induced Vascular Endothelial Dysfunction.
Q92814951Salidroside attenuates oxidized low‑density lipoprotein‑induced endothelial cell injury via promotion of the AMPK/SIRT1 pathway
Q99567219Salidroside downregulates microRNA‑133a and inhibits endothelial cell apoptosis induced by oxidized low‑density lipoprotein
Q33846848Salidroside inhibits high-glucose induced proliferation of vascular smooth muscle cells via inhibiting mitochondrial fission and oxidative stress
Q64922996Salidroside protects against ox-LDL-induced endothelial injury by enhancing autophagy mediated by SIRT1-FoxO1 pathway.
Q47427319Salidroside slows the progression of EA.hy926 cell senescence by regulating the cell cycle in an atherosclerosis model

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