Drosophila melanogaster Hox transcription factors access the RNA polymerase II machinery through direct homeodomain binding to a conserved motif of mediator subunit Med19

scientific article (publication date: May 2014)

Drosophila melanogaster Hox transcription factors access the RNA polymerase II machinery through direct homeodomain binding to a conserved motif of mediator subunit Med19 is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PGEN.1004303
P3181OpenCitations bibliographic resource ID1766192
P932PMC publication ID4006704
P698PubMed publication ID24786462
P5875ResearchGate publication ID262018333

P50authorBruno HudryQ57319582
P2093author name stringHenri-Marc Bourbon
David L Cribbs
Sandra Bernat-Fabre
Yacine Graba
Samir Merabet
Muriel Boube
Clément Immarigeon
Yannick Carrier
P2860cites workStructural relationships among genes that control development: sequence homology between the Antennapedia, Ultrabithorax, and fushi tarazu loci of DrosophilaQ24595240
Hox gene Ultrabithorax regulates distinct sets of target genes at successive stages of Drosophila haltere morphogenesisQ24620002
MED19 and MED26 are synergistic functional targets of the RE1 silencing transcription factor in epigenetic silencing of neuronal gene expressionQ24644562
Evolution of an insect-specific GROUCHO-interaction motif in the ENGRAILED selector proteinQ27487450
Functional Specificity of a Hox Protein Mediated by the Recognition of Minor Groove StructureQ27648950
Targeted gene expression as a means of altering cell fates and generating dominant phenotypesQ27861039
Mediator structural conservation and implications for the regulation mechanismQ27936934
Homeobox genes and axial patterningQ28181571
Evidence for a mediator of RNA polymerase II transcriptional regulation conserved from yeast to manQ28216498
A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase IIQ28264676
A conserved Mediator-CDK8 kinase module association regulates Mediator-RNA polymerase II interactionQ28288539
Genome-wide analysis of the binding of the Hox protein Ultrabithorax and the Hox cofactor Homothorax in DrosophilaQ28741383
Genome-wide tissue-specific occupancy of the Hox protein Ultrabithorax and Hox cofactor Homothorax in DrosophilaQ28741387
A gene complex controlling segmentation in DrosophilaQ29547506
Visualization of interactions among bZIP and Rel family proteins in living cells using bimolecular fluorescence complementationQ29616037
The developmental transcriptome of Drosophila melanogasterQ29617262
Visualization of protein interactions in living Drosophila embryos by the bimolecular fluorescence complementation assayQ30498214
Hox genes: from master genes to micromanagersQ32001271
Function and specificity of synthetic Hox transcription factors in vivo.Q33732917
The relationship between the functional complexity and the molecular organization of the Antennapedia locus of Drosophila melanogasterQ33952553
Mutations in the second-largest subunit of Drosophila RNA polymerase II interact with Ubx.Q33959739
Cytogenetic Analysis of Chromosome 3 in DROSOPHILA MELANOGASTER: The Homoeotic Gene Complex in Polytene Chromosome Interval 84a-B.Q33994021
A conserved DNA sequence in homoeotic genes of the Drosophila Antennapedia and bithorax complexesQ34255549
Homeodomain proteinsQ34326855
Ultrabithorax regulates genes at several levels of the wing-patterning hierarchy to shape the development of the Drosophila haltereQ34467941
The UBX-regulated network in the haltere imaginal disc of D. melanogaster.Q34591909
Overexpression of LCMR1 is significantly associated with clinical stage in human NSCLCQ34611184
Functional synthetic Antennapedia genes and the dual roles of YPWM motif and linker size in transcriptional activation and repressionQ35123250
Regulation of Hox activity: insights from protein motifs.Q51901164
Timing of Wingless signalling distinguishes maxillary and antennal identities in Drosophila melanogaster.Q51956200
Direct integration of Hox and segmentation gene inputs during Drosophila development.Q52086921
Evidence for a direct functional antagonism of the selector genes proboscipedia and eyeless in Drosophila head development.Q52111054
Site-specific recombination between homologous chromosomes in Drosophila.Q52448342
The pattern of campaniform sensilla on the wing and haltere of Drosophila melanogaster and several of its homeotic mutants.Q52528000
The YPWM motif links Antennapedia to the basal transcriptional machinery.Q52689753
Med19(Rox3) regulates Intermodule interactions in the Saccharomyces cerevisiae mediator complex.Q64903253
Drosophila homologs of transcriptional mediator complex subunits are required for adult cell and segment identity specificationQ35207123
The Cyc8-Tup1 complex inhibits transcription primarily by masking the activation domain of the recruiting proteinQ35624743
Variable motif utilization in homeotic selector (Hox)-cofactor complex formation controls specificityQ35641370
Distinct hox protein sequences determine specificity in different tissuesQ35669364
Mediator and the mechanism of transcriptional activationQ36129156
A genetic and developmental analysis of mutations in the Deformed locus in Drosophila melanogasterQ36431973
Comparative genomics supports a deep evolutionary origin for the large, four-module transcriptional mediator complexQ36777813
Cross-regulatory protein-protein interactions between Hox and Pax transcription factorsQ36869905
Mediator links epigenetic silencing of neuronal gene expression with x-linked mental retardationQ36975019
Shaping segments: Hox gene function in the genomic age.Q37271912
Classification of sequence signatures: a guide to Hox protein function.Q37427646
Evolution of the Hox gene complex from an evolutionary ground stateQ37570811
The role of Med19 in the proliferation and tumorigenesis of human hepatocellular carcinoma cellsQ37728861
The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulationQ37799722
Interactions between subunits of the Mediator complex with gene-specific transcription factorsQ37917031
Gene-specific transcription activation via long-range allosteric shape-shiftingQ37932011
Comparative analysis of Hox downstream genes in Drosophila.Q38306545
A genome-wide RNA interference screen identifies new regulators of androgen receptor function in prostate cancer cellsQ39195814
Med19 promotes gastric cancer progression and cellular growthQ39352335
Homeotic genes and the homeoboxQ39461605
The segmentation and homeotic gene network in early Drosophila developmentQ39464883
Suppression of MED19 expression by shRNA induces inhibition of cell proliferation and tumorigenesis in human prostate cancer cellsQ39483748
Knockdown of MED19 by short hairpin RNA-mediated gene silencing inhibits pancreatic cancer cell proliferationQ39491738
Suppression of lung cancer metastasis-related protein 1 (LCMR1) inhibits the growth of colorectal cancer cellsQ39512233
Knockdown of MED19 by lentivirus-mediated shRNA in human osteosarcoma cells inhibits cell proliferation by inducing cell cycle arrest in the G0/G1 phaseQ39548296
MED19 promotes proliferation and tumorigenesis of lung cancerQ39553019
Expression of Med19 in bladder cancer tissues and its role on bladder cancer cell growthQ39561662
Lentivirus-mediated inhibition of Med19 suppresses growth of breast cancer cells in vitroQ39648495
Dissecting the functional specificities of two Hox proteinsQ42174676
Minutes: Mutants of Drosophila autonomously affecting cell division rateQ44889355
A conserved mediator hinge revealed in the structure of the MED7.MED21 (Med7.Srb7) heterodimerQ45264869
Evolution of a transcriptional repression domain in an insect Hox proteinQ48317104
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectDrosophila melanogasterQ130888
Mediator complex subunit 19 Dmel_CG5546Q29817348
P304page(s)e1004303
P577publication date2014-05-01
P1433published inPLOS GeneticsQ1893441
P1476titleDrosophila melanogaster Hox transcription factors access the RNA polymerase II machinery through direct homeodomain binding to a conserved motif of mediator subunit Med19
P478volume10

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cites work (P2860)
Q57232451A high-throughput method to identify trans-activation domains within transcription factor sequences
Q35665874Controlled expression of Drosophila homeobox loci using the Hostile takeover system
Q33608508Controlling the Master: Chromatin Dynamics at the MYC Promoter Integrate Developmental Signaling
Q37264327Defining the essential function of FBP/KSRP proteins: Drosophila Psi interacts with the mediator complex to modulate MYC transcription and tissue growth
Q36627901Evolution of disorder in Mediator complex and its functional relevance
Q36139777Flexibility and Disorder in Gene Regulation: LacI/GalR and Hox Proteins.
Q26783539Homeodomain proteins: an update
Q92182315Hox genes: Downstream "effectors" of retinoic acid signaling in vertebrate embryogenesis
Q35359452Inhibitory activities of short linear motifs underlie Hox interactome specificity in vivo.
Q38717980Knockdown of mediator subunit Med19 suppresses bladder cancer cell proliferation and migration by downregulating Wnt/β-catenin signalling pathway
Q37213980Mechanisms of Specificity for Hox Factor Activity.
Q35857114Recruitment of Mediator Complex by Cell Type and Stage-Specific Factors Required for Tissue-Specific TAF Dependent Gene Activation in an Adult Stem Cell Lineage
Q38999725Regulatory Enhancer-Core-Promoter Communication via Transcription Factors and Cofactors.
Q38363835Roles of Hoxb5 in the development of vagal and trunk neural crest cells.
Q50571630The Brakeless co-regulator can directly activate and repress transcription in early Drosophila embryos.
Q47857382The Hox proteins Ubx and AbdA collaborate with the transcription pausing factor M1BP to regulate gene transcription
Q35305255The intrinsically disordered regions of the Drosophila melanogaster Hox protein ultrabithorax select interacting proteins based on partner topology
Q57465564Transcription factor TFIIEβ interacts with two exposed positions in helix 2 of the Antennapedia homeodomain to control homeotic function in Drosophila
Q34341268Visualization of the Drosophila dKeap1-CncC interaction on chromatin illumines cooperative, xenobiotic-specific gene activation.

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