| scholarly article | Q13442814 |
| P50 | author | Alex Domling | Q73024340 |
| P2093 | author name string | Wei Wang | |
| Kan Wang | |||
| P2860 | cites work | A New Heterocyclic Multicomponent Reaction For the Combinatorial Synthesis of Fused 3-Aminoimidazoles | Q88520514 |
| Over one hundred peptide-activated G protein-coupled receptors recognize ligands with turn structure. | Q36065156 | ||
| Targeting protein-protein interactions for cancer therapy | Q36311496 | ||
| Recent advances in heterocycle generation using the efficient Ugi multiple-component condensation reaction. | Q36324452 | ||
| The structural and functional diversity of Hsp70 proteins from Plasmodium falciparum | Q36393529 | ||
| Conformational thermostabilization of the beta1-adrenergic receptor in a detergent-resistant form | Q36458843 | ||
| Progress and problems in the exploration of therapeutic targets | Q36458861 | ||
| Pyrimidinone-peptoid hybrid molecules with distinct effects on molecular chaperone function and cell proliferation | Q36580588 | ||
| MDM2 inhibitors for cancer therapy | Q36663493 | ||
| Scaffold selection and scaffold hopping in lead generation: a medicinal chemistry perspective | Q36727198 | ||
| Chemo-differentiating ABB' multicomponent reactions. Privileged building blocks. | Q36746383 | ||
| Chemotherapy of schistosomiasis: present and future | Q36891317 | ||
| Cyanoacetamide MCR (III): three-component Gewald reactions revisited. | Q37042104 | ||
| Targeting Mdm2 and Mdmx in cancer therapy: better living through medicinal chemistry? | Q37068706 | ||
| Isocyanide-based multicomponent reactions in drug discovery | Q37099268 | ||
| Intramembrane proteolysis | Q37155734 | ||
| Therapeutic application of histone deacetylase inhibitors for central nervous system disorders | Q37283454 | ||
| IAP-targeted therapies for cancer | Q37302745 | ||
| Inhibition of Simian Virus 40 replication by targeting the molecular chaperone function and ATPase activity of T antigen | Q37377925 | ||
| Biomedical application of orexin/hypocretin receptor ligands in neuroscience | Q37387228 | ||
| Emerging molecular diversity from the intra-molecular Ugi reaction: iterative efficiency in medicinal chemistry | Q37389351 | ||
| X-ray structure breakthroughs in the GPCR transmembrane region | Q37485060 | ||
| Unlocking the molecular secrets of sodium-coupled transporters. | Q37490830 | ||
| Synthetic approaches to the neuraminidase inhibitors zanamivir (Relenza) and oseltamivir phosphate (Tamiflu) for the treatment of influenza | Q37523830 | ||
| Ugi-Smiles couplings: new entries to N-aryl carboxamide derivatives. | Q37543191 | ||
| Neglected tropical diseases: multi-target-directed ligands in the search for novel lead candidates against Trypanosoma and Leishmania | Q37552902 | ||
| The Gewald multicomponent reaction. | Q37700274 | ||
| Orexin receptor antagonists: a new concept in CNS disorders? | Q37764786 | ||
| Praziquantel and schistosomiasis. | Q37777113 | ||
| Beyond Ugi and Passerini reactions: multicomponent approaches based on isocyanides and alkynes as an efficient tool for diversity oriented synthesis. | Q37877752 | ||
| When analoging is not enough: scaffold discovery in medicinal chemistry | Q38028518 | ||
| Asymmetrically induced four component condensation with extremely high stereoselectivity and multiplication of stereoselectivity | Q39215862 | ||
| Screening multicomponent reactions for X-linked inhibitor of apoptosis-baculoviral inhibitor of apoptosis protein repeats domain binder. | Q39607001 | ||
| Dihydropyrazolopyrimidines containing benzimidazoles as K(V)1.5 potassium channel antagonists | Q39814897 | ||
| Synthesis, biological evaluation, and molecular docking of Ugi products containing a zinc-chelating moiety as novel inhibitors of histone deacetylases. | Q39864415 | ||
| Africa's 32 cents solution for HIV/AIDS | Q21092298 | ||
| Molecular imaging in drug development | Q22122025 | ||
| N2-substituted O6-cyclohexylmethylguanine derivatives: potent inhibitors of cyclin-dependent kinases 1 and 2 | Q24298676 | ||
| Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain | Q24314763 | ||
| Design of selective phenylglycine amide tissue factor/factor VIIa inhibitors | Q24338687 | ||
| Mutations in the kinesin-like protein Eg5 disrupting localization to the mitotic spindle | Q24562852 | ||
| Chloride channels as drug targets | Q24601830 | ||
| Genomic-scale prioritization of drug targets: the TDR Targets database | Q24635333 | ||
| The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist | Q24654563 | ||
| Crystal structure of the ATP-gated P2X(4) ion channel in the closed state | Q24657193 | ||
| High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor | Q24657484 | ||
| Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family | Q24670396 | ||
| High-resolution structure of human apo dipeptidyl peptidase IV/CD26 and its complex with 1-[([2-[(5-iodopyridin-2-yl)amino]-ethyl]amino)-acetyl]-2-cyano-(S)-pyrrolidine | Q27641526 | ||
| Inhibition of a mitotic motor protein: where, how, and conformational consequences | Q27642775 | ||
| In vivo activation of the p53 pathway by small-molecule antagonists of MDM2 | Q27642888 | ||
| Structure of human Eg5 in complex with a new monastrol-based inhibitor bound in the R configuration | Q27643649 | ||
| Synthesis and SAR of thiophene containing kinesin spindle protein (KSP) inhibitors | Q27644760 | ||
| Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases | Q27647894 | ||
| Crystal structure of the human beta2 adrenergic G-protein-coupled receptor | Q27648868 | ||
| Discovery and X-ray crystallographic analysis of a spiropiperidine iminohydantoin inhibitor of beta-secretase | Q27652273 | ||
| Discovery and structure-activity relationship of P1-P3 ketoamide derived macrocyclic inhibitors of hepatitis C virus NS3 protease | Q27653236 | ||
| Identification of PDE4B Over 4D subtype-selective inhibitors revealing an unprecedented binding mode | Q27655941 | ||
| The discovery and optimization of hexahydro-2H-pyrano[3,2-c]quinolines (HHPQs) as potent and selective inhibitors of the mitotic kinesin-5 | Q27659742 | ||
| Discovery of novel and orally active FXR agonists for the potential treatment of dyslipidemia & diabetes | Q27666200 | ||
| Optimization of a novel class of benzimidazole-based farnesoid X receptor (FXR) agonists to improve physicochemical and ADME properties | Q27666590 | ||
| Crystal structure analysis of deamino-oxytocin: conformational flexibility and receptor binding | Q27728510 | ||
| The structure of glycogen phosphorylase b with an alkyldihydropyridine-dicarboxylic acid compound, a novel and potent inhibitor | Q27748069 | ||
| Three-dimensional structure of a human Fab with high affinity for tetanus toxoid | Q27749024 | ||
| Structural basis of inhibitor selectivity in MAP kinases | Q27765381 | ||
| Structure-based design of aliskiren, a novel orally effective renin inhibitor | Q28202603 | ||
| Irreversible inhibitors of serine, cysteine, and threonine proteases | Q28217093 | ||
| Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain | Q28240653 | ||
| Cell cycle kinases as therapeutic targets for cancer | Q28250447 | ||
| Discovery of 1-(4-fluorophenyl)-(3R)-[3-(4-fluorophenyl)-(3S)-hydroxypropyl]-(4S)-(4 -hydroxyphenyl)-2-azetidinone (SCH 58235): a designed, potent, orally active inhibitor of cholesterol absorption | Q28266499 | ||
| Aliskiren: the first renin inhibitor for clinical treatment | Q28272666 | ||
| New perspectives in cell adhesion: RGD and integrins | Q28280381 | ||
| Catalytic triads and their relatives | Q28286602 | ||
| A convenient synthesis of immunosuppressive agent FTY720 using the petasis reaction | Q28301345 | ||
| Discovery of the first selective inhibitor of excitatory amino acid transporter subtype 1 | Q28307412 | ||
| Designing focused chemical libraries enriched in protein-protein interaction inhibitors using machine-learning methods | Q28473098 | ||
| Inhibitor binding in a class 2 dihydroorotate dehydrogenase causes variations in the membrane-associated N-terminal domain | Q28581357 | ||
| The art and practice of structure-based drug design: A molecular modeling perspective | Q29029768 | ||
| Ueber einen neuen aus Aldehyd - Ammoniak und Blausäure entstehenden Körper | Q29304798 | ||
| The druggable genome | Q29547361 | ||
| An inhibitor of Bcl-2 family proteins induces regression of solid tumours | Q29547595 | ||
| Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at risk | Q29547716 | ||
| Serine protease mechanism and specificity | Q29616734 | ||
| Design and synthesis of cyclic RGD pentapeptoids by consecutive Ugi reactions | Q30319701 | ||
| A structural model for monastrol inhibition of dimeric kinesin Eg5. | Q30477323 | ||
| The Ugi reaction in the generation of new nucleosides as potential antiviral and antileishmanial agents | Q30826533 | ||
| Topography-biased compound library design: the shape of things to come? | Q30836240 | ||
| 2,5-Diketopiperazines as potent and selective oxytocin antagonists 1: Identification, stereochemistry and initial SAR. | Q30851373 | ||
| The discovery of new isocyanide-based multi-component reactions | Q30873352 | ||
| N-phenylphenylglycines as novel corticotropin releasing factor receptor antagonists | Q31053861 | ||
| "Multi-component reactions : emerging chemistry in drug discovery" 'from xylocain to crixivan'. | Q31130331 | ||
| 1,4-Benzodiazepine-2,5-diones as small molecule antagonists of the HDM2-p53 interaction: discovery and SAR. | Q31142959 | ||
| Glycoconjugate libraries accessed by multicomponent reactions | Q33184108 | ||
| Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells. | Q33211997 | ||
| Identification of Hsp70 modulators through modeling of the substrate binding domain. | Q47820375 | ||
| Origin of the relative stereoselectivity of the beta-lactam formation in the Staudinger reaction. | Q51212459 | ||
| Spirodiketopiperazine-based CCR5 antagonists: Lead optimization from biologically active metabolite. | Q51802017 | ||
| Synthesis and biological evaluation of new conformationally biased integrin ligands based on a tetrahydroazoninone scaffold. | Q53014759 | ||
| Heterocycles as key substrates in multicomponent reactions: the fast lane towards molecular complexity. | Q53536521 | ||
| Concise construction of novel bridged bicyclic lactams by sequenced Ugi/RCM/Heck reactions. | Q53558659 | ||
| Synthesis of novel and uniquely shaped 3-azabicyclo[4.2.0]octan-4-one derivatives by sequential Ugi/[2+2] ene-enone photocycloadditions. | Q53577204 | ||
| Three-component condensation leading to beta-amino acid diamides: convergent assembly of beta-peptide analogues. | Q54134092 | ||
| Cheminformatics Analysis of Organic Substituents: Identification of the Most Common Substituents, Calculation of Substituent Properties, and Automatic Identification of Drug-like Bioisosteric Groups | Q56032354 | ||
| Novel Multicomponent Reaction for the Combinatorial Synthesis of 2-Imidazolines | Q56838181 | ||
| Polyamines in drug discovery: from the universal template approach to the multitarget-directed ligand design strategy | Q56987967 | ||
| 1) Ueber α-Alkylcinchoninsäuren und α-Alkylchinoline | Q57636385 | ||
| Probing Integrin Selectivity: Rational Design of Highly Active and Selective Ligands for the α5β1 and αvβ3 Integrin Receptor | Q58856002 | ||
| Cysteine Proteases and Their Inhibitors | Q61066438 | ||
| Phenol Ugi-Smiles Systems: Strategies for the Multicomponent N-Arylation of Primary Amines with Isocyanides, Aldehydes, and Phenols | Q61861949 | ||
| Short and diverse route toward complex natural product-like macrocycles | Q73178688 | ||
| Dissociation of antithrombotic effect and bleeding time prolongation in rabbits by inhibiting tissue factor function | Q73727752 | ||
| Inhibition of arterial thrombosis by a soluble tissue factor mutant and active site-blocked factors IXa and Xa in the guinea pig | Q73769031 | ||
| An investigation of imidazole and oxazole syntheses using aryl-substituted TosMIC reagents | Q73799056 | ||
| Nickel-catalyzed cyclizations, couplings, and cycloadditions involving three reactive components | Q74061724 | ||
| Solid-supported synthesis of a peptide beta-turn mimetic | Q74320064 | ||
| Renin inhibition by substituted piperidines: a novel paradigm for the inhibition of monomeric aspartic proteinases? | Q74599384 | ||
| Atom-economical synthesis of the N(10)-C(17) fragment of cyclotheonamides via a novel Passerini reaction-deprotection-acyl migration strategy | Q74607802 | ||
| Indole alkaloids from the tunicate Aplidium meridianum | Q77333270 | ||
| An efficient synthesis of morpholin-2-one derivatives using glycolaldehyde dimer by the Ugi multicomponent reaction | Q77469772 | ||
| Domino Reactions in Organic Synthesis | Q77646150 | ||
| [ISONITRILES. V. PREPARATION OF ALPHA,BETA-UNSATURATED ISONITRILES, BETA-KETO- AND BETA-CHLORO-ISONITRILES. SYNTHESIS OF XANTHOCILLIN DIMETHYL ETHER] | Q78437219 | ||
| Massive parallel catalyst screening: toward asymmetric MCRs | Q79194266 | ||
| Asymmetric synthesis of 5-(1-hydroxyalkyl)tetrazoles by catalytic enantioselective Passerini-type reactions | Q79758309 | ||
| Synthetic studies on (+)-naphthyridinomycin: stereoselective synthesis of the tetracyclic core framework | Q80494675 | ||
| A resource-efficient and highly flexible procedure for a three-component synthesis of 2-imidazolines | Q80604861 | ||
| Use of the X-ray structure of the Beta2-adrenergic receptor for drug discovery | Q80616052 | ||
| New entry to convertible isocyanides for the Ugi reaction and its application to the stereocontrolled formal total synthesis of the proteasome inhibitor omuralide | Q80728800 | ||
| An NMR-based antagonist induced dissociation assay for targeting the ligand-protein and protein-protein interactions in competition binding experiments | Q80791870 | ||
| One-pot synthesis of quinoline-based tetracycles by a tandem three-component reaction | Q80810091 | ||
| Piperazinebenzylamines as potent and selective antagonists of the human melanocortin-4 receptor | Q80858982 | ||
| Catalytic three-component Ugi reaction | Q81001266 | ||
| NMR structure of a complex between MDM2 and a small molecule inhibitor | Q81042317 | ||
| Synthesis of 4-azasteroids by an intramolecular Ugi reaction | Q81616611 | ||
| Scaffold-hopping cascade yields potent inhibitors of 5-lipoxygenase | Q81758946 | ||
| Short and novel stereospecific synthesis of trisubstituted 2,5-diketopiperazines | Q81808883 | ||
| Nonracemizable isocyanoacetates for multicomponent reactions | Q83045136 | ||
| Dose-dependent antithrombotic activity of an orally active tissue factor/factor VIIa inhibitor without concomitant enhancement of bleeding propensity | Q83169189 | ||
| Passerini reaction-amine deprotection-acyl migration peptide assembly: efficient formal synthesis of cyclotheonamide C | Q83317105 | ||
| A multicomponent reaction towards N-(cyanomethyl)amides | Q83885287 | ||
| The efficient one-pot reaction of up to eight components by the union of multicomponent reactions | Q84177103 | ||
| Discovery of novel analgesic and anti-inflammatory 3-arylamine-imidazo[1,2-a]pyridine symbiotic prototypes | Q39908290 | ||
| Antiplasmodial, beta-haematin inhibition, antitrypanosomal and cytotoxic activity in vitro of novel 4-aminoquinoline 2-imidazolines | Q39917596 | ||
| Dihydropyrazolopyrimidine inhibitors of K(V)1.5 (I(Kur)). | Q39917770 | ||
| A concise entry into nonsymmetrical alkyl polyamines | Q39944577 | ||
| (9S)-9-(2-hydroxy-4,4-dimethyl-6-oxo-1-cyclohexen-1-yl)-3,3-dimethyl-2,3,4,9-tetrahydro-1H-xanthen-1-one, a selective and orally active neuropeptide Y Y5 receptor antagonist | Q39959755 | ||
| Isoquinolin-1-one inhibitors of the MDM2-p53 interaction | Q39989774 | ||
| Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay. 4. Structure-activity relationships of N-alkyl substituted pyrrole fused at the 7,8-positions | Q40024821 | ||
| Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based HTS assay. Part 5: modifications of the 2- and 3-positions | Q40036129 | ||
| Amino acid derivatives as histone deacetylase inhibitors | Q40043991 | ||
| Morpholin-2-one derivatives as novel selective T-type Ca2+ channel blockers | Q40250075 | ||
| Discovery of protein-protein binding disruptors using multi-component condensations small molecules | Q40269487 | ||
| Novel 1,4-benzodiazepine-2,5-diones as Hdm2 antagonists with improved cellular activity | Q40285926 | ||
| Enantiomerically pure 1,4-benzodiazepine-2,5-diones as Hdm2 antagonists | Q40289147 | ||
| Enhanced pharmacokinetic properties of 1,4-benzodiazepine-2,5-dione antagonists of the HDM2-p53 protein-protein interaction through structure-based drug design | Q40294895 | ||
| Small molecule modulators of endogenous and co-chaperone-stimulated Hsp70 ATPase activity. | Q40479992 | ||
| First pharmacophoric hypothesis for T-type calcium channel blockers | Q40577281 | ||
| Inhibition of hepatitis B virus replication by drug-induced depletion of nucleocapsids | Q40606293 | ||
| Synthesis and study of pigment aggregation response of some melatonin derivatives. | Q40628353 | ||
| New synthetic technology for efficient construction of alpha-hydroxy-beta-amino amides via the Passerini reaction | Q41758291 | ||
| Robust generation of lead compounds for protein-protein interactions by computational and MCR chemistry: p53/Hdm2 antagonists. | Q41861051 | ||
| 1,4-Thienodiazepine-2,5-diones via MCR (I): synthesis, virtual space and p53-Mdm2 activity. | Q41880343 | ||
| Application of multi-component reactions to antimalarial drug discovery. Part 1: Parallel synthesis and antiplasmodial activity of new 4-aminoquinoline Ugi adducts | Q41913855 | ||
| Application of multicomponent reactions to antimalarial drug discovery. Part 3: discovery of aminoxazole 4-aminoquinolines with potent antiplasmodial activity in vitro | Q41942570 | ||
| Synthesis and biological evaluation of phenolic Mannich bases of benzaldehyde and (thio)semicarbazone derivatives against the cysteine protease falcipain-2 and a chloroquine resistant strain of Plasmodium falciparum | Q41944333 | ||
| Enantioselective synthesis of SNAP-7941: chiral dihydropyrimidone inhibitor of MCH1-R. | Q42185844 | ||
| Stereochemical control of the Passerini reaction | Q42794138 | ||
| Thienopyrimidine ureas as novel and potent multitargeted receptor tyrosine kinase inhibitors. | Q42810185 | ||
| On the Preparation of Enantiomerically Pure Isonitriles from Amino Acid Esters and Peptides | Q42873120 | ||
| Efficient multicomponent reaction synthesis of the schistosomiasis drug praziquantel. | Q42906063 | ||
| Application of ring-closing metathesis for the synthesis of macrocyclic peptidomimetics as inhibitors of HCV NS3 protease | Q43038905 | ||
| (-)-Bacillamide C: the convergent approach | Q43187806 | ||
| Polycyclic indole alkaloid-type compounds by MCR. | Q43189174 | ||
| Cyanoacetamide multicomponent reaction (I): Parallel synthesis of cyanoacetamides | Q43289105 | ||
| Bioisosteric replacement of the hydrazide pharmacophore of the cannabinoid-1 receptor antagonist SR141716A. Part I: potent, orally-active 1,4-disubstituted imidazoles. | Q43291235 | ||
| Targeting structural and stereochemical complexity by organocascade catalysis: construction of spirocyclic oxindoles having multiple stereocenters | Q43294254 | ||
| Expeditious access to unprotected racemic pyroglutamic acids | Q43529314 | ||
| Potent, selective and orally bioavailable dihydropyrimidine inhibitors of Rho kinase (ROCK1) as potential therapeutic agents for cardiovascular diseases | Q43782577 | ||
| Total synthesis of ecteinascidin 743. | Q44016187 | ||
| A four component coupling strategy for the synthesis of D-phenylglycinamide-derived non-covalent factor Xa inhibitors | Q44489544 | ||
| Design, synthesis, and evaluation of oxygen-containing macrocyclic peptidomimetics as inhibitors of HCV NS3 protease | Q44607805 | ||
| Passerini reaction--amine deprotection--acyl migration (PADAM): A convenient strategy for the solid-phase preparation of peptidomimetic compounds | Q44833008 | ||
| Synthesis and SAR of 1,2,3,4-tetrahydroisoquinolin-1-ones as novel G-protein-coupled receptor 40 (GPR40) antagonists | Q44837955 | ||
| Novel nonpeptidic inhibitors of HIV-1 protease obtained via a new multicomponent chemistry strategy. | Q44900660 | ||
| Synthesis and biological activity of macrocyclic inhibitors of hepatitis C virus (HCV) NS3 protease | Q45214947 | ||
| Synthetic studies on (-)-lemonomycin: stereocontrolled construction of the 3,8-diazabicyclo[3.2.1] skeleton | Q45220449 | ||
| Phenylglycine and sulfonamide correctors of defective delta F508 and G551D cystic fibrosis transmembrane conductance regulator chloride-channel gating | Q45275835 | ||
| Functionalized 3-amino-imidazo[1,2-a]pyridines: a novel class of drug-like Mycobacterium tuberculosis glutamine synthetase inhibitors. | Q45949483 | ||
| A heterobimetallic Ga/Yb-Schiff base complex for catalytic asymmetric alpha-addition of isocyanides to aldehydes. | Q45988241 | ||
| Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloride channel. | Q46007362 | ||
| Synthesis and SAR of amino acid-derived heterocyclic progesterone receptor full and partial agonists | Q46045695 | ||
| Dihydroorotate dehydrogenase inhibitors: quantitative structure-activity relationship analysis | Q46054963 | ||
| Discovery of small molecule human C5a receptor antagonists | Q46145799 | ||
| Aryloxy cyclohexyl imidazoles: a novel class of antileishmanial agents | Q46193004 | ||
| Alantrypinone and its derivatives: synthesis and antagonist activity toward insect GABA receptors. | Q46210428 | ||
| ??? | Q27644509 | ||
| Viral proteases | Q35021909 | ||
| Diketopiperazines in peptide and combinatorial chemistry. | Q35066877 | ||
| Prolyl peptidases: a serine protease subfamily with high potential for drug discovery. | Q35206949 | ||
| Kinomics-structural biology and chemogenomics of kinase inhibitors and targets | Q35692110 | ||
| Asymmetric multicomponent reactions (AMCRs): the new frontier | Q36047385 | ||
| Multicomponent synthesis of 2-imidazolines. | Q46449434 | ||
| A simple and efficient approach to the synthesis of 4H-furo[3,4-b]pyrans via a three-component reaction of isocyanides | Q46515109 | ||
| Simple synthesis of 7H-phenaleno[1,2-b]furan-7-one derivatives by one-pot, three-component reactions | Q46540331 | ||
| Novel cell-penetrating alpha-keto-amide calpain inhibitors as potential treatment for muscular dystrophy | Q46721993 | ||
| Concise syntheses of meridianins by carbonylative alkynylation and a four-component pyrimidine synthesis | Q46737108 | ||
| Selective and orally bioavailable phenylglycine tissue factor/factor VIIa inhibitors. | Q46742412 | ||
| One-pot synthesis of diverse 4-di(tri)fluoromethyl-3-cyanopyridine-2(1H)-thiones and their utilities in the cascade synthesis of annulated heterocycles | Q46758272 | ||
| 2,5-diketopiperazines as potent, selective, and orally bioavailable oxytocin antagonists. 2. Synthesis, chirality, and pharmacokinetics | Q46775768 | ||
| Efficient C2 functionalisation of 2H-2-imidazolines. | Q46853887 | ||
| Multicomponent reactions in fungicide research: the discovery of mandipropamid | Q46930746 | ||
| A pair-feeding study reveals that a Y5 antagonist causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure | Q47313856 | ||
| Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery. | Q47440423 | ||
| Wanted: new multicomponent reactions for generating libraries of polycyclic natural products | Q33216561 | ||
| Structure-based development of target-specific compound libraries | Q33238328 | ||
| Design, synthesis, and biological evaluation of the combinatorial library with a new spirodiketopiperazine scaffold. Discovery of novel potent and selective low-molecular-weight CCR5 antagonists | Q33248893 | ||
| Library synthesis and screening: 2,4-diphenylthiazoles and 2,4-diphenyloxazoles as potential novel prion disease therapeutics | Q33274168 | ||
| Optimization of three- and four-component reactions for polysubstituted piperidines: application to the synthesis and preliminary biological screening of a prototype library | Q33285535 | ||
| Structure-based tailoring of compound libraries for high-throughput screening: discovery of novel EphB4 kinase inhibitors | Q33326721 | ||
| Emerging approaches for the syntheses of bicyclic imidazo[1,2-x]-heterocycles | Q33328007 | ||
| Isosteric exchange of the acylsulfonamide moiety in Abbott's Bcl-XL protein interaction antagonist. | Q33347042 | ||
| Synthesis of novel Gn-RH analogues using Ugi-4MCR. | Q33395201 | ||
| Affinity ligands for immunoglobulins based on the multicomponent Ugi reaction | Q33426617 | ||
| 1,4-Thienodiazepine-2,5-diones via MCR (II): scaffold hopping by Gewald and Ugi-deprotection-cyclization strategy | Q33603523 | ||
| The rise of fragment-based drug discovery | Q33838157 | ||
| High-yielding synthesis of the anti-influenza neuramidase inhibitor (-)-oseltamivir by three "one-pot" operations | Q33845772 | ||
| Rapid and efficient hydrophilicity tuning of p53/mdm2 antagonists | Q33937376 | ||
| A genomic perspective on human proteases as drug targets | Q33953223 | ||
| Eph receptors and ephrins in cancer: bidirectional signalling and beyond | Q34021365 | ||
| Serine proteases from nematode and protozoan parasites: isolation of sequence homologs using generic molecular probes | Q34284973 | ||
| Evolutionary chemistry approach toward finding novel inhibitors of the type 2 diabetes target glucose-6-phosphate translocase | Q34402170 | ||
| Kinetic and catalytic mechanisms of protein kinases | Q34465987 | ||
| Catalytic, enantioselective alpha-additions of isocyanides: Lewis base catalyzed Passerini-type reactions | Q34468341 | ||
| Recent developments in isocyanide based multicomponent reactions in applied chemistry | Q34482940 | ||
| Mapping the active site of Escherichia coli malonyl-CoA-acyl carrier protein transacylase (FabD) by protein crystallography | Q34525718 | ||
| Targeting proteases: successes, failures and future prospects | Q34563752 | ||
| Drugs, their targets and the nature and number of drug targets | Q34571023 | ||
| A neuropeptide Y Y5 antagonist selectively ameliorates body weight gain and associated parameters in diet-induced obese mice | Q34598657 | ||
| Promotion of sleep by targeting the orexin system in rats, dogs and humans | Q34607196 | ||
| Use of a novel and highly selective oxytocin receptor antagonist to characterize uterine contractions in the rat. | Q34613868 | ||
| Recent advances in isocyanide-based multicomponent chemistry. | Q34649010 | ||
| The discovery of GSK221149A: a potent and selective oxytocin antagonist | Q34716885 | ||
| Novel animal-health drug targets from ligand-gated chloride channels. | Q34742130 | ||
| The biochemistry and molecular biology of the glucose-6-phosphatase system | Q34793479 | ||
| Drugs targeting the renin-angiotensin-aldosterone system | Q34981356 | ||
| Structure and mechanism of the pepsin-like family of aspartic peptidases | Q35021899 | ||
| Caspases: keys in the ignition of cell death | Q35021904 | ||
| P433 | issue | 6 | |
| P304 | page(s) | 3083-3135 | |
| P577 | publication date | 2012-03-22 | |
| P1433 | published in | Chemical Reviews | Q900502 |
| P1476 | title | Chemistry and biology of multicomponent reactions | |
| P478 | volume | 112 |
| Q64997493 | 2-Nitrobenzyl Isocyanide as a Universal Convertible Isocyanide. |
| Q36953783 | 4-Trifluoromethyl-p-quinols as dielectrophiles: three-component, double nucleophilic addition/aromatization reactions |
| Q90113319 | A Concise Approach to N-Substituted Rhodanines through a Base-Assisted One-Pot Coupling and Cyclization Process |
| Q53209817 | A Four-Component Reaction for the Synthesis of Dioxadiazaborocines. |
| Q50868632 | A General, Concise Strategy that Enables Collective Total Syntheses of over 50 Protoberberine and Five Aporhoeadane Alkaloids within Four to Eight Steps. |
| Q92715706 | A Mild, Fast, and Scalable Synthesis of Substituted α-Acyloxy Ketones via Multicomponent Reaction Using a Continuous Flow Approach |
| Q89184965 | A Minimalist Approach to the Design of Complexity-Enriched Bioactive Small Molecules: Discovery of Phenanthrenoid Mimics as Antiproliferative Agents |
| Q37688738 | A Rh(II)-catalyzed multicomponent reaction by trapping an α-amino enol intermediate in a traditional two-component reaction pathway. |
| Q59793276 | A Simple and Efficient Synthesis of Highly Substituted Indeno[1,2-]pyrrole and Acenaphtho[1,2-]pyrrole Derivatives by Tandem Three-Component Reactions |
| Q36680142 | A Van Leusen deprotection-cyclization strategy as a fast entry into two imidazoquinoxaline families |
| Q48111627 | A convergent synthesis of vinyloxyimidazopyridine via Cu(i)-catalyzed three-component coupling. |
| Q90020183 | A facile solvent-free three-component domino synthesis of novel 2,4-diaryl-5,6-dihydrobenzo[j][1,7]phenanthrolines |
| Q86716382 | A facile synthesis of functionalized dispirooxindole derivatives via a three-component 1,3-dipolar cycloaddition reaction |
| Q36278024 | A green synthetic approach toward the synthesis of structurally diverse spirooxindole derivative libraries under catalyst-free conditions |
| Q92504189 | A microdroplet-accelerated Biginelli reaction: mechanisms and separation of isomers using IMS-MS |
| Q50700408 | A new four-component reaction involving the Michael addition and the Gewald reaction, leading to diverse biologically active 2-aminothiophenes. |
| Q28817207 | A new paradigm for designing ring construction strategies for green organic synthesis: implications for the discovery of multicomponent reactions to build molecules containing a single ring |
| Q45919341 | A new rapid multicomponent domino heteroannulation of heterocyclic ketene aminals: solvent-free regioselective synthesis of functionalized benzo[g]imidazo[1,2-a]quinolinediones. |
| Q43579290 | A novel domino strategy for forming poly-substituted quaternary imidazoles through a Cs2CO3-promoted aryl migration process |
| Q50483025 | A novel three-component [5 + 1] heterocyclization leading to 2-azafluorenone synthesis and its polyfunctionalizations. |
| Q42426664 | A one-pot multicomponent strategy for stereospecific construction of tricyclic pyrrolo[1,2-a]quinolines |
| Q92133588 | A one-step, atom economical synthesis of thieno[2,3-d]pyrimidin-4-amine derivatives via a four-component reaction |
| Q33692158 | A practical and efficient approach to imidazo[1,2-a]pyridine-fused isoquinolines through the post-GBB transformation strategy |
| Q50666452 | A tunable copper-catalyzed multicomponent reaction towards alkaloid-inspired indole/lactam polycycles. |
| Q45979988 | A β-enaminone-initiated multicomponent domino reaction for the synthesis of indoloquinolizines and benzoquinolizines from acyclic precursors. |
| Q64093557 | Acoustic Droplet Ejection Enabled Automated Reaction Scouting |
| Q71098987 | Ag₂O on ZrO₂ as a Recyclable Catalyst for Multicomponent Synthesis of Indenopyrimidine Derivatives |
| Q37056185 | Aldol reactions in multicomponent reaction based domino pathways: a multipurpose enabling tool in heterocyclic chemistry |
| Q59808480 | Aminoazole-Based Diversity-Oriented Synthesis of Heterocycles |
| Q30355992 | An Efficient Passerini Tetrazole Reaction (PT-3CR). |
| Q42154026 | An Ugi Reaction Incorporating a Redox-Neutral Amine C-H Functionalization Step |
| Q57974287 | An efficient green synthesis of dispirohydroquinolines via a diastereoselective one-pot eight-component reaction |
| Q53466556 | An efficient three-component synthesis of highly functionalized tetrahydroacenaphtho[1,2-b]indolone derivatives catalyzed by L-proline. |
| Q47683557 | AnchorQuery: Rapid online virtual screening for small-molecule protein-protein interaction inhibitors. |
| Q36051912 | Application of Silica-Supported Alkylating Reagents in a One-Pot, Sequential Protocol to Diverse Benzoxathiazepine 1,1-Dioxides |
| Q59806462 | Application of Silver Nanoparticles in the Multicomponent Reaction Domain: A Combined Catalytic Reduction Methodology to Efficiently Access Potential Hypertension or Inflammation Inhibitors |
| Q44057521 | Aqueous SDS micelle-promoted acid-catalyzed domino ABB' imino Diels-Alder reaction: a mild and efficient synthesis of privileged 2-methyl-tetrahydroquinoline scaffolds. |
| Q92236290 | Artificial Macrocycles |
| Q41590844 | Asymmetric Ugi 3CR on isatin-derived ketimine: synthesis of chiral 3,3-disubstituted 3-aminooxindole derivatives. |
| Q64268342 | Atorvastatin (Lipitor) by MCR |
| Q89671328 | Automated, Accelerated Nanoscale Synthesis of Iminopyrrolidines |
| Q36708875 | BOROX catalysis: self-assembled amino-BOROX and imino-BOROX chiral Brønsted acids in a five component catalyst assembly/catalytic asymmetric aziridination. |
| Q50907321 | Bifunctional Furfuryl Cations Strategy: Three-Component Synthesis of Enamidyl Triazoles. |
| Q58581073 | Bran-New Four-Molecule and Five-Molecule Cascade Reactions for One-Pot Synthesis of Pyrano[3,2-]chromen-5-ones and Spiro[benzo[][1,4]diazepine-2,2'-pyrano[3,2-]chromen]-5'-ones under Catalyst- and Solvent-Free Conditions |
| Q35333827 | Carbohydrates as a reagent in multicomponent reactions: one-pot access to a new library of hydrophilic substituted pyrimidine-fused heterocycles. |
| Q57508815 | Cascade Reactions: A Multicomponent Approach to Functionalized Indane Derivatives by a Tandem Palladium- Catalyzed Carbamoylation/Carbocylization Process |
| Q41689925 | Cascade bicyclization of triethylammonium thiolates with hydrazines: efficient access to pyrazolo[3,4-c]quinolines |
| Q96229929 | Catalyst-Free One-Pot Synthesis of Densely Substituted Pyrazole-Pyrazines as Anti-Colorectal Cancer Agents |
| Q50245038 | Catalyst-free sonosynthesis of highly substituted propanamide derivatives in water. |
| Q58200639 | Click chemistry inspired synthesis of piperazine-triazole derivatives and evaluation of their antimicrobial activities |
| Q51070448 | Combinatorial multicomponent access to natural-products-inspired peptidomimetics: discovery of selective inhibitors of microbial metallo-aminopeptidases. |
| Q92798023 | Concise Synthesis of Macrocycles by Multicomponent Reactions |
| Q53117684 | Consecutive One-Pot versus Domino Multicomponent Approaches to 3-(Diarylmethylene)oxindoles. |
| Q30317250 | Consecutive isocyanide-based multicomponent reactions: synthesis of cyclic pentadepsipeptoids |
| Q49064904 | Construction of Tropane Derivatives by the Organocatalytic Asymmetric Dearomatization of Isoquinolines |
| Q31136306 | Construction of functionalized tricyclic dihydropyrazino-quinazolinedione chemotypes via an Ugi/N-acyliminium ion cyclization cascade |
| Q93097261 | Continuous-Flow Visible Light Organophotocatalysis for Direct Arylation of 2H-Indazoles: Fast Access to Drug Molecules |
| Q58341714 | Controlled growth of Au/Ni bimetallic nanocrystals with different nanostructures |
| Q59345967 | Convergent Three-Component Tetrazole Synthesis |
| Q89745185 | Copper-mediated synthesis of drug-like bicyclopentanes |
| Q92504792 | Crystal structure and Hirshfeld surface analysis of two 5,11-methano-benzo[g][1,2,4]triazolo[1,5-c][1,3,5]oxa-diazo-cine derivatives |
| Q49639711 | Crystal structure of ethyl 2-cyano-2-(1,3-di-thian-2-yl-idene)acetate. |
| Q92437683 | Design and preparation of Fe3O4@PVA polymeric magnetic nanocomposite film and surface coating by sulfonic acid via in situ methods and evaluation of its catalytic performance in the synthesis of dihydropyrimidines |
| Q39034707 | Design and synthesis of anti-cancer cyclopeptides containing triazole skeleton |
| Q50176114 | Design, synthesis and fluorescence property evaluation of blue emitting triazole-linked chromene peptidomimetics |
| Q41861949 | Diastereoselective Synthesis of Cyclopenta[c]furans by a Catalytic Multicomponent Reaction. |
| Q46852960 | Direct Conversion of Nitriles into Alkene "Isonitriles". |
| Q48217289 | Direct access to isoxazolino and isoxazolo benzazepines from 2-((hydroxyimino)methyl)benzoic acid via a post-Ugi heteroannulation |
| Q40523781 | Discovery of a Potent Allosteric Kinase Modulator by Combining Computational and Synthetic Methods |
| Q40759300 | Domino reaction of arylglyoxals with pyrazol-5-amines: selective access to pyrazolo-fused 1,7-naphthyridines, 1,3-diazocanes, and pyrroles |
| Q61800275 | Donepezil + chromone + melatonin hybrids as promising agents for Alzheimer's disease therapy |
| Q44844100 | Eco-efficient ultrasonic responsive synthesis of pyrimidines/pyridines. |
| Q92466015 | Efficient Rapid Access to Biginelli for the Multicomponent Synthesis of 1,2,3,4-Tetrahydropyrimidines in Room-Temperature Diisopropyl Ethyl Ammonium Acetate |
| Q46650598 | Efficient Rhodium-Catalyzed Multicomponent Reaction for the Synthesis of Novel Propargylamines |
| Q55109991 | Efficient Synthesis and Antimicrobial Evaluation of Pyrazolopyranopyrimidines in the Presence of SBA-Pr-SO3H as a Nanoporous Acid Catalyst. |
| Q41816711 | Efficient assembly of iminodicarboxamides by a "truly" four-component reaction. |
| Q27300835 | Efficient isocyanide-less isocyanide-based multicomponent reactions |
| Q44561129 | Efficient metal-free synthesis of various pyrido[2',1':2,3]imidazo- [4,5-b]quinolines |
| Q43987619 | Enantioselective organocatalytic multicomponent synthesis of 2,6-diazabicyclo[2.2.2]octanones |
| Q50216219 | Enzymatic Ugi Reaction with Amines and Cyclic Imines |
| Q34207033 | Evolution of a strategy for preparing bioactive small molecules by sequential multicomponent assembly processes, cyclizations, and diversification |
| Q56273707 | Expanding the medicinal chemistry synthetic toolbox |
| Q41899640 | Expanding the substrate scope of Ugi five-center, four-component reaction U-5C-4CR): ketones as coupling partners for secondary amino acids. |
| Q33773093 | Exploiting the Divalent Nature of Isonitriles: a novel Pictet-Spengler Amidination process |
| Q92219664 | Exploiting the Nucleophilicity of the Nitrogen Atom of Imidazoles: One-Pot Three-Component Synthesis of Imidazo-Pyrazines |
| Q51783651 | Exploring Ugi-Azide Four-Component Reaction Products for Broad-Spectrum Influenza Antivirals with a High Genetic Barrier to Drug Resistance. |
| Q89156992 | Facile construction of fused benzimidazole-isoquinolinones that induce cell-cycle arrest and apoptosis in colorectal cancer cells |
| Q41873670 | Facile one-pot four-component synthesis of 3,4-dihydro-2-pyridone derivatives: novel urease inhibitor scaffold |
| Q53098322 | Facile synthesis of photo-cleavable polymers via Passerini reaction. |
| Q60046821 | Fe(III)-Catalyzed Bicyclization of Yne-Allenones With Indoles for the Atom-Economic Synthesis of 3-Indolyl Cyclobutarenes |
| Q26795719 | Focusing on shared subpockets - new developments in fragment-based drug discovery |
| Q34563970 | Four-component bicyclization approaches to skeletally diverse pyrazolo[3,4-b]pyridine derivatives |
| Q40787385 | Four-component strategy for selective synthesis of azepino[5,4,3-cd]indoles and pyrazolo[3,4-b]pyridines |
| Q42314637 | Gd-TEMDO: Design, Synthesis, and MRI Application. |
| Q58696556 | Gold Catalyzed Multicomponent Reactions beyond A³ Coupling |
| Q92765112 | Gold Nanoparticles Supported on Imidazole-Modified Bentonite: Environmentally Benign Heterogeneous Catalyst for the Three-Component Synthesis of Propargylamines in Water |
| Q35874808 | Gold-catalyzed three-component spirocyclization: a one-pot approach to functionalized pyrazolidines. |
| Q55645763 | Hexafluoroisopropanol as the Acid Component in the Passerini Reaction: One-Pot Access to β-Amino Alcohols. |
| Q35952116 | High-Throughput Screening Platform for the Discovery of New Immunomodulator Molecules from Natural Product Extract Libraries |
| Q30316563 | Highly stereoselective synthesis of natural-product-like hybrids by an organocatalytic/multicomponent reaction sequence. |
| Q47588188 | I2/CHP mediated [1 + 1 + 1 + 1] cyclization of aromatic isocyanides with amines to construct 1,3-diazetidine-2,4-diimine derivatives. |
| Q53671501 | IBX-mediated oxidation of unactivated cyclic amines: application in highly diastereoselective oxidative Ugi-type and aza-Friedel-Crafts reactions. |
| Q89152321 | Improving small molecule virtual screening strategies for the next generation of therapeutics |
| Q51112075 | In situ generation of nitrilium from nitrile ylide and the subsequent Mumm rearrangement: copper-catalyzed synthesis of unsymmetrical diacylglycine esters. |
| Q50219150 | Indium triflate promoted one-pot multicomponent synthesis of structurally diverse 3-amino-imidazo[1,2-a]pyridines |
| Q63344408 | Integrative Theory/Experiment-Driven Exploration of a Multicomponent Reaction towards Imidazoline-2-(thi)ones |
| Q61135987 | Iridium-catalyzed reductive Ugi-type reactions of tertiary amides |
| Q26772038 | Isocyanide-Based Multicomponent Reactions for the Synthesis of Heterocycles |
| Q38194138 | Isocyanide-based multicomponent reactions towards cyclic constrained peptidomimetics. |
| Q41180414 | Isocyanides as Influenza A Virus Subtype H5N1 Wild-Type M2 Channel Inhibitors |
| Q48160563 | Library-to-Library Synthesis of Highly Substituted α-Aminomethyl Tetrazoles via Ugi Reaction. |
| Q59125639 | Ligand Synthesis Catalyst and Complex Metal Ion: Multicomponent Synthesis of 1,3-Bis(4-phenyl-[1,2,3]triazol-1-yl)-propan-2-ol Copper(I) Complex and Application in Copper-Catalyzed Alkyne-Azide Cycloaddition |
| Q51066070 | Ligand-free MCR for linking quinoxaline framework with a benzimidazole nucleus: a new strategy for the identification of novel hybrid molecules as potential inducers of apoptosis. |
| Q64077252 | MCR Scaffolds Get Hotter with F-Labeling |
| Q36522303 | MCR synthesis of a tetracyclic tetrazole scaffold. |
| Q37585590 | MCRs reshaped into a switchable microwave-assisted protocol toward 5-aminoimidazoles and dihydrotriazines |
| Q49330680 | Malononitrile dimer as a privileged reactant in design and skeletal diverse synthesis of heterocyclic motifs |
| Q64024224 | Manganese-Catalyzed Multicomponent Synthesis of Pyrroles through Acceptorless Dehydrogenation Hydrogen Autotransfer Catalysis: Experiment and Computation |
| Q41862828 | Metal-free [3 + 2 + 1]/[2 + 2 + 1] biscyclization: stereospecific construction with concomitant functionalization of indolizin-5(1H)-one |
| Q55280256 | Methyl isocyanide as a convertible functional group for the synthesis of spirocyclic oxindole γ-lactams via post-Ugi-4CR/transamidation/cyclization in a one-pot, three-step sequence. |
| Q41586281 | Microwave-assisted Cu(I)-catalyzed, three-component synthesis of 2-(4-((1-phenyl-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-1H-benzo[d]imidazoles |
| Q92133027 | Microwave-assisted efficient and facile synthesis of tetramic acid derivatives via a one-pot post-Ugi cascade reaction |
| Q90730314 | Microwave-assisted facile construction of quinoxalinone and benzimidazopyrazinone derivatives via two paths of post-Ugi cascade reaction |
| Q34060368 | Modern Multicomponent Reactions for better Drug Syntheses** |
| Q58580341 | Multicomponent Reactions Accelerated by Aqueous Micelles |
| Q92111103 | Multicomponent Reactions Upon the Known Drug Trimethoprim as a Source of Novel Antimicrobial Agents |
| Q57671097 | Multicomponent Reactions for Diverse Synthesis ofN-Substituted and NH 1,4-Dihydropyridines |
| Q38603972 | Multicomponent Reactions, Union of MCRs and Beyond. |
| Q87351967 | Multicomponent Synthesis and Evaluation of New 1,2,3-Triazole Derivatives of Dihydropyrimidinones as Acidic Corrosion Inhibitors for Steel |
| Q55281876 | Multicomponent mechanochemical synthesis. |
| Q55331828 | Multicomponent polysaccharide-protein bioconjugation in the development of antibacterial glycoconjugate vaccine candidates. |
| Q64938155 | Multicomponent reactions (MCRs): a useful access to the synthesis of benzo-fused γ-lactams. |
| Q35013315 | Multicomponent reactions for de novo synthesis of BODIPY probes: in vivo imaging of phagocytic macrophages. |
| Q38243795 | Multicomponent reactions in nucleoside chemistry. |
| Q41816455 | Multicomponent synthesis of diverse 1,4-benzodiazepine scaffolds. |
| Q42316764 | N-Hydroxyimide Ugi Reaction toward α-Hydrazino Amides. |
| Q36263479 | N-N bond formation in Ugi processes: from nitric acid to libraries of nitramines |
| Q57631428 | Nano-Mgo-Catalyzed One-Pot Synthesis of Phosphonate Ester Functionalized 2-Amino-3-Cyano-4H-Chromene Scaffolds at Room Temperature |
| Q41013054 | New Three-Component Bicyclization Leading to Densely Functionalized Pyrazolo[3,4-d]thiazolo[3,2-a]pyrimidines |
| Q50094238 | Nickel-catalyzed acetamidation and lactamization of arylboronic acids |
| Q49503885 | Nitrilium ions - synthesis and applications. |
| Q53764216 | Novel domino procedures for the synthesis of chromene derivatives and their isomerization. |
| Q35121833 | Novel potent imidazo[1,2-a]pyridine-N-Glycinyl-hydrazone inhibitors of TNF-α production: in vitro and in vivo studies |
| Q48401352 | Novel tacrine-grafted Ugi adducts as multipotent anti-Alzheimer drugs: a synthetic renewal in tacrine-ferulic acid hybrids |
| Q99414328 | One Pot Synthesis of Micromolar BACE-1 Inhibitors Based on the Dihydropyrimidinone Scaffold and Their Thia and Imino Analogues |
| Q52698369 | One-Pot Multicomponent Synthesis of β-Amino Amides. |
| Q64269467 | One-Pot Synthesis of Triazolobenzodiazepines Through Decarboxylative [3 + 2] Cycloaddition of Nonstabilized Azomethine Ylides and Cu-Free Click Reactions |
| Q48223559 | One-pot asymmetric synthesis of a spiro[dihydrofurocoumarin/pyrazolone] scaffold by a Michael addition/I2-mediated cyclization sequence |
| Q35695271 | One-pot sonochemical synthesis of ferrocenyl derivatives via a three-component reaction in aqueous media |
| Q97542697 | One-pot synthesis of 1,3,5-triazine-2,4-dithione derivatives via three-component reactions |
| Q51546552 | One-pot synthesis of 1H-isochromenes and 1,2-dihydroisoquinolines by a sequential isocyanide-based multicomponent/Wittig reaction. |
| Q37164635 | One-pot synthesis of tetracyclic fused imidazo[1,2-a]pyridines via a three-component reaction |
| Q59190744 | One-pot three-component synthesis of 1,2,3-triazoles using magnetic NiFe2O4–glutamate–Cu as an efficient heterogeneous catalyst in water |
| Q58200668 | One-pot, three component tandem reaction of 2-aminopyridines, acetophenones and aldehydes: synthesis of 3-aroylimidazo[1,2-a]pyridines |
| Q42691078 | Optimal affinity ranking for automated virtual screening validated in prospective D3R grand challenges. |
| Q50491750 | Organocatalytic asymmetric epoxidation and tandem epoxidation/Passerini reaction under eco-friendly reaction conditions. |
| Q92746119 | Pd-Catalyzed de Novo Assembly of Diversely Substituted Indole-Fused Polyheterocycles |
| Q42154323 | Post-Ugi gold-catalyzed diastereoselective domino cyclization for the synthesis of diversely substituted spiroindolines |
| Q56516918 | Predicting new Ugi-smiles couplings: a combined experimental and theoretical study |
| Q58337799 | Probing the mechanism of the Ugi four-component reaction with charge-tagged reagents by ESI-MS(/MS) |
| Q36784453 | Pyridine group assisted addition of diazo-compounds to imines in the 3-CC reaction of 2-aminopyridines, aldehydes, and diazo-compounds |
| Q34429069 | REGIOSELECTIVE MULTICOMPONENT DOMINO REACTIONS PROVIDING RAPID AND EFFICIENT ROUTES TO FUSED ACRIDINES |
| Q61806973 | Raising the Diversity of Ugi Reactions Through Selective Alkylations and Allylations of Ugi Adducts |
| Q90429055 | Rapid Discovery of Aspartyl Protease Inhibitors Using an Anchoring Approach |
| Q91693944 | Rapid approach to complex boronic acids |
| Q57074875 | Reaction of α-tetralone, 1H-tetrazol-5-amine, and aromatic aldehydes upon microwave irradiation – a convenient method for the synthesis of 5,6,7,12-tetrahydrobenzo[h]tetrazolo[5,1-b]quinazolines |
| Q92899634 | Reactivity and Synthetic Applications of Multicomponent Petasis Reactions |
| Q38199956 | Recent advances in the synthesis of pyrroles by multicomponent reactions. |
| Q38914464 | Recent developments in transition metal catalysis for quinazolinone synthesis |
| Q38059359 | Recent developments of ketene dithioacetal chemistry |
| Q92412874 | Regioselective Hydroalkylation and Arylalkylation of Alkynes by Photoredox/Nickel Dual Catalysis: Application and Mechanism |
| Q50489072 | Regioselective multicomponent sequential synthesis of hydantoins. |
| Q96128079 | Ruthenium-catalysed multicomponent synthesis of the 1,3-dienyl-6-oxy polyketide motif |
| Q90614729 | Saturated Five-Membered Thiazolidines and Their Derivatives: From Synthesis to Biological Applications |
| Q50072047 | Scaffold hopping via ANCHOR.QUERY: β-lactams as potent p53-MDM2 antagonists†. |
| Q57344669 | Simultaneous dual end-functionalization of peg via the passerini three-component reaction for the synthesis of ABC miktoarm terpolymers |
| Q90142298 | Solid-Phase Multicomponent Synthesis of 3-Substituted Isoindolinones Generates New Cell-Penetrating Probes as Drug Carriers |
| Q50198426 | Sonochemical rate enhanced by a new nanomagnetic embedded core/shell nanoparticles and catalytic performance in the multicomponent synthesis of pyridoimidazoisoquinolines |
| Q89623136 | Stereoselective Four-Component Synthesis of Functionalized 2,3-Dihydro-4-Nitropyrroles |
| Q53272138 | Stereoselective Synthesis of Quaternary Pyrrolidine-2,3-diones and β-Amino Acids. |
| Q44983057 | Stereoselective synthesis of N-heterocycles through amine addition to nitroalkenes |
| Q41593245 | Stereoselective synthesis of fused tetrahydroquinazolines through one-pot double [3 + 2] dipolar cycloadditions followed by [5 + 1] annulation |
| Q45389897 | Switching the regioselectivity via indium(III) and gold(I) catalysis: a post-Ugi intramolecular hydroarylation to azepino- and azocino-[c,d]indolones. |
| Q36293059 | Synergy Effects in the Chemical Synthesis and Extensions of Multicomponent Reactions (MCRs)-The Low Energy Way to Ultra-Short Syntheses of Tailor-Made Molecules. |
| Q92526977 | Synthesis of (macro)heterocycles by consecutive/repetitive isocyanide-based multicomponent reactions |
| Q93002646 | Synthesis of Biologically Active Molecules through Multicomponent Reactions |
| Q99241267 | Synthesis of Chromeno[4,3-b]pyrrol-4(1H)-ones through a Multicomponent Reaction and Cyclization Strategy |
| Q48016708 | Synthesis of N-acetoxy-N-arylamides via diacetoxyiodobenzene promoted double acylation reaction of hydroxylamines with aldehydes. |
| Q33761604 | Synthesis of diverse nitrogen-enriched heterocyclic scaffolds using a suite of tunable one-pot multicomponent reactions |
| Q38287815 | Synthesis of heterocycles by formal cycloadditions of isocyanides. |
| Q59812811 | Synthesis of indole-cycloalkyl[]pyridine hybrids via a four-component six-step tandem process |
| Q50801394 | Synthesis of isoindolin-1-one derivatives via multicomponent reactions of methyl 2-formylbenzoate and intramolecular amidation. |
| Q39124337 | Synthesis of novel peptides through Ugi-ligation and their anti-cancer activities. |
| Q89304763 | Synthesis of some new triamide derivatives via Ugi five-component reaction in aqueous solution |
| Q92082934 | Synthesis, Docking and Biological Evaluation of a Novel Class of Imidazothiazoles as IDO1 Inhibitors |
| Q44367699 | Temporary intramolecular generation of pyridine carbenes in metal-free three-component C-H bond functionalisation/aryl-transfer reactions. |
| Q61802827 | Tetrazoles via Multicomponent Reactions |
| Q64108237 | The Asymmetric A³(Aldehyde⁻Alkyne⁻Amine) Coupling: Highly Enantioselective Access to Propargylamines |
| Q58337787 | The Biginelli reaction under batch and continuous flow conditions: catalysis, mechanism and antitumoral activity |
| Q93090829 | The Catalytic Enantioselective Ugi Four-Component Reactions |
| Q92815392 | The Pictet-Spengler Reaction Updates Its Habits |
| Q41866212 | The Ugi four-component reaction as a concise modular synthetic tool for photo-induced electron transfer donor-anthraquinone dyads. |
| Q51058568 | The multicomponent Hantzsch reaction: comprehensive mass spectrometry monitoring using charge-tagged reagents. |
| Q50942408 | Thiazine-2-thiones as Masked 1-Azadienes in Cascade Dimerization Reactions). |
| Q92948303 | Three-Component One-Pot Synthesis of Highly Functionalized Bis-Indole Derivatives |
| Q37671337 | Three-component coupling approach for the synthesis of diverse heterocycles utilizing reactive nitrilium trapping. |
| Q37095319 | Toward the Ideal Synthesis and Transformative Therapies: The Roles of Step Economy and Function Oriented Synthesis |
| Q39411624 | Towards a facile and convenient synthesis of highly functionalized indole derivatives based on multi-component reactions. |
| Q27680560 | Transient Protein States in Designing Inhibitors of the MDM2-p53 Interaction |
| Q47405673 | Transition metal-catalyzed C-H bond functionalization in multicomponent reactions: a tool toward molecular diversity. |
| Q38970149 | Two Cycles with One Catch: Hydrazine in Ugi 4-CR and Its Postcyclizations. |
| Q48254415 | Two-Step Macrocycle Synthesis by Classical Ugi Reaction. |
| Q36436882 | Unexpected isocyanide-based three-component bicyclization for the stereoselective synthesis of densely functionalized pyrano[3,4-c]pyrroles |
| Q42612607 | Various cyclization scaffolds by a truly Ugi 4-CR. |
| Q48126099 | With unprotected amino acids to tetrazolo peptidomimetics. |
| Q92946813 | Zn-Catalyzed Multicomponent KA2 Coupling: One-Pot Assembly of Propargylamines Bearing Tetrasubstituted Carbon Centers |
| Q38678578 | α-Amino Acid-Isosteric α-Amino Tetrazoles. |
| Q92799249 | β-Carbolinone Analogues from the Ugi Silver Mine |
| Q38297563 | β-ketothioamides: efficient reagents in the synthesis of heterocycles |
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