MDM2 mediates ubiquitination and degradation of activating transcription factor 3

scientific article

MDM2 mediates ubiquitination and degradation of activating transcription factor 3 is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M110.132597
P932PMC publication ID2930690
P698PubMed publication ID20592017

P2093author name stringDouglas D Boyd
Hua Lu
Hongbo Wang
Chunhong Yan
Pingli Mo
P2860cites workMdm2 promotes the rapid degradation of p53Q24322597
Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53Q24328775
Regulation of p53 stability by Mdm2Q27860744
Surfing the p53 networkQ28032484
The ubiquitin ligase COP1 is a critical negative regulator of p53Q28258057
The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivationQ28280958
Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress responseQ28508156
APAF-1 is a transcriptional target of p53 in DNA damage-induced apoptosisQ28609685
Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53Q29614430
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53Q29617850
ATF3 and stress responses.Q33706914
Activating transcription factor 3 activates p53 by preventing E6-associated protein from binding to E6.Q33800021
Stress signals utilize multiple pathways to stabilize p53Q33963268
ATF3 represses 72-kDa type IV collagenase (MMP-2) expression by antagonizing p53-dependent trans-activation of the collagenase promoterQ34109489
Transcriptional activation of the human stress-inducible transcriptional repressor ATF3 gene promoter by p53.Q34153744
ATF3 induction following DNA damage is regulated by distinct signaling pathways and over-expression of ATF3 protein suppresses cells growthQ34155048
A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells.Q34193296
Induction of ATF3 by ionizing radiation is mediated via a signaling pathway that includes ATM, Nibrin1, stress-induced MAPkinases and ATF-2.Q34209909
The p53-Mdm2 module and the ubiquitin system.Q35036580
p53-independent activities of MDM2 and their relevance to cancer therapyQ36047888
Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4.Q38313431
Histone H3 acetylation and H3 K4 methylation define distinct chromatin regions permissive for transgene expressionQ38409875
Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradationQ39540070
Multiple lysine mutations in the C-terminal domain of p53 interfere with MDM2-dependent protein degradation and ubiquitinationQ39540284
BRCA1 and Tip60 determine the cellular response to ultraviolet irradiation through distinct pathwaysQ39789468
MDM2 promotes p21waf1/cip1 proteasomal turnover independently of ubiquitylationQ40323831
Activating transcription factor 3, a stress sensor, activates p53 by blocking its ubiquitinationQ40413949
Fluorescent cDNA microarray hybridization reveals complexity and heterogeneity of cellular genotoxic stress responses.Q40946010
Role for activating transcription factor 3 in stress-induced beta-cell apoptosisQ41296267
The regulation of ATF3 gene expression by mitogen-activated protein kinasesQ42104816
Repression of 92-kDa type IV collagenase expression by MTA1 is mediated through direct interactions with the promoter via a mechanism, which is both dependent on and independent of histone deacetylationQ42527855
Activating transcription factor 3, a stress-inducible gene, suppresses Ras-stimulated tumorigenesisQ46937302
Regulation of the p53 protein by the MDM2 oncoprotein--thirty-eighth G.H.A. Clowes Memorial Award LectureQ48379741
ATF3 regulates the stability of p53: a link to cancerQ53626549
Transcriptional autorepression of the stress-inducible gene ATF3Q73626798
Dual-site regulation of MDM2 E3-ubiquitin ligase activityQ79954190
Transcription - guarding the genome by sensing DNA damageQ80518102
P433issue35
P407language of work or nameEnglishQ1860
P921main subjectprotein ubiquitinationQ3547638
P304page(s)26908-26915
P577publication date2010-06-30
P1433published inJournal of Biological ChemistryQ867727
P1476titleMDM2 mediates ubiquitination and degradation of activating transcription factor 3
P478volume285

Reverse relations

cites work (P2860)
Q35095241A Small-Molecule p53 Activator Induces Apoptosis through Inhibiting MDMX Expression in Breast Cancer Cells
Q41098388Activating Transcription Factor 3 and the Nervous System
Q53182665Activating transcription factor 3 SUMOylation is involved in angiotensin II-induced endothelial cell inflammation and dysfunction
Q50225374Atf3 deficiency promotes genome instability and spontaneous tumorigenesis in mice
Q91657624Competitive ubiquitination activates the tumor suppressor p53
Q90010524Deleting key autophagy elongation proteins induces acquirement of tumor-associated phenotypes via ISG15
Q40629780Emerging roles of ATF3 in the suppression of prostate cancer
Q39165172Loss of SUMOylation on ATF3 inhibits proliferation of prostate cancer cells by modulating CCND1/2 activity
Q28271894MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53
Q38149734MDM2's social network
Q33788018Mdm2 links genotoxic stress and metabolism to p53
Q53182297Nanog regulates molecules involved in stemness and cell cycle-signaling pathway for maintenance of pluripotency of P19 embryonal carcinoma stem cells
Q53160111Polymorphisms in TP53 and MDM2 contribute to higher risk of colorectal cancer in Chinese population: a hospital-based, case-control study
Q64086789Regulatory mechanisms of fluvastatin and lovastatin for the p21 induction in human cervical cancer HeLa cells
Q39023830Role of activating transcription factor 3 protein ATF3 in necrosis and apoptosis induced by 5-fluoro-2'-deoxyuridine
Q39275947SUMOylation of ATF3 alters its transcriptional activity on regulation of TP53 gene
Q37424099The Hsp90 inhibitor 17-(allylamino)-17-demethoxygeldanamycin increases cisplatin antitumor activity by inducing p53-mediated apoptosis in head and neck cancer
Q41287020The Many Faces of MDM2 Binding Partners
Q39336988The Stress Response Mediator ATF3 Represses Androgen Signaling by Binding the Androgen Receptor
Q36898296The Stress-responsive Gene ATF3 Mediates Dichotomous UV Responses by Regulating the Tip60 and p53 Proteins.
Q37691694The activating transcription factor 3 protein suppresses the oncogenic function of mutant p53 proteins
Q36008822The common stress responsive transcription factor ATF3 binds genomic sites enriched with p300 and H3K27ac for transcriptional regulation
Q34995975The induction of activating transcription factor 3 (ATF3) contributes to anti-cancer activity of Abeliophyllum distichum Nakai in human colorectal cancer cells
Q38888300The stress-responsive gene ATF3 regulates the histone acetyltransferase Tip60.
Q58771668Trans-chalcone increases p53 activity via DNAJB1/HSP40 induction and CRM1 inhibition
Q38967025XI-011 enhances cisplatin-induced apoptosis by functional restoration of p53 in head and neck cancer

Search more.