Necroptosis and Cancer.

scientific article

Necroptosis and Cancer. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.TRECAN.2017.03.002
P932PMC publication ID5402749
P698PubMed publication ID28451648

P50authorAyaz NajafovQ57325964
Hongbo ChenQ62838254
P2093author name stringJunying Yuan
P2860cites workFas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector moleculeQ24290576
Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinaseQ24302381
Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosisQ24311815
TNF-alpha induces two distinct caspase-8 activation pathwaysQ24313656
Structural basis of RIP1 inhibition by necrostatinsQ24323347
Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alphaQ24338113
Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammationQ24338129
Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cellsQ24530100
The pseudokinase MLKL mediates necroptosis via a molecular switch mechanismQ27685465
CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family membersQ28201693
Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaBQ28201706
The future of immune checkpoint therapyQ28259862
RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosisQ28594624
Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell deathQ28660873
Identification of RIP1 kinase as a specific cellular target of necrostatinsQ29616006
Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injuryQ29616008
RIPK1 and NF-κB signaling in dying cells determines cross-priming of CD8⁺ T cells.Q30679385
RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS.Q33728908
Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis.Q34216810
RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosisQ34387272
Cross-primingQ34503836
The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemiaQ34527239
Identification of a molecular signaling network that regulates a cellular necrotic cell death pathwayQ34910947
Pronecrotic mixed lineage kinase domain-like protein expression is a prognostic biomarker in patients with early-stage resected pancreatic adenocarcinoma.Q35320095
A decade of caspasesQ35591686
RIP3 is downregulated in human myeloid leukemia cells and modulates apoptosis and caspase-mediated p65/RelA cleavageQ35679558
Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeuticsQ35686077
Activation of necroptosis in multiple sclerosisQ35828763
A novel role for RIP1 kinase in mediating TNFα productionQ36071998
Necrostatin-1 reduces intestinal inflammation and colitis-associated tumorigenesis in miceQ36309417
Mixed lineage kinase domain-like protein is a prognostic biomarker for cervical squamous cell cancerQ36464781
Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease modelsQ36525166
Necroptosis in Niemann-Pick disease, type C1: a potential therapeutic target.Q36774925
The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression.Q36803448
The function of TRADD in signaling through tumor necrosis factor receptor 1 and TRIF-dependent Toll-like receptorsQ36961482
Inflammation: a driving force speeds cancer metastasisQ36986448
Down-regulation of CYLD expression by Snail promotes tumor progression in malignant melanomaQ37061845
Low expression of mixed lineage kinase domain-like protein is associated with poor prognosis in ovarian cancer patientsQ37278775
IAP-targeted therapies for cancerQ37302745
Blocking TCR restimulation induced necroptosis in adoptively transferred T cells improves tumor control.Q37688373
Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell deathQ38152946
Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis.Q38754063
NF-κB-Independent Role of IKKα/IKKβ in Preventing RIPK1 Kinase-Dependent Apoptotic and Necroptotic Cell Death during TNF Signaling.Q38837455
Necroptosis is active in children with inflammatory bowel disease and contributes to heighten intestinal inflammationQ39045044
RIPK3 Restricts Myeloid Leukemogenesis by Promoting Cell Death and Differentiation of Leukemia Initiating CellsQ39605503
Cutting Edge: RIP1 kinase activity is dispensable for normal development but is a key regulator of inflammation in SHARPIN-deficient mice.Q40416781
Activity and specificity of necrostatin-1, small-molecule inhibitor of RIP1 kinaseQ42725146
Clinical significance of down-regulated cylindromatosis gene in chronic lymphocytic leukemia.Q46030980
FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation.Q52614520
Receptor-interacting protein kinase 3 is a predictor of survival and plays a tumor suppressive role in colorectal cancer.Q54270795
SnapShot: Necroptosis.Q54337095
The Adaptor Protein FADD Protects Epidermal Keratinocytes from Necroptosis In Vivo and Prevents Skin InflammationQ62819741
P433issue4
P921main subjectnecroptosisQ3346925
P304page(s)294-301
P577publication date2017-04-01
P1433published inTrends in cancerQ27726777
P1476titleNecroptosis and Cancer
P478volume3

Reverse relations

cites work (P2860)
Q92602547Characterization of TNF-induced cell death in Drosophila reveals caspase- and JNK-dependent necrosis and its role in tumor suppression
Q93155695Elimination of Osteosarcoma by Necroptosis with Graphene Oxide-Associated Anti-HER2 Antibodies
Q90170173Medicinal Plants from Brazilian Cerrado: Antioxidant and Anticancer Potential and Protection against Chemotherapy Toxicity
Q92544553Necroptosis, tumor necrosis and tumorigenesis
Q90370565Resibufogenin suppresses colorectal cancer growth and metastasis through RIP3-mediated necroptosis
Q64244093Synergistic Effects of Bortezomib-OV Therapy and Anti-Invasive Strategies in Glioblastoma: A Mathematical Model
Q55386853The role of necroptosis in the treatment of diseases.
Q40063923Thioredoxin-1 actively maintains the pseudokinase MLKL in a reduced state to suppress disulfide bond-dependent MLKL polymer formation and necroptosis.
Q89983838Transcription factors in ferroptotic cell death
Q94521018Tumor suppressor death-associated protein kinase 1 inhibits necroptosis by p38 MAPK activation
Q92408464Understanding Apoptosis and Apoptotic Pathways Targeted Cancer Therapeutics
Q92431578miR-425 deficiency promotes necroptosis and dopaminergic neurodegeneration in Parkinson's disease

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