| scholarly article | Q13442814 |
| P819 | ADS bibcode | 2010PNAS..107.2842O |
| P356 | DOI | 10.1073/PNAS.0914036107 |
| P932 | PMC publication ID | 2840362 |
| P698 | PubMed publication ID | 20133743 |
| P5875 | ResearchGate publication ID | 41408595 |
| P50 | author | Kazuhiro Mio | Q56501628 |
| Chikara Sato | Q58883334 | ||
| P2093 | author name string | Toshihiko Ogura | |
| Masayuki Yamamoto | |||
| Kit I Tong | |||
| Yuusuke Maruyama | |||
| Hirofumi Kurokawa | |||
| P2860 | cites work | Functional polymorphisms in the transcription factor NRF2 in humans increase the risk of acute lung injury | Q40154556 |
| Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity. | Q46808839 | ||
| The Sodium Channel Has Four Domains Surrounding a Central Pore | Q47686490 | ||
| A fully automatic 3D reconstruction method using simulated annealing enables accurate posterioric angular assignment of protein projections | Q51934118 | ||
| An automatic particle pickup method using a neural network applicable to low-contrast electron micrographs. | Q52039243 | ||
| Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: a two-site interaction model for the Nrf2-Keap1 complex | Q53616483 | ||
| Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling | Q24298930 | ||
| BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase | Q24558689 | ||
| Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex | Q24559743 | ||
| Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2 | Q24563807 | ||
| Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain | Q24609907 | ||
| Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity | Q24655442 | ||
| Crystal structure of the BTB domain from the LRF/ZBTB7 transcriptional regulator | Q27640942 | ||
| Different Electrostatic Potentials Define ETGE and DLG Motifs as Hinge and Latch in Oxidative Stress Response | Q27647812 | ||
| A new generation of the IMAGIC image processing system | Q28131751 | ||
| The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm | Q28216217 | ||
| Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants | Q28218883 | ||
| An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements | Q28244853 | ||
| Crystal structure of the Kelch domain of human Keap1 | Q28287182 | ||
| Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer | Q28469051 | ||
| Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model | Q28910182 | ||
| Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice | Q29615438 | ||
| Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer | Q29616499 | ||
| The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase | Q29616502 | ||
| Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers | Q29616503 | ||
| Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation | Q29618051 | ||
| Auto-accumulation method using simulated annealing enables fully automatic particle pickup completely free from a matching template or learning data | Q30923909 | ||
| Topology representing network enables highly accurate classification of protein images taken by cryo electron-microscope without masking. | Q31015634 | ||
| Automatic particle pickup method using a neural network has high accuracy by applying an initial weight derived from eigenimages: a new reference free method for single-particle analysis. | Q33201007 | ||
| Single-particle electron cryo-microscopy: towards atomic resolution. | Q33936480 | ||
| Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis | Q33981477 | ||
| Chemoprotection against cancer by induction of phase 2 enzymes | Q34160772 | ||
| The BACK domain in BTB-kelch proteins. | Q35950674 | ||
| Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome | Q35974394 | ||
| Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species | Q36556032 | ||
| Genetic or pharmacologic amplification of nrf2 signaling inhibits acute inflammatory liver injury in mice | Q36732083 | ||
| Oxidative stress and antioxidants in the pathogenesis of pulmonary fibrosis: a potential role for Nrf2. | Q36999941 | ||
| The Nrf2-Keap1 defence pathway: role in protection against drug-induced toxicity | Q37033412 | ||
| Nrf2 signaling: an adaptive response pathway for protection against environmental toxic insults | Q37046924 | ||
| The transcription factor Nrf2 is a therapeutic target against brain inflammation | Q39970287 | ||
| Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth. | Q40006300 | ||
| P433 | issue | 7 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | Kelch-like ECH-associated protein 1 | Q21979992 |
| P304 | page(s) | 2842-2847 | |
| P577 | publication date | 2010-01-27 | |
| P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
| P1476 | title | Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains | |
| P478 | volume | 107 |
| Q55461978 | 2-Deoxy-D-glucose and 6-aminonicotinamide-mediated Nrf2 down regulation leads to radiosensitization of malignant cells via abrogation of GSH-mediated defense |
| Q51018076 | 3D structure determination of protein using TEM single particle analysis |
| Q37702145 | 4-Hydroxyestradiol induces mammary epithelial cell transformation through Nrf2-mediated heme oxygenase-1 overexpression |
| Q57464878 | A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling |
| Q37971269 | Activation of stress signaling pathways by electrophilic oxidized and nitrated lipids |
| Q24704009 | Advances in mechanisms of anti-oxidation |
| Q38984573 | An overview of the mechanisms and novel roles of Nrf2 in cardiovascular diseases |
| Q36994823 | Analysis of dimerization of BTB-IVR domains of Keap1 and its interaction with Cul3, by molecular modeling |
| Q38807055 | CDDO and Its Role in Chronic Diseases. |
| Q37071189 | Cell signaling pathways involved in drug-mediated fetal hemoglobin induction: Strategies to treat sickle cell disease |
| Q38822665 | Characterizations of Three Major Cysteine Sensors of Keap1 in Stress Response. |
| Q26995211 | Concerted action of Nrf2-ARE pathway, MRN complex, HMGB1 and inflammatory cytokines - implication in modification of radiation damage |
| Q54380424 | Development of an efficient E. coli expression and purification system for a catalytically active, human Cullin3-RINGBox1 protein complex and elucidation of its quaternary structure with Keap1. |
| Q34263561 | Dietary regulation of Keap1/Nrf2/ARE pathway: focus on plant-derived compounds and trace minerals |
| Q34403519 | Direct observation of protein microcrystals in crystallization buffer by atmospheric scanning electron microscopy |
| Q90066617 | Dual roles and therapeutic potential of Keap1-Nrf2 pathway in pancreatic cancer: a systematic review |
| Q46470953 | Effects of Novel Nitric Oxide-Releasing Molecules against Oxidative Stress on Retinal Pigmented Epithelial Cells |
| Q34800018 | Electrophilic nitro-fatty acids activate NRF2 by a KEAP1 cysteine 151-independent mechanism |
| Q38869922 | Emerging role of NRF2 in chemoresistance by regulating drug-metabolizing enzymes and efflux transporters. |
| Q38746625 | Identification and Characterization of MCM3 as a Kelch-like ECH-associated Protein 1 (KEAP1) Substrate |
| Q38409709 | Identification and Structural Analysis of New Nrf2 Activators by Mechanism-Based Chemical Transformation of 15-Deoxy-Δ12, 14 -PGJ2. |
| Q28591483 | Interaction of an intracellular pentraxin with a BTB-Kelch protein is associated with ubiquitylation, aggregation and neuronal apoptosis |
| Q47581478 | Investigation of the intermolecular recognition mechanism between the E3 ubiquitin ligase Keap1 and substrate based on multiple substrates analysis. |
| Q49834826 | KEAP1 and Done? Targeting the NRF2 Pathway with Sulforaphane |
| Q41728387 | KLHL3 Knockout Mice Reveal the Physiological Role of KLHL3 and the Pathophysiology of Pseudohypoaldosteronism Type II Caused by Mutant KLHL3. |
| Q37525077 | Keap1 cysteine 288 as a potential target for diallyl trisulfide-induced Nrf2 activation |
| Q30497261 | Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals |
| Q38920601 | Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants. |
| Q50921781 | Keap1-Nrf2 pathway: A promising target towards lung cancer prevention and therapeutics |
| Q27681060 | Kinetic, Thermodynamic, and Structural Characterizations of the Association between Nrf2-DLGex Degron and Keap1 |
| Q28384271 | Mechanisms of Nrf2/Keap1-Dependent Phase II Cytoprotective and Detoxifying Gene Expression and Potential Cellular Targets of Chemopreventive Isothiocyanates |
| Q28394732 | Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease |
| Q23919668 | Molecular basis of electrophilic and oxidative defense: promises and perils of Nrf2 |
| Q40709652 | Multiple binding modes of a small molecule to human Keap1 revealed by X-ray crystallography and molecular dynamics simulation. |
| Q49945078 | NRF2 Addiction in Cancer Cells |
| Q50020783 | Negative regulation of the Keap1-Nrf2 pathway by a p62/Sqstm1 splicing variant. |
| Q41980350 | New strategies to inhibit KEAP1 and the Cul3-based E3 ubiquitin ligases. |
| Q38193757 | Nrf2: bane or blessing in cancer? |
| Q28383171 | Nuclear Factor-Erythroid-2-Related Factor 2 in Aging and Lung Fibrosis |
| Q26799344 | Overview of Nrf2 as Therapeutic Target in Epilepsy |
| Q50002018 | PClass: Protein Quaternary Structure Classification by Using Bootstrapping Strategy as Model Selection. |
| Q28392715 | Paradoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health Implications |
| Q41678966 | Perspectives of the Nrf-2 signaling pathway in cancer progression and therapy |
| Q89920945 | Potential Applications of NRF2 Modulators in Cancer Therapy |
| Q36144939 | Probing the structural requirements of non-electrophilic naphthalene-based Nrf2 activators. |
| Q34514734 | Proteasome inhibitor up regulates liver antioxidative enzymes in rat model of alcoholic liver disease |
| Q36745578 | Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination |
| Q28076840 | Quercetin as an Emerging Anti-Melanoma Agent: A Four-Focus Area Therapeutic Development Strategy |
| Q37756926 | Regulation of NF-E2-related factor 2 signaling for cancer chemoprevention: antioxidant coupled with antiinflammatory |
| Q36040945 | Regulation of innate immunity by NADPH oxidase |
| Q37191843 | Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex |
| Q23919669 | Role of Nrf2 in Oxidative Stress and Toxicity |
| Q37952857 | Soyabean glyceollins: biological effects and relevance to human health |
| Q30858730 | Spotlite: web application and augmented algorithms for predicting co-complexed proteins from affinity purification--mass spectrometry data. |
| Q27675990 | Structural Basis for Cul3 Protein Assembly with the BTB-Kelch Family of E3 Ubiquitin Ligases |
| Q34762436 | Structural assembly of cullin-RING ubiquitin ligase complexes |
| Q38522152 | Structural basis of Keap1 interactions with Nrf2. |
| Q27685443 | Structural basis of high-order oligomerization of the cullin-3 adaptor SPOP |
| Q27684072 | Structure of the BTB domain of Keap1 and its interaction with the triterpenoid antagonist CDDO |
| Q34225909 | Succination of Keap1 and activation of Nrf2-dependent antioxidant pathways in FH-deficient papillary renal cell carcinoma type 2 |
| Q89281668 | Targeting Nrf-2 is a promising intervention approach for the prevention of ethanol-induced liver disease |
| Q27341433 | The C-terminal domain of Nrf1 negatively regulates the full-length CNC-bZIP factor and its shorter isoform LCR-F1/Nrf1β; both are also inhibited by the small dominant-negative Nrf1γ/δ isoforms that down-regulate ARE-battery gene expression |
| Q38837451 | The Keap1-Nrf2-ARE Pathway As a Potential Preventive and Therapeutic Target: An Update |
| Q83563984 | The Keap1–Nrf2 system as an in vivo sensor for electrophiles |
| Q28392347 | The Keap1–Nrf2 system in cancers: stress response and anabolic metabolism |
| Q33586008 | The critical role of nitric oxide signaling, via protein S-guanylation and nitrated cyclic GMP, in the antioxidant adaptive response |
| Q37848718 | The cytoprotective role of the Keap1-Nrf2 pathway |
| Q37271797 | The emerging role of the Nrf2-Keap1 signaling pathway in cancer |
| Q38889475 | The role of modulation of antioxidant enzyme systems in the treatment of neurodegenerative diseases |
| Q90893987 | Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases |
| Q38105775 | Toward clinical application of the Keap1–Nrf2 pathway |
| Q24320275 | Ubiquitin Ligase Activity of Cul3-KLHL7 Protein Is Attenuated by Autosomal Dominant Retinitis Pigmentosa Causative Mutation |
| Q41962064 | Validation of the multiple sensor mechanism of the Keap1-Nrf2 system |
| Q34341268 | Visualization of the Drosophila dKeap1-CncC interaction on chromatin illumines cooperative, xenobiotic-specific gene activation. |
| Q35838990 | Wilms Tumor Gene on X Chromosome (WTX) Inhibits Degradation of NRF2 Protein through Competitive Binding to KEAP1 Protein |
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