Coupled activation and degradation of eEF2K regulates protein synthesis in response to genotoxic stress

scientific article published on 05 June 2012

Coupled activation and degradation of eEF2K regulates protein synthesis in response to genotoxic stress is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1126/SCISIGNAL.2002718
P932PMC publication ID3812825
P698PubMed publication ID22669845
P5875ResearchGate publication ID225273251

P50authorFlore KruiswijkQ38546143
Shabaz MohammedQ41889840
Teck Yew LowQ43146391
Ratna LimQ114454143
Michele PaganoQ28357961
Daniele GuardavaccaroQ28358019
Christopher G. ProudQ30502222
P2093author name stringAlbert J R Heck
Laurensia Yuniati
Roberto Magliozzi
Renske Bolder
P2860cites workRole of AMP-activated protein kinase in mechanism of metformin actionQ22241898
SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint responseQ24298620
Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligaseQ24306203
The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpointQ24317772
Identification of a new class of protein kinases represented by eukaryotic elongation factor-2 kinaseQ24319188
M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCPQ24329203
Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.Q24535599
Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cellsQ24548951
A novel mTOR-regulated phosphorylation site in elongation factor 2 kinase modulates the activity of the kinase and its binding to calmodulinQ24599904
Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancerQ24648025
Mass Spectrometric Sequencing of Proteins from Silver-Stained Polyacrylamide GelsQ27860531
The ubiquitin systemQ27860803
p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signalingQ28117922
Function and regulation of cullin-RING ubiquitin ligasesQ28131707
Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivoQ28177348
Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damageQ28182301
SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphataseQ28234989
Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398Q28237559
Regulation of peptide-chain elongation in mammalian cellsQ34992462
The mTOR pathway in the control of protein synthesisQ36600753
Claspin: timing the cell cycle arrest when the genome is damagedQ36685762
DNA damage checkpoints: from initiation to recovery or adaptationQ36736655
Phosphopeptide fragmentation and analysis by mass spectrometryQ37510777
Identification of calmodulin-dependent protein kinase III and its major Mr 100,000 substrate in mammalian tissuesQ37537893
Regulated degradation of FANCM in the Fanconi anemia pathway during mitosisQ39875666
Ribosomal slowdown mediates translational arrest during cellular division.Q40100414
Identification of the ubiquitin-proteasome pathway in the regulation of the stability of eukaryotic elongation factor-2 kinaseQ40427685
Identification and characterization of an inhibitor of eukaryotic elongation factor 2 kinase against human cancer cell linesQ40622035
Control of the translational machinery in mammalian cellsQ40691293
p53 activation results in rapid dephosphorylation of the eIF4E-binding protein 4E-BP1, inhibition of ribosomal protein S6 kinase and inhibition of translation initiationQ40714283
Regulation of translation elongation factor-2 by insulin via a rapamycin-sensitive signalling pathwayQ41064925
Three phosphorylation sites in elongation factor 2.Q41923582
Phosphorylation of elongation factor 2 in normal and malignant rat glial cellsQ42511654
A hierarchy of ATP-consuming processes in mammalian cellsQ42822664
Radiation-induced changes in gene expression involve recruitment of existing messenger RNAs to and away from polysomesQ48681530
Phosphorylation of the elongation factor 2: the fifth Ca2+/calmodulin-dependent system of protein phosphorylationQ69041268
Mechanism of elongation factor 2 (EF-2) inactivation upon phosphorylation. Phosphorylated EF-2 is unable to catalyze translocationQ69665326
Identification of the phosphorylation sites in elongation factor-2 from rabbit reticulocytesQ70162872
Purification and phosphorylation of elongation factor-2 kinase from rabbit reticulocytesQ70587552
Evidence for control of protein synthesis in HeLa cells via the elongation rateQ71332333
Analysis of the domain structure of elongation factor-2 kinase by mutagenesisQ78203491
Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stressQ28255529
Elongation factor-2 kinase: its role in protein synthesis and autophagyQ28259016
Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recoveryQ28260190
The DNA damage response: ten years afterQ28261230
Regulation of elongation factor-2 by multisite phosphorylationQ28263254
S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growthQ28269583
Purification and characterization of calmodulin-dependent protein kinase III from rabbit reticulocytes and rat pancreasQ28270230
Control of chromosome stability by the beta-TrCP-REST-Mad2 axisQ28273354
The SCF ubiquitin ligase: insights into a molecular machineQ28279993
Cell-cycle checkpoints and cancerQ28293996
Phosphorylation of elongation factor 2 by EF-2 kinase affects rate of translationQ28297499
Functional properties of phosphorylated elongation factor 2Q28572074
Cloning and expression of cDNA encoding protein synthesis elongation factor-2 kinaseQ28576070
Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasisQ28585415
Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTDQ28585633
MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantificationQ29547200
Growing roles for the mTOR pathwayQ29616212
mTOR and cancer: many loops in one pathway.Q33348248
Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysisQ33352234
Translational reprogramming following UVB irradiation is mediated by DNA-PKcs and allows selective recruitment to the polysomes of mRNAs encoding DNA repair enzymes.Q33447106
Beta-TrCP recognizes a previously undescribed nonphosphorylated destruction motif in Cdc25A and Cdc25B phosphatasesQ33756957
The coordinate regulation of the p53 and mTOR pathways in cellsQ33840457
Cyclin-dependent kinase (CDK) phosphorylation destabilizes somatic Wee1 via multiple pathwaysQ33920035
In vivo interference with Skp1 function leads to genetic instability and neoplastic transformationQ34286428
Elongation factor-2 phosphorylation and the regulation of protein synthesis by calciumQ34383415
Regulation of mammalian translation factors by nutrientsQ34992453
P433issue227
P921main subjectgenotoxicityQ1009245
P304page(s)ra40
P577publication date2012-06-05
P1433published inScience SignalingQ7433604
P1476titleCoupled activation and degradation of eEF2K regulates protein synthesis in response to genotoxic stress
P478volume5

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