| review article | Q7318358 |
| scholarly article | Q13442814 |
| P2093 | author name string | R G Korneluk | |
| D J Mahoney | |||
| H H Cheung | |||
| S Baird | |||
| S Plenchette | |||
| E C LaCasse | |||
| P2860 | cites work | The Hallmarks of Cancer | Q221226 |
| Silencing of the XAF1 gene by promoter hypermethylation in cancer cells and reactivation to TRAIL-sensitization by IFN-beta | Q21260407 | ||
| A human IAP-family gene, apollon, expressed in human brain cancer cells | Q22010740 | ||
| AMP-Activated Protein Kinase in Metabolic Control and Insulin Signaling | Q22241925 | ||
| Crystal structure of human survivin reveals a bow tie-shaped dimer with two unusual alpha-helical extensions | Q24290114 | ||
| Livin, a novel inhibitor of apoptosis protein family member | Q24290377 | ||
| Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin | Q24290497 | ||
| ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas | Q24290531 | ||
| Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma | Q24290550 | ||
| Do the survivin (BIRC5) splice variants modulate or add to the prognostic value of total survivin in breast cancer? | Q80008989 | ||
| Activated intrinsic apoptosis pathway is a key related prognostic parameter in acute myeloid leukemia | Q80076954 | ||
| Nuclear survivin is associated with disease recurrence and poor survival in patients with cutaneous malignant melanoma | Q80417281 | ||
| Non-peptidic small molecule inhibitors of XIAP | Q81306115 | ||
| CIAP2 inhibits anigen receptor signaling by targeting Bcl10 for degredation | Q83995293 | ||
| TAK1 is a ubiquitin-dependent kinase of MKK and IKK | Q24291454 | ||
| The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif | Q24291797 | ||
| HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins | Q24291802 | ||
| SMAC negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP) | Q24292189 | ||
| IAP suppression of apoptosis involves distinct mechanisms: the TAK1/JNK1 signaling cascade and caspase inhibition | Q24292370 | ||
| TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2 | Q24292505 | ||
| Distinct BIR domains of cIAP1 mediate binding to and ubiquitination of tumor necrosis factor receptor-associated factor 2 and second mitochondrial activator of caspases | Q24294565 | ||
| Molecular analysis of survivin isoforms: evidence that alternatively spliced variants do not play a role in mitosis | Q24295217 | ||
| Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together | Q24298466 | ||
| Mature DIABLO/Smac is produced by the IMP protease complex on the mitochondrial inner membrane | Q24299687 | ||
| cIAP2 is a ubiquitin protein ligase for BCL10 and is dysregulated in mucosa-associated lymphoid tissue lymphomas | Q24300394 | ||
| IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis | Q24300707 | ||
| IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis | Q24300734 | ||
| Manipulation of NK cytotoxicity by the IAP family member Livin | Q24301293 | ||
| Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains | Q24306305 | ||
| T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20 | Q24307779 | ||
| The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy | Q24308680 | ||
| Final stages of cytokinesis and midbody ring formation are controlled by BRUCE | Q24308799 | ||
| TNF-alpha induces two distinct caspase-8 activation pathways | Q24313656 | ||
| Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes | Q24315805 | ||
| X-linked IAP is a direct inhibitor of cell-death proteases | Q24318710 | ||
| A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma | Q24322614 | ||
| The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex | Q24323338 | ||
| TNF-alpha induced c-IAP1/TRAF2 complex translocation to a Ubc6-containing compartment and TRAF2 ubiquitination | Q24529129 | ||
| IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases | Q24533214 | ||
| HSF1 down-regulates XAF1 through transcriptional regulation. | Q34469575 | ||
| Overcoming resistance to interferon-induced apoptosis of renal carcinoma and melanoma cells by DNA demethylation | Q34542069 | ||
| Correlation between the single-site CpG methylation and expression silencing of the XAF1 gene in human gastric and colon cancers. | Q34579614 | ||
| Inhibition of melanoma tumor growth in vivo by survivin targeting | Q34623127 | ||
| CARD-Bcl10-Malt1 signalosomes: missing link to NF-kappaB. | Q34624811 | ||
| Frequent alteration of XAF1 in human colorectal cancers: implication for tumor cell resistance to apoptotic stresses. | Q34637760 | ||
| Degradation of survivin by the X-linked inhibitor of apoptosis (XIAP)-XAF1 complex | Q34646527 | ||
| Yeast and apoptosis | Q34664796 | ||
| The proteolytic activity of the paracaspase MALT1 is key in T cell activation | Q34748769 | ||
| Antisense therapy: current status in prostate cancer and other malignancies | Q34980551 | ||
| Antisense therapy for cancer--the time of truth | Q34992794 | ||
| Splice variants of mIAP1 have an enhanced ability to inhibit apoptosis | Q35069365 | ||
| The inhibitors of apoptosis: there is more to life than Bcl2. | Q35591690 | ||
| Incidence and subtype specificity of API2-MALT1 fusion translocations in extranodal, nodal, and splenic marginal zone lymphomas | Q35810062 | ||
| Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cells | Q35847722 | ||
| Role of survivin and its splice variants in tumorigenesis | Q35990300 | ||
| Compartmentalized phosphorylation of IAP by protein kinase A regulates cytoprotection | Q36002989 | ||
| Anti-apoptotic action of API2-MALT1 fusion protein involved in t(11;18)(q21;q21) MALT lymphoma | Q36042483 | ||
| IAPs, RINGs and ubiquitylation | Q36085601 | ||
| Human cancer cells harbor T-stumps, a distinct class of extremely short telomeres | Q36149659 | ||
| Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma. | Q36155317 | ||
| Lingering mysteries of ubiquitin-chain assembly | Q36368593 | ||
| Small-molecule XIAP antagonist restores caspase-9 mediated apoptosis in XIAP-positive diffuse large B-cell lymphoma cells | Q36384652 | ||
| Survivin, a cancer target with an emerging role in normal adult tissues | Q36491426 | ||
| X-linked inhibitor of apoptosis antagonism: strategies in cancer treatment | Q36494869 | ||
| Survivin-dependent and -independent pathways and the induction of cancer cell death by tetra-O-methyl nordihydroguaiaretic acid | Q36557312 | ||
| Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB control | Q36580820 | ||
| Method validation and preliminary qualification of pharmacodynamic biomarkers employed to evaluate the clinical efficacy of an antisense compound (AEG35156) targeted to the X-linked inhibitor of apoptosis protein XIAP. | Q36611534 | ||
| Antigen-receptor signaling to nuclear factor kappa B. | Q36650654 | ||
| Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation | Q36691082 | ||
| Novel therapeutic targets in lung cancer: Inhibitor of apoptosis proteins from laboratory to clinic | Q36702243 | ||
| The RING domain of cIAP1 mediates the degradation of RING-bearing inhibitor of apoptosis proteins by distinct pathways | Q36739928 | ||
| TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFalpha. | Q36749651 | ||
| Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2 | Q24534641 | ||
| Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family | Q24550944 | ||
| A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors | Q24562976 | ||
| Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors | Q24600405 | ||
| Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis | Q24609324 | ||
| Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death | Q24630370 | ||
| Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach | Q24633776 | ||
| Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family | Q24670396 | ||
| The inhibitor of apoptosis protein-binding domain of Smac is not essential for its proapoptotic activity | Q24683990 | ||
| ASD: a bioinformatics resource on alternative splicing | Q25257737 | ||
| Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat | Q27619017 | ||
| NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP | Q27620280 | ||
| Structural and biochemical basis of apoptotic activation by Smac/DIABLO | Q27626899 | ||
| Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain | Q27629143 | ||
| Structural basis of IAP recognition by Smac/DIABLO | Q27629148 | ||
| XIAP Induces NF-κB Activation via the BIR1/TAB1 Interaction and BIR1 Dimerization | Q27645534 | ||
| Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition | Q28115131 | ||
| Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli | Q28116145 | ||
| The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins | Q28117866 | ||
| Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins | Q28117928 | ||
| Two splicing variants of a new inhibitor of apoptosis gene with different biological properties and tissue distribution pattern | Q28185610 | ||
| The polypeptide chain-releasing factor GSPT1/eRF3 is proteolytically processed into an IAP-binding protein | Q28187577 | ||
| Proliferation, cell cycle and apoptosis in cancer | Q28189476 | ||
| Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction | Q28199278 | ||
| Identification of XAF1 as an antagonist of XIAP anti-Caspase activity | Q28200039 | ||
| ILPIP, a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis | Q28202543 | ||
| A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis | Q28204205 | ||
| DNMT1 and DNMT3b cooperate to silence genes in human cancer cells | Q28212826 | ||
| Nuclear and cytoplasmic survivin: molecular mechanism, prognostic, and therapeutic potential | Q28235606 | ||
| Induction of apoptosis and inhibition of cell proliferation by survivin gene targeting | Q28268610 | ||
| XIAP deficiency in humans causes an X-linked lymphoproliferative syndrome | Q28271832 | ||
| Neuronal apoptosis-inhibitory protein does not interact with Smac and requires ATP to bind caspase-9 | Q28274451 | ||
| Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function | Q28276098 | ||
| The inhibitor of apoptosis protein fusion c-IAP2.MALT1 stimulates NF-kappaB activation independently of TRAF1 AND TRAF2. | Q46200610 | ||
| Birc2 (cIap1) regulates endothelial cell integrity and blood vessel homeostasis. | Q46203326 | ||
| Expression of X-linked inhibitor of apoptosis protein is a strong predictor of human prostate cancer recurrence | Q46229131 | ||
| Demonstration of direct binding of cIAP1 degradation-promoting bestatin analogs to BIR3 domain: Synthesis and application of fluorescent bestatin ester analogs | Q46617828 | ||
| A small molecule Smac-mimic compound induces apoptosis and sensitizes TRAIL- and etoposide-induced apoptosis in breast cancer cells | Q46619108 | ||
| Immunocytochemical detection of XIAP in body cavity effusions and washes | Q46666280 | ||
| The proapoptotic protein Smac/DIABLO dimer has the highest stability as measured by pressure and urea denaturation | Q46728205 | ||
| c-IAP1 cooperates with Myc by acting as a ubiquitin ligase for Mad1. | Q46848528 | ||
| The kinase activity of Rip1 is not required for tumor necrosis factor-alpha-induced IkappaB kinase or p38 MAP kinase activation or for the ubiquitination of Rip1 by Traf2. | Q47400705 | ||
| Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo | Q48548442 | ||
| YM155, a novel small-molecule survivin suppressant, induces regression of established human hormone-refractory prostate tumor xenografts. | Q51794884 | ||
| Expression of IAP family proteins in myelodysplastic syndromes transforming to overt leukemia. | Q52087420 | ||
| Assessment of IAP (inhibitor of apoptosis) proteins as predictors of response to chemotherapy in advanced non-small-cell lung cancer patients. | Q52590107 | ||
| XIAP expression is an independent prognostic marker in clear-cell renal carcinomas. | Q53366105 | ||
| Involvement of caspase-2 and caspase-9 in endoplasmic reticulum stress-induced apoptosis: a role for the IAPs. | Q53622762 | ||
| Survivin nuclear labeling index: a superior biomarker in superficial urothelial carcinoma of human urinary bladder. | Q54588466 | ||
| Survivin, cancer networks and pathway-directed drug discovery. | Q55046676 | ||
| Identification of mammalian mitochondrial proteins that interact with IAPs via N-terminal IAP binding motifs | Q57369787 | ||
| Selective Expansion of Marginal Zone B Cells in Eμ-API2-MALT1 Mice Is Linked to Enhanced IκB Kinase γ Polyubiquitination | Q57374743 | ||
| Integrative genomic and proteomic analysis of prostate cancer reveals signatures of metastatic progression | Q57693549 | ||
| Small-Molecule Targeting of Heat Shock Protein 90 Chaperone Function: Rational Identification of a New Anticancer Lead | Q57795122 | ||
| Dealing the CARDs between life and death | Q60188636 | ||
| Human ovarian cancer and cisplatin resistance: possible role of inhibitor of apoptosis proteins | Q64380181 | ||
| Adenovirus-mediated p53 gene transfer in advanced non-small-cell lung cancer | Q64381516 | ||
| Role of survivin, whose gene is mapped to 17q25, in human neuroblastoma and identification of a novel dominant-negative isoform, survivin-beta/2B | Q73271517 | ||
| Inhibition of survivin expression suppresses the growth of aggressive non-Hodgkin's lymphoma | Q75355864 | ||
| Marginal-zone B-cell lymphoma of extranodal mucosa-associated lymphoid tissue type: molecular genetics provides new insights into pathogenesis | Q77167353 | ||
| The inhibitors of apoptosis (IAPs) and their emerging role in cancer | Q77900361 | ||
| Nuclear expression of survivin is associated with improved survival in metastatic ovarian carcinoma | Q79432039 | ||
| Anti-apoptotic proteins, apoptotic and proliferative parameters and their prognostic significance in cervical carcinoma. | Q42505005 | ||
| Nuclear and cytoplasmic cellular distribution of survivin as survival predictor in resected non-small-cell lung cancer | Q42628781 | ||
| Inhibitor of apoptosis protein cIAP2 is essential for lipopolysaccharide-induced macrophage survival | Q43181903 | ||
| Protein-protein recognition as a first step towards the inhibition of XIAP and Survivin anti-apoptotic proteins. | Q43561028 | ||
| Survivin inhibition induces human neural tumor cell death through caspase-independent and -dependent pathways | Q43777410 | ||
| A small molecule ubiquitination inhibitor blocks NF-kappa B-dependent cytokine expression in cells and rats | Q43957787 | ||
| Ectopic overexpression of second mitochondria-derived activator of caspases (Smac/DIABLO) or cotreatment with N-terminus of Smac/DIABLO peptide potentiates epothilone B derivative-(BMS 247550) and Apo-2L/TRAIL-induced apoptosis | Q43966232 | ||
| Molecular targeting of inhibitor of apoptosis proteins based on small molecule mimics of natural binding partners | Q44014089 | ||
| Synthetic Smac/DIABLO peptides enhance the effects of chemotherapeutic agents by binding XIAP and cIAP1 in situ | Q44129457 | ||
| Smac/DIABLO selectively reduces the levels of c-IAP1 and c-IAP2 but not that of XIAP and livin in HeLa cells | Q44762625 | ||
| Involvement of two NF-kappa B binding elements in tumor necrosis factor alpha -, CD40-, and epstein-barr virus latent membrane protein 1-mediated induction of the cellular inhibitor of apoptosis protein 2 gene | Q45743372 | ||
| AMPK activation with AICAR provokes an acute fall in plasma [K+]. | Q46118954 | ||
| The mitochondrial death squad: hardened killers or innocent bystanders? | Q28276624 | ||
| cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination | Q28284721 | ||
| A Novel TRAF6 binding site in MALT1 defines distinct mechanisms of NF-kappaB activation by API2middle dotMALT1 fusions | Q28287278 | ||
| The membrane-associated inhibitor of apoptosis protein, BRUCE/Apollon, antagonizes both the precursor and mature forms of Smac and caspase-9 | Q28289960 | ||
| Application of XIAP antisense to cancer and other proliferative disorders: development of AEG35156/ GEM640 | Q28289976 | ||
| Isoform-specific silencing of the Livin gene by RNA interference defines Livin beta as key mediator of apoptosis inhibition in HeLa cells | Q28293793 | ||
| Cancer gene therapy using a survivin mutant adenovirus | Q28360690 | ||
| TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo | Q28504462 | ||
| A giant ubiquitin-conjugating enzyme related to IAP apoptosis inhibitors | Q28504926 | ||
| X-linked inhibitor of apoptosis (XIAP) inhibits c-Jun N-terminal kinase 1 (JNK1) activation by transforming growth factor beta1 (TGF-beta1) through ubiquitin-mediated proteosomal degradation of the TGF-beta1-activated kinase 1 (TAK1) | Q28584353 | ||
| Ubiquitination of RIP1 regulates an NF-kappaB-independent cell-death switch in TNF signaling | Q28757756 | ||
| Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO | Q29618712 | ||
| Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected] | Q29618714 | ||
| Chromosomal passengers: conducting cell division | Q29620468 | ||
| Cell division and cell survival in the absence of survivin | Q30448522 | ||
| Genomic organization of the X-linked inhibitor of apoptosis and identification of a novel testis-specific transcript | Q30733915 | ||
| Development and characterization of nonpeptidic small molecule inhibitors of the XIAP/caspase-3 interaction | Q30787767 | ||
| Expression and genetic analysis of XIAP-associated factor 1 (XAF1) in cancer cell lines | Q30967010 | ||
| Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity | Q31038912 | ||
| Expression of a murine homologue of the inhibitor of apoptosis protein is related to cell proliferation | Q31904245 | ||
| AICAR inhibits proliferation and induced S-phase arrest, and promotes apoptosis in CaSki cells | Q33306763 | ||
| Regulation of survivin function by Hsp90 | Q33713035 | ||
| Posttranscriptional downregulation of c-IAP2 by the ubiquitin protein ligase c-IAP1 in vivo | Q33724470 | ||
| Antisense oligonucleotides as therapeutic agents | Q33738466 | ||
| LKB1 and AMPK and the regulation of skeletal muscle metabolism | Q33919567 | ||
| Aminopeptidase-N/CD13 (EC 3.4.11.2) inhibitors: chemistry, biological evaluations, and therapeutic prospects. | Q33990607 | ||
| The molecular basis and potential role of survivin in cancer diagnosis and therapy | Q34104044 | ||
| Identification of X-linked inhibitor of apoptosis-associated factor-1 as an interferon-stimulated gene that augments TRAIL Apo2L-induced apoptosis | Q34130066 | ||
| Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance | Q34132152 | ||
| A small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell death | Q34346499 | ||
| The inhibitors of apoptosis (IAPs) as cancer targets | Q36851057 | ||
| Both cIAP1 and cIAP2 regulate TNFalpha-mediated NF-kappaB activation | Q36954601 | ||
| The inhibitor of apoptosis proteins as therapeutic targets in cancer | Q36975583 | ||
| Intracellular NOD-like receptors in host defense and disease | Q36984454 | ||
| MALT lymphoma : recent advances in aetiology and molecular genetics | Q37015216 | ||
| The age of crosstalk: phosphorylation, ubiquitination, and beyond | Q37033138 | ||
| IAPs as a target for anticancer therapy. | Q37065372 | ||
| NLRs at the intersection of cell death and immunity | Q37117573 | ||
| Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma | Q37314736 | ||
| Selective activation of JNK1 is necessary for the anti-apoptotic activity of hILP. | Q37376986 | ||
| Tetra-O-methyl nordihydroguaiaretic acid induces growth arrest and cellular apoptosis by inhibiting Cdc2 and survivin expression | Q37513265 | ||
| Participation of Survivin in mitotic and apoptotic activities of normal and tumor-derived cells | Q38296509 | ||
| Nuclear factor-kappa B regulates induction of apoptosis and inhibitor of apoptosis protein-1 expression in vascular smooth muscle cells | Q38326377 | ||
| Disturbed balance of expression between XIAP and Smac/DIABLO during tumour progression in renal cell carcinomas | Q38801768 | ||
| Requirement of Both the Second and Third BIR Domains for the Relief of X-linked Inhibitor of Apoptosis Protein (XIAP)-mediated Caspase Inhibition by Smac | Q39389950 | ||
| The genomic underpinnings of apoptosis in Strongylocentrotus purpuratus | Q39402257 | ||
| Altered cytoplasmic-to-nuclear ratio of survivin is a prognostic indicator in breast cancer | Q39986329 | ||
| A Smac mimetic rescue screen reveals roles for inhibitor of apoptosis proteins in tumor necrosis factor-alpha signaling | Q40033734 | ||
| Transfection of Smac/DIABLO sensitizes drug-resistant tumor cells to TRAIL or paclitaxel-induced apoptosis in vitro | Q40047160 | ||
| Terminally differentiated neutrophils predominantly express Survivin-2 alpha, a dominant-negative isoform of survivin | Q40061181 | ||
| The effects of knockdown of wild-type survivin, survivin-2B or survivin-delta3 on the radiosensitization in a soft tissue sarcoma cells in vitro under different oxygen conditions | Q40077795 | ||
| Homodimerization antagonizes nuclear export of survivin | Q40090638 | ||
| Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth | Q40105523 | ||
| Dual antiglioma action of metformin: cell cycle arrest and mitochondria-dependent apoptosis. | Q40143359 | ||
| Targeting the apoptotic machinery in pancreatic cancers using small-molecule antagonists of the X-linked inhibitor of apoptosis protein | Q40163044 | ||
| A dual role for the API2 moiety in API2-MALT1-dependent NF-kappaB activation: heterotypic oligomerization and TRAF2 recruitment | Q40164027 | ||
| Tumor necrosis factor receptor 2 signaling induces selective c-IAP1-dependent ASK1 ubiquitination and terminates mitogen-activated protein kinase signaling | Q40183663 | ||
| Exonization of Alu-generated splice variants in the survivin gene of human and non-human primates. | Q40186571 | ||
| Potent antitumor efficacy of XAF1 delivered by conditionally replicative adenovirus vector via caspase-independent apoptosis | Q40226159 | ||
| Design, synthesis, and characterization of new embelin derivatives as potent inhibitors of X-linked inhibitor of apoptosis protein | Q40233896 | ||
| All-trans retinoic acid induces XAF1 expression through an interferon regulatory factor-1 element in colon cancer | Q40306318 | ||
| Xaf1 can cooperate with TNFalpha in the induction of apoptosis, independently of interaction with XIAP. | Q40325875 | ||
| The human anti-apoptotic proteins cIAP1 and cIAP2 bind but do not inhibit caspases | Q40341729 | ||
| Rational design of shepherdin, a novel anticancer agent. | Q40422406 | ||
| Constitutive NF-kappaB activation by the t(11;18)(q21;q21) product in MALT lymphoma is linked to deregulated ubiquitin ligase activity | Q40422412 | ||
| The BIR domain of IAP-like protein 2 is conformationally unstable: implications for caspase inhibition | Q40504414 | ||
| Loss of XIAP protein expression by RNAi and antisense approaches sensitizes cancer cells to functionally diverse chemotherapeutics | Q40513940 | ||
| Cellular, biochemical, and genetic analysis of mechanism of small molecule IAP inhibitors | Q40520839 | ||
| Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer | Q40524353 | ||
| XIAP and survivin as therapeutic targets for radiation sensitization in preclinical models of lung cancer | Q40534371 | ||
| An IAP-IAP complex inhibits apoptosis | Q40541576 | ||
| Translocation of the inhibitor of apoptosis protein c-IAP1 from the nucleus to the Golgi in hematopoietic cells undergoing differentiation: a nuclear export signal-mediated event | Q40547569 | ||
| Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database | Q40561637 | ||
| Smac/Diablo antagonizes ubiquitin ligase activity of inhibitor of apoptosis proteins | Q40567922 | ||
| Specific downregulation of bcl-2 and xIAP by RNAi enhances the effects of chemotherapeutic agents in MCF-7 human breast cancer cells. | Q40576657 | ||
| Interaction of checkpoint kinase 1 and the X-linked inhibitor of apoptosis during mitosis | Q40593626 | ||
| Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP). | Q40612863 | ||
| Smac3, a Novel Smac/DIABLO Splicing Variant, Attenuates the Stability and Apoptosis-inhibiting Activity of X-linked Inhibitor of Apoptosis Protein | Q40629425 | ||
| Identification of ubiquitination sites on the X-linked inhibitor of apoptosis protein | Q40647783 | ||
| A comprehensive search for DNA amplification in lung cancer identifies inhibitors of apoptosis cIAP1 and cIAP2 as candidate oncogenes. | Q40662030 | ||
| Rapid kinetics of tBid-induced cytochrome c and Smac/DIABLO release and mitochondrial depolarization | Q40763878 | ||
| c-IAP1 is cleaved by caspases to produce a proapoptotic C-terminal fragment | Q40838878 | ||
| Caspase-3 and inhibitor of apoptosis protein(s) interactions in Saccharomyces cerevisiae and mammalian cells | Q40855442 | ||
| Pleiotropic cell-division defects and apoptosis induced by interference with survivin function | Q40913411 | ||
| The product of the t(11;18), an API2-MLT fusion, marks nearly half of gastric MALT type lymphomas without large cell proliferation | Q42074394 | ||
| P433 | issue | 48 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 6252-6275 | |
| P577 | publication date | 2008-10-01 | |
| P1433 | published in | Oncogene | Q1568657 |
| P1476 | title | IAP-targeted therapies for cancer | |
| P478 | volume | 27 |
| Q35038107 | A New Player in the Development of TRAIL Based Therapies for Hepatocarcinoma Treatment: ATM Kinase |
| Q36040441 | A functional microRNA library screen reveals miR-410 as a novel anti-apoptotic regulator of cholangiocarcinoma. |
| Q35338435 | A novel antagonist to the inhibitors of apoptosis (IAPs) potentiates cell death in EGFR-overexpressing non-small-cell lung cancer cells |
| Q36460712 | A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment |
| Q37249659 | A potent bivalent Smac mimetic (SM-1200) achieving rapid, complete, and durable tumor regression in mice |
| Q36495236 | A potential role of X-linked inhibitor of apoptosis protein in mitochondrial membrane permeabilization and its implication in cancer therapy |
| Q28482952 | A small molecule SMAC mimic LBW242 potentiates TRAIL- and anticancer drug-mediated cell death of ovarian cancer cells |
| Q42418016 | A steroid-controlled global switch in sensitivity to apoptosis during Drosophila development. |
| Q35138968 | A time to kill: targeting apoptosis in cancer |
| Q42094231 | ABT-737, a small molecule Bcl-2/Bcl-xL antagonist, increases antimitotic-mediated apoptosis in human prostate cancer cells |
| Q90189039 | ANTP-SmacN7 fusion peptide-induced radiosensitization in A549 cells and its potential mechanisms |
| Q37077676 | APS8, a polymeric alkylpyridinium salt blocks α7 nAChR and induces apoptosis in non-small cell lung carcinoma |
| Q37913380 | ARTS, the unusual septin: structural and functional aspects |
| Q37944935 | ARTS-based anticancer therapy: taking aim at cancer stem cells |
| Q91726589 | Acid microenvironment promotes cell survival of human bone sarcoma through the activation of cIAP proteins and NF-κB pathway |
| Q33764288 | Action of YM155 on clear cell renal cell carcinoma does not depend on survivin expression levels |
| Q52425308 | Activation of concurrent apoptosis and necroptosis by SMAC mimetics for the treatment of refractory and relapsed ALL. |
| Q36907121 | Activation of executioner caspases is a predictor of progression-free survival in glioblastoma patients: a systems medicine approach |
| Q36312152 | Adenovirus-mediated expression of mutated forkhead human transcription like-1 suppresses tumor growth in a mouse melanoma xenograft model |
| Q28830527 | Alterations in Red Blood Cell Functionality Induced by an Indole Scaffold Containing a Y-Iminodiketo Moiety: Potential Antiproliferative Conditions |
| Q37078019 | An NF-κB p65-cIAP2 link is necessary for mediating resistance to TNF-α induced cell death in gliomas |
| Q41998116 | An apoptosis-independent role of SMAC in tumor suppression |
| Q37777758 | Antagonists of IAP proteins as cancer therapeutics |
| Q37654710 | Anti-cancer IAP antagonists promote bone metastasis: a cautionary tale |
| Q93134462 | Anti-cancer effects of the HuR inhibitor, MS-444, in malignant glioma cells |
| Q38924245 | Apigenin induces apoptosis by targeting inhibitor of apoptosis proteins and Ku70-Bax interaction in prostate cancer. |
| Q34334545 | Apollon modulates chemosensitivity in human esophageal squamous cell carcinoma |
| Q38228349 | Apoptosis and molecular targeting therapy in cancer |
| Q37403072 | Apoptosis and necrosis in the liver |
| Q26750639 | Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies |
| Q37800273 | Apoptosis assays for quantifying the bioactivity of anticancer drug products |
| Q35397889 | Apoptosis in cancer: from pathogenesis to treatment |
| Q38187815 | Apoptosis inducers in chronic lymphocytic leukemia |
| Q37453523 | Apoptosis pathways and their therapeutic exploitation in pancreatic cancer |
| Q35088734 | Apoptotic cell signaling in cancer progression and therapy |
| Q33755766 | Apoptotic death of cancer stem cells for cancer therapy |
| Q39335751 | Ardisianone, a natural benzoquinone, efficiently induces apoptosis in human hormone-refractory prostate cancers through mitochondrial damage stress and survivin downregulation. |
| Q38829473 | Autophagy-Mediated Degradation of IAPs and c-FLIP(L) Potentiates Apoptosis Induced by Combination of TRAIL and Chal-24. |
| Q53022205 | BIRC6 promotes hepatocellular carcinogenesis: interaction of BIRC6 with p53 facilitating p53 degradation. |
| Q33961325 | BV6, an IAP antagonist, activates apoptosis and enhances radiosensitization of non-small cell lung carcinoma in vitro |
| Q34592766 | Betulinic acid selectively increases protein degradation and enhances prostate cancer-specific apoptosis: possible role for inhibition of deubiquitinase activity |
| Q38833708 | Breast cancer cells respond differently to docetaxel depending on their phenotype and on survivin upregulation |
| Q37839530 | Breast cancer stem cells: treatment resistance and therapeutic opportunities |
| Q36483749 | Broad targeting of resistance to apoptosis in cancer. |
| Q39673773 | CIIA Is a Novel Regulator of Detachment-Induced Cell Death |
| Q35783607 | CLIPR-59 regulates TNF-α-induced apoptosis by controlling ubiquitination of RIP1. |
| Q34019760 | Cell death |
| Q38239700 | Cell death and deubiquitinases: perspectives in cancer |
| Q40582910 | Cell death pathways as therapeutic targets in rhabdomyosarcoma |
| Q36067026 | Cell-permeable intrinsic cellular inhibitors of apoptosis protect and rescue intestinal epithelial cells from radiation-induced cell death |
| Q24306110 | Cellular inhibitor of apoptosis protein-1 (cIAP1) can regulate E2F1 transcription factor-mediated control of cyclin transcription |
| Q33674213 | Cellular stress responses: cell survival and cell death |
| Q37017587 | Chemistry and biology of multicomponent reactions. |
| Q38855877 | Chromosomal instability, tolerance of mitotic errors and multidrug resistance are promoted by tetraploidization in human cells |
| Q37761322 | Combining naturally occurring polyphenols with TNF-related apoptosis-inducing ligand: a promising approach to kill resistant cancer cells? |
| Q90428040 | Conformational characterization of full-length X-chromosome-linked inhibitor of apoptosis protein (XIAP) through an integrated approach |
| Q38553219 | Control of Apoptosis in Treatment and Biology of Pancreatic Cancer |
| Q39414084 | Control of cell survival and proliferation by mammalian eukaryotic initiation factor 4B. |
| Q34457270 | Conversion of the LIMA1 tumour suppressor into an oncogenic LMO-like protein by API2-MALT1 in MALT lymphoma. |
| Q26774488 | Could the eIF2α-Independent Translation Be the Achilles Heel of Cancer? |
| Q27660497 | Crystal Structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 Complexes: Affinity, Specificity, and Regulation |
| Q36373429 | Curcumin Induces Pancreatic Adenocarcinoma Cell Death Via Reduction of the Inhibitors of Apoptosis |
| Q39688777 | DHA alters expression of target proteins of cancer therapy in chemotherapy resistant SW620 colon cancer cells |
| Q38927472 | Debio 1143, an antagonist of multiple inhibitor-of-apoptosis proteins, activates apoptosis and enhances radiosensitization of non-small cell lung cancer cells in vitro. |
| Q38333998 | Deregulated apoptosis signaling in core-binding factor leukemia differentiates clinically relevant, molecular marker-independent subgroups |
| Q52653329 | Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor α degradation. |
| Q89235427 | Design of Potent pan-IAP and Lys-Covalent XIAP Selective Inhibitors Using a Thermodynamics Driven Approach |
| Q39523263 | Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP. |
| Q34372606 | Dietary soy and tea mitigate chronic inflammation and prostate cancer via NFκB pathway in the Noble rat model |
| Q37383943 | Differential effect of grape seed extract against human non-small-cell lung cancer cells: the role of reactive oxygen species and apoptosis induction |
| Q34015365 | Differential effects of whole soy extract and soy isoflavones on apoptosis in prostate cancer cells |
| Q57663667 | Differentiated macrophages acquire a pro-inflammatory and cell death-resistant phenotype due to increasing XIAP and p38-mediated inhibition of RipK1 |
| Q38844170 | Discovery of Novel, Potent, and Specific Cell-Death Inducers in the Jurkat Acute Lymphoblastic Leukemia Cell Line |
| Q37391671 | Down-Regulation of MicroRNA-133b Suppresses Apoptosis of Lens Epithelial Cell by Up-Regulating BCL2L2 in Age-Related Cataracts. |
| Q42365258 | Downregulation of X-linked inhibitor of apoptosis protein by '7-Benzylidenenaltrexone maleate' sensitizes pancreatic cancer cells to TRAIL-induced apoptosis |
| Q37390019 | Effects of Fluid Shear Stress on Expression of Smac/DIABLO in Human Umbilical Vein Endothelial Cells |
| Q40983623 | Elevated XIAP expression alone does not confer chemoresistance |
| Q27006986 | Elucidation of the binding preferences of peptide recognition modules: SH3 and PDZ domains |
| Q47974502 | Emerging roles of hnRNPA1 in modulating malignant transformation |
| Q41788901 | Evasion of apoptosis as a cellular stress response in cancer |
| Q37974461 | Exploiting inhibitor of apoptosis proteins as therapeutic targets in hematological malignancies |
| Q36774434 | Expression of the IAP protein family acts cooperatively to predict prognosis in human bladder cancer patients |
| Q39194735 | Functional compartmentalisation of NF-kB-associated proteins in A431 cells |
| Q60912613 | Fusobacterium nucleatum promotes chemoresistance to 5-fluorouracil by upregulation of BIRC3 expression in colorectal cancer |
| Q38560697 | Genetic susceptibility to cervical cancer: role of common polymorphisms in apoptosis-related genes |
| Q37785490 | Harnessing the complexity of DNA-damage response pathways to improve cancer treatment outcomes |
| Q24302531 | Histone deacetylase inhibitors sensitize glioblastoma cells to TRAIL-induced apoptosis by c-myc-mediated downregulation of cFLIP |
| Q34190534 | Host Insect Inhibitor-of-Apoptosis SfIAP Functionally Replaces Baculovirus IAP but Is Differentially Regulated by Its N-Terminal Leader |
| Q36072569 | Hypoxia-activated pro-drug TH-302 exhibits potent tumor suppressive activity and cooperates with chemotherapy against osteosarcoma. |
| Q38714695 | IAP Antagonists Enhance Apoptotic Response to Enzalutamide in Castration-Resistant Prostate Cancer Cells via Autocrine TNF-α Signaling |
| Q38134633 | IAPs on the move: role of inhibitors of apoptosis proteins in cell migration |
| Q24292870 | IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer |
| Q37957747 | IAPs: guardians of RIPK1 |
| Q35672175 | IRES-mediated translation of cellular messenger RNA operates in eIF2α- independent manner during stress. |
| Q47136316 | Identification of ARNT-regulated BIRC3 as the target factor in cadmium renal toxicity |
| Q24324245 | Identification of a novel anti-apoptotic E3 ubiquitin ligase that ubiquitinates antagonists of inhibitor of apoptosis proteins SMAC, HtrA2, and ARTS |
| Q47148201 | Immunohistochemical expression of X-linked inhibitor of apoptosis in eyelid sebaceous gland carcinoma predicts a worse prognosis |
| Q54297420 | Immunoscoring of epidermal growth factor receptor expression in recurrent cases of oral squamous cell carcinoma. |
| Q54518992 | In cancer drug resistance, germline matters too. |
| Q35022255 | Increase in retinal ganglion cells' susceptibility to elevated intraocular pressure and impairment of their endogenous neuroprotective mechanism by age. |
| Q38868257 | Increased resistance to proteasome inhibitors in multiple myeloma mediated by cIAP2--implications for a combinatorial treatment |
| Q49787695 | Inhibition of IAP's and activation of p53 leads to caspase-dependent apoptosis in gastric cancer cells treated with Scutellarein |
| Q38835111 | Inhibition of Survival Pathways MAPK and NF-kB Triggers Apoptosis in Pancreatic Ductal Adenocarcinoma Cells via Suppression of Autophagy. |
| Q35048722 | Inhibition of survivin influences the biological activities of canine histiocytic sarcoma cell lines |
| Q34167279 | Inhibitor of Apoptosis (IAP) proteins as drug targets for the treatment of cancer |
| Q37520240 | Inhibitor of Apoptosis Proteins (IAPs) are commonly dysregulated in GIST and can be pharmacologically targeted to enhance the pro-apoptotic activity of imatinib |
| Q42949488 | Inhibitor of Apoptosis Proteins: Promising Targets for Cancer Therapy |
| Q26824586 | Inhibitor of apoptosis (IAP) proteins-modulators of cell death and inflammation |
| Q37875078 | Inhibitor of apoptosis proteins: fascinating biology leads to attractive tumor therapeutic targets |
| Q58801140 | Inhibitor of apoptosis protein‑like protein‑2: A novel growth accelerator for breast cancer cells |
| Q33435646 | Inhibitors of apoptosis proteins (IAPs) expression and their prognostic significance in hepatocellular carcinoma. |
| Q24338917 | Interaction of Beclin 1 with survivin regulates sensitivity of human glioma cells to TRAIL-induced apoptosis |
| Q41830995 | Investigating isoquinoline derivatives for inhibition of inhibitor of apoptosis proteins for ovarian cancer treatment |
| Q38009194 | Killing a cancer: what are the alternatives? |
| Q35803259 | LRIG1 modulates cancer cell sensitivity to Smac mimetics by regulating TNFα expression and receptor tyrosine kinase signaling |
| Q35780628 | Lipid-conjugated Smac analogues |
| Q41845149 | Mcl-1 protects prostate cancer cells from cell death mediated by chemotherapy-induced DNA damage |
| Q28477146 | Mechanism of the interaction between the intrinsically disordered C-terminus of the pro-apoptotic ARTS protein and the Bir3 domain of XIAP |
| Q37785808 | Medical therapies for meningiomas |
| Q35564267 | Methyl jasmonate down-regulates survivin expression and sensitizes colon carcinoma cells towards TRAIL-induced cytotoxicity. |
| Q27303920 | Minnelide: a novel therapeutic that promotes apoptosis in non-small cell lung carcinoma in vivo |
| Q33977612 | Multiple mechanisms modulate distinct cellular susceptibilities toward apoptosis in the developing Drosophila eye. |
| Q38359190 | NF-κB in cancer therapy. |
| Q39268644 | Necroptosis and Cancer. |
| Q45684338 | Negative correlation between X-linked inhibitors of apoptosis and second mitochondria-derived activator of caspase expression levels in cervical carcinoma and cervical intraepithelial neoplasia |
| Q36560463 | Non-cell autonomous control of apoptosis by ligand-independent Hedgehog signaling in Drosophila |
| Q52358778 | Novel smac mimetic APG-1387 elicits ovarian cancer cell killing through TNF-alpha, Ripoptosome and autophagy mediated cell death pathway. |
| Q38409089 | Nuclear cIAP1 overexpression is a tumor stage- and grade-independent predictor of poor prognosis in human bladder cancer patients |
| Q49505114 | Oncogenic and Tumor-Suppressive Roles of MicroRNAs with Special Reference to Apoptosis: Molecular Mechanisms and Therapeutic Potential. |
| Q37267506 | Oral Debio1143 (AT406), an antagonist of inhibitor of apoptosis proteins, combined with daunorubicin and cytarabine in patients with poor-risk acute myeloid leukemia--results of a phase I dose-escalation study |
| Q33841579 | Overcoming chemotherapy drug resistance by targeting inhibitors of apoptosis proteins (IAPs) |
| Q35561267 | Overexpression of BIRC6 Is a Predictor of Prognosis for Colorectal Cancer |
| Q35851953 | PACE4 regulates apoptosis in human prostate cancer cells via endoplasmic reticulum stress and mitochondrial signaling pathways |
| Q32176120 | PCSK9 regulates apoptosis in human lung adenocarcinoma A549 cells via endoplasmic reticulum stress and mitochondrial signaling pathways |
| Q35653477 | PCSK9 regulates apoptosis in human neuroglioma u251 cells via mitochondrial signaling pathways. |
| Q34135017 | Paeonol inhibits tumor growth in gastric cancerin vitroandin vivo |
| Q36750717 | Patient-derived glioblastoma cells show significant heterogeneity in treatment responses to the inhibitor-of-apoptosis-protein antagonist birinapant |
| Q89040090 | Pharmacological Targeting of Cell Cycle, Apoptotic and Cell Adhesion Signaling Pathways Implicated in Chemoresistance of Cancer Cells |
| Q35072876 | Potent and selective small-molecule inhibitors of cIAP1/2 proteins reveal that the binding of Smac mimetics to XIAP BIR3 is not required for their effective induction of cell death in tumor cells. |
| Q35024837 | Potent bivalent Smac mimetics: effect of the linker on binding to inhibitor of apoptosis proteins (IAPs) and anticancer activity. |
| Q26771601 | Potential of apoptotic pathway-targeted cancer therapeutic research: Where do we stand? |
| Q37784920 | Proapoptotic DR4 and DR5 signaling in cancer cells: toward clinical translation |
| Q37967032 | Programmed cell removal: a new obstacle in the road to developing cancer |
| Q34554617 | Prospects on strategies for therapeutically targeting oncogenic regulatory factors by small-molecule agents |
| Q89598452 | Proteasome Inhibitors: Harnessing Proteostasis to Combat Disease |
| Q51631259 | Proteome-wide prediction of overlapping small molecule and protein binding sites using structure |
| Q34001266 | Purine Nucleoside Phosphorylase mediated molecular chemotherapy and conventional chemotherapy: a tangible union against chemoresistant cancer |
| Q39298005 | RIP1 is required for IAP inhibitor-mediated sensitization for TRAIL-induced apoptosis via a RIP1/FADD/caspase-8 cell death complex |
| Q24299986 | RIP1 is required for IAP inhibitor-mediated sensitization of childhood acute leukemia cells to chemotherapy-induced apoptosis |
| Q41311490 | RIP1 protein-dependent assembly of a cytosolic cell death complex is required for inhibitor of apoptosis (IAP) inhibitor-mediated sensitization to lexatumumab-induced apoptosis |
| Q34259434 | Rb inactivation accelerates neoplastic growth and substitutes for recurrent amplification of cIAP1, cIAP2 and Yap1 in sporadic mammary carcinoma associated with p53 deficiency |
| Q47378913 | Recent advances in nanomedicine and survivin targeting in brain cancers |
| Q37608457 | Receptor-interacting protein 1 increases chemoresistance by maintaining inhibitor of apoptosis protein levels and reducing reactive oxygen species through a microRNA-146a-mediated catalase pathway |
| Q37995693 | Regulation of cell death and autophagy by IKK and NF-κB: critical mechanisms in immune function and cancer |
| Q37619921 | Regulation of cell death by the ubiquitin-proteasome system |
| Q39412878 | Requirement of nuclear factor κB for Smac mimetic-mediated sensitization of pancreatic carcinoma cells for gemcitabine-induced apoptosis |
| Q38999750 | Reversion of apoptotic resistance of TP53-mutated Burkitt lymphoma B-cells to spindle poisons by exogenous activation of JNK and p38 MAP kinases |
| Q39467184 | Rocaglamide and a XIAP inhibitor cooperatively sensitize TRAIL-mediated apoptosis in Hodgkin's lymphomas |
| Q55480165 | Role for the transcriptional activator ZRF1 in early metastatic events in breast cancer progression and endocrine resistance. |
| Q36184769 | Role of Apollon in human melanoma resistance to antitumor agents that activate the intrinsic or the extrinsic apoptosis pathways |
| Q41973053 | SMAC Mimetic BV6 Enables Sensitization of Resistant Tumor Cells but also Affects Cytokine-Induced Killer (CIK) Cells: A Potential Challenge for Combination Therapy |
| Q33955061 | SMAC mimetic BV6 induces cell death in monocytes and maturation of monocyte-derived dendritic cells |
| Q47107025 | Sensitization of neuroblastoma for vincristine-induced apoptosis by Smac mimetic LCL161 is attended by G2 cell cycle arrest but is independent of NFκB, RIP1 and TNF-α. |
| Q34206039 | Sept4/ARTS is required for stem cell apoptosis and tumor suppression |
| Q41926326 | Sept4/ARTS regulates stem cell apoptosis and skin regeneration |
| Q60925541 | Shikonin sensitizes A549 cells to TRAIL-induced apoptosis through the JNK, STAT3 and AKT pathways |
| Q39573956 | Simultaneous targeting of P-gp and XIAP with siRNAs increases sensitivity of P-gp overexpressing CML cells to imatinib. |
| Q41840140 | Smac mimetic LCL161 supports neuroblastoma chemotherapy in a drug class-dependent manner and synergistically interacts with ALK inhibitor TAE684 in cells with ALK mutation F1174L. |
| Q34512395 | Smac mimetic SM-164 potentiates APO2L/TRAIL- and doxorubicin-mediated anticancer activity in human hepatocellular carcinoma cells |
| Q24294685 | Smac mimetic bypasses apoptosis resistance in FADD- or caspase-8-deficient cells by priming for tumor necrosis factor α-induced necroptosis |
| Q39642704 | Smac mimetic compounds potentiate interleukin-1beta-mediated cell death |
| Q39370420 | Smac mimetic sensitizes glioblastoma cells to Temozolomide-induced apoptosis in a RIP1- and NF-κB-dependent manner. |
| Q34556212 | Smac mimetic-derived augmentation of chemotherapeutic response in experimental pancreatic cancer |
| Q28303498 | Smac modulates chemosensitivity in head and neck cancer cells through the mitochondrial apoptotic pathway |
| Q35032216 | Small-molecule IAP antagonists sensitize cancer cells to TRAIL-induced apoptosis: roles of XIAP and cIAPs. |
| Q37269355 | Small-molecule XIAP inhibitors enhance gamma-irradiation-induced apoptosis in glioblastoma |
| Q39704979 | Suppression of livin gene expression by siRNA leads to growth inhibition and apoptosis induction in human bladder cancer T24 cells |
| Q37761935 | Survival signalling and apoptosis resistance in glioblastomas: opportunities for targeted therapeutics |
| Q35414780 | Survivin and IAP proteins in cell-death mechanisms |
| Q47101674 | Survivin and XIAP expression in distinct tumor compartments of surgically resected gastric cancer: XIAP as a prognostic marker in diffuse and mixed type adenocarcinomas |
| Q33933202 | Survivin as a potential mediator to support autoreactive cell survival in myasthenia gravis: a human and animal model study |
| Q39377777 | Survivin inhibition by an interacting recombinant peptide, derived from the human ferritin heavy chain, impedes tumor cell growth |
| Q39506220 | Survivin promotes glioma angiogenesis through vascular endothelial growth factor and basic fibroblast growth factor in vitro and in vivo. |
| Q39773449 | Survivin: a potential prognostic marker and chemoradiotherapeutic target for colorectal cancer |
| Q26747332 | Survivin: a unique target for tumor therapy |
| Q35176405 | Synergistic anticancer effect of cisplatin and Chal-24 combination through IAP and c-FLIPL degradation, Ripoptosome formation and autophagy-mediated apoptosis |
| Q39257705 | TWEAK and cIAP1 regulate myoblast fusion through the noncanonical NF-κB signaling pathway |
| Q47328917 | Tan IIA inhibits H1299 cell viability through the MDM4‑IAP3 signaling pathway |
| Q42077750 | Targeted alpha-therapy using [Bi-213]anti-CD20 as novel treatment option for radio- and chemoresistant non-Hodgkin lymphoma cells |
| Q57175584 | Targeted genome editing in acute lymphoblastic leukemia: a review |
| Q34736820 | Targeted therapy of the XIAP/proteasome pathway overcomes TRAIL-resistance in carcinoma by switching apoptosis signaling to a Bax/Bak-independent 'type I' mode |
| Q26798203 | Targeting Apoptosis and Multiple Signaling Pathways with Icariside II in Cancer Cells |
| Q37980321 | Targeting IAP proteins for therapeutic intervention in cancer |
| Q42040100 | Targeting apoptosis signaling in pancreatic cancer |
| Q42175008 | Targeting apoptosis signaling pathways for anticancer therapy |
| Q46711978 | Targeting inhibitor of apoptosis proteins by Smac mimetic elicits cell death in poor prognostic subgroups of chronic lymphocytic leukemia |
| Q37855868 | Targeting inhibitor of apoptosis proteins for therapeutic intervention. |
| Q37277197 | Targeting inhibitor of apoptosis proteins in combination with ErbB antagonists in breast cancer |
| Q34954296 | Targeting survivin in cancer: novel drug development approaches |
| Q61809001 | Targeting the BIR Domains of Inhibitor of Apoptosis (IAP) Proteins in Cancer Treatment |
| Q34218232 | Targeting the mechanisms of resistance to chemotherapy and radiotherapy with the cancer stem cell hypothesis |
| Q49874345 | Temporal Effects of Combined Birinapant and Paclitaxel on Pancreatic Cancer Cells Investigated via Large-scale, Ion-Current-Based Quantitative Proteomics (IonStar). |
| Q38970758 | The BIRC6 gene as a novel target for therapy of prostate cancer: dual targeting of inhibitors of apoptosis |
| Q26747452 | The Modulation of Apoptotic Pathways by Gammaherpesviruses |
| Q38755349 | The SMAC mimetic BV6 induces cell death and sensitizes different cell lines to TNF-α and TRAIL-induced apoptosis. |
| Q36069954 | The SMAC mimetic BV6 sensitizes colorectal cancer cells to ionizing radiation by interfering with DNA repair processes and enhancing apoptosis |
| Q35903344 | The Smac mimetic RMT5265.2HCL induces apoptosis in EBV and HTLV-I associated lymphoma cells by inhibiting XIAP and promoting the mitochondrial release of cytochrome C and Smac |
| Q30895986 | The death effector domains of caspase-8 induce terminal differentiation |
| Q42288562 | The opposing roles of cellular inhibitor of apoptosis proteins in cancer |
| Q31147980 | The role of HTS in drug discovery at the University of Michigan. |
| Q42212254 | The role of apoptosis in the pathology of pancreatic cancer |
| Q36119477 | The role of apoptosis-induced proliferation for regeneration and cancer |
| Q38270942 | The versatile roles of CARDs in regulating apoptosis, inflammation, and NF-κB signaling. |
| Q34970050 | Therapeutic potential and molecular mechanism of a novel, potent, nonpeptide, Smac mimetic SM-164 in combination with TRAIL for cancer treatment |
| Q39745633 | Therapeutic potential of siRNA-mediated combined knockdown of the IAP genes (Livin, XIAP, and Survivin) on human bladder cancer T24 cells |
| Q24301502 | To fight or die - inhibitor of apoptosis proteins at the crossroad of innate immunity and death |
| Q38219616 | Towards combinatorial targeted therapy in melanoma: from pre-clinical evidence to clinical application (review). |
| Q37586472 | Translation initiation: a critical signalling node in cancer |
| Q37990333 | Tristetraprolin: roles in cancer and senescence |
| Q37454149 | X chromosome-linked inhibitor of apoptosis regulates cell death induction by proapoptotic receptor agonists |
| Q37777537 | X-linked Inhibitor of Apoptosis: A Chemoresistance Factor or a Hollow Promise |
| Q37372003 | X-linked inhibitor of apoptosis protein and its E3 ligase activity promote transforming growth factor-{beta}-mediated nuclear factor-{kappa}B activation during breast cancer progression |
| Q39869165 | XIAP and cIAP1 amplifications induce Beclin 1-dependent autophagy through NFκB activation |
| Q57060877 | XIAP facilitates breast and colon carcinoma growth via promotion of p62 depletion through ubiquitination-dependent proteasomal degradation |
| Q34189300 | XIAP is a predictor of cisplatin-based chemotherapy response and prognosis for patients with advanced head and neck cancer |
| Q24304410 | XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling |
| Q39523533 | XIAP-associated factor 1 (XAF1), a novel target of p53, enhances p53-mediated apoptosis via post-translational modification |
| Q55431782 | [Radiosensitization Induced by ANTP-SmacN7 Fusion Peptide in H460 Cell Line]. |
| Q89018067 | cIAP2 Is an Independent Signaling and Survival Factor during Mammary Lactational Involution and Tumorigenesis |
| Q43777713 | cIAP2 Upregulated by E6 Oncoprotein via Epidermal Growth Factor Receptor/Phosphatidylinositol 3-Kinase/AKT Pathway Confers Resistance to Cisplatin in Human Papillomavirus 16/18–Infected Lung Cancer |
| Q37605889 | cIAP2 as a therapeutic target in colorectal cancer and other malignancies. |
| Q39266738 | cIAP2 represses IKKα/β-mediated activation of MDM2 to prevent p53 degradation |
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