Visualization of the Drosophila dKeap1-CncC interaction on chromatin illumines cooperative, xenobiotic-specific gene activation.

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Visualization of the Drosophila dKeap1-CncC interaction on chromatin illumines cooperative, xenobiotic-specific gene activation. is …
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scholarly articleQ13442814

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P356DOI10.1242/DEV.110528
P932PMC publication ID4197530
P698PubMed publication ID25063457
P5875ResearchGate publication ID264246820

P50authorTom K. KerppolaQ38319401
P2093author name stringHuai Deng
P2860cites workAn integrated encyclopedia of DNA elements in the human genomeQ22122150
Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control regionQ24563505
Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2Q24563807
Nrf2 regulates haematopoietic stem cell functionQ24604639
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domainQ24609907
Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 geneQ24649776
Drosophila melanogaster Hox transcription factors access the RNA polymerase II machinery through direct homeodomain binding to a conserved motif of mediator subunit Med19Q27316136
Regulation of Drosophila metamorphosis by xenobiotic response regulatorsQ27324641
Targeted gene expression as a means of altering cell fates and generating dominant phenotypesQ27861039
Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarrayQ28202142
Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2Q28382872
Opposing roles of FoxP1 and Nfat3 in transcriptional control of cardiomyocyte hypertrophyQ28579882
The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compoundsQ28755952
Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition modelQ28910182
Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expressionQ29615644
Visualization of interactions among bZIP and Rel family proteins in living cells using bimolecular fluorescence complementationQ29616037
Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activationQ29618051
Different polycomb group CBX family proteins associate with distinct regions of chromatin using nonhomologous protein sequencesQ30484141
WAVE Forms Hetero- and Homo-oligomeric Complexes at Integrin Junctions in Drosophila Visualized by Bimolecular Fluorescence ComplementationQ30497636
Visualization of protein interactions in living Drosophila embryos by the bimolecular fluorescence complementation assayQ30498214
Polytene chromosome squash methods for studying transcription and epigenetic chromatin modification in Drosophila using antibodiesQ33652253
Deficiency in the nuclear factor E2-related factor-2 transcription factor results in impaired adipogenesis and protects against diet-induced obesityQ33726669
Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domainsQ33734064
Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2Q33900511
Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysisQ34146310
The eve stripe 2 enhancer employs multiple modes of transcriptional synergyQ34371968
Role of antioxidants in paraquat toxicityQ34904565
Transcriptional regulation of xenobiotic detoxification in DrosophilaQ35220210
A cis-regulatory map of the Drosophila genome.Q35229726
Hormonal cross talk in insect developmentQ35994193
Opposite orientations of a transcription factor heterodimer bind DNA cooperatively with interaction partners but have different effects on interferon-β gene transcriptionQ36234728
Keap1/Nrf2 signaling regulates oxidative stress tolerance and lifespan in DrosophilaQ36481370
Keap1-nrf2 signaling: a target for cancer prevention by sulforaphaneQ36557973
Cross-regulatory protein-protein interactions between Hox and Pax transcription factorsQ36869905
Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice.Q37214176
Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolutionQ37830775
Nrf2: control of sensitivity to carcinogensQ37849195
An overview of transcriptional regulation in response to toxicological insult.Q38038498
Identification of the NF-E2-related factor-2-dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysisQ38358203
Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survivalQ38359163
A role for juvenile hormone in the prepupal development of Drosophila melanogasterQ39513143
The synthetic triterpenoids CDDO-methyl ester and CDDO-ethyl amide prevent lung cancer induced by vinyl carbamate in A/J miceQ40158424
Cap 'n' collar B cooperates with a small Maf subunit to specify pharyngeal development and suppress deformed homeotic function in the Drosophila head.Q41757128
Krüppel homolog 1 (Kr-h1) mediates juvenile hormone action during metamorphosis of Drosophila melanogasterQ41766039
Validation of the multiple sensor mechanism of the Keap1-Nrf2 systemQ41962064
How does juvenile hormone control insect metamorphosis and reproduction?Q42012655
Characterization of juvenile hormone epoxide hydrolase and related genes in the larval development of the silkworm Bombyx mori.Q42020408
Juvenile hormone epoxide hydrolase. Photoaffinity labeling, purification, and characterization from tobacco hornworm eggs.Q42069589
Tert-butylhydroquinone induces mitochondrial oxidative stress causing Nrf2 activationQ42470857
Participation of covalent modification of Keap1 in the activation of Nrf2 by tert-butylbenzoquinone, an electrophilic metabolite of butylated hydroxyanisoleQ42732652
EcR isoforms in Drosophila: testing tissue-specific requirements by targeted blockade and rescueQ44238500
A cap 'n' collar protein isoform contains a selective Hox repressor function.Q46732843
Gene expression profiles induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of C57BL/6J mice and C57BL/6J/Nrf2 (-/-) miceQ46974887
Subcellular localization and cytoplasmic complex status of endogenous Keap1.Q46976303
Dimer formation via the homeodomain is required for function and specificity of Sex combs reduced in Drosophila.Q47072425
A comparative analysis of juvenile hormone metabolyzing enzymes in two species of Drosophila during development.Q52199903
The effects of phenobarbital pretreatment on the metabolism and toxicity of paraoxon in the mouse.Q52546531
Immunostaining of whole-mount imaginal discs.Q52642615
Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: a two-site interaction model for the Nrf2-Keap1 complex.Q53616483
Pharmacogenomics of phenolic antioxidant butylated hydroxyanisole (BHA) in the small intestine and liver of Nrf2 knockout and C57BL/6J mice.Q54581515
P433issue16
P407language of work or nameEnglishQ1860
P921main subjectDrosophilaQ312154
P1104number of pages12
P304page(s)3277-3288
P577publication date2014-07-25
P1433published inDevelopmentQ3025404
P1476titleVisualization of the Drosophila dKeap1-CncC interaction on chromatin illumines cooperative, xenobiotic-specific gene activation
P478volume141

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cites work (P2860)
Q46364818Cap-n-Collar Promotes Tissue Regeneration by Regulating ROS and JNK Signaling in the Drosophila melanogaster Wing Imaginal Disc
Q41985716Dual Roles of Glutathione in Ecdysone Biosynthesis and Antioxidant Function During the Larval Development in Drosophila.
Q51731708Increasing autophagy and blocking Nrf2 suppress laminopathy-induced age-dependent cardiac dysfunction and shortened lifespan.
Q33763536Mechanisms and functions of Nrf2 signaling in Drosophila
Q92476511Regulation of position effect variegation at pericentric heterochromatin by Drosophila Keap1-Nrf2 xenobiotic response factors
Q26751266Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism
Q41241392Visualization of the Genomic Loci That Are Bound by Specific Multiprotein Complexes by Bimolecular Fluorescence Complementation Analysis on Drosophila Polytene Chromosomes
Q29248295Zinc oxide nanoparticles exhibit cytotoxicity and genotoxicity through oxidative stress responses in human lung fibroblasts and Drosophila melanogaster