Autophagy: cancer therapy's friend or foe?

scientific article published on February 2010

Autophagy: cancer therapy's friend or foe? is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.4155/FMC.09.155
P698PubMed publication ID21426194

P50authorTheocharis PanaretakisQ40049207
P2093author name stringDan Grandér
P2860cites workBif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesisQ24294860
Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1Q24303558
DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagyQ24323360
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processingQ24597817
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stressQ24633606
Autophagy suppresses tumorigenesis through elimination of p62Q24650670
Regulation of autophagy by cytoplasmic p53Q24651258
Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4Q24670840
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signalingQ24672005
The reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathwayQ24678032
Autophagy in the Pathogenesis of DiseaseQ27860558
TSC2 mediates cellular energy response to control cell growth and survivalQ27860970
A ubiquitin-like system mediates protein lipidationQ27934137
Autophagosome requires specific early Sec proteins for its formation and NSF/SNARE for vacuolar fusionQ27934199
Induction of autophagy and inhibition of tumorigenesis by beclin 1Q28131718
The AMP-activated protein kinase cascade--a unifying system for energy controlQ28239257
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington diseaseQ28261987
Metabolic profiles of cancer cellsQ28269762
Metabolomic profiling of drug responses in acute myeloid leukaemia cell linesQ28474545
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metforminQ28590162
JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagyQ29614479
FoxO3 controls autophagy in skeletal muscle in vivoQ29614483
Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulumQ29614500
Autophagy defends cells against invading group A StreptococcusQ29615620
Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAGQ29615716
DRAM, a p53-induced modulator of autophagy, is critical for apoptosisQ29616308
AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolismQ29617261
Role of autophagy in cancerQ29620348
The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosisQ29622875
Apoptosis inhibition by Bcl-2 gives way to autophagy in glucocorticoid-treated lymphocytesQ30538797
Arsenic trioxide induces not only apoptosis but also autophagic cell death in leukemia cell lines via up-regulation of Beclin-1.Q33252513
Dynamic effects of autophagy on arsenic trioxide-induced death of human leukemia cell line HL60 cellsQ33312343
Phase II trial of single-agent temsirolimus (CCI-779) for relapsed mantle cell lymphomaQ33366976
Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseasesQ33613123
Arsenic trioxide induces autophagic cell death in malignant glioma cells by upregulation of mitochondrial cell death protein BNIP3.Q34375642
Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivationQ40066410
Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cellsQ40071790
The combination of novel low molecular weight inhibitors of RAF (LBT613) and target of rapamycin (RAD001) decreases glioma proliferation and invasionQ40085993
Arsenic salts induced autophagic cell death and hypermethylation of DAPK promoter in SV-40 immortalized human uroepithelial cellsQ40096979
Differential effects of endoplasmic reticulum stress-induced autophagy on cell survival.Q40202994
Vitamin D analog EB1089 triggers dramatic lysosomal changes and Beclin 1-mediated autophagic cell death.Q40419639
Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cellsQ40600919
The ARF tumor suppressor can promote the progression of some tumors.Q41819519
Autophagy in aging, disease and death: the true identity of a cell death impostorQ42609173
Early detection of graft failure using the blood metabolic profile of a liver recipientQ43095449
Cell death induced by dexamethasone in lymphoid leukemia is mediated through initiation of autophagyQ43991443
Life and death partners: apoptosis, autophagy and the cross-talk between themQ46072576
A novel Bcl-XL inhibitor Z36 that induces autophagic cell death in Hela cellsQ46109715
Regulation of estrogenic effects by beclin 1 in breast cancer cellsQ46336425
Oxidation as a post-translational modification that regulates autophagyQ48405295
Coordinate activation of autophagy and the proteasome pathway by FoxO transcription factorQ51455030
Apoptosis and autophagy in photoreceptors exposed to oxidative stressQ53556342
Autophagy and cancerQ56772657
Chronic Lymphocytic Leukemia: Keeping Cell Death at BayQ57253596
ROS, mitochondria and the regulation of autophagyQ34679713
The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapyQ34763495
Autophagy is involved in T cell death after binding of HIV-1 envelope proteins to CXCR4.Q34872907
Frameshift mutations of autophagy-related genes ATG2B, ATG5, ATG9B and ATG12 in gastric and colorectal cancers with microsatellite instabilityQ34938849
Role of BNIP3 and NIX in cell death, autophagy, and mitophagyQ34948698
Autophagy: in sickness and in healthQ35753167
Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistanceQ35850687
Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesisQ35855667
Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viabilityQ35916071
Protein degradation and agingQ36241977
Abl kinases regulate autophagy by promoting the trafficking and function of lysosomal componentsQ37015051
Tuberous sclerosis complex, implication from a rare genetic disease to common cancer treatmentQ37134137
ARF, autophagy and tumor suppression.Q37155201
Therapeutic activity of mTOR inhibitors in mantle cell lymphoma: clues but no clear answersQ37158978
Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cellsQ37170788
Clinical applications of metabolomics in oncology: a reviewQ37177549
Autophagy genes in immunityQ37273997
The paradox of autophagy and its implication in cancer etiology and therapyQ37378496
AMPK/SNF1 structure: a menage a trois of energy-sensingQ37410000
Beclin-1 expression is a predictor of clinical outcome in patients with esophageal squamous cell carcinoma and correlated to hypoxia-inducible factor (HIF)-1alpha expressionQ37469223
The role of ATF4 stabilization and autophagy in resistance of breast cancer cells treated with BortezomibQ39856430
Superoxide is the major reactive oxygen species regulating autophagyQ39858156
Stimulation of autophagy by the p53 target gene Sestrin2.Q39859248
RAD001 (Everolimus) induces autophagy in acute lymphoblastic leukemiaQ39861488
PUMA- and Bax-induced autophagy contributes to apoptosisQ39870608
Autophagy facilitates the progression of ERalpha-positive breast cancer cells to antiestrogen resistanceQ39883237
Inhibition of autophagy at a late stage enhances imatinib-induced cytotoxicity in human malignant glioma cellsQ39910064
SAHA induces caspase-independent, autophagic cell death of endometrial stromal sarcoma cells by influencing the mTOR pathwayQ39930036
Induction of autophagy by proteasome inhibitor is associated with proliferative arrest in colon cancer cells.Q39959646
Vitamin D3 induces autophagy of human myeloid leukemia cellsQ39961212
The Bcr-Abl kinase inhibitor INNO-406 induces autophagy and different modes of cell death execution in Bcr-Abl-positive leukemiasQ39962747
Enhancer of zeste homolog 2 downregulates E-cadherin by mediating histone H3 methylation in gastric cancer cellsQ39996922
Vitamin K2 induces autophagy and apoptosis simultaneously in leukemia cellsQ39997033
Temsirolimus downregulates p21 without altering cyclin D1 expression and induces autophagy and synergizes with vorinostat in mantle cell lymphomaQ40002119
Blocked autophagy sensitizes resistant carcinoma cells to radiation therapyQ40006232
P433issue2
P921main subjectautophagyQ288322
P304page(s)285-297
P577publication date2010-02-01
P13046publication type of scholarly workreview articleQ7318358
P1433published inFuture Medicinal ChemistryQ19280078
P1476titleAutophagy: cancer therapy's friend or foe?
P478volume2

Reverse relations

cites work (P2860)
Q57809709AMPK-dependent autophagy upregulation serves as a survival mechanism in response to Tumor Treating Fields (TTFields)
Q35319792Autophagy during beef aging
Q55213455Autophagy inhibition enhances radiosensitivity of Eca‑109 cells via the mitochondrial apoptosis pathway.
Q34389503Grape seed extract and resveratrol prevent 4-nitroquinoline 1-oxide induced oral tumorigenesis in mice by modulating AMPK activation and associated biological responses
Q37468676High dose of extracellular ATP switched autophagy to apoptosis in anchorage-dependent and anchorage-independent hepatoma cells
Q93111157MTMR3 is upregulated in patients with breast cancer and regulates proliferation, cell cycle progression and autophagy in breast cancer cells
Q57050339Microgravity induces autophagy via mitochondrial dysfunction in human Hodgkin's lymphoma cells
Q35558057Novel and emerging targeted-based cancer therapy agents and methods
Q89909298Resveratrol suppresses melanoma growth by promoting autophagy through inhibiting the PI3K/AKT/mTOR signaling pathway
Q38261907Sorafenib-induced defective autophagy promotes cell death by necroptosis
Q38579547Targeting autophagy to overcome drug resistance in cancer therapy
Q35723957Targeting of distinct signaling cascades and cancer-associated fibroblasts define the efficacy of Sorafenib against prostate cancer cells
Q47138725The downregulation of ATG4B mediated by microRNA-34a/34c-5p suppresses rapamycin-induced autophagy
Q39726023The expression of p33ING1, p53, and autophagy-related gene Beclin1 in patients with non-small cell lung cancer
Q28483781The inhibition of autophagy sensitises colon cancer cells with wild-type p53 but not mutant p53 to topotecan treatment
Q37151496The pancreatitis-associated protein VMP1, a key regulator of inducible autophagy, promotes Kras(G12D)-mediated pancreatic cancer initiation.
Q39715088The significance of expression of autophagy-related gene Beclin, Bcl-2, and Bax in breast cancer tissues
Q61445010WZY-321, a novel evodiamine analog, inhibits glioma cell growth in an autophagy-associated manner

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