| scholarly article | Q13442814 |
| P2093 | author name string | Brenda A Schulman | |
| J Wade Harper | |||
| Philip D Jeffrey | |||
| Geng Wu | |||
| Nikola P Pavletich | |||
| Guozhou Xu | |||
| P2860 | cites work | The F-box protein family. | Q21194893 |
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| Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling | Q24297062 | ||
| Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL | Q24299061 | ||
| The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro | Q24608829 | ||
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| Mechanisms underlying ubiquitination | Q27860656 | ||
| The ubiquitin system | Q27860803 | ||
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| F-Box Proteins Are Receptors that Recruit Phosphorylated Substrates to the SCF Ubiquitin-Ligase Complex | Q27934075 | ||
| SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box | Q27936367 | ||
| A Complex of Cdc4p, Skp1p, and Cdc53p/Cullin Catalyzes Ubiquitination of the Phosphorylated CDK Inhibitor Sic1p | Q27939049 | ||
| Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1. | Q27940059 | ||
| The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase | Q28145635 | ||
| NF-kappaB regulation in the immune system | Q28205043 | ||
| SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation | Q28282094 | ||
| Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination | Q28615601 | ||
| Critical role for lysines 21 and 22 in signal-induced, ubiquitin-mediated proteolysis of I kappa B-alpha | Q28618972 | ||
| β-catenin is a target for the ubiquitin–proteasome pathway | Q29547589 | ||
| SCF and Cullin/Ring H2-based ubiquitin ligases | Q29547637 | ||
| The oncogenic activation of beta-catenin | Q33540073 | ||
| The von Hippel-Lindau tumor suppressor protein | Q34132816 | ||
| Distribution of end-to-end distances of oligopeptides in solution as estimated by energy transfer | Q35078720 | ||
| Regulation of E2F1 activity by acetylation | Q40387087 | ||
| The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell. | Q40967633 | ||
| P433 | issue | 6 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | Beta-transducin repeat containing E3 ubiquitin protein ligase | Q21116841 |
| S-phase kinase associated protein 1 | Q21149853 | ||
| ubiquitin ligase activator activity | Q22313903 | ||
| P304 | page(s) | 1445-56 | |
| P577 | publication date | 2003-06-01 | |
| P1433 | published in | Molecular Cell | Q3319468 |
| P1476 | title | Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase | |
| P478 | volume | 11 |
| Q27664416 | A Dual E3 Mechanism for Rub1 Ligation to Cdc53 |
| Q28301510 | A comparative analysis of the ubiquitination kinetics of multiple degrons to identify an ideal targeting sequence for a proteasome reporter |
| Q24293710 | A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP) |
| Q28246411 | A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors |
| Q36898798 | A mobile functional region of Kaposi's sarcoma-associated herpesvirus ORF50 protein independently regulates DNA binding and protein abundance |
| Q48313988 | A neural-specific F-box protein Fbs1 functions as a chaperone suppressing glycoprotein aggregation |
| Q36897684 | A novel mechanism by which thiazolidinediones facilitate the proteasomal degradation of cyclin D1 in cancer cells |
| Q24646885 | A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery |
| Q99586405 | A regulatory region on RIPK2 is required for XIAP binding and NOD signaling activity |
| Q36684288 | A short peptide at the amino terminus of the Sendai virus C protein acts as an independent element that induces STAT1 instability |
| Q37622653 | A snapshot of ubiquitin chain elongation: lysine 48-tetra-ubiquitin slows down ubiquitination |
| Q57666020 | A systems-wide screen identifies substrates of the SCF TrCP ubiquitin ligase |
| Q47136896 | ALX4, an epigenetically down regulated tumor suppressor, inhibits breast cancer progression by interfering Wnt/β-catenin pathway |
| Q53291164 | ARABIDILLO proteins have a novel and conserved domain structure important for the regulation of their stability. |
| Q40834731 | Activation of β-Catenin Signaling in Androgen Receptor–Negative Prostate Cancer Cells |
| Q37285218 | Adapter-mediated substrate selection for endoplasmic reticulum-associated degradation |
| Q37459809 | Adenovirus E1A inhibits SCF(Fbw7) ubiquitin ligase |
| Q37649280 | An N-terminal splice variant of human Stat5a that interacts with different transcription factors is the dominant form expressed in invasive ductal carcinoma |
| Q27932507 | Analysis of polyubiquitin conjugates reveals that the Rpn10 substrate receptor contributes to the turnover of multiple proteasome targets |
| Q90825437 | Analyzing Protein Disorder with IUPred2A |
| Q33644316 | Ataxin-3 plays a role in mouse myogenic differentiation through regulation of integrin subunit levels |
| Q60046528 | Attenuation of Tumor Suppressive Function of FBXO16 Ubiquitin Ligase Activates Wnt Signaling In Glioblastoma |
| Q33723850 | BMP-2 modulates beta-catenin signaling through stimulation of Lrp5 expression and inhibition of beta-TrCP expression in osteoblasts |
| Q51652979 | Backbone and side chain assignments of human cell cycle regulatory protein S-phase kinase-associated protein 1. |
| Q33756957 | Beta-TrCP recognizes a previously undescribed nonphosphorylated destruction motif in Cdc25A and Cdc25B phosphatases |
| Q42824517 | Beta-TrCP1-mediated degradation of PERIOD2 is essential for circadian dynamics |
| Q42279592 | BimEL is phosphorylated at mitosis by Aurora A and targeted for degradation by βTrCP1 |
| Q27665361 | Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2) |
| Q37066323 | Bioengineering of AAV2 capsid at specific serine, threonine, or lysine residues improves its transduction efficiency in vitro and in vivo. |
| Q38457617 | Bioinformatics Approaches for Predicting Disordered Protein Motifs. |
| Q36756282 | Breaking down protein degradation mechanisms in cardiac muscle |
| Q27680055 | Bub3 reads phosphorylated MELT repeats to promote spindle assembly checkpoint signaling |
| Q37108042 | CD147 modulates androgen receptor activity through the Akt/Gsk-3β/β-catenin/AR pathway in prostate cancer cells |
| Q98778870 | CD147 promotes epithelial-mesenchymal transition of prostate cancer cells via the Wnt/β-catenin pathway |
| Q35541468 | COP9 signalosome: a multifunctional regulator of SCF and other cullin-based ubiquitin ligases |
| Q38015388 | CRL Ubiquitin Ligases and DNA Damage Response |
| Q87611125 | CTNNB1 mutational analysis of solid-pseudopapillary neoplasms of the pancreas using endoscopic ultrasound-guided fine-needle aspiration and next-generation deep sequencing |
| Q57498153 | Cancer stem cells and tumorigenesis |
| Q41854976 | Caught in the act. |
| Q35691551 | Cdc25A phosphatase: combinatorial phosphorylation, ubiquitylation and proteolysis |
| Q24294306 | Characterization of FBX25, encoding a novel brain-expressed F-box protein |
| Q35861963 | Cloning and Functional Characterization of Two BTB Genes in the Predatory Mite Metaseiulus occidentalis |
| Q37827465 | Control of Cullin-Ring Ubiquitin Ligase Activity by Nedd8 |
| Q28273354 | Control of chromosome stability by the beta-TrCP-REST-Mad2 axis |
| Q33707732 | Control of mammalian circadian rhythm by CKIepsilon-regulated proteasome-mediated PER2 degradation. |
| Q37267450 | Coupled activation and degradation of eEF2K regulates protein synthesis in response to genotoxic stress |
| Q33627336 | Crumbs promotes expanded recognition and degradation by the SCF(Slimb/β-TrCP) ubiquitin ligase |
| Q27650057 | Crystal Structure of a Full-Length β-Catenin |
| Q36026254 | Crystal structure of Ski8p, a WD-repeat protein with dual roles in mRNA metabolism and meiotic recombination |
| Q27667308 | Crystal structure of inhibitor of κB kinase β |
| Q28287182 | Crystal structure of the Kelch domain of human Keap1 |
| Q21203558 | Cullin-RING ubiquitin ligases: global regulation and activation cycles |
| Q38329727 | Cullins 3a and 3b assemble with members of the broad complex/tramtrack/bric-a-brac (BTB) protein family to form essential ubiquitin-protein ligases (E3s) in Arabidopsis. |
| Q33920035 | Cyclin-dependent kinase (CDK) phosphorylation destabilizes somatic Wee1 via multiple pathways |
| Q35668793 | DNA Damage Regulates Translation through β-TRCP Targeting of CReP |
| Q39214600 | DNA Damage Regulates UHRF1 Stability via the SCFβ-TrCP E3 Ligase |
| Q34075952 | DNA damage induces the accumulation of Tiam1 by blocking β-TrCP-dependent degradation |
| Q38407259 | Datasets from an interaction proteomics screen for substrates of the SCF(βTrCP) ubiquitin ligase |
| Q92550947 | De Novo Missense Variants in FBXW11 Cause Diverse Developmental Phenotypes Including Brain, Eye, and Digit Anomalies |
| Q36216079 | Deconjugation of Nedd8 from Cul1 Is Directly Regulated by Skp1-F-box and Substrate, and the COP9 Signalosome Inhibits Deneddylated SCF by a Noncatalytic Mechanism |
| Q28182301 | Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage |
| Q42547521 | Degradation of Tiam1 by casein kinase 1 and the SCFβTrCP ubiquitin ligase controls the duration of mTOR-S6K signaling |
| Q28748325 | Degradation of postsynaptic scaffold GKAP and regulation of dendritic spine morphology by the TRIM3 ubiquitin ligase in rat hippocampal neurons |
| Q64940546 | Delineating the role of cooperativity in the design of potent PROTACs for BTK. |
| Q42956366 | Detection of sequential polyubiquitylation on a millisecond timescale |
| Q35013503 | Developmental downregulation of Xenopus cyclin E is phosphorylation and nuclear import dependent and is mediated by ubiquitination |
| Q53616483 | Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: a two-site interaction model for the Nrf2-Keap1 complex |
| Q24313387 | Direct characterization of E2-dependent target specificity and processivity using an artificial p27-linker-E2 ubiquitination system |
| Q35879408 | Direct role for proliferating cell nuclear antigen in substrate recognition by the E3 ubiquitin ligase CRL4Cdt2. |
| Q33809974 | Direct ubiquitination of beta-catenin by Siah-1 and regulation by the exchange factor TBL1. |
| Q36698954 | Dispersed sites of HIV Vif-dependent polyubiquitination in the DNA deaminase APOBEC3F. |
| Q24642979 | Diversity of degradation signals in the ubiquitin-proteasome system |
| Q34742076 | Diversity of interferon antagonist activities mediated by NSP1 proteins of different rotavirus strains |
| Q51433130 | Double phosphorylation-induced structural changes in the signal-receiving domain of IκBα in complex with NF-κB. |
| Q42211475 | Downmodulation of CCR7 by HIV-1 Vpu results in impaired migration and chemotactic signaling within CD4⁺ T cells |
| Q36525810 | Drug discovery in the ubiquitin-proteasome system. |
| Q33228956 | Druggability of SCF ubiquitin ligase-protein interfaces |
| Q78756247 | Dynamic release of Cdc34 from SCF. the hand that rocks the cradle |
| Q81596451 | Ectopic targeting of substrates to the ubiquitin pathway |
| Q42039611 | Electrostatic and functional analysis of the seven-bladed WD beta-propellers |
| Q38869922 | Emerging role of NRF2 in chemoresistance by regulating drug-metabolizing enzymes and efflux transporters. |
| Q37292420 | Engineering New Protein–Protein Interactions on the β‐Propeller Fold by Yeast Cell Surface Display |
| Q36226432 | Enteric pathogens deploy cell cycle inhibiting factors to block the bactericidal activity of Perforin-2 |
| Q36689662 | Eradication of pathogenic β-catenin by Skp1/Cullin/F box ubiquitination machinery |
| Q28740322 | Essential Role for Ubiquitin-Ubiquitin-Conjugating Enzyme Interaction in Ubiquitin Discharge from Cdc34 to Substrate |
| Q40415975 | Evidence for a phosphorylation-independent role for Ser 32 and 36 in proteasome inhibitor-resistant (PIR) IkappaBalpha degradation in B cells |
| Q35096690 | Exogenous Signal-Independent Nuclear IκB Kinase Activation Triggered by Nkx3.2 Enables Constitutive Nuclear Degradation of IκB-α in Chondrocytes |
| Q26798369 | Expanding the ubiquitin code through post-translational modification |
| Q33715456 | Exploring the functional complexity of cellular proteins by protein knockout |
| Q37220619 | Expression, purification and crystallization of the FP domain of the human F-box protein Fbxo7 |
| Q48094154 | FBXW7 regulates DISC1 stability via the ubiquitin-proteosome system |
| Q35562631 | Flexible Cullins in Cullin-RING E3 Ligases Allosterically Regulate Ubiquitination |
| Q28131707 | Function and regulation of cullin-RING ubiquitin ligases |
| Q27316805 | Functional diversity and structural disorder in the human ubiquitination pathway |
| Q35815962 | Functions of NF-kappaB1 and NF-kappaB2 in immune cell biology |
| Q33712410 | GSK3: a multifaceted kinase in Wnt signaling |
| Q35091509 | Genetic analysis of colon tumors induced by a dietary carcinogen PhIP in CYP1A humanized mice: Identification of mutation of β-catenin/Ctnnb1 as the driver gene for the carcinogenesis |
| Q27930957 | Genome-wide analysis identifies MYND-domain protein Mub1 as an essential factor for Rpn4 ubiquitylation |
| Q53644931 | Genome-wide surveys for phosphorylation-dependent substrates of SCF ubiquitin ligases |
| Q94591415 | Genomic competition for noise reduction shaped evolutionary landscape of mir-4673 |
| Q35681247 | Getting into position: the catalytic mechanisms of protein ubiquitylation |
| Q42039276 | High-level expression and purification of recombinant SCF ubiquitin ligases |
| Q37102876 | Hormone signaling through protein destruction: a lesson from plants |
| Q29547350 | How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers |
| Q40525624 | Hsp27 and F-Box Protein β-TrCP Promote Degradation of mRNA Decay Factor AUF1 |
| Q39629705 | Human TOP1 residues implicated in species specificity of HIV-1 infection are required for interaction with BTBD2, and RNAi of BTBD2 in old world monkey and human cells increases permissiveness to HIV-1 infection |
| Q27934187 | Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells |
| Q24316389 | Identification and characterization of a novel human PP1 phosphatase complex |
| Q24657175 | Identification of a consensus site for TRAF6/p62 polyubiquitination |
| Q27938799 | Identification of residues in the WD-40 repeat motif of the F-box protein Met30p required for interaction with its substrate Met4p |
| Q40341917 | Identification of substrates for F-box proteins |
| Q28298559 | Identification of the preferential ubiquitination site and ubiquitin-dependent degradation signal of Rpn4 |
| Q24624622 | Identification, analysis, and prediction of protein ubiquitination sites |
| Q34391209 | Identifying the Hotspots on the Top Faces of WD40-Repeat Proteins from Their Primary Sequences by β-Bulges and DHSW Tetrads |
| Q45041111 | In vitro SCFbeta-Trcp1-mediated IkappaBalpha ubiquitination assay for high-throughput screen |
| Q33841019 | Inducible dissociation of SCF(Met30) ubiquitin ligase mediates a rapid transcriptional response to cadmium |
| Q33419081 | Inhibition of GSK3 phosphorylation of beta-catenin via phosphorylated PPPSPXS motifs of Wnt coreceptor LRP6. |
| Q35676735 | Inhibition of cortical neuron differentiation by Groucho/TLE1 requires interaction with WRPW, but not Eh1, repressor peptides. |
| Q40629419 | Interaction of Epstein-Barr virus latent membrane protein 1 with SCFHOS/beta-TrCP E3 ubiquitin ligase regulates extent of NF-kappaB activation. |
| Q37574182 | Interaction-based discovery of functionally important genes in cancers |
| Q38999863 | Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1βMYPT1 phosphatase complex and the SCFβTrCP E3 ubiquitin ligase |
| Q45065720 | Involvement of 14-3-3 signaling protein binding in the functional regulation of the transcriptional activator REPRESSION OF SHOOT GROWTH by gibberellins. |
| Q57080287 | Is there a biological cost of protein disorder? Analysis of cancer-associated mutations |
| Q26741279 | JNK Signaling: Regulation and Functions Based on Complex Protein-Protein Partnerships |
| Q24559743 | Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex |
| Q58755298 | LncRNA SLCO4A1-AS1 facilitates growth and metastasis of colorectal cancer through β-catenin-dependent Wnt pathway |
| Q28508267 | Lysine 269 is essential for cyclin D1 ubiquitylation by the SCF(Fbx4/alphaB-crystallin) ligase and subsequent proteasome-dependent degradation |
| Q41792401 | Lysine activation and functional analysis of E2-mediated conjugation in the SUMO pathway. |
| Q40254298 | Lysine residues Lys-19 and Lys-49 of beta-catenin regulate its levels and function in T cell factor transcriptional activation and neoplastic transformation |
| Q38201971 | Lysine-targeting specificity in ubiquitin and ubiquitin-like modification pathways. |
| Q24329203 | M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP |
| Q37136216 | Measuring Activity in the Ubiquitin–Proteasome System: From Large Scale Discoveries to Single Cells Analysis |
| Q36156706 | Mechanism of degradation of CPEB during Xenopus oocyte maturation |
| Q34296531 | Mechanism of p53 stabilization by ATM after DNA damage |
| Q34442830 | Mechanism of the Neurospora circadian clock, a FREQUENCY-centric view |
| Q27679532 | Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3 |
| Q28394732 | Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease |
| Q34341554 | Mechanisms of generating polyubiquitin chains of different topology |
| Q42493490 | Mechanisms of mono- and poly-ubiquitination: Ubiquitination specificity depends on compatibility between the E2 catalytic core and amino acid residues proximal to the lysine. |
| Q34085131 | Method for targeting protein destruction by using a ubiquitin-independent, proteasome-mediated degradation pathway |
| Q33594018 | Modulation of SCF beta-TrCP-dependent I kappaB alpha ubiquitination by hydrogen peroxide |
| Q27678830 | Molecular Architecture of the Ankyrin SOCS Box Family of Cul5-Dependent E3 Ubiquitin Ligases |
| Q37018242 | Molecular and structural insight into lysine selection on substrate and ubiquitin lysine 48 by the ubiquitin-conjugating enzyme Cdc34 |
| Q40337840 | Molecular basis for lysine specificity in the yeast ubiquitin-conjugating enzyme Cdc34. |
| Q40551971 | Molecular dissection of a rice microtubule-associated RING finger protein and its potential role in salt tolerance in Arabidopsis. |
| Q33665546 | Molecular dynamics reveal the essential role of linker motions in the function of cullin-RING E3 ligases |
| Q37825823 | Molecular mechanism of the Neurospora circadian oscillator |
| Q34546063 | Molecular recognition of histone H3 by the WD40 protein WDR5. |
| Q39387545 | Molecular regulation and pharmacological targeting of the β-catenin destruction complex |
| Q50298718 | Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) |
| Q37101488 | Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation |
| Q36782739 | Multiple Weak Linear Motifs Enhance Recruitment and Processivity in SPOP-Mediated Substrate Ubiquitination |
| Q36272766 | Multiscale mutation clustering algorithm identifies pan-cancer mutational clusters associated with pathway-level changes in gene expression |
| Q41493138 | Multisite protein kinase A and glycogen synthase kinase 3beta phosphorylation leads to Gli3 ubiquitination by SCFbetaTrCP. |
| Q24317702 | Mutant huntingtin-impaired degradation of beta-catenin causes neurotoxicity in Huntington's disease |
| Q24563960 | N-Terminal ubiquitination of extracellular signal-regulated kinase 3 and p21 directs their degradation by the proteasome |
| Q89686909 | NEDD8 nucleates a multivalent cullin-RING-UBE2D ubiquitin ligation assembly |
| Q64092200 | NF-κB activation is a turn on for vaccinia virus phosphoprotein A49 to turn off NF-κB activation |
| Q35612365 | Negative feedback loop in T cell activation through IkappaB kinase-induced phosphorylation and degradation of Bcl10 |
| Q30412479 | Nek2 phosphorylates and stabilizes β-catenin at mitotic centrosomes downstream of Plk1. |
| Q38201970 | New insights into ubiquitin E3 ligase mechanism |
| Q36467640 | Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity. |
| Q37706087 | Nutrient-induced FNIP degradation by SCFβ-TRCP regulates FLCN complex localization and promotes renal cancer progression |
| Q54381671 | Oncogenic Y641 mutations in EZH2 prevent Jak2/β-TrCP-mediated degradation. |
| Q91783268 | Oncogenic β-catenin mutations evade pH-regulated degradation |
| Q36323864 | Overlapping SETBP1 gain-of-function mutations in Schinzel-Giedion syndrome and hematologic malignancies |
| Q35679046 | Ozz; a new name on the long list of beta-catenin's nemeses |
| Q89574799 | PAM forms an atypical SCF ubiquitin ligase complex that ubiquitinates and degrades NMNAT2 |
| Q43050938 | PAPTi: a peptide aptamer interference toolkit for perturbation of protein-protein interaction networks |
| Q40219081 | PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated Keap1-dependent ubiquitin ligase complex |
| Q35768058 | Parallel duplication and partial subfunctionalization of β-catenin/armadillo during insect evolution. |
| Q28297156 | Phospho-Ser/Thr-binding domains: navigating the cell cycle and DNA damage response |
| Q36063743 | Phosphorylation and SCF-mediated degradation regulate CREB-H transcription of metabolic targets. |
| Q40520820 | Phosphorylation and specific ubiquitin acceptor sites are required for ubiquitination and degradation of the IFNAR1 subunit of type I interferon receptor |
| Q42074762 | Phosphorylation and ubiquitination of degron proximal residues are essential for class II transactivator (CIITA) transactivation and major histocompatibility class II expression |
| Q24295177 | Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase |
| Q35673284 | Phosphorylation of the Gal4 DNA-binding domain is essential for activator mono-ubiquitylation and efficient promoter occupancy. |
| Q93081405 | Plasma Membrane-Associated Restriction Factors and Their Counteraction by HIV-1 Accessory Proteins |
| Q24306531 | Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1 |
| Q28083265 | Poxviral ankyrin proteins |
| Q36825432 | Poxvirus ankyrin repeat proteins are a unique class of F-box proteins that associate with cellular SCF1 ubiquitin ligase complexes |
| Q34611139 | Poxvirus targeting of E3 ligase β-TrCP by molecular mimicry: a mechanism to inhibit NF-κB activation and promote immune evasion and virulence |
| Q39789707 | Prediction of lysine ubiquitination with mRMR feature selection and analysis |
| Q24304915 | Priming and extending: a UbcH5/Cdc34 E2 handoff mechanism for polyubiquitination on a SCF substrate |
| Q58739082 | Proliferative and Invasive Colorectal Tumors in Pet Dogs Provide Unique Insights into Human Colorectal Cancer |
| Q64104255 | Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction |
| Q38268314 | Proteasome-dependent degradation of transcription factor activating enhancer-binding protein 4 (TFAP4) controls mitotic division |
| Q26865081 | Protein monoubiquitination and polyubiquitination generate structural diversity to control distinct biological processes |
| Q33580119 | Protein post-translational modifications: In silico prediction tools and molecular modeling |
| Q26852269 | Protein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligases |
| Q42673758 | Proteome-wide analysis of human disease mutations in short linear motifs: neglected players in cancer? |
| Q92138246 | Proteomic screen with the proto-oncogene beta-catenin identifies interaction with Golgi coatomer complex I |
| Q35072342 | Putative E3 ubiquitin ligase of human rotavirus inhibits NF-κB activation by using molecular mimicry to target β-TrCP. |
| Q32884473 | RPA-Mediated Recruitment of the E3 Ligase RFWD3 Is Vital for Interstrand Crosslink Repair and Human Health |
| Q45057145 | Recognition of phosphodegron motifs in human cyclin E by the SCF(Fbw7) ubiquitin ligase |
| Q64982277 | Recognition of the Diglycine C-End Degron by CRL2KLHDC2 Ubiquitin Ligase. |
| Q34470982 | Recruitment of the inhibitor Cand1 to the cullin substrate adaptor site mediates interaction to the neddylation site |
| Q39721420 | Regulation of Ci-SCFSlimb binding, Ci proteolysis, and hedgehog pathway activity by Ci phosphorylation. |
| Q37995680 | Regulation of NF‐κB by ubiquitination and degradation of the IκBs |
| Q38193259 | Regulation of Wnt/β-catenin signaling by posttranslational modifications |
| Q34182208 | Regulation of constitutive p50/c-Rel activity via proteasome inhibitor-resistant IkappaBalpha degradation in B cells. |
| Q28577634 | Regulation of postsynaptic RapGAP SPAR by Polo-like kinase 2 and the SCFbeta-TRCP ubiquitin ligase in hippocampal neurons |
| Q36124788 | Regulation of the protein stability of EMT transcription factors |
| Q42778545 | Regulation of ubiquitin chain initiation to control the timing of substrate degradation. |
| Q44587836 | Release of ubiquitin-charged Cdc34-S - Ub from the RING domain is essential for ubiquitination of the SCF(Cdc4)-bound substrate Sic1. |
| Q35188534 | Remote activation of the Wnt/β-catenin signalling pathway using functionalised magnetic particles |
| Q28276789 | Reversible protein phosphorylation regulates circadian rhythms |
| Q92201008 | Robust cullin-RING ligase function is established by a multiplicity of poly-ubiquitylation pathways |
| Q38289055 | Role of the ubiquitin proteasome system in hematologic malignancies. |
| Q40066025 | Rotavirus NSP1 Requires Casein Kinase II-Mediated Phosphorylation for Hijacking of Cullin-RING Ligases |
| Q27931730 | Rpn4 is a physiological substrate of the Ubr2 ubiquitin ligase |
| Q54982486 | S6K1 phosphorylation-dependent degradation of Mxi1 by β-Trcp ubiquitin ligase promotes Myc activation and radioresistance in lung cancer. |
| Q37589134 | SCF β-TRCP targets MTSS1 for ubiquitination-mediated destruction to regulate cancer cell proliferation and migration |
| Q36118305 | SCF(β-TRCP) suppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF receptor 2. |
| Q24567471 | SCF(β-TRCP)-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway |
| Q27938903 | SCFCdc4 enables mating type switching in yeast by cyclin-dependent kinase-mediated elimination of the Ash1 transcriptional repressor. |
| Q28588762 | SCFFbxw5 mediates transient degradation of actin remodeller Eps8 to allow proper mitotic progression |
| Q24303638 | SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein |
| Q24653723 | SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation |
| Q28234989 | SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase |
| Q24298620 | SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response |
| Q38102567 | SCFs in the new millennium |
| Q34100910 | SCFβ-TRCP regulates osteoclastogenesis via promoting CYLD ubiquitination |
| Q46520705 | STD and TRNOESY NMR studies on the conformation of the oncogenic protein beta-catenin containing the phosphorylated motif DpSGXXpS bound to the beta-TrCP protein |
| Q36120393 | Self-regulation of functional pathways by motifs inside the disordered tails of beta-catenin |
| Q24812693 | Sequence and structural analysis of BTB domain proteins |
| Q91626057 | Serine Phosphorylation by mTORC1 Promotes IRS-1 Degradation through SCFβ-TRCP E3 Ubiquitin Ligase |
| Q36743136 | Serine phosphorylation is critical for the activation of ubiquitin-specific protease 1 and its interaction with WD40-repeat protein UAF1. |
| Q34025425 | Serine residues in the cytosolic tail of the T-cell antigen receptor alpha-chain mediate ubiquitination and endoplasmic reticulum-associated degradation of the unassembled protein |
| Q37250049 | Setting the pace of the Neurospora circadian clock by multiple independent FRQ phosphorylation events |
| Q26863643 | Short linear motifs - ex nihilo evolution of protein regulation |
| Q53491312 | Signal transduction via unstructured protein conduits |
| Q40355223 | Site-specific monoubiquitination of IkappaB kinase IKKbeta regulates its phosphorylation and persistent activation |
| Q36176561 | Site-specific ubiquitination exposes a linear motif to promote interferon-alpha receptor endocytosis |
| Q34341635 | Slmb antagonises the aPKC/Par-6 complex to control oocyte and epithelial polarity |
| Q24297098 | Smad3 prevents beta-catenin degradation and facilitates beta-catenin nuclear translocation in chondrocytes |
| Q92376522 | Snail1: A Transcriptional Factor Controlled at Multiple Levels |
| Q38346254 | Stability of homologue of Slimb F-box protein is regulated by availability of its substrate |
| Q41039086 | Stability of the PHF10 subunit of PBAF signature module is regulated by phosphorylation: role of β-TrCP. |
| Q37583516 | Stable ubiquitination of human T-cell leukemia virus type 1 tax is required for proteasome binding |
| Q27675990 | Structural Basis for Cul3 Protein Assembly with the BTB-Kelch Family of E3 Ubiquitin Ligases |
| Q36869465 | Structural Basis for Substrate Selectivity of the E3 Ligase COP1 |
| Q33552279 | Structural and functional analysis of essential pre-mRNA splicing factor Prp19p |
| Q36172880 | Structural and functional characterization of Nrf2 degradation by the glycogen synthase kinase 3/β-TrCP axis |
| Q34762436 | Structural assembly of cullin-RING ubiquitin ligase complexes |
| Q24293794 | Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1 |
| Q27644251 | Structural basis for the selection of glycosylated substrates by SCFFbs1 ubiquitin ligase |
| Q24314963 | Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40 protein WDR5 |
| Q24310859 | Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex |
| Q24300948 | Structural basis of dimerization-dependent ubiquitination by the SCF(Fbx4) ubiquitin ligase |
| Q24299395 | Structural basis of selective ubiquitination of TRF1 by SCFFbx4 |
| Q38344257 | Structural basis of sugar-recognizing ubiquitin ligase |
| Q24337721 | Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase |
| Q64069399 | Structural basis of βTrCP1-associated GLI3 processing |
| Q42694183 | Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases |
| Q24314520 | Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation |
| Q35151712 | Structural regulation of cullin-RING ubiquitin ligase complexes |
| Q27667443 | Structure and function of WD40 domain proteins |
| Q58173499 | Structure and regulatory networks of WD40 protein in plants |
| Q27670574 | Structure of a Glomulin-RBX1-CUL1 Complex: Inhibition of a RING E3 Ligase through Masking of Its E2-Binding Surface |
| Q24299638 | Structure of a RING E3 trapped in action reveals ligation mechanism for the ubiquitin-like protein NEDD8 |
| Q24313433 | Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases |
| Q27688887 | Structure of the FP domain of Fbxo7 reveals a novel mode of protein-protein interaction |
| Q24298930 | Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling |
| Q46463573 | Substrate recognition and ubiquitination of SCFSkp2/Cks1 ubiquitin-protein isopeptide ligase. |
| Q36802367 | Suramin inhibits cullin-RING E3 ubiquitin ligases. |
| Q95300946 | Surface charge of Merkel cell polyomavirus small T antigen determines cell transformation through allosteric FBW7 WD40 domain targeting |
| Q34043797 | Targeting Cullin-RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation |
| Q37333805 | The Cdc42/Rac nucleotide exchange factor protein β1Pix (Pak-interacting exchange factor) modulates β-catenin transcriptional activity in colon cancer cells: evidence for direct interaction of β1PIX with β-catenin |
| Q37849305 | The Cullin-RING Ubiquitin-Protein Ligases |
| Q27664983 | The Effect of Asp-His-Ser/Thr-Trp Tetrad on the Thermostability of WD40-Repeat Proteins |
| Q33419571 | The F-box protein beta-TrCp1/Fbw1a interacts with p300 to enhance beta-catenin transcriptional activity |
| Q39167053 | The F-box protein β-TrCP promotes ubiquitination of TRF1 and regulates the ALT-associated PML bodies formation in U2OS cells |
| Q27695666 | The FP domains of PI31 and Fbxo7 have the same protein fold but very different modes of protein-protein interaction |
| Q24669733 | The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate |
| Q38344853 | The Multifunctions of WD40 Proteins in Genome Integrity and Cell Cycle Progression |
| Q47236804 | The OsFBK1 E3 ligase subunit affects anther and root secondary cell wall thickenings by mediating turn-over of a cinnamoyl-CoA reductase. |
| Q30413242 | The Plant Proteome Folding Project: Structure and Positive Selection in Plant Protein Families |
| Q41817040 | The Prp19 U-box crystal structure suggests a common dimeric architecture for a class of oligomeric E3 ubiquitin ligases |
| Q27661523 | The Prp19 WD40 Domain Contains a Conserved Protein Interaction Region Essential for Its Function |
| Q92446155 | The Role of Ubiquitination in Regulating Embryonic Stem Cell Maintenance and Cancer Development |
| Q54343211 | The Roles of Intrinsic Disorder in Orchestrating the Wnt-Pathway |
| Q28279993 | The SCF ubiquitin ligase: insights into a molecular machine |
| Q37562004 | The SCFβ-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis. |
| Q36437659 | The SKP1-like gene family of Arabidopsis exhibits a high degree of differential gene expression and gene product interaction during development |
| Q35804479 | The Structural Differences between a Glycoprotein Specific F-Box Protein Fbs1 and Its Homologous Protein FBG3. |
| Q26748938 | The Ubiquitination of NF-κB Subunits in the Control of Transcription |
| Q34021500 | The Vpu protein: new concepts in virus release and CD4 down-modulation |
| Q34493925 | The WD40 repeats of FANCL are required for Fanconi anemia core complex assembly |
| Q37496493 | The WD40-Repeat Protein-Containing Deubiquitinase Complex: Catalysis, Regulation, and Potential for Therapeutic Intervention |
| Q38074799 | The WNT signaling pathway from ligand secretion to gene transcription: Molecular mechanisms and pharmacological targets |
| Q38867422 | The WNT-less wonder: WNT-independent β-catenin signaling |
| Q37681979 | The enzymes in ubiquitin-like post-translational modifications |
| Q34028582 | The many blades of the β-propeller proteins: conserved but versatile |
| Q26865781 | The many faces and functions of β-catenin |
| Q35691542 | The many faces of beta-TrCP E3 ubiquitin ligases: reflections in the magic mirror of cancer |
| Q33508245 | The mechanism of ubiquitination in the cullin-RING E3 ligase machinery: conformational control of substrate orientation |
| Q39795993 | The myxoma virus m-t5 ankyrin repeat host range protein is a novel adaptor that coordinately links the cellular signaling pathways mediated by Akt and Skp1 in virus-infected cells |
| Q41967221 | The nucleosome acidic patch plays a critical role in RNF168-dependent ubiquitination of histone H2A. |
| Q44777782 | The origins and evolution of ubiquitination sites |
| Q36802821 | The phospho-occupancy of an atypical SLIMB-binding site on PERIOD that is phosphorylated by DOUBLETIME controls the pace of the clock. |
| Q30542776 | The rice RING finger E3 ligase, OsHCI1, drives nuclear export of multiple substrate proteins and its heterogeneous overexpression enhances acquired thermotolerance |
| Q34749877 | The specificities of Kaposi's sarcoma-associated herpesvirus-encoded E3 ubiquitin ligases are determined by the positions of lysine or cysteine residues within the intracytoplasmic domains of their targets |
| Q40133210 | The ubiquitin ligase SCF(betaTrCP) regulates the degradation of the growth hormone receptor |
| Q24336640 | The ubiquitin-specific protease USP47 is a novel beta-TRCP interactor regulating cell survival |
| Q37798661 | The various roles of ubiquitin in Wnt pathway regulation. |
| Q28279593 | The β-catenin destruction complex |
| Q37240247 | Thiazolidinediones mimic glucose starvation in facilitating Sp1 degradation through the up-regulation of beta-transducin repeat-containing protein |
| Q42514932 | Transcriptional Regulation by Nrf2. |
| Q34344682 | Transfer of Ho Endonuclease and Ufo1 to the Proteasome by the UbL-UbA Shuttle Protein, Ddi1, Analysed by Complex Formation In Vitro |
| Q37113911 | Transforming growth factor-beta stimulates cyclin D1 expression through activation of beta-catenin signaling in chondrocytes |
| Q43065281 | Tripartite degrons confer diversity and specificity on regulated protein degradation in the ubiquitin-proteasome system. |
| Q35787947 | Tumor viruses and cell signaling pathways: deubiquitination versus ubiquitination |
| Q34225698 | Twists and turns in ubiquitin‐like protein conjugation cascades |
| Q36642707 | Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism |
| Q52315014 | Ube2s stabilizes β-Catenin through K11-linked polyubiquitination to promote mesendoderm specification and colorectal cancer development |
| Q38678006 | Ubiquitin, the centrosome, and chromosome segregation |
| Q34958467 | Ubiquitin-conjugating enzyme Cdc34 and ubiquitin ligase Skp1-cullin-F-box ligase (SCF) interact through multiple conformations |
| Q28274205 | Ubiquitination and degradation of the inhibitors of NF-kappaB |
| Q58606339 | Ubiquitination in Scleroderma Fibrosis and Its Treatment |
| Q37852608 | Ubiquitination in host immune response to human papillomavirus infection |
| Q46568443 | Ubiquitination of p27Kip1 requires physical interaction with cyclin E and probable phosphate recognition by SKP2. |
| Q42820389 | Ubiquitylation of the amino terminus of Myc by SCF(β-TrCP) antagonizes SCF(Fbw7)-mediated turnover |
| Q36455676 | Understanding cullin-RING E3 biology through proteomics-based substrate identification |
| Q38047273 | Unraveling the ubiquitin-regulated signaling networks by mass spectrometry-based proteomics. |
| Q30370948 | Vaccinia virus protein A49 is an unexpected member of the B-cell Lymphoma (Bcl)-2 protein family |
| Q33455505 | Vpu antagonizes BST-2-mediated restriction of HIV-1 release via beta-TrCP and endo-lysosomal trafficking |
| Q44852706 | Vpu-mediated degradation of CD4 reconstituted in yeast reveals mechanistic differences to cellular ER-associated protein degradation |
| Q35253276 | WDSPdb: a database for WD40-repeat proteins |
| Q35838990 | Wilms Tumor Gene on X Chromosome (WTX) Inhibits Degradation of NRF2 Protein through Competitive Binding to KEAP1 Protein |
| Q90028643 | Wnt Regulation: Exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex |
| Q24653563 | Wnt signaling: the good and the bad |
| Q91910450 | Wnt/β-catenin signalling in ovarian cancer: Insights into its hyperactivation and function in tumorigenesis |
| Q33307883 | Wrenches in the works: drug discovery targeting the SCF ubiquitin ligase and APC/C complexes |
| Q39792638 | beta-TrCP-mediated ubiquitination and degradation of PHLPP1 are negatively regulated by Akt. |
| Q28276987 | beta-catenin destruction complex: insights and questions from a structural perspective |
| Q38767528 | lnc-β-Catm elicits EZH2-dependent β-catenin stabilization and sustains liver CSC self-renewal |
| Q28251026 | mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR |
| Q28251047 | mTOR generates an auto-amplification loop by triggering the βTrCP- and CK1α-dependent degradation of DEPTOR |
| Q40362912 | p300 modulates ATF4 stability and transcriptional activity independently of its acetyltransferase domain |
| Q57471387 | β-Catenin is a pH sensor with decreased stability at higher intracellular pH |
| Q37132132 | β-Transducin Repeat-containing Protein 1 (β-TrCP1)-mediated Silencing Mediator of Retinoic Acid and Thyroid Hormone Receptor (SMRT) Protein Degradation Promotes Tumor Necrosis Factor α (TNFα)-induced Inflammatory Gene Expression |
| Q39451480 | βTrCP Controls GH Receptor Degradation via Two Different Motifs |
| Q38316122 | βTrCP interacts with the ubiquitin-dependent endocytosis motif of the GH receptor in an unconventional manner |
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