Rb inactivation accelerates neoplastic growth and substitutes for recurrent amplification of cIAP1, cIAP2 and Yap1 in sporadic mammary carcinoma associated with p53 deficiency

scientific article published on August 2, 2010

Rb inactivation accelerates neoplastic growth and substitutes for recurrent amplification of cIAP1, cIAP2 and Yap1 in sporadic mammary carcinoma associated with p53 deficiency is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1015373795
P356DOI10.1038/ONC.2010.300
P8608Fatcat IDrelease_46jkvien4jgrzazdxcfvhbs2xi
P953full work available at URLhttps://europepmc.org/articles/pmc2967730?pdf=render
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20676140/?tool=EBI
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20676140/pdf/?tool=EBI
https://europepmc.org/articles/PMC2967730
https://europepmc.org/articles/PMC2967730?pdf=render
https://www.nature.com/articles/onc2010300.pdf
https://www.nature.com/articles/onc2010300
P932PMC publication ID2967730
P698PubMed publication ID20676140
P5875ResearchGate publication ID45440993

P2093author name stringW. Wang
L. Cheng
Z. Zhou
J. Camps
A. Y. Nikitin
T. Ried
A. Flesken-Nikitin
I. A. Toshkov
P2860cites workpRb inactivation in mammary cells reveals common mechanisms for tumor initiation and progression in divergent epitheliaQ21090243
Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approachQ24633776
Expression of Yes-associated protein in common solid tumorsQ24657592
Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 ampliconQ24682018
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implicationsQ27860709
Repeated observation of breast tumor subtypes in independent gene expression data setsQ28131820
Fate of the mammalian cardiac neural crestQ28139176
Principles of tumor suppressionQ28240740
Cancer statistics, 2009Q29547625
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumoursQ29547697
Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesisQ29616631
Tumor spectrum analysis in p53-mutant miceQ29617436
Transcriptional control of human p53-regulated genesQ29617650
The molecular portraits of breast tumors are conserved across microarray platformsQ33241398
The mammary pathology of genetically engineered mice: the consensus report and recommendations from the Annapolis meetingQ33860801
WAP-TAg transgenic mice and the study of dysregulated cell survival, proliferation, and mutation during breast carcinogenesisQ33860814
RB has a critical role in mediating the in vivo checkpoint response, mitigating secondary DNA damage and suppressing liver tumorigenesis initiated by aflatoxin B1Q34298366
Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic miceQ34342812
Positive cross-talk between estrogen receptor and NF-kappaB in breast cancerQ34374852
Cyclin D1 and breast cancerQ34567256
The RB and p53 pathways in cancerQ34804764
MMP13, Birc2 (cIAP1), and Birc3 (cIAP2), amplified on chromosome 9, collaborate with p53 deficiency in mouse osteosarcoma progressionQ34960600
TP53 and breast cancerQ35078761
High frequency of aberrant p16(INK4A) expression in human breast cancerQ35782316
Development of spontaneous mammary tumors in BALB/c p53 heterozygous mice. A model for Li-Fraumeni syndromeQ35829654
Role of raloxifene in breast cancer prevention in postmenopausal women: clinical evidence and potential mechanisms of actionQ35840621
Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancerQ35901185
RB family members as predictive and prognostic factors in human cancerQ36579289
Role of the retinoblastoma tumor suppressor in the maintenance of genome integrityQ36651860
RB in breast cancer: at the crossroads of tumorigenesis and treatmentQ36760000
Cellular mechanisms of tumour suppression by the retinoblastoma gene.Q37225340
Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancersQ37272977
IAP-targeted therapies for cancerQ37302745
Atelocollagen-mediated synthetic small interfering RNA delivery for effective gene silencing in vitro and in vivoQ37346696
Tumour suppression by p53: a role for the DNA damage response?Q37591937
Rb inactivation leads to E2F1-mediated DNA double-strand break accumulationQ40368518
Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellumQ40442891
Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control.Q40526270
Germline p53 mutations and heritable cancerQ40614036
Somatic mutation of p53 leads to estrogen receptor alpha-positive and -negative mouse mammary tumors with high frequency of metastasisQ46557073
Mice expressing a mammary gland-specific R270H mutation in the p53 tumor suppressor gene mimic human breast cancer development.Q46706112
Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.Q52544495
Induction of carcinogenesis by concurrent inactivation of p53 and Rb1 in the mouse ovarian surface epithelium.Q53378102
RB loss abrogates cell cycle control and genome integrity to promote liver tumorigenesis.Q53528048
Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis.Q53588886
Comparative Oncogenomics Identifies NEDD9 as a Melanoma Metastasis GeneQ57274900
Liver-specific pRB loss results in ectopic cell cycle entry and aberrant ploidyQ64378607
Functional mammary gland development and oncogene-induced tumor formation are not affected by the absence of the retinoblastoma geneQ77158823
Synergy of p53 and Rb deficiency in a conditional mouse model for metastatic prostate cancerQ80121826
Prostate cancer associated with p53 and Rb deficiency arises from the stem/progenitor cell-enriched proximal region of prostatic ductsQ80441313
P433issue42
P407language of work or nameEnglishQ1860
P304page(s)5700-5711
P577publication date2010-08-02
P1433published inOncogeneQ1568657
P1476titleRb inactivation accelerates neoplastic growth and substitutes for recurrent amplification of cIAP1, cIAP2 and Yap1 in sporadic mammary carcinoma associated with p53 deficiency
P478volume29

Reverse relations

cites work (P2860)
Q90070043Anti-apoptotic factor Birc3 is up-regulated by ELL2 knockdown and stimulates proliferation in LNCaP cells
Q51702011BIRC3 single nucleotide polymorphism associate with asthma susceptibility and the abundance of eosinophils and neutrophils.
Q38514410Control of Proliferation and Cancer Growth by the Hippo Signaling Pathway
Q34485060Cooperativity of Rb, Brca1, and p53 in malignant breast cancer evolution
Q47445570From cancer genomes to oncogenic drivers, tumour dependencies and therapeutic targets
Q35682449Genomic instability influences the transcriptome and proteome in endometrial cancer subtypes
Q37209606IAP proteins as targets for drug development in oncology
Q36056530Implanted adipose progenitor cells as physicochemical regulators of breast cancer.
Q37651843Induced p53 loss in mouse luminal cells causes clonal expansion and development of mammary tumours.
Q90828113Integrative analysis of copy number and gene expression data identifies potential oncogenic drivers that promote mammary tumor recurrence
Q46082295Iron overload signature in chrysotile-induced malignant mesothelioma
Q38794695MicroRNA-34a promotes genomic instability by a broad suppression of genome maintenance mechanisms downstream of the oncogene KSHV-vGPCR.
Q90163150Moderate Exercise Modulates Tumor Metabolism of Triple-Negative Breast Cancer
Q41892098Organ size control is dominant over Rb family inactivation to restrict proliferation in vivo
Q37395680RB1 deficiency in triple-negative breast cancer induces mitochondrial protein translation
Q26766039Report on the use of non-clinical studies in the regulatory evaluation of oncology drugs
Q47100005Risk Factors and Preventions of Breast Cancer
Q42363612The Chromatin Remodeling Component Arid1a Is a Suppressor of Spontaneous Mammary Tumors in Mice
Q37512362The Inhibitor of Apoptosis (IAPs) in Adaptive Response to Cellular Stress
Q47850800p53 shades of Hippo.

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