PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated Keap1-dependent ubiquitin ligase complex

scientific article published on 17 October 2006

PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated Keap1-dependent ubiquitin ligase complex is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M606539200
P698PubMed publication ID17046835

P2093author name stringMark Hannink
Shih-Ching Lo
P2860cites workBcl-x(L) sequesters its C-terminal membrane anchor in soluble, cytosolic homodimersQ24292693
Evolution of the phosphoglycerate mutase processed gene in human and chimpanzee revealing the origin of a new primate geneQ24294724
Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signalingQ24298930
Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligaseQ24306203
Identification, cDNA cloning, and targeted deletion of p70, a novel, ubiquitously expressed SH3 domain-containing proteinQ24540267
Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complexQ24559743
Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2Q24563807
The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitroQ24608829
Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligaseQ27640370
TIGAR, a p53-inducible regulator of glycolysis and apoptosisQ28118306
Function and regulation of cullin-RING ubiquitin ligasesQ28131707
Structure, function, and evolution of phosphoglycerate mutases: comparison with fructose-2,6-bisphosphatase, acid phosphatase, and alkaline phosphataseQ28144542
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidantsQ28218883
Nrf1 is targeted to the endoplasmic reticulum membrane by an N-terminal transmembrane domain. Inhibition of nuclear translocation and transacting functionQ28239381
Expression of the fetal Alz-50 clone 1 protein induces apoptotic cell deathQ28270185
Fetal Alz-50 clone 1 interacts with the human orthologue of the Kelch-like Ech-associated proteinQ28283167
Crystal structure of the Kelch domain of human Keap1Q28287182
Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligaseQ28506124
Regulation of ZAP-70 activation and TCR signaling by two related proteins, Sts-1 and Sts-2Q28587191
Pathways of Oxidative DamageQ29615094
Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancerQ29616499
Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1Q29616500
The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligaseQ29616502
Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducersQ29616503
Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative StressQ29617845
Points of control in inflammationQ29620319
Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeuticsQ29620467
Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinasesQ30164059
In vitro selection and characterization of Bcl-X(L)-binding proteins from a mix of tissue-specific mRNA display librariesQ31889951
Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2Q33900511
The contribution of endogenous sources of DNA damage to the multiple mutations in cancerQ34263814
Coronary atherosclerosis and somatic mutations: an overview of the contributive factors for oxidative DNA damage.Q35037752
Identification of the NF-E2-related factor-2-dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysisQ38358203
Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survivalQ38359163
Identification of the interactive interface and phylogenic conservation of the Nrf2-Keap1 system.Q38363758
CAND1-mediated substrate adaptor recycling is required for efficient repression of Nrf2 by Keap1.Q40322697
Specific patterns of electrophile adduction trigger Keap1 ubiquitination and Nrf2 activationQ40403963
Development of Protacs to Target Cancer-promoting Proteins for Ubiquitination and DegradationQ40558374
Nuclear oncoprotein prothymosin alpha is a partner of Keap1: implications for expression of oxidative stress-protecting genes.Q40890652
Oxidative damage is the earliest event in Alzheimer diseaseQ43696731
The processivity of multiubiquitination by the APC determines the order of substrate degradation.Q45345067
Comparison of (-)-epigallocatechin-3-gallate elicited liver and small intestine gene expression profiles between C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice.Q46678343
Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphaneQ46854767
Dimethylarsinic acid effects on DNA damage and oxidative stress related biochemical parameters in B6C3F1 mice.Q53421815
P433issue49
P407language of work or nameEnglishQ1860
P304page(s)37893-37903
P577publication date2006-10-17
P1433published inJournal of Biological ChemistryQ867727
P1476titlePGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated Keap1-dependent ubiquitin ligase complex
P478volume281