| review article | Q7318358 |
| scholarly article | Q13442814 |
| P6179 | Dimensions Publication ID | 1042814478 |
| P356 | DOI | 10.1007/S13238-010-0140-9 |
| P932 | PMC publication ID | 4875075 |
| P698 | PubMed publication ID | 21213101 |
| P2093 | author name string | Baojie Li | |
| Zhongfeng Wang | |||
| P2860 | cites work | Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53 | Q22253350 |
| Stabilization and activation of p53 by the coactivator protein TAFII31 | Q24291008 | ||
| The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2 | Q24296502 | ||
| Critical role for Daxx in regulating Mdm2 | Q24297332 | ||
| The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop | Q24297633 | ||
| RFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage | Q24300412 | ||
| Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain | Q24314763 | ||
| 14-3-3 Binding to Pim-phosphorylated Ser166 and Ser186 of human Mdm2--Potential interplay with the PKB/Akt pathway and p14(ARF) | Q24321314 | ||
| The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex | Q24323508 | ||
| A newly identified Pirh2 substrate SCYL1-BP1 can bind to MDM2 and accelerate MDM2 self-ubiquitination | Q24337268 | ||
| Gambogic acid mediates apoptosis as a p53 inducer through down-regulation of mdm2 in wild-type p53-expressing cancer cells | Q46318821 | ||
| The Wip1 phosphatase and Mdm2: cracking the "Wip" on p53 stability | Q46857521 | ||
| The proliferation of normal human fibroblasts is dependent upon negative regulation of p53 function by mdm2. | Q47775725 | ||
| p53-independent activation of the hdm2-P2 promoter through multiple transcription factor response elements results in elevated hdm2 expression in estrogen receptor alpha-positive breast cancer cells. | Q51025221 | ||
| MDM2 transformation in the absence of p53 and abrogation of the p107 G1 cell-cycle arrest. | Q53459120 | ||
| Induction of p53-dependent senescence by the MDM2 antagonist nutlin-3a in mouse cells of fibroblast origin. | Q53536765 | ||
| c-Abl phosphorylates Hdm2 at tyrosine 276 in response to DNA damage and regulates interaction with ARF. | Q53622636 | ||
| A novel MDM2 anti-sense oligonucleotide has anti-tumor activity and potentiates cytotoxic drugs acting by different mechanisms in human colon cancer. | Q54727272 | ||
| Roles for negative cell regulator 14-3-3σ in control of MDM2 activities | Q58884817 | ||
| Association of p53 protein expression with tumor cell proliferation rate and clinical outcome in node-negative breast cancer | Q70537331 | ||
| Enhancement of drug-induced apoptosis by antisense oligodeoxynucleotides targeted against Mdm2 and p21WAF1/CIP1 | Q73790804 | ||
| The contribution of the RING finger domain of MDM2 to cell cycle progression | Q74200562 | ||
| Direct transcriptional regulation of MDM2 by Fli-1 | Q81127083 | ||
| Role of Mdm2 acid domain interactions in recognition and ubiquitination of the transcription factor IRF-2 | Q82718800 | ||
| The Mdm-2 amino terminus is required for Mdm2 binding and SUMO-1 conjugation by the E2 SUMO-1 conjugating enzyme Ubc9 | Q95815063 | ||
| Activation of p53 signaling by MI-63 induces apoptosis in acute myeloid leukemia cells | Q41779296 | ||
| The C terminus of p53 binds the N-terminal domain of MDM2. | Q42532759 | ||
| Mdm2 association with p53 targets its ubiquitination | Q42824389 | ||
| SUMO-specific protease SUSP4 positively regulates p53 by promoting Mdm2 self-ubiquitination | Q42833939 | ||
| ELF4/MEF activates MDM2 expression and blocks oncogene-induced p16 activation to promote transformation | Q43109424 | ||
| Functional role of Mdm2 phosphorylation by ATR in attenuation of p53 nuclear export | Q44679404 | ||
| c-Abl in oxidative stress, aging and cancer | Q45227901 | ||
| HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function | Q24338503 | ||
| Tyrosine phosphorylation of Mdm2 by c-Abl: implications for p53 regulation | Q24534983 | ||
| Transcriptional regulation of the mdm2 oncogene by p53 requires TRRAP acetyltransferase complexes | Q24537716 | ||
| MicroRNA-221 regulates chondrogenic differentiation through promoting proteosomal degradation of slug by targeting Mdm2 | Q24621351 | ||
| MDM2 regulates dihydrofolate reductase activity through monoubiquitination | Q24634031 | ||
| Mdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal protein L26 | Q24653892 | ||
| In vivo activation of the p53 pathway by small-molecule antagonists of MDM2 | Q27642888 | ||
| The DNA damage response: putting checkpoints in perspective | Q28131713 | ||
| Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase | Q28139082 | ||
| Beta-arrestin 2 functions as a G-protein-coupled receptor-activated regulator of oncoprotein Mdm2 | Q28218131 | ||
| A dynamic role of HAUSP in the p53-Mdm2 pathway | Q28253645 | ||
| ATM-mediated phosphorylations inhibit Mdmx/Mdm2 stabilization by HAUSP in favor of p53 activation | Q28265951 | ||
| The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation | Q28280958 | ||
| Cell-cycle checkpoints and cancer | Q28293996 | ||
| ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage | Q28364113 | ||
| S6K1 is a multifaceted regulator of Mdm2 that connects nutrient status and DNA damage response | Q28509658 | ||
| Regulation of expression of the rat orthologue of mouse double minute 2 (MDM2) by H(2)O(2)-induced oxidative stress in neonatal rat cardiac myocytes | Q28573672 | ||
| The p53-mdm-2 autoregulatory feedback loop | Q28609811 | ||
| Oligomerization is required for p53 to be efficiently ubiquitinated by MDM2 | Q28609844 | ||
| Mapping of the p53 and mdm-2 Interaction Domains | Q28609886 | ||
| Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53 | Q29614430 | ||
| Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53 | Q29617850 | ||
| p53 mutant mice that display early ageing-associated phenotypes | Q29622826 | ||
| A novel site of AKT-mediated phosphorylation in the human MDM2 onco-protein | Q33292174 | ||
| ATM activates p53 by regulating MDM2 oligomerization and E3 processivity | Q33552958 | ||
| TGF-beta1-induced expression of human Mdm2 correlates with late-stage metastatic breast cancer | Q33559621 | ||
| The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma. | Q33756262 | ||
| A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus | Q33944754 | ||
| Regulation of the mdm2 oncogene by thyroid hormone receptor | Q33957291 | ||
| Controlling the Mdm2-Mdmx-p53 Circuit | Q34011009 | ||
| The Mdm2-p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor | Q34030117 | ||
| MDM2 mediates ubiquitination and degradation of activating transcription factor 3 | Q34094359 | ||
| NF-kappaB inhibits T-cell activation-induced, p73-dependent cell death by induction of MDM2 | Q34241420 | ||
| Mono- versus polyubiquitination: differential control of p53 fate by Mdm2. | Q34283106 | ||
| Hypophosphorylation of Mdm2 augments p53 stability | Q34285604 | ||
| The MDM2-p53 interaction. | Q34288001 | ||
| Mechanism of p53 stabilization by ATM after DNA damage | Q34296531 | ||
| Degradation of MDM2 by the Interaction between Berberine and DAXX Leads to Potent Apoptosis in MDM2-Overexpressing Cancer Cells | Q34393712 | ||
| Runt-related transcription factor RUNX3 is a target of MDM2-mediated ubiquitination | Q34688242 | ||
| Novel targets of Akt, p21(Cipl/WAF1), and MDM2. | Q34759285 | ||
| P53 mRNA controls p53 activity by managing Mdm2 functions | Q34927261 | ||
| MI-63: a novel small-molecule inhibitor targets MDM2 and induces apoptosis in embryonal and alveolar rhabdomyosarcoma cells with wild-type p53. | Q34999483 | ||
| The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity | Q35610627 | ||
| MDM2, an introduction. | Q35621040 | ||
| MDM2 antagonists induce p53-dependent apoptosis in AML: implications for leukemia therapy | Q35848425 | ||
| Genome-wide analyses reveal properties of redundant and specific promoter occupancy within the ETS gene family | Q35917053 | ||
| Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition | Q36499146 | ||
| Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage | Q36777971 | ||
| MDM2 is a novel E3 ligase for HIV-1 Vif. | Q37069041 | ||
| The regulation of MDM2 by multisite phosphorylation--opportunities for molecular-based intervention to target tumours? | Q37629235 | ||
| Proteolytic cleavage of the mdm2 oncoprotein during apoptosis | Q38343171 | ||
| Mdm2 inhibition induces apoptosis in p53 deficient human colon cancer cells by activating p73- and E2F1-mediated expression of PUMA and Siva-1 | Q39660439 | ||
| Disruption of p73-MDM2 binding synergizes with gemcitabine to induce apoptosis in HuCCT1 cholangiocarcinoma cell line with p53 mutation. | Q39710403 | ||
| Oligomerization conditions Mdm2-mediated efficient p53 polyubiquitylation but not its proteasomal degradation | Q39751187 | ||
| Gambogic acid down-regulates MDM2 oncogene and induces p21(Waf1/CIP1) expression independent of p53. | Q39854320 | ||
| MDM2 acts downstream of p53 as an E3 ligase to promote FOXO ubiquitination and degradation. | Q39868313 | ||
| The p53 mRNA-Mdm2 interaction | Q39902053 | ||
| Elevated levels of oncogenic protein kinase Pim-1 induce the p53 pathway in cultured cells and correlate with increased Mdm2 in mantle cell lymphoma. | Q39984104 | ||
| MDM2 antagonist nutlin-3 is a potent inducer of apoptosis in pediatric acute lymphoblastic leukemia cells with wild-type p53 and overexpression of MDM2. | Q40013409 | ||
| Roles for CSN5 in control of p53/MDM2 activities. | Q40078645 | ||
| Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2-p53 interaction. | Q40270647 | ||
| DNA-protein cross-links and replication-dependent histone H2AX phosphorylation induced by aminoflavone (NSC 686288), a novel anticancer agent active against human breast cancer cells | Q40408935 | ||
| Regulation of p53 and MDM2 activity by MTBP. | Q40474914 | ||
| A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans | Q40490424 | ||
| Ras inhibition leads to transcriptional activation of p53 and down-regulation of Mdm2: two mechanisms that cooperatively increase p53 function in colon cancer cells | Q40520938 | ||
| Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylation | Q40550797 | ||
| HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation | Q40767550 | ||
| Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms | Q40773986 | ||
| MDM2 can promote the ubiquitination, nuclear export, and degradation of p53 in the absence of direct binding | Q40778485 | ||
| Transfection with mdm2-antisense or wtp53 results in radiosensitization and an increased apoptosis of a soft tissue sarcoma cell line | Q40787177 | ||
| Opposing effects of Ras on p53: transcriptional activation of mdm2 and induction of p19ARF. | Q40845331 | ||
| SUMO-1 modification of Mdm2 prevents its self-ubiquitination and increases Mdm2 ability to ubiquitinate p53. | Q40868752 | ||
| Activation of an MDM2-specific caspase by p53 in the absence of apoptosis | Q40954121 | ||
| p53-independent role of MDM2 in TGF-beta1 resistance | Q40987634 | ||
| mdm2 and bax, downstream mediators of the p53 response, are degraded by the ubiquitin-proteasome pathway | Q41070621 | ||
| MDM2 protein confers the resistance of a human glioblastoma cell line to cisplatin-induced apoptosis | Q41344841 | ||
| Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential | Q41451986 | ||
| Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene. | Q41511192 | ||
| The p53-binding protein MDM2 gene is differentially expressed in human breast carcinoma | Q41542054 | ||
| P433 | issue | 12 | |
| P921 | main subject | genotoxicity | Q1009245 |
| P304 | page(s) | 1063-1072 | |
| P577 | publication date | 2010-12-01 | |
| P1433 | published in | Protein & Cell | Q26854012 |
| P1476 | title | Mdm2 links genotoxic stress and metabolism to p53. | |
| P478 | volume | 1 |
| Q39347932 | A crucial role for bone morphogenetic protein-Smad1 signalling in the DNA damage response. |
| Q37937423 | Aminoacyl-tRNA synthetases and tumorigenesis: more than housekeeping |
| Q42719237 | Comparison of hepatocarcinogen-induced gene expression profiles in conventional primary rat hepatocytes with in vivo rat liver |
| Q36862753 | DNA damage-induced activation of ATM promotes β-TRCP-mediated Mdm2 ubiquitination and destruction |
| Q38435836 | Gα12 gep oncogene deregulation of p53-responsive microRNAs promotes epithelial-mesenchymal transition of hepatocellular carcinoma. |
| Q28487720 | Identification of 5-Iodotubercidin as a genotoxic drug with anti-cancer potential |
| Q39062038 | Modulation of p53 expression using antisense oligonucleotides complementary to the 5'-terminal region of p53 mRNA in vitro and in the living cells |
| Q36329784 | Murine double minute-2 expression is required for capillary maintenance and exercise-induced angiogenesis in skeletal muscle |
| Q37978967 | Present status and perspectives in functional analysis of p53 in chronic lymphocytic leukemia |
| Q42761969 | Senescence determines the fate of activated rat pancreatic stellate cells. |
| Q28481334 | Simulating molecular mechanisms of the MDM2-mediated regulatory interactions: a conformational selection model of the MDM2 lid dynamics |
| Q36857374 | The Role of p53 and MDM2 in Head and Neck Cancer |
| Q49294166 | Variants of the 5'-terminal region of p53 mRNA influence the ribosomal scanning and translation efficiency. |
| Q44049352 | p53 as Batman: using a movie plot to understand control of the cell cycle |
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