| Q90228199 | "Keaping" a lid on lung cancer: the Keap1-Nrf2 pathway |
| Q52642898 | A Complementary Chemical and Genomic Screening Approach for Druggable Targets in the Nrf2 Pathway and Small Molecule Inhibitors to Overcome Cancer Cell Drug Resistance. |
| Q90451937 | A Naturally-Occurring Dominant-Negative Inhibitor of Keap1 Competitively against Its Negative Regulation of Nrf2 |
| Q58701423 | A catalogue of somatic NRF2 gain-of-function mutations in cancer |
| Q58718413 | A distinct class of antioxidant response elements is consistently activated in tumors with NRF2 mutations |
| Q22061872 | A molecular marker of artemisinin-resistant Plasmodium falciparum malaria |
| Q39710585 | A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62. |
| Q39953670 | A systematic molecular dynamics approach to the study of peptide Keap1-Nrf2 protein-protein interaction inhibitors and its application to p62 peptides |
| Q36548027 | Aberrant Keap1 methylation in breast cancer and association with clinicopathological features |
| Q39720613 | Accumulation of phosphorylated p62 is associated with NF-E2-related factor 2 activation in hepatocellular carcinoma |
| Q36291365 | Actin Cytoskeletal Organization in Drosophila Germline Ring Canals Depends on Kelch Function in a Cullin-RING E3 Ligase |
| Q33707203 | Activation of NRF2 by nitrosative agents and H2O2 involves KEAP1 disulfide formation |
| Q37241323 | Activation of Nrf2-antioxidant signaling attenuates NFkappaB-inflammatory response and elicits apoptosis |
| Q92511933 | Activators and Inhibitors of NRF2: A Review of Their Potential for Clinical Development |
| Q35895250 | Adenovirus-Mediated Over-Expression of Nrf2 Within Mesenchymal Stem Cells (MSCs) Protected Rats Against Acute Kidney Injury. |
| Q41357989 | An Intriguing Correlation Based on the Superimposition of Residue Pairs with Inhibitors that Target Protein-Protein Interfaces |
| Q40070103 | An auto-regulatory loop between stress sensors INrf2 and Nrf2 controls their cellular abundance. |
| Q36994823 | Analysis of dimerization of BTB-IVR domains of Keap1 and its interaction with Cul3, by molecular modeling |
| Q92703882 | Anthocyanins from Hibiscus syriacus L. Inhibit Oxidative Stress-Mediated Apoptosis by Activating the Nrf2/HO-1 Signaling Pathway |
| Q35851546 | Antioxidant-induced INrf2 (Keap1) tyrosine 85 phosphorylation controls the nuclear export and degradation of the INrf2-Cul3-Rbx1 complex to allow normal Nrf2 activation and repression |
| Q28392399 | Antioxidant-induced modification of INrf2 cysteine 151 and PKC-delta-mediated phosphorylation of Nrf2 serine 40 are both required for stabilization and nuclear translocation of Nrf2 and increased drug resistance |
| Q55611195 | Antioxidant-induced modification of INrf2 cysteine 151 and PKC-δ-mediated phosphorylation of Nrf2 serine 40 are both required for stabilization and nuclear translocation of Nrf2 and increased drug resistance. |
| Q28383028 | Aromatase Inhibitor-Mediated Downregulation of INrf2 (Keap1) Leads to Increased Nrf2 and Resistance in Breast Cancer |
| Q39165710 | Arsenic inhibits autophagic flux, activating the Nrf2-Keap1 pathway in a p62-dependent manner |
| Q28387886 | Arsenic-induced malignant transformation of human keratinocytes: involvement of Nrf2 |
| Q28386384 | Arsenic-mediated activation of the Nrf2-Keap1 antioxidant pathway |
| Q64082195 | Artemisinin resistance-associated markers in Plasmodium falciparum parasites from the China-Myanmar border: predicted structural stability of K13 propeller variants detected in a low-prevalence area |
| Q37167304 | Aryl hydrocarbon receptor and lung cancer |
| Q38551047 | Association of Nrf2 with airway pathogenesis: lessons learned from genetic mouse models. |
| Q38084832 | Atypical protein phosphatases: emerging players in cellular signaling |
| Q42099409 | Autophagy-deficient mice develop multiple liver tumors |
| Q28391506 | Basic principles and emerging concepts in the redox control of transcription factors |
| Q42041592 | Binding of disordered proteins to a protein hub. |
| Q37134317 | Brusatol Enhances the Radiosensitivity of A549 Cells by Promoting ROS Production and Enhancing DNA Damage |
| Q34534013 | Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism |
| Q28384997 | CACUL1/CAC1 Regulates the Antioxidant Response by Stabilizing Nrf2 |
| Q24652502 | Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy |
| Q36665424 | Carcinogenesis and transcriptional regulation through Maf recognition elements |
| Q34584779 | Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1. |
| Q28384232 | Cellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disorders |
| Q37856648 | Chronic obstructive pulmonary disease and lung cancer: new molecular insights |
| Q99630447 | Clinical significance of SQSTM1/P62 and nuclear factor-κB expression in pancreatic carcinoma |
| Q92134518 | Comparative structural and evolutionary analyses predict functional sites in the artemisinin resistance malaria protein K13 |
| Q38558127 | Conservation of the Keap1-Nrf2 System: An Evolutionary Journey through Stressful Space and Time. |
| Q37254582 | Coordinate control of expression of Nrf2-modulated genes in the human small airway epithelium is highly responsive to cigarette smoking |
| Q85006082 | Correlation of Nrf2, HO-1, and MRP3 in Gallbladder Cancer and Their Relationships to Clinicopathologic Features and Survival |
| Q45391363 | Critical role of Nrf2 in oxidative stress-induced retinal ganglion cell death. |
| Q35920278 | Cross-regulations among NRFs and KEAP1 and effects of their silencing on arsenic-induced antioxidant response and cytotoxicity in human keratinocytes |
| Q26747274 | Cullin 3 Ubiquitin Ligases in Cancer Biology: Functions and Therapeutic Implications |
| Q37133559 | Cullin 3 as a novel target in diverse pathologies |
| Q28118714 | Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection |
| Q35832006 | Cyclo(His-Pro) promotes cytoprotection by activating Nrf2-mediated up-regulation of antioxidant defence. |
| Q57069735 | Design and development of Nrf2 modulators for cancer chemoprevention and therapy: a review |
| Q36961488 | Dietary phytochemicals and cancer prevention: Nrf2 signaling, epigenetics, and cell death mechanisms in blocking cancer initiation and progression. |
| Q27647812 | Different Electrostatic Potentials Define ETGE and DLG Motifs as Hinge and Latch in Oxidative Stress Response |
| Q53616483 | Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: a two-site interaction model for the Nrf2-Keap1 complex. |
| Q24646029 | Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response |
| Q28079559 | Drugging the addict: non-oncogene addiction as a target for cancer therapy |
| Q42142167 | Dual neuroprotective pathways of a pro-electrophilic compound via HSF-1-activated heat-shock proteins and Nrf2-activated phase 2 antioxidant response enzymes |
| Q28247844 | Dual regulation of the transcriptional activity of Nrf1 by β-TrCP- and Hrd1-dependent degradation mechanisms |
| Q37119963 | Dual roles of Nrf2 in cancer |
| Q28469051 | Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer |
| Q60920505 | Dysregulation of Nrf2 in Hepatocellular Carcinoma: Role in Cancer Progression and Chemoresistance |
| Q89783904 | Effects of Co-occurring Genomic Alterations on Outcomes in Patients with KRAS-Mutant Non-Small Cell Lung Cancer |
| Q90061778 | Emerging Screening Approaches in the Development of Nrf2-Keap1 Protein-Protein Interaction Inhibitors |
| Q38869922 | Emerging role of NRF2 in chemoresistance by regulating drug-metabolizing enzymes and efflux transporters. |
| Q37292420 | Engineering new protein-protein interactions on the β-propeller fold by yeast cell surface display |
| Q53696229 | Epigenetic versus Genetic Deregulation of the KEAP1/NRF2 Axis in Solid Tumors: Focus on Methylation and Noncoding RNAs. |
| Q38609700 | Expanding roles of superoxide dismutases in cell regulation and cancer |
| Q34204333 | Expression of ABCG2 (BCRP) Is Regulated by Nrf2 in Cancer Cells That Confers Side Population and Chemoresistance Phenotype |
| Q33566485 | Expression of stress-response ATF3 is mediated by Nrf2 in astrocytes |
| Q35349299 | Expression of xCT and activity of system xc(-) are regulated by NRF2 in human breast cancer cells in response to oxidative stress |
| Q42867141 | Frequent alteration of the protein synthesis of enzymes for glucose metabolism in hepatocellular carcinomas |
| Q38539087 | Functional polymorphisms in Nrf2: implications for human disease. |
| Q36522434 | Gain of Nrf2 function in non-small-cell lung cancer cells confers radioresistance. |
| Q89288057 | Gene regulatory effects of disease-associated variation in the NRF2 network |
| Q32872076 | Generation of a New Model Rat: Nrf2 Knockout Rats Are Sensitive to Aflatoxin B1 Toxicity. |
| Q33877576 | Genetic analysis of cytoprotective functions supported by graded expression of Keap1 |
| Q33557928 | Genetic deletion of Nrf2 promotes immortalization and decreases life span of murine embryonic fibroblasts |
| Q37106139 | Genetic disruption of the Nrf2 compromises cell-cycle progression by impairing GSH-induced redox signaling |
| Q52688263 | Genetic mutations associated with lung cancer metastasis to the brain. |
| Q92300433 | Genome-wide global identification of NRF2 binding sites in A549 non-small cell lung cancer cells by ChIP-Seq reveals NRF2 regulation of genes involved in focal adhesion pathways |
| Q37044968 | Genomic structure and variation of nuclear factor (erythroid-derived 2)-like 2 |
| Q38664878 | Glycosylation of KEAP1 links nutrient sensing to redox stress signaling. |
| Q33959077 | High levels of Nrf2 determine chemoresistance in type II endometrial cancer |
| Q33701406 | Hsp90 Interaction with INrf2(Keap1) Mediates Stress-induced Nrf2 Activation |
| Q58582517 | Hyperactivity of the transcription factor Nrf2 causes metabolic reprogramming in mouse esophagus |
| Q34441957 | INrf2 (Keap1) targets Bcl-2 degradation and controls cellular apoptosis |
| Q38409709 | Identification and Structural Analysis of New Nrf2 Activators by Mechanism-Based Chemical Transformation of 15-Deoxy-Δ12, 14 -PGJ2. |
| Q57786820 | Importance of the Keap1-Nrf2 pathway in NSCLC: Is it a possible biomarker? |
| Q39707915 | Increased cell migration and plasticity in Nrf2-deficient cancer cell lines |
| Q51778003 | Increased susceptibility to hepatocarcinogenicity of Nrf2-deficient mice exposed to 2-amino-3-methylimidazo[4,5-f]quinoline. |
| Q34358791 | Induction of heme oxygenase-1 inhibits cell death in crotonaldehyde-stimulated HepG2 cells via the PKC-δ-p38-Nrf2 pathway |
| Q48179094 | Inflammation, oxidative stress, and higher expression levels of Nrf2 and NQO1 proteins in the airways of women chronically exposed to biomass fuel smoke |
| Q89484746 | Inhibition of TXNRD or SOD1 overcomes NRF2-mediated resistance to β-lapachone |
| Q28395156 | Inhibitor of Nrf2 (INrf2 or Keap1) protein degrades Bcl-xL via phosphoglycerate mutase 5 and controls cellular apoptosis |
| Q27852382 | Integrated molecular analysis of clear-cell renal cell carcinoma |
| Q47581478 | Investigation of the intermolecular recognition mechanism between the E3 ubiquitin ligase Keap1 and substrate based on multiple substrates analysis. |
| Q37406535 | KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta |
| Q35711633 | KEAP1 gene mutations and NRF2 activation are common in pulmonary papillary adenocarcinoma |
| Q41865879 | KEAP1-NRF2 complex in ischemia-induced hepatocellular damage of mouse liver transplants |
| Q33734064 | Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains |
| Q42950523 | Keap1 mutations in lung cancer patients |
| Q28910182 | Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model |
| Q38920601 | Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants. |
| Q57753359 | Keap1-MCM3 interaction is a potential coordinator of molecular machineries of antioxidant response and genomic DNA replication in metazoa |
| Q50921781 | Keap1-Nrf2 pathway: A promising target towards lung cancer prevention and therapeutics. |
| Q36481370 | Keap1/Nrf2 signaling regulates oxidative stress tolerance and lifespan in Drosophila |
| Q35555898 | Kinetic analyses of Keap1-Nrf2 interaction and determination of the minimal Nrf2 peptide sequence required for Keap1 binding using surface plasmon resonance |
| Q27681060 | Kinetic, Thermodynamic, and Structural Characterizations of the Association between Nrf2-DLGex Degron and Keap1 |
| Q55461310 | Knockdown of Nrf2 suppresses glioblastoma angiogenesis by inhibiting hypoxia-induced activation of HIF-1α. |
| Q37223268 | Lipid mediators involved in the oxidative stress and antioxidant defence of human lung cancer cells. |
| Q28292085 | Long isoforms of NRF1 contribute to arsenic-induced antioxidant response in human keratinocytes |
| Q33652512 | Loss of Kelch-like ECH-associated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growth. |
| Q64100829 | Mechanisms of Ferroptosis and Relations With Regulated Cell Death: A Review |
| Q28394732 | Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease |
| Q28277182 | Mechanistic studies of the Nrf2-Keap1 signaling pathway |
| Q28069081 | Metabolic rewiring in melanoma |
| Q34156322 | Methylation of the KEAP1 gene promoter region in human colorectal cancer |
| Q27313374 | Microsecond molecular dynamics simulations of intrinsically disordered proteins involved in the oxidative stress response |
| Q26852282 | Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel? |
| Q64955421 | Mitohormesis Primes Tumor Invasion and Metastasis. |
| Q37233557 | Modification of platinum sensitivity by KEAP1/NRF2 signals in non-small cell lung cancer |
| Q59701095 | Modulating NRF2 in Disease: Timing Is Everything |
| Q23919668 | Molecular basis of electrophilic and oxidative defense: promises and perils of Nrf2 |
| Q46787391 | Molecular effects of cancer-associated somatic mutations on the structural and target recognition properties of Keap1. |
| Q44138968 | Molecular evolution of Keap1. Two Keap1 molecules with distinctive intervening region structures are conserved among fish |
| Q26778356 | Molecular mechanisms of Nrf2 regulation and how these influence chemical modulation for disease intervention |
| Q37073173 | Molecular mechanisms of Nrf2-mediated antioxidant response |
| Q40709652 | Multiple binding modes of a small molecule to human Keap1 revealed by X-ray crystallography and molecular dynamics simulation. |
| Q28383318 | Multiple roles of Nrf2-Keap1 signaling: regulation of development and xenobiotic response using distinct mechanisms |
| Q36561564 | Mutant p53 confers chemoresistance in non-small cell lung cancer by upregulating Nrf2 |
| Q34558564 | Mutations in Plasmodium falciparum K13 propeller gene from Bangladesh (2009-2013). |
| Q33608699 | NF-E2 domination over Nrf2 promotes ROS accumulation and megakaryocytic maturation |
| Q49945078 | NRF2 Addiction in Cancer Cells |
| Q42730519 | NRF2 Is a Potential Modulator of Hyperresistance to Arsenic Toxicity in Stem-Like Keratinocytes |
| Q97636643 | NRF2 activation promotes the recurrence of dormant tumour cells through regulation of redox and nucleotide metabolism |
| Q38061832 | NRF2 and p53: Januses in cancer? |
| Q88582817 | NRF2 and the Hallmarks of Cancer |
| Q57476124 | NRF2 transcriptionally activates the heat shock factor 1 promoter under oxidative stress and affects survival and migration potential of MCF7 cells |
| Q34148599 | NRF2, cancer and calorie restriction |
| Q42378386 | NRF2-regulated metabolic gene signature as a prognostic biomarker in non-small cell lung cancer. |
| Q50020783 | Negative regulation of the Keap1-Nrf2 pathway by a p62/Sqstm1 splicing variant. |
| Q28254462 | Negative regulation of the Nrf1 transcription factor by its N-terminal domain is independent of Keap1: Nrf1, but not Nrf2, is targeted to the endoplasmic reticulum |
| Q91151492 | Nestin regulates cellular redox homeostasis in lung cancer through the Keap1-Nrf2 feedback loop |
| Q36277241 | Non-electrophilic modulators of the canonical Keap1/Nrf2 pathway |
| Q36843160 | Novel role of the muskelin-RanBP9 complex as a nucleocytoplasmic mediator of cell morphology regulation |
| Q36502594 | Nrf-2 overexpression in mesenchymal stem cells reduces oxidative stress-induced apoptosis and cytotoxicity |
| Q28388093 | Nrf2 Induces IL-17D to Mediate Tumor and Virus Surveillance |
| Q34062498 | Nrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic features |
| Q92833196 | Nrf2 and SQSTM1/p62 jointly contribute to mesenchymal transition and invasion in glioblastoma |
| Q45806326 | Nrf2 deficiency leads to behavioral, neurochemical and transcriptional changes in mice |
| Q33623150 | Nrf2 enhances cholangiocyte expansion in Pten-deficient livers |
| Q28382823 | Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2 |
| Q34467239 | Nrf2 expression in endometrial serous carcinomas and its precancers. |
| Q38481027 | Nrf2 promotes survival following exposure to ionizing radiation |
| Q28383226 | Nrf2 protein up-regulates antiapoptotic protein Bcl-2 and prevents cellular apoptosis |
| Q28394210 | Nrf2 signaling and cell survival |
| Q37785105 | Nrf2-ARE stress response mechanism: A control point in oxidative stress-mediated dysfunctions and chronic inflammatory diseases |
| Q34298880 | Nrf2-MafG heterodimers contribute globally to antioxidant and metabolic networks |
| Q39217937 | Nrf2-induced antiapoptotic Bcl-xL protein enhances cell survival and drug resistance |
| Q38193757 | Nrf2: bane or blessing in cancer? |
| Q33575690 | Nrf2: friend or foe for chemoprevention? |
| Q29615712 | Nrf2:INrf2 (Keap1) signaling in oxidative stress |
| Q33527780 | Nuclear factor (erythroid-derived 2)-like 2 regulates drug resistance in pancreatic cancer cells |
| Q36310216 | Nuclear factor, erythroid 2-like 2-associated molecular signature predicts lung cancer survival |
| Q36772839 | Nutrigenomics: concepts and applications to pharmacogenomics and clinical medicine |
| Q28392781 | Oncogene PKCε controls INrf2-Nrf2 interaction in normal and cancer cells through phosphorylation of INrf2 |
| Q33589309 | Oncogenic transformation of mesenchymal stem cells decreases Nrf2 expression favoring in vivo tumor growth and poorer survival |
| Q59360270 | Oxeiptosis-a cell death pathway to mitigate damage caused by radicals |
| Q29616835 | Oxidative stress, inflammation, and cancer: how are they linked? |
| Q36420949 | Oxidative stress, mammospheres and Nrf2-new implication for breast cancer therapy? |
| Q35867950 | PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function |
| Q28384526 | PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria |
| Q40219081 | PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated Keap1-dependent ubiquitin ligase complex |
| Q39193337 | PGC1α expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress. |
| Q34825204 | Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells |
| Q41678966 | Perspectives of the Nrf-2 signaling pathway in cancer progression and therapy |
| Q64250667 | Pharmacological Applications of Nrf2 Inhibitors as Potential Antineoplastic Drugs |
| Q24655442 | Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity |
| Q37000698 | Phytochemical regulation of UDP-glucuronosyltransferases: implications for cancer prevention. |
| Q28069384 | Plasmodium falciparum: multifaceted resistance to artemisinins |
| Q64056540 | Potential Applications of NRF2 Inhibitors in Cancer Therapy |
| Q34091754 | Preventing Ca2+-mediated nitrosative stress in neurodegenerative diseases: possible pharmacological strategies |
| Q30371642 | Prospective type 1 and type 2 disulfides of Keap1 protein. |
| Q39874226 | Prothymosin-alpha mediates nuclear import of the INrf2/Cul3 Rbx1 complex to degrade nuclear Nrf2. |
| Q37620581 | RETRACTED ARTICLE: Wogonin reversed resistant human myelogenous leukemia cells via inhibiting Nrf2 signaling by Stat3/NF-κB inactivation |
| Q34759878 | RNAi-mediated silencing of nuclear factor erythroid-2-related factor 2 gene expression in non-small cell lung cancer inhibits tumor growth and increases efficacy of chemotherapy |
| Q29617340 | ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis |
| Q41233476 | ROS enhance angiogenic properties via regulation of NRF2 in tumor endothelial cells |
| Q99616637 | Recent advances in the development of protein-protein interactions modulators: mechanisms and clinical trials |
| Q39270529 | Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016). |
| Q64982277 | Recognition of the Diglycine C-End Degron by CRL2KLHDC2 Ubiquitin Ligase. |
| Q39324573 | Recombinant adenovirus Ad-RUNrf2 reduces paraquat-induced A549 injury. |
| Q26740191 | Redox Homeostasis and Cellular Antioxidant Systems: Crucial Players in Cancer Growth and Therapy |
| Q26774916 | Redox Modulating NRF2: A Potential Mediator of Cancer Stem Cell Resistance |
| Q36849043 | Redox regulation of hepatocyte apoptosis |
| Q36756386 | Redox-based regulation of signal transduction: principles, pitfalls, and promises |
| Q27324641 | Regulation of Drosophila metamorphosis by xenobiotic response regulators |
| Q39617672 | Regulation of KEAP1 expression by promoter methylation in malignant gliomas and association with patient's outcome |
| Q28388589 | Regulation of Nrf2-an update |
| Q34252986 | Regulation of the Nrf2-Keap1 antioxidant response by the ubiquitin proteasome system: an insight into cullin-ring ubiquitin ligases |
| Q36978267 | Regulatory nexus of synthesis and degradation deciphers cellular Nrf2 expression levels. |
| Q90148010 | Role of 17β-Estradiol on Cell Proliferation and Mitochondrial Fitness in Glioblastoma Cells |
| Q23919669 | Role of Nrf2 in oxidative stress and toxicity |
| Q54196732 | SIRT5 facilitates cancer cell growth and drug resistance in non-small cell lung cancer. |
| Q38543567 | Simultaneous Activation of Nrf2 and Elevation of Dietary and Endogenous Antioxidant Chemicals for Cancer Prevention in Humans |
| Q28386244 | Small molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agents |
| Q35981250 | Small molecules, big targets: drug discovery faces the protein-protein interaction challenge |
| Q53659826 | Somatic mutations of the KEAP1 gene in common solid cancers. |
| Q30858730 | Spotlite: web application and augmented algorithms for predicting co-complexed proteins from affinity purification--mass spectrometry data. |
| Q26765060 | Squamous cell carcinomas of the lung and of the head and neck: new insights on molecular characterization |
| Q28392546 | Src subfamily kinases regulate nuclear export and degradation of transcription factor Nrf2 to switch off Nrf2-mediated antioxidant activation of cytoprotective gene expression |
| Q35738960 | State-of-the-art strategies for targeting protein-protein interactions by small-molecule inhibitors |
| Q28384783 | Stress-activated cap'n'collar transcription factors in aging and human disease |
| Q27675990 | Structural Basis for Cul3 Protein Assembly with the BTB-Kelch Family of E3 Ubiquitin Ligases |
| Q91675797 | Structural Basis for Recruitment of DAPK1 to the KLHL20 E3 Ligase |
| Q27657628 | Structural Basis of Alternative DNA Recognition by Maf Transcription Factors |
| Q27650252 | Structural analysis of the complex of Keap1 with a prothymosin α peptide |
| Q27682289 | Structural and biochemical characterization of the KLHL3–WNK kinase interaction important in blood pressure regulation |
| Q34762436 | Structural assembly of cullin-RING ubiquitin ligase complexes |
| Q38522152 | Structural basis of Keap1 interactions with Nrf2. |
| Q27654126 | Structural basis of tRNA modification with CO2 fixation and methylation by wybutosine synthesizing enzyme TYW4 |
| Q36672463 | Structural insights into the similar modes of Nrf2 transcription factor recognition by the cytoplasmic repressor Keap1. |
| Q24298930 | Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling |
| Q27657740 | Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases |
| Q46976303 | Subcellular localization and cytoplasmic complex status of endogenous Keap1. |
| Q24337474 | Suppression of NF-kappaB signaling by KEAP1 regulation of IKKbeta activity through autophagic degradation and inhibition of phosphorylation |
| Q35040534 | Sustained activation of nuclear erythroid 2-related factor 2/antioxidant response element signaling promotes reductive stress in the human mutant protein aggregation cardiomyopathy in mice |
| Q34062505 | Targeted deletion of Nrf2 reduces urethane-induced lung tumor development in mice |
| Q90595758 | Targeted substrate degradation by Kelch controls the actin cytoskeleton during ring canal expansion |
| Q35001318 | Targeting NRF2 signaling for cancer chemoprevention |
| Q27341433 | The C-terminal domain of Nrf1 negatively regulates the full-length CNC-bZIP factor and its shorter isoform LCR-F1/Nrf1β; both are also inhibited by the small dominant-negative Nrf1γ/δ isoforms that down-regulate ARE-battery gene expression |
| Q39986392 | The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction |
| Q24306576 | The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses |
| Q38629284 | The Dietary Components Carnosic Acid and Carnosol as Neuroprotective Agents: a Mechanistic View |
| Q39317112 | The KEAP1-NRF2 System in Cancer |
| Q33659621 | The Keap1-Nrf2 pathway: promising therapeutic target to counteract ROS-mediated damage in cancers and neurodegenerative diseases |
| Q28392347 | The Keap1-Nrf2 system in cancers: stress response and anabolic metabolism |
| Q38837451 | The Keap1-Nrf2-ARE Pathway As a Potential Preventive and Therapeutic Target: An Update |
| Q36848739 | The NRF2 activation and antioxidative response are not impaired overall during hyperoxia-induced lung epithelial cell death |
| Q37802176 | The Nrf2 system as a potential target for the development of indirect antioxidants. |
| Q33655603 | The clinical impact of artemisinin resistance in Southeast Asia and the potential for future spread |
| Q28389296 | The complexity of the Nrf2 pathway: beyond the antioxidant response |
| Q27861035 | The consensus coding sequences of human breast and colorectal cancers |
| Q33586008 | The critical role of nitric oxide signaling, via protein S-guanylation and nitrated cyclic GMP, in the antioxidant adaptive response |
| Q34279067 | The cystine/glutamate antiporter system x(c)(-) in health and disease: from molecular mechanisms to novel therapeutic opportunities. |
| Q37848718 | The cytoprotective role of the Keap1-Nrf2 pathway |
| Q37163747 | The emerging family of CULLIN3-RING ubiquitin ligases (CRL3s): cellular functions and disease implications. |
| Q37271797 | The emerging role of the Nrf2-Keap1 signaling pathway in cancer |
| Q39941077 | The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system |
| Q34529161 | The instability of the BTB-KELCH protein Gigaxonin causes Giant Axonal Neuropathy and constitutes a new penetrant and specific diagnostic test |
| Q36734146 | The involvement of NRF2 in lung cancer |
| Q27692102 | The multifaceted roles of autophagy in tumors-implications for breast cancer |
| Q26777478 | The mutational landscape of hepatocellular carcinoma |
| Q91259733 | The oncoprotein HBXIP competitively binds KEAP1 to activate NRF2 and enhance breast cancer cell growth and metastasis |
| Q28235174 | The p65 isoform of Nrf1 is a dominant negative inhibitor of ARE-mediated transcription |
| Q38984911 | The polycomb group protein EZH2 inhibits lung cancer cell growth by repressing the transcription factor Nrf2. |
| Q39377881 | The role of Nrf2-Keap1 axis in colorectal cancer, progression, and chemoresistance |
| Q38889475 | The role of modulation of antioxidant enzyme systems in the treatment of neurodegenerative diseases |
| Q38161353 | The role of nrf2 and cytoprotection in regulating chemotherapy resistance of human leukemia cells |
| Q38300447 | The role of the Nrf2/Keap1 pathway in obesity and metabolic syndrome |
| Q38851918 | The role of thioredoxin reductase 1 in melanoma metabolism and metastasis |
| Q24300456 | The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1 |
| Q42485470 | The subcellular localization and activity of cortactin is regulated by acetylation and interaction with Keap1. |
| Q28393090 | The transcription factor NF-E2-related factor 2 (Nrf2): a protooncogene? |
| Q58436305 | The transcription factor Nrf2 as a new therapeutic target in Parkinson's disease |
| Q41982836 | The yin and yang of nrf2-regulated selenoproteins in carcinogenesis |
| Q90893987 | Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases |
| Q35914005 | Toll-Like Receptor Signaling Induces Nrf2 Pathway Activation through p62-Triggered Keap1 Degradation |
| Q92520812 | Transcription factor NRF2 uses the Hippo pathway effector TAZ to induce tumorigenesis in glioblastomas |
| Q28577485 | Traumatic brain injury induces the activation of the Nrf2-ARE pathway in the lung in rats |
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