Overcoming chemotherapy drug resistance by targeting inhibitors of apoptosis proteins (IAPs)

scientific article

Overcoming chemotherapy drug resistance by targeting inhibitors of apoptosis proteins (IAPs) is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1007/S10495-017-1375-1
P932PMC publication ID5486846
P698PubMed publication ID28424988

P50authorDietrich BüsselbergQ42608731
P2093author name stringJennifer E McCallum
Ana-Maria Florea
Elizabeth Varghese
Rama Rathore
P2860cites workStructure-based design of potent, conformationally constrained Smac mimeticsQ95801450
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Smac mimetic bypasses apoptosis resistance in FADD- or caspase-8-deficient cells by priming for tumor necrosis factor α-induced necroptosisQ24294685
IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosisQ24300707
XIAP: cell death regulation meets copper homeostasisQ24300814
Final stages of cytokinesis and midbody ring formation are controlled by BRUCEQ24308799
cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoformsQ24311676
Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by BaxQ24323186
cIAP1 Localizes to the nuclear compartment and modulates the cell cycleQ24338725
Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein familyQ24550944
Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosisQ24609324
Survivin: a unique target for tumor therapyQ26747332
Cancer therapy in the necroptosis eraQ26766339
Structural and biochemical basis of apoptotic activation by Smac/DIABLOQ27626899
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Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibitionQ28115131
Activation of NF-kappa B by XIAP, the X chromosome-linked inhibitor of apoptosis, in endothelial cells involves TAK1Q28144306
Direct interaction between survivin and Smac/DIABLO is essential for the anti-apoptotic activity of survivin during taxol-induced apoptosisQ28186614
X-linked inhibitor of apoptosis protein (XIAP) inhibits caspase-3 and -7 in distinct modesQ28189754
Survivin - an anti-apoptosis protein: its biological roles and implications for cancer and beyondQ28199137
Die another way--non-apoptotic mechanisms of cell deathQ28240157
Cell death: critical control pointsQ28240722
XIAP deficiency in humans causes an X-linked lymphoproliferative syndromeQ28271832
Neuronal apoptosis-inhibitory protein does not interact with Smac and requires ATP to bind caspase-9Q28274451
Mithramycin A sensitizes cancer cells to TRAIL-mediated apoptosis by down-regulation of XIAP gene promoter through Sp1 sitesQ28275221
Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection functionQ28276098
IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugsQ28291174
Cell-cycle checkpoints and cancerQ28293996
Survivin splice variants regulate the balance between proliferation and cell deathQ28305497
Apoptosis: a review of programmed cell deathQ28305845
A novel small molecule FL118 that selectively inhibits survivin, Mcl-1, XIAP and cIAP2 in a p53-independent manner, shows superior antitumor activityQ28483886
An intravenous (i.v.) route-compatible formulation of FL118, a survivin, Mcl-1, XIAP, and cIAP2 selective inhibitor, improves FL118 antitumor efficacy and therapeutic index (TI)Q28485864
A giant ubiquitin-conjugating enzyme related to IAP apoptosis inhibitorsQ28504926
Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosisQ28511080
Inhibition of MARCH5 ubiquitin ligase abrogates MCL1-dependent resistance to BH3 mimetics via NOXAQ28830560
Structural Basis of Caspase Inhibition by XIAPQ29011600
Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastomaQ29615607
cIAP-2 block apoptotic events in bladder cancer cellsQ31154242
Phase I trial of AEG35156 an antisense oligonucleotide to XIAP plus gemcitabine in patients with metastatic pancreatic ductal adenocarcinomaQ33400365
Inhibitors of apoptosis proteins (IAPs) expression and their prognostic significance in hepatocellular carcinoma.Q33435646
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A Smac-mimetic sensitizes prostate cancer cells to TRAIL-induced apoptosis via modulating both IAPs and NF-kappaB.Q33515420
Endogenous Bak inhibitors Mcl-1 and Bcl-xL: differential impact on TRAIL resistance in Bax-deficient carcinoma.Q33544118
The multikinase inhibitor sorafenib potentiates TRAIL lethality in human leukemia cells in association with Mcl-1 and cFLIPL down-regulationQ44932731
PROCLAIM: Randomized Phase III Trial of Pemetrexed-Cisplatin or Etoposide-Cisplatin Plus Thoracic Radiation Therapy Followed by Consolidation Chemotherapy in Locally Advanced Nonsquamous Non-Small-Cell Lung CancerQ46202942
A small molecule Smac-mimic compound induces apoptosis and sensitizes TRAIL- and etoposide-induced apoptosis in breast cancer cellsQ46619108
Smac mimetic and glucocorticoids synergize to induce apoptosis in childhood ALL by promoting ripoptosome assemblyQ46890911
Inhibitor of apoptosis protein (IAP) antagonists demonstrate divergent immunomodulatory properties in human immune subsets with implications for combination therapyQ47221521
High expression levels of x-linked inhibitor of apoptosis protein and survivin correlate with poor overall survival in childhood de novo acute myeloid leukemiaQ47406547
Birc1e is the gene within the Lgn1 locus associated with resistance to Legionella pneumophilaQ48269403
Whole-genome characterization of chemoresistant ovarian cancer.Q50272478
Expression of IAP family proteins and its clinical importance in breast cancer patients.Q51022871
Assessment of IAP (inhibitor of apoptosis) proteins as predictors of response to chemotherapy in advanced non-small-cell lung cancer patients.Q52590107
Disruption of BIRC3 associates with fludarabine chemorefractoriness in TP53 wild-type chronic lymphocytic leukemia.Q52621343
Inhibition of Bcl-2 improves effect of LCL161, a SMAC mimetic, in hepatocellular carcinoma cells.Q53169400
Expression of cIAP-1 correlates with nodal metastasis in squamous cell carcinoma of the tongue.Q53466753
Multiple mechanisms underlie resistance of leukemia cells to Apo2 Ligand/TRAIL.Q53591297
Survivin stable knockdown by siRNA inhibits tumor cell growth and angiogenesis in breast and cervical cancers.Q53609510
The inhibitors of apoptosis (IAPs) as cancer targetsQ36851057
DNA damage response (DDR) pathway engagement in cisplatin radiosensitization of non-small cell lung cancerQ36855596
AT-406, an orally active antagonist of multiple inhibitor of apoptosis proteins, inhibits progression of human ovarian cancerQ36919815
Mechanisms of action of Bcl-2 family proteinsQ36932838
Overcoming resistance to TRAIL-induced apoptosis in solid tumor cells by simultaneously targeting death receptors, c-FLIP and IAPsQ36992161
The pyrrolo-1,5-benzoxazepine, PBOX-15, enhances TRAIL‑induced apoptosis by upregulation of DR5 and downregulation of core cell survival proteins in acute lymphoblastic leukaemia cellsQ36992184
Prognostic biomarkers of renal cell carcinoma: Recent advancesQ37197505
IAP-targeted therapies for cancerQ37302745
Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myelomaQ37314736
Phase I/II trial of AEG35156 X-linked inhibitor of apoptosis protein antisense oligonucleotide combined with idarubicin and cytarabine in patients with relapsed or primary refractory acute myeloid leukemiaQ37355664
Expression of livin and vascular endothelial growth factor in different clinical stages of human esophageal carcinomaQ37356468
Inhibitor of apoptosis protein expression in glioblastomas and their in vitro and in vivo targeting by SMAC mimetic GDC-0152Q37412477
SM-164: a novel, bivalent Smac mimetic that induces apoptosis and tumor regression by concurrent removal of the blockade of cIAP-1/2 and XIAP.Q37445045
X chromosome-linked inhibitor of apoptosis regulates cell death induction by proapoptotic receptor agonistsQ37454149
Reactivation of Smac-mediated apoptosis in chronic lymphocytic leukemia cells: mechanistic studies of Smac mimeticQ37457562
Following TRAIL's path in the immune systemQ37498946
Mitochondrial survivin inhibits apoptosis and promotes tumorigenesis.Q37574259
Anti-cancer IAP antagonists promote bone metastasis: a cautionary taleQ37654710
Molecular biology of Bax and Bak activation and actionQ37824965
Targeting survivin in cancer: the cell-signalling perspectiveQ37867746
Death receptors as targets in cancerQ38103591
Cellular mechanisms controlling caspase activation and functionQ38111614
Molecular pathways: targeting death receptors and smac mimeticsQ38211503
X-linked inhibitor of apoptosis protein - a critical death resistance regulator and therapeutic target for personalized cancer therapy.Q38239689
Two death-inducing human TRAIL receptors to target in cancer: similar or distinct regulation and function?Q38242499
The mitochondrial voltage-dependent anion channel 1 in tumor cells.Q38275475
Platinum-based chemotherapy: gastrointestinal immunomodulation and enteric nervous system toxicity.Q38287054
SADS: A new component of Fas-DISC is the accelerator for cell death signaling and is downregulated in patients with colon carcinomaQ38305316
Mutation analysis of the apoptotic "death-receptors" and the adaptors TRADD and FADD/MORT-1 in osteosarcoma tumor samples and osteosarcoma cell linesQ38344110
Mitochondrial apoptosis: killing cancer using the enemy within.Q38367962
Molecular determinants of Smac mimetic induced degradation of cIAP1 and cIAP2.Q38391583
Small molecule inhibitor of apoptosis proteins antagonists: a patent reviewQ38484840
The radiosensitizing activity of the SMAC-mimetic, Debio 1143, is TNFα-mediated in head and neck squamous cell carcinoma.Q38861440
Doxorubicin overcomes resistance to drozitumab by antagonizing Inhibitor of Apoptosis Proteins (IAPs).Q38928915
Cytochrome c maintains mitochondrial transmembrane potential and ATP generation after outer mitochondrial membrane permeabilization during the apoptotic processQ36316624
Kurarinone promotes TRAIL-induced apoptosis by inhibiting NF-κB-dependent cFLIP expression in HeLa cellsQ36431068
A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatmentQ36460712
Hypoxia signalling in cancer and approaches to enforce tumour regressionQ36488739
Survivin, a cancer target with an emerging role in normal adult tissuesQ36491426
Pharmacodynamic markers and clinical results from the phase 2 study of the SMAC mimetic birinapant in women with relapsed platinum-resistant or -refractory epithelial ovarian cancerQ36547383
Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapyQ36558024
Antagonism of inhibitor of apoptosis proteins increases bone metastasis via unexpected osteoclast activationQ36604919
The CASBAH: a searchable database of caspase substratesQ36726238
Withdrawal of IL-7 induces Bax translocation from cytosol to mitochondria through a rise in intracellular pH.Q36746298
Intrinsic and chemo-sensitizing activity of SMAC-mimetics on high-risk childhood acute lymphoblastic leukemia.Q36751715
BSP gene silencing inhibits migration, invasion, and bone metastasis of MDA-MB-231BO human breast cancer cellsQ36824242
The SMAC mimetic, LCL-161, reduces survival in aggressive MYC-driven lymphoma while promoting susceptibility to endotoxic shockQ36846723
Detection of anti-livin antibody in gastrointestinal cancer patients.Q54767281
Birinapant, a Smac-Mimetic with Improved Tolerability for the Treatment of Solid Tumors and Hematological MalignanciesQ61776445
Survivin regulates hematopoietic progenitor cell proliferation through p21WAF1/Cip1-dependent and -independent pathwaysQ73932730
Overexpression of XIAP expression in renal cell carcinoma predicts a worse prognosisQ79857928
Livin and Bcl-2 expression in high-grade osteosarcomaQ80619467
Expression and localization of inhibitor of apoptosis proteins in normal human tissuesQ81637512
Detection of autoantibodies to livin and survivin in Sera from lung cancer patientsQ81648016
Targeting apoptosis pathways in cancer therapyQ81742188
Comparative study of gene expression by cDNA microarray in human colorectal cancer tissues and normal mucosaQ83988443
Overcoming multidrug resistance in cancer: clinical studies of p-glycoprotein inhibitorsQ84966132
Bleomycin induced sensitivity to TRAIL/Apo-2L-mediated apoptosis in human seminomatous testicular cancer cells is correlated with upregulation of death receptorsQ38961445
The BIRC6 gene as a novel target for therapy of prostate cancer: dual targeting of inhibitors of apoptosisQ38970758
Synergistic effects of IAP inhibitor LCL161 and paclitaxel on hepatocellular carcinoma cellsQ38979846
Class I-specific histone deacetylase inhibitor MS-275 overrides TRAIL-resistance in melanoma cells by downregulating c-FLIP.Q38982947
Birinapant (TL32711), a bivalent SMAC mimetic, targets TRAF2-associated cIAPs, abrogates TNF-induced NF-κB activation, and is active in patient-derived xenograft modelsQ39021475
Smac mimetic compound LCL161 sensitizes esophageal carcinoma cells to radiotherapy by inhibiting the expression of inhibitor of apoptosis proteinQ39068951
Smac mimetic and demethylating agents synergistically trigger cell death in acute myeloid leukemia cells and overcome apoptosis resistance by inducing necroptosisQ39096643
The novel SMAC mimetic birinapant exhibits potent activity against human melanoma cellsQ39195579
Ardisianone, a natural benzoquinone, efficiently induces apoptosis in human hormone-refractory prostate cancers through mitochondrial damage stress and survivin downregulation.Q39335751
Smac mimetic sensitizes glioblastoma cells to Temozolomide-induced apoptosis in a RIP1- and NF-κB-dependent manner.Q39370420
Overexpression of survivin is correlated with increased invasion and metastasis of colorectal cancerQ39446582
The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPsQ39511129
Nimbolide retards tumor cell migration, invasion, and angiogenesis by downregulating MMP-2/9 expression via inhibiting ERK1/2 and reducing DNA-binding activity of NF-κB in colon cancer cellsQ39523519
TRAIL-activated stress kinases suppress apoptosis through transcriptional upregulation of MCL-1.Q39737623
XIAP gene downregulation by small interfering RNA inhibits proliferation, induces apoptosis, and reverses the cisplatin resistance of ovarian carcinomaQ39798856
Roscovitine sensitizes breast cancer cells to TRAIL-induced apoptosis through a pleiotropic mechanismQ39985088
Expression of inhibitor-of-apoptosis protein (IAP) livin by neuroblastoma cells: correlation with prognostic factors and outcomeQ40343583
Loss of XIAP protein expression by RNAi and antisense approaches sensitizes cancer cells to functionally diverse chemotherapeuticsQ40513940
Subcellular expression of c-IAP1 and c-IAP2 in colorectal cancers: relationships with clinicopathological features and prognosisQ40601815
Increased survivin expression confers chemoresistance to tumor-associated endothelial cellsQ40645812
Resistance to chemotherapy via Stat3-dependent overexpression of Bcl-2 in metastatic breast cancer cellsQ40694264
Smac mimetics combined with innate immune stimuli create the perfect cytokine storm to kill tumor cellsQ40877996
The porin VDAC2 is the mitochondrial platform for Bax retrotranslocation.Q41073152
Cellular inhibitor of apoptosis 1 (cIAP-1) degradation by caspase 8 during TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosisQ41536623
Defining characteristics of Types I and II apoptotic cells in response to TRAIL.Q41687820
Inability to resolve specific infection generates innate immunodeficiency syndrome in Xiap-/- miceQ41752725
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.Q42064781
Phosphorylation of XIAP by CDK1-cyclin-B1 controls mitotic cell deathQ42113128
The opposing roles of cellular inhibitor of apoptosis proteins in cancerQ42288562
CLL cells are resistant to smac mimetics because of an inability to form a ripoptosome complex.Q42585598
Smac mimetic Birinapant induces apoptosis and enhances TRAIL potency in inflammatory breast cancer cells in an IAP-dependent and TNF-α-independent mechanism.Q42713862
Mitochondrial survivin - an Achilles' heel in cancer chemoresistance.Q42730045
Prognostic significance of XIAP expression in DLBCL and effect of its inhibition on AKT signalling.Q42969753
Tumor-cell resistance to death receptor--induced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog Bax.Q43903493
Synthetic Smac/DIABLO peptides enhance the effects of chemotherapeutic agents by binding XIAP and cIAP1 in situQ44129457
Synergistic interactions of chemotherapeutic drugs and tumor necrosis factor-related apoptosis-inducing ligand/Apo-2 ligand on apoptosis and on regression of breast carcinoma in vivoQ44590630
IAP regulation of metastasisQ33638504
Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokinesQ33861276
Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2.Q33999606
The rheostat in the membrane: BCL-2 family proteins and apoptosisQ34038716
Predominant suppression of apoptosome by inhibitor of apoptosis protein in non-small cell lung cancer H460 cells: therapeutic effect of a novel polyarginine-conjugated Smac peptideQ34178083
XIAP discriminates between type I and type II FAS-induced apoptosisQ34205704
Survivin expression promotes VEGF-induced tumor angiogenesis via PI3K/Akt enhanced β-catenin/Tcf-Lef dependent transcriptionQ34254214
A small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell deathQ34346499
Estrogen promotes breast cancer cell survival in an inhibitor of apoptosis (IAP)-dependent manner.Q34378269
Nimbolide sensitizes human colon cancer cells to TRAIL through reactive oxygen species- and ERK-dependent up-regulation of death receptors, p53, and Bax.Q34488880
Characterization of Potent SMAC Mimetics that Sensitize Cancer Cells to TNF Family-Induced ApoptosisQ34540067
LCL161 increases paclitaxel-induced apoptosis by degrading cIAP1 and cIAP2 in NSCLC.Q34542571
Distribution of neuronal apoptosis inhibitory protein in human tissues.Q34629464
Degradation of survivin by the X-linked inhibitor of apoptosis (XIAP)-XAF1 complexQ34646527
Triggering caspase-independent cell death to combat cancer.Q34688272
Targeted therapy of the XIAP/proteasome pathway overcomes TRAIL-resistance in carcinoma by switching apoptosis signaling to a Bax/Bak-independent 'type I' modeQ34736820
Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosisQ34802453
X-linked inhibitor of apoptosis protein (XIAP) mediates cancer cell motility via Rho GDP dissociation inhibitor (RhoGDI)-dependent regulation of the cytoskeletonQ34962925
Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2.Q34982664
Drozitumab, a human antibody to death receptor 5, has potent antitumor activity against rhabdomyosarcoma with the expression of caspase-8 predictive of responseQ34988055
Chemotherapy overcomes TRAIL-R4-mediated TRAIL resistance at the DISC levelQ35051505
The hippocampal neurons of neuronal apoptosis inhibitory protein 1 (NAIP1)-deleted mice display increased vulnerability to kainic acid-induced injuryQ35053511
A phase I/II study of bortezomib in combination with paclitaxel, carboplatin, and concurrent thoracic radiation therapy for non-small-cell lung cancer: North Central Cancer Treatment Group (NCCTG)-N0321Q35058595
Overcoming resistance of cancer cells to apoptosisQ35136082
BRUCE regulates DNA double-strand break response by promoting USP8 deubiquitination of BRIT1.Q35212757
TRAIL and apoptosis induction by TNF-family death receptors.Q35591708
The X-linked inhibitor of apoptosis protein (XIAP) is up-regulated in metastatic melanoma, and XIAP cleavage by Phenoxodiol is associated with Carboplatin sensitizationQ35632517
Structural biology of the Bcl-2 family of proteinsQ35680498
RETRACTED ARTICLE: An apoptosis-enhancing drug overcomes platinum resistance in a tumour-initiating subpopulation of ovarian cancerQ35941858
Death receptor signalingQ36011453
Overexpression of cellular inhibitor of apoptosis protein 2 is an early event in the progression of pancreatic cancerQ36014277
XIAP antisense oligonucleotide (AEG35156) achieves target knockdown and induces apoptosis preferentially in CD34+38− cells in a phase 1/2 study of patients with relapsed/refractory AMLQ36034921
IAP antagonists Birinapant and AT-406 efficiently synergise with either TRAIL, BRAF, or BCL-2 inhibitors to sensitise BRAFV600E colorectal tumour cells to apoptosisQ36103378
Role of Apollon in human melanoma resistance to antitumor agents that activate the intrinsic or the extrinsic apoptosis pathwaysQ36184769
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue7
P921main subjectinhibitor of apoptosis proteinsQ174299
neoplasmQ1216998
antineoplastic resistanceQ13416904
apoptotic processQ14599311
Smac/DIABLO proteinQ24741030
mitochondrial proteinQ67455737
intracellular signaling peptides and proteinsQ67575047
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)898-919
P577publication date2017-04-19
2017-07-01
P1433published inApoptosisQ15749546
P1476titleOvercoming chemotherapy drug resistance by targeting inhibitors of apoptosis proteins (IAPs)
P478volume22

Reverse relations

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