| scholarly article | Q13442814 |
| P50 | author | Simone Fulda | Q21264686 |
| P2860 | cites work | Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function | Q24293924 |
| Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak | Q24296478 | ||
| Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins | Q24302494 | ||
| The Bcl-2 apoptotic switch in cancer development and therapy | Q24620437 | ||
| BH3 mimetics to improve cancer therapy; mechanisms and examples | Q24655483 | ||
| Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family | Q24670396 | ||
| The anti-tumor effect of Apo2L/TRAIL on patient pancreatic adenocarcinomas grown as xenografts in SCID mice | Q24811656 | ||
| Structural and functional analysis of the interaction between the agonistic monoclonal antibody Apomab and the proapoptotic receptor DR5 | Q27649718 | ||
| Differential expression of TRAIL-R3 and TRAIL-R4 in human pancreatic cancer | Q28201795 | ||
| Application of XIAP antisense to cancer and other proliferative disorders: development of AEG35156/ GEM640 | Q28289976 | ||
| Mitochondrial membrane permeabilization in cell death | Q29547425 | ||
| An inhibitor of Bcl-2 family proteins induces regression of solid tumours | Q29547595 | ||
| The biochemistry of apoptosis | Q29547741 | ||
| Cellular, biochemical, and genetic analysis of mechanism of small molecule IAP inhibitors | Q40520839 | ||
| Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database | Q40561637 | ||
| Bcl-x(L) antisense oligonucleotides induce apoptosis and increase sensitivity of pancreatic cancer cells to gemcitabine | Q40680294 | ||
| Tumor necrosis factor-related apoptosis-inducing ligand and its receptor expression and the pathway of apoptosis in human pancreatic cancer | Q43759157 | ||
| XAF1 as a prognostic biomarker and therapeutic target in pancreatic cancer | Q45855138 | ||
| High levels of endogenous tumor necrosis factor-related apoptosis-inducing ligand expression correlate with increased cell death in human pancreas | Q45877017 | ||
| Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo | Q48548442 | ||
| Small molecule XIAP inhibitors enhance TRAIL-induced apoptosis and antitumor activity in preclinical models of pancreatic carcinoma. | Q51788134 | ||
| Effects and expression of TRAIL and its apoptosis-promoting receptors in human pancreatic cancer. | Q54022571 | ||
| Targeting XIAP Bypasses Bcl-2-Mediated Resistance to TRAIL and Cooperates with TRAIL to Suppress Pancreatic Cancer Growth In vitro and In vivo | Q57243493 | ||
| Sensitization of pancreatic carcinoma cells for γ-irradiation-induced apoptosis by XIAP inhibition | Q57243513 | ||
| Regulation of TRAIL-induced apoptosis by XIAP in pancreatic carcinoma cells | Q57243535 | ||
| Caspase activation cascades in apoptosis | Q60188553 | ||
| Bcl-XL protects pancreatic adenocarcinoma cells against CD95- and TRAIL-receptor-mediated apoptosis | Q73292505 | ||
| Expression of the IAP protein family is dysregulated in pancreatic cancer cells and is important for resistance to chemotherapy | Q79801646 | ||
| TRAIL promotes metastasis of human pancreatic ductal adenocarcinoma | Q83919556 | ||
| ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor | Q29616727 | ||
| Apoptosis: controlled demolition at the cellular level | Q29620114 | ||
| Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics | Q29620467 | ||
| Pancreatic cancer | Q29622871 | ||
| Pancreatic cancer. | Q30490247 | ||
| Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity | Q31038912 | ||
| Mapatumumab, a fully human agonistic monoclonal antibody that targets TRAIL-R1, in combination with gemcitabine and cisplatin: a phase I study. | Q33385878 | ||
| Smac mimetic increases chemotherapy response and improves survival in mice with pancreatic cancer | Q33767013 | ||
| Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL. | Q34006269 | ||
| BH3 mimetic obatoclax enhances TRAIL-mediated apoptosis in human pancreatic cancer cells | Q34168014 | ||
| BH3 mimetic ABT-737 potentiates TRAIL-mediated apoptotic signaling by unsequestering Bim and Bak in human pancreatic cancer cells | Q34168023 | ||
| Combination treatment with TRA-8 anti death receptor 5 antibody and CPT-11 induces tumor regression in an orthotopic model of pancreatic cancer | Q34610496 | ||
| Pathways of apoptotic and non-apoptotic death in tumour cells | Q35852309 | ||
| Caspases, IAPs and Smac/DIABLO: mechanisms from structural biology | Q35874476 | ||
| Pancreatic cancer: basic and clinical aspects | Q36123805 | ||
| Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis | Q36288687 | ||
| Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy | Q36558024 | ||
| TRAIL signalling: decisions between life and death. | Q36778214 | ||
| Cell death in health and disease | Q37010413 | ||
| Trail receptors: targets for cancer therapy | Q37148071 | ||
| TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and invasion in pancreatic cancer | Q37154117 | ||
| Targeting the extrinsic apoptosis pathway in cancer | Q37169988 | ||
| To kill a tumor cell: the potential of proapoptotic receptor agonists | Q37181734 | ||
| IAP-targeted therapies for cancer | Q37302745 | ||
| New wirings in the survivin networks | Q37302750 | ||
| Directing cancer cells to self-destruct with pro-apoptotic receptor agonists | Q37319386 | ||
| Tumor resistance to apoptosis | Q37323744 | ||
| Apoptosis pathways and their therapeutic exploitation in pancreatic cancer | Q37453523 | ||
| Multiple and synergistic deregulations of apoptosis-controlling genes in pancreatic carcinoma cells | Q38602933 | ||
| Inhibition of RIP and c-FLIP enhances TRAIL-induced apoptosis in pancreatic cancer cells | Q40095247 | ||
| Effect of the XIAP inhibitor Embelin on TRAIL-induced apoptosis of pancreatic cancer cells. | Q40104929 | ||
| Targeting the apoptotic machinery in pancreatic cancers using small-molecule antagonists of the X-linked inhibitor of apoptosis protein | Q40163044 | ||
| TRAIL/bortezomib cotreatment is potentially hepatotoxic but induces cancer-specific apoptosis within a therapeutic window. | Q40165924 | ||
| Inhibition of CDK4 impairs proliferation of pancreatic cancer cells and sensitizes towards TRAIL-induced apoptosis via downregulation of survivin | Q40170364 | ||
| Silencing of X-linked inhibitor of apoptosis (XIAP) decreases gemcitabine resistance of pancreatic cancer cells | Q40210407 | ||
| Preclinical characterization of AEG35156/GEM 640, a second-generation antisense oligonucleotide targeting X-linked inhibitor of apoptosis | Q40236215 | ||
| Bcl-XL antisense oligonucleotides coupled with antennapedia enhances radiation-induced apoptosis in pancreatic cancer. | Q40244291 | ||
| Crosstalk between extrinsic and intrinsic cell death pathways in pancreatic cancer: synergistic action of estrogen metabolite and ligands of death receptor family | Q40291583 | ||
| Predominant Bcl-XL knockdown disables antiapoptotic mechanisms: tumor necrosis factor-related apoptosis-inducing ligand-based triple chemotherapy overcomes chemoresistance in pancreatic cancer cells in vitro | Q40444098 | ||
| P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P433 | issue | 1 | |
| P921 | main subject | pancreatic cancer | Q212961 |
| P304 | page(s) | 241-251 | |
| P577 | publication date | 2011-01-11 | |
| P1433 | published in | Cancers | Q27722963 |
| P1476 | title | Targeting apoptosis signaling in pancreatic cancer | |
| P478 | volume | 3 |
| Q28386389 | Alisertib induces cell cycle arrest and autophagy and suppresses epithelial-to-mesenchymal transition involving PI3K/Akt/mTOR and sirtuin 1-mediated signaling pathways in human pancreatic cancer cells |
| Q36373429 | Curcumin Induces Pancreatic Adenocarcinoma Cell Death Via Reduction of the Inhibitors of Apoptosis |
| Q35614990 | Growth inhibition and apoptosis induction by alternol in pancreatic carcinoma cells |
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