p53 prevents entry into mitosis with uncapped telomeres

scientific article published on 11 March 2010

p53 prevents entry into mitosis with uncapped telomeres is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.CUB.2010.01.046
P932PMC publication ID4959573
P698PubMed publication ID20226664
P5875ResearchGate publication ID41942185

P50authorMaria A BlascoQ54086437
P2093author name stringMadalena Tarsounas
Maria Thanasoula
Paula Martinez
Jose Miguel Escandell
Sophie Badie
Purificacion Muñoz
P2860cites workShugoshin prevents dissociation of cohesin from centromeres during mitosis in vertebrate cellsQ21146367
CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repairQ24299313
RAD51C facilitates checkpoint signaling by promoting CHK2 phosphorylationQ24311792
Telomere maintenance requires the RAD51D recombination/repair proteinQ24338140
TRF2 Protects Human Telomeres from End-to-End FusionsQ28111898
Cell-cycle checkpoints and cancerQ28293996
p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2Q28609749
Requirement for p53 and p21 to sustain G2 arrest after DNA damageQ29547667
DNA damage foci at dysfunctional telomeresQ29614811
Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATMQ29614843
Telomere shortening and tumor formation by mouse cells lacking telomerase RNAQ29615386
How shelterin protects mammalian telomeresQ29615744
A DNA damage checkpoint response in telomere-initiated senescenceQ29615919
Tumor spectrum analysis in p53-mutant miceQ29617436
Radiation-induced cell cycle arrest compromised by p21 deficiencyQ29620237
Functional human telomeres are recognized as DNA damage in G2 of the cell cycleQ33227804
The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.Q33889383
Disease states associated with telomerase deficiency appear earlier in mice with short telomeresQ33890968
Regulation of the G2/M transition by p53.Q33943437
Connecting chromosomes, crisis, and cancerQ34141381
Phosphorylation of H2AX at short telomeres in T cells and fibroblastsQ34550319
High-throughput telomere length quantification by FISH and its application to human population studiesQ34609809
Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in miceQ34997279
DNA damage induces phosphorylation of the amino terminus of p53Q35199554
Spreading of mammalian DNA-damage response factors studied by ChIP-chip at damaged telomeresQ35837052
Functional links between telomeres and proteins of the DNA-damage responseQ35853775
gammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomesQ36418967
Reversal of senescence in mouse fibroblasts through lentiviral suppression of p53.Q40674805
Induction of senescence by oncogenic Ras.Q40800050
Intact G2-phase checkpoint in cells of a human cell line lacking DNA-dependent protein kinase activity.Q41125546
XPF nuclease-dependent telomere loss and increased DNA damage in mice overexpressing TRF2 result in premature aging and cancer.Q55041190
53BP1, an activator of ATM in response to DNA damageQ64388924
Nbs1 promotes ATM dependent phosphorylation events including those required for G1/S arrestQ74355482
The DNA damage machinery and homologous recombination pathway act consecutively to protect human telomeresQ79365400
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)521-526
P577publication date2010-03-11
P1433published inCurrent BiologyQ1144851
P1476titlep53 prevents entry into mitosis with uncapped telomeres
P478volume20

Reverse relations

cites work (P2860)
Q3589423953BP1 deficiency combined with telomere dysfunction activates ATR-dependent DNA damage response
Q36494808A three-state model of telomere control over human proliferative boundaries
Q28387570ATM/ATR checkpoint activation downregulates CDC25C to prevent mitotic entry with uncapped telomeres
Q48007327Alternative Lengthening of Telomeres Mediated by Mitotic DNA Synthesis Engages Break-Induced Replication Processes
Q35116646BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres
Q28115349BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping
Q28594209CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustion
Q28475293Chromosome Tips Damaged in Anaphase Inhibit Cytokinesis
Q61799774Complex structural rearrangements are present in high-grade dysplastic Barrett's oesophagus samples
Q34300546Cooperation between p53 and the telomere-protecting shelterin component Pot1a in endometrial carcinogenesis.
Q41894182Cyclin B-dependent kinase 1 regulates human TRF1 to modulate the resolution of sister telomeres.
Q34044618DNA damage to a single chromosome end delays anaphase onset
Q93111214Discovery of potent telomerase activators: Unfolding new therapeutic and anti-aging perspectives
Q33942627Effects of age and heart failure on human cardiac stem cell function
Q42166975Eroded human telomeres are more prone to remain uncapped and to trigger a G2 checkpoint response.
Q34248736Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations
Q34445264Genomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesis.
Q37668369Hematopoietic stem cells are acutely sensitive to Acd shelterin gene inactivation
Q34142564IL-7Rα deficiency in p53null mice exacerbates thymocyte telomere erosion and lymphomagenesis
Q46234448In aged primary T cells, mitochondrial stress contributes to telomere attrition measured by a novel imaging flow cytometry assay.
Q35667156Maintaining the end: roles of telomere proteins in end-protection, telomere replication and length regulation
Q37210618TRF2-Mediated Control of Telomere DNA Topology as a Mechanism for Chromosome-End Protection
Q89909105Telomere length and telomerase activity in osteoporosis and osteoarthritis
Q37046752Telomere targeting with a novel G-quadruplex-interactive ligand BRACO-19 induces T-loop disassembly and telomerase displacement in human glioblastoma cells.
Q30845102The Drosophila telomere-capping protein Verrocchio binds single-stranded DNA and protects telomeres from DNA damage response.
Q47654278The small molecule AU14022 promotes colorectal cancer cell death via p53-mediated G2/M-phase arrest and mitochondria-mediated apoptosis.
Q35904248Therapeutic inhibition of TRF1 impairs the growth of p53-deficient K-RasG12V-induced lung cancer by induction of telomeric DNA damage
Q34420523Zscan4 interacts directly with human Rap1 in cancer cells regardless of telomerase status
Q38930927γH2AX foci on apparently intact mitotic chromosomes: not signatures of misrejoining events but signals of unresolved DNA damage

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