Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.

scientific article published on 24 May 2011

Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.BMCL.2011.05.049
P932PMC publication ID3440873
P698PubMed publication ID21680182
P5875ResearchGate publication ID51225773

P50authorPeter D. MaceQ42423701
P2093author name stringJohn C Reed
Kate Welsh
Hongbin Yuan
Stefan J Riedl
Ying Su
Kristiina Vuori
Nicholas D P Cosford
Peter Teriete
Robert J Ardecky
Darren Finlay
Marcos González-López
Santhi Reddy Ganji
P2860cites workStructural basis of caspase-7 inhibition by XIAPQ24290942
Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domainQ24290943
Structural basis for the inhibition of caspase-3 by XIAPQ24290945
PHENIX: a comprehensive Python-based system for macromolecular structure solutionQ24654617
Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domainQ27629143
Structural basis of IAP recognition by Smac/DIABLOQ27629148
A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosisQ28204205
IAP family proteins--suppressors of apoptosisQ28297514
Structural Basis of Caspase Inhibition by XIAPQ29011600
Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activityQ31038912
Apoptosis in cancerQ33846227
Targeting XIAP for the treatment of malignancyQ33991803
Cyclopeptide Smac mimetics as antagonists of IAP proteinsQ34382271
Human caspases: activation, specificity, and regulationQ34608215
Potent bivalent Smac mimetics: effect of the linker on binding to inhibitor of apoptosis proteins (IAPs) and anticancer activity.Q35024837
Caspases, IAPs and Smac/DIABLO: mechanisms from structural biologyQ35874476
The apoptosome: signalling platform of cell deathQ36766418
Neuronal apoptosis in neurodegenerationQ36850374
X-linked inhibitor of apoptosis protein as a therapeutic targetQ37008849
Design of small-molecule peptidic and nonpeptidic Smac mimeticsQ37176751
IAP-targeted therapies for cancerQ37302745
IAP antagonists: promising candidates for cancer therapyQ37680131
Small-molecule pan-IAP antagonists: a patent reviewQ37680967
Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancerQ40524353
Development and optimization of a binding assay for the XIAP BIR3 domain using fluorescence polarization.Q45027288
Structure-based design, synthesis and biochemical testing of novel and potent Smac peptido-mimetics.Q53873372
Characterization of dequalinium as a XIAP antagonist that targets the BIR2 domainQ83459597
P433issue14
P407language of work or nameEnglishQ1860
P921main subjectprotein designQ410814
apoptotic processQ14599311
P304page(s)4332-4336
P577publication date2011-05-24
P1433published inBioorganic & Medicinal Chemistry LettersQ2709483
P1476titleDesign, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP
P478volume21

Reverse relations

cites work (P2860)
Q54268307A critical role for cellular inhibitor of protein 2 (cIAP2) in colitis-associated colorectal cancer and intestinal homeostasis mediated by the inflammasome and survival pathways.
Q34540067Characterization of Potent SMAC Mimetics that Sensitize Cancer Cells to TNF Family-Induced Apoptosis
Q39143046Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.
Q28283505Expedient synthesis of highly potent antagonists of inhibitor of apoptosis proteins (IAPs) with unique selectivity for ML-IAP
Q33632016Inducing death in tumor cells: roles of the inhibitor of apoptosis proteins.
Q41830995Investigating isoquinoline derivatives for inhibition of inhibitor of apoptosis proteins for ovarian cancer treatment
Q102144611Pharmacological Activation of Non-canonical NF-κB Signaling Activates Latent HIV-1 Reservoirs In Vivo
Q35032216Small-molecule IAP antagonists sensitize cancer cells to TRAIL-induced apoptosis: roles of XIAP and cIAPs.
Q37980321Targeting IAP proteins for therapeutic intervention in cancer
Q61809001Targeting the BIR Domains of Inhibitor of Apoptosis (IAP) Proteins in Cancer Treatment
Q51746852Targeting the intrinsic apoptosis pathway as a strategy for melanoma therapy.
Q27679855The structure of XIAP BIR2: understanding the selectivity of the BIR domains
Q38239689X-linked inhibitor of apoptosis protein - a critical death resistance regulator and therapeutic target for personalized cancer therapy.

Search more.