Ardisianone, a natural benzoquinone, efficiently induces apoptosis in human hormone-refractory prostate cancers through mitochondrial damage stress and survivin downregulation.

scientific article

Ardisianone, a natural benzoquinone, efficiently induces apoptosis in human hormone-refractory prostate cancers through mitochondrial damage stress and survivin downregulation. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/PROS.22548
P698PubMed publication ID22674285
P5875ResearchGate publication ID225275548

P50authorIh Sheng ChenQ26714512
Jih-Hwa GuhQ40601635
Yunn-Fang HoQ58437432
P2093author name stringLih-Ching Hsu
Jui-Ling Hsu
Hsun-Shuo Chang
Chia-Chun Yu
Yu-Jia Chang
Ping-Jung Wu
P2860cites workPhosphorylation and regulation of Akt/PKB by the rictor-mTOR complexQ24295120
Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteinsQ24519078
Apoptosis-inducing factor (AIF): a ubiquitous mitochondrial oxidoreductase involved in apoptosisQ28141949
Direct interaction between survivin and Smac/DIABLO is essential for the anti-apoptotic activity of survivin during taxol-induced apoptosisQ28186614
Mechanisms of caspase activationQ28187994
Validating survivin as a cancer therapeutic targetQ28201382
Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progressionQ29617473
IAP proteins: blocking the road to death's doorQ29619844
Pancreatic tumor suppression by benzyl isothiocyanate is associated with inhibition of PI3K/AKT/FOXO pathwayQ30499567
Rapid accumulation of Akt in mitochondria following phosphatidylinositol 3-kinase activationQ31034955
Characterization of XIAP-deficient miceQ33559119
Targeting the translational machinery as a novel treatment strategy for hematologic malignanciesQ33747291
Interaction of natural products with cell survival and signaling pathways in the biochemical elucidation of drug targets in cancerQ33985206
Survivin inhibition is critical for Bcl-2 inhibitor-induced apoptosis in hepatocellular carcinoma cellsQ33988315
Recent advances in apoptosis, mitochondria and drug resistance in cancer cellsQ34174664
Mammalian TOR: a homeostatic ATP sensorQ34519173
Survivin and IAP proteins in cell-death mechanismsQ35414780
The BCL-2 family reunionQ35568029
Recent advances in understanding the cell death pathways activated by anticancer therapyQ36059491
Executioner caspase-3 and caspase-7 are functionally distinct proteasesQ36861736
IAPs: what's in a name?Q37148694
IAP-targeted therapies for cancerQ37302745
Mitochondria as targets for cancer chemotherapyQ37356281
Mitochondrial function and energy metabolism in cancer cells: past overview and future perspectivesQ37491422
Targeting mitochondrial apoptosis by betulinic acid in human cancersQ37516642
VDAC, a multi-functional mitochondrial protein regulating cell life and deathQ37719811
Drugs targeting Bcl-2 family members as an emerging strategy in cancerQ37786022
Emerging mitochondrial signaling mechanisms in physiology, aging processes, and as drug targetsQ37789845
Functions and regulation of the 70kDa ribosomal S6 kinases.Q37798912
Role of Bcl-2 family proteins and caspases in the regulation of apoptosis.Q37826384
Induction of cIAP-2 in Human Colon Cancer Cells through PKCδ/NF-κBQ38349616
3-Thiomorpholin-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrile (S1) based molecules as potent, dual inhibitors of B-cell lymphoma 2 (Bcl-2) and myeloid cell leukemia sequence 1 (Mcl-1): structure-based design and structure-activity relationship stQ39607925
Cytotoxic alkyl benzoquinones and alkyl phenols from Ardisia virensQ39787039
Antroquinonol displays anticancer potential against human hepatocellular carcinoma cells: a crucial role of AMPK and mTOR pathways.Q39805239
Genistein induces apoptosis in human hepatocellular carcinomas via interaction of endoplasmic reticulum stress and mitochondrial insult.Q40190565
Bcl-xL is overexpressed in hormone-resistant prostate cancer and promotes survival of LNCaP cells via interaction with proapoptotic Bak.Q40263616
ErbB2 increases vascular endothelial growth factor protein synthesis via activation of mammalian target of rapamycin/p70S6K leading to increased angiogenesis and spontaneous metastasis of human breast cancer cellsQ40314359
An IAP-IAP complex inhibits apoptosisQ40541576
Translational induction of the inhibitor of apoptosis protein HIAP2 during endoplasmic reticulum stress attenuates cell death and is mediated via an inducible internal ribosome entry site element.Q40590393
BI-97C1, an optically pure Apogossypol derivative as pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.Q40886681
Endoplasmic reticulum stress-induced apoptosis in Leishmania through Ca2+-dependent and caspase-independent mechanismQ41912110
Involvement of ROS in chlorogenic acid-induced apoptosis of Bcr-Abl+ CML cellsQ42910611
Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitorsQ43092357
The E3 ubiquitin ligase cIAP1 binds and ubiquitinates caspase-3 and -7 via unique mechanisms at distinct steps in their processingQ43136832
Executioner caspase-3, -6, and -7 perform distinct, non-redundant roles during the demolition phase of apoptosis.Q43509147
Involvement of Akt in mitochondria-dependent apoptosis induced by a cdc25 phosphatase inhibitor naphthoquinone analogQ44673360
Costunolide induces apoptosis through nuclear calcium2+ overload and DNA damage response in human prostate cancer.Q53260250
P433issue2
P921main subjectprostate cancerQ181257
P304page(s)133-145
P577publication date2012-06-05
P1433published inThe ProstateQ7758608
P1476titleArdisianone, a natural benzoquinone, efficiently induces apoptosis in human hormone-refractory prostate cancers through mitochondrial damage stress and survivin downregulation
P478volume73

Reverse relations

cites work (P2860)
Q38775002A CD13 inhibitor, ubenimex, synergistically enhances the effects of anticancer drugs in hepatocellular carcinoma
Q38767151A tale of two glutaminases: homologous enzymes with distinct roles in tumorigenesis
Q58800467Anti-Cancer Natural Products and Their Bioactive Compounds Inducing ER Stress-Mediated Apoptosis: A Review
Q39066878Antiproliferative and antimicrobial activities of alkylbenzoquinone derivatives from Ardisia kivuensis
Q39158194Cyclohexa-2,5-diene-1,4-dione-based antiproliferative agents: design, synthesis, and cytotoxic evaluation.
Q91504757Monocyclic Quinone Structure-Activity Patterns: Synthesis of Catalytic Inhibitors of Topoisomerase II with Potent Antiproliferative Activity
Q33841579Overcoming chemotherapy drug resistance by targeting inhibitors of apoptosis proteins (IAPs)
Q36625600ROS-mediated activation of AKT induces apoptosis via pVHL in prostate cancer cells
Q38852408Repurposing of phentolamine as a potential anticancer agent against human castration-resistant prostate cancer: A central role on microtubule stabilization and mitochondrial apoptosis pathway
Q38647185Role of Forkhead Box Class O proteins in cancer progression and metastasis
Q64248879The Role of the ER-Induced UPR Pathway and the Efficacy of Its Inhibitors and Inducers in the Inhibition of Tumor Progression

Search more.