Resistance to 3-HTMC-Induced Apoptosis Through Activation of PI3K/Akt, MEK/ERK, and p38/COX-2/PGE2 Pathways in Human HT-29 and HCT116 Colorectal Cancer Cells.

scientific article published on 18 May 2016

Resistance to 3-HTMC-Induced Apoptosis Through Activation of PI3K/Akt, MEK/ERK, and p38/COX-2/PGE2 Pathways in Human HT-29 and HCT116 Colorectal Cancer Cells. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/JCB.25600
P698PubMed publication ID27192488

P50authorVincent SolQ57562722
Youness LimamiQ89368029
Bertrand LiagreQ90419811
Benjamin RiouxQ92499567
P2093author name stringMona Diab-Assaf
Lama Hassan
Alain Simon
Christelle Pouget
Aline Pinon
Catherine Fagnère
Josiane Semaan
P2860cites workOverexpression of COX-2 in human osteosarcoma cells decreases proliferation and increases apoptosisQ40259853
Combination of isoliquiritigenin and tumor necrosis factor-related apoptosis-inducing ligand induces apoptosis in colon cancer HT29 cellsQ41377344
Synthesis and biological evaluation of 3',4',5'-trimethoxychalcone analogues as inhibitors of nitric oxide production and tumor cell proliferationQ43252300
Phosphorylated Akt overexpression and loss of PTEN expression in non-small cell lung cancer confers poor prognosisQ47680928
The P2Y2/Src/p38/COX-2 pathway is involved in the resistance to ursolic acid-induced apoptosis in colorectal and prostate cancer cells.Q54516019
HT-29 colorectal cancer cells undergoing apoptosis overexpress COX-2 to delay ursolic acid-induced cell death.Q54618743
Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicingQ24563789
Protein kinases and phosphatases in the control of cell fateQ24604987
Molecular targeted approaches to cancer therapy and prevention using chalconesQ27021479
Global cancer statistics, 2012Q27860501
Control of the G2/M transitionQ28236097
Genetic alterations during colorectal-tumor developmentQ28281200
Cell-cycle checkpoints and cancerQ28293996
Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumorsQ28297412
Apoptosis: a review of programmed cell deathQ28305845
Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomasQ29620630
Flavokawain B, a kava chalcone, induces apoptosis via up-regulation of death-receptor 5 and Bim expression in androgen receptor negative, hormonal refractory prostate cancer cell lines and reduces tumor growthQ33925625
Regulation of the G2/M transition by p53.Q33943437
Molecular targets of dietary agents for prevention and therapy of cancerQ34505253
A review on plant-derived natural products and their analogs with anti-tumor activityQ34511478
Colorectal Cancer Epidemiology: Incidence, Mortality, Survival, and Risk FactorsQ34624887
Dietary chalcones with chemopreventive and chemotherapeutic potentialQ34975832
The role of COX-2 in intestinal inflammation and colorectal cancerQ35234704
Apoptosis in cancer: from pathogenesis to treatmentQ35397889
Fishing for prostanoids: deciphering the developmental functions of cyclooxygenase-derived prostaglandinsQ36323269
Incidence, mechanism and prognostic value of activated AKT in pancreas cancerQ36648105
Current overview of the role of Akt in cancer studies via applied immunohistochemistryQ37104138
The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironmentQ37366259
Chalcones derivatives acting as cell cycle blockers: potential anti cancer drugs?Q37437957
Natural compounds for cancer treatment and preventionQ37476223
Autophagy-Mediated Degradation of IAPs and c-FLIP(L) Potentiates Apoptosis Induced by Combination of TRAIL and Chal-24.Q38829473
The Upregulation of PI3K/Akt and MAP Kinase Pathways is Associated with Resistance of Microtubule-Targeting Drugs in Prostate CancerQ38914271
Chalcones with electron-withdrawing and electron-donating substituents: anticancer activity against TRAIL resistant cancer cells, structure-activity relationship analysis and regulation of apoptotic proteins.Q39011086
The chalcone 2'-hydroxy-4',5'-dimethoxychalcone activates death receptor 5 pathway and leads to apoptosis in human nonsmall cell lung cancer cells.Q39171821
Cyclooxygenase-2 positively regulates Akt signalling and enhances survival of erythroleukemia cells exposed to anticancer agents.Q39189510
Regulation of cyclooxygenase 2 mRNA stability by the mitogen-activated protein kinase p38 signaling cascadeQ39453587
Combretastatin-like chalcones as inhibitors of microtubule polymerization. Part 1: synthesis and biological evaluation of antivascular activityQ39786412
P433issue12
P921main subjectcolorectal cancerQ188874
P304page(s)2875-2885
P577publication date2016-05-18
P1433published inJournal of Cellular BiochemistryQ6294917
P1476titleResistance to 3-HTMC-Induced Apoptosis Through Activation of PI3K/Akt, MEK/ERK, and p38/COX-2/PGE2 Pathways in Human HT-29 and HCT116 Colorectal Cancer Cells.
P478volume117

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cites work (P2860)
Q37732985Celecoxib enhances the radiosensitivity of HCT116 cells in a COX-2 independent manner by up-regulating BCCIP.
Q48274748MiR-216a-3p inhibits colorectal cancer cell proliferation through direct targeting COX-2 and ALOX5.
Q55013675NUDCD1 promotes metastasis through inducing EMT and inhibiting apoptosis in colorectal cancer.
Q59810238Targeting Cancer with Phytochemicals via Their Fine Tuning of the Cell Survival Signaling Pathways

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