Flexibility and Disorder in Gene Regulation: LacI/GalR and Hox Proteins.

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Flexibility and Disorder in Gene Regulation: LacI/GalR and Hox Proteins. is …
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scholarly articleQ13442814

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P356DOI10.1074/JBC.R115.685032
P932PMC publication ID4598980
P698PubMed publication ID26342073

P50authorLiskin Swint-KruseQ38318339
Sarah E BondosQ56922805
P2093author name stringKathleen S Matthews
P2860cites workProtein sliding along DNA: dynamics and structural characterizationQ82851590
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Multiple intrinsically disordered sequences alter DNA binding by the homeodomain of the Drosophila hox protein ultrabithoraxQ34782212
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The intrinsically disordered regions of the Drosophila melanogaster Hox protein ultrabithorax select interacting proteins based on partner topologyQ35305255
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Novel insights from hybrid LacI/GalR proteins: family-wide functional attributes and biologically significant variation in transcription repression.Q36422240
Allosteric transition pathways in the lactose repressor protein core domains: asymmetric motions in a homodimer.Q36631435
Fine-tuning function: correlation of hinge domain interactions with functional distinctions between LacI and PurRQ36639184
Ligand-induced conformational changes and conformational dynamics in the solution structure of the lactose repressor proteinQ36724953
Context-dependent regulation of Hox protein functions by CK2 phosphorylation sitesQ36744924
Cooperative binding of an Ultrabithorax homeodomain protein to nearby and distant DNA sitesQ36825673
Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferencesQ36865636
Intrinsic disorder in transcription factorsQ36882145
Global jumping and domain-specific intersegment transfer between DNA cognate sites of the multidomain transcription factor Oct-1.Q36893573
Extrinsic interactions dominate helical propensity in coupled binding and folding of the lactose repressor protein hinge helixQ37239949
Internal regulatory interactions determine DNA binding specificity by a Hox transcription factor.Q37337672
Tetramer opening in LacI-mediated DNA looping.Q37377277
Flexibility in the inducer binding region is crucial for allostery in the Escherichia coli lactose repressorQ37410991
Function of YY1 in Long-Distance DNA InteractionsQ37570810
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Operator DNA sequence variation enhances high affinity binding by hinge helix mutants of lactose repressor proteinQ38308180
Flexibility and adaptability in binding of E. coli cytidine repressor to different operators suggests a role in differential gene regulationQ38310524
Altering residues N125 and D149 impacts sugar effector binding and allosteric parameters in Escherichia coli lactose repressorQ38331796
Optimal DNA sequence recognition by the Ultrabithorax homeodomain of DrosophilaQ38335522
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Transcription activation by ultrabithorax Ib protein requires a predicted alpha-helical region.Q40750055
Differential mobility of the N-terminal headpiece in the lac-repressor proteinQ41022481
Engineered disulfide linking the hinge regions within lactose repressor dimer increases operator affinity, decreases sequence selectivity, and alters allosteryQ43826250
The leukemogenicity of Hoxa9 depends on alternative splicing.Q44517584
Hox transcription factor ultrabithorax Ib physically and genetically interacts with disconnected interacting protein 1, a double-stranded RNA-binding protein.Q44811165
Using networks to identify fine structural differences between functionally distinct protein statesQ45026331
Functional dissection of Ultrabithorax proteins in D. melanogaster.Q46003798
Integrated insights from simulation, experiment, and mutational analysis yield new details of LacI functionQ46651142
Phosphorylation, expression and function of the Ultrabithorax protein family in Drosophila melanogasterQ46698121
Three-stage regulation of the amphibolic gal operon: from repressosome to GalR-free DNA.Q46980938
Physical and genetic interactions link hox function with diverse transcription factors and cell signaling proteinsQ47070207
Evolution of a transcriptional repression domain in an insect Hox proteinQ48317104
Diffusion-driven mechanisms of protein translocation on nucleic acids. 1. Models and theory.Q52732418
The lac repressor displays facilitated diffusion in living cells.Q54333953
A role for the interdomain linker region of the Escherichia coli CytR regulator in repression complex formation.Q54501314
Structure and flexibility adaptation in nonspecific and specific protein-DNA complexes.Q54502915
A family of bacterial regulators homologous to Gal and Lac repressors.Q54674811
P433issue41
P407language of work or nameEnglishQ1860
P1104number of pages9
P304page(s)24669-24677
P577publication date2015-09-04
P1433published inJournal of Biological ChemistryQ867727
P1476titleFlexibility and Disorder in Gene Regulation: LacI/GalR and Hox Proteins
P478volume290

Reverse relations

cites work (P2860)
Q42289860Exploratory adaptation in large random networks
Q39018532Hox functional diversity: Novel insights from flexible motif folding and plastic protein interaction
Q47214879Lactose Repressor Hinge Domain Independently Binds DNA.
Q37213980Mechanisms of Specificity for Hox Factor Activity.
Q39427217Regulation of Metabolic Pathways by MarR Family Transcription Factors
Q38785758The herpes viral transcription factor ICP4 forms a novel DNA recognition complex
Q30398082Time, space, and disorder in the expanding proteome universe

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