| scholarly article | Q13442814 |
| P50 | author | John D. Hayes | Q38318853 |
| Michael McMahon | Q39606285 | ||
| P2093 | author name string | Masayuki Yamamoto | |
| Ken Itoh | |||
| Nerys Thomas | |||
| P2860 | cites work | Crystal structure of the BTB domain from PLZF | Q22003945 |
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| Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase | Q24529056 | ||
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| Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2 | Q24563807 | ||
| Mechanism of SMRT corepressor recruitment by the BCL6 BTB domain | Q27642845 | ||
| Mechanisms underlying ubiquitination | Q27860656 | ||
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| Homodimer of two F-box proteins betaTrCP1 or betaTrCP2 binds to IkappaBalpha for signal-dependent ubiquitination | Q28143145 | ||
| The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm | Q28216217 | ||
| Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron | Q28261724 | ||
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| Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages | Q29614557 | ||
| Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression | Q29615644 | ||
| Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer | Q29616499 | ||
| The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase | Q29616502 | ||
| Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers | Q29616503 | ||
| Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress | Q29617845 | ||
| A hitchhiker's guide to the cullin ubiquitin ligases: SCF and its kin | Q29618006 | ||
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| Beta-TrCP recognizes a previously undescribed nonphosphorylated destruction motif in Cdc25A and Cdc25B phosphatases | Q33756957 | ||
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| The many faces of beta-TrCP E3 ubiquitin ligases: reflections in the magic mirror of cancer | Q35691542 | ||
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| The BACK domain in BTB-kelch proteins. | Q35950674 | ||
| Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome | Q35974394 | ||
| Identification of the interactive interface and phylogenic conservation of the Nrf2-Keap1 system. | Q38363758 | ||
| P433 | issue | 34 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | ubiquitination | Q33059483 |
| P304 | page(s) | 24756-24768 | |
| P577 | publication date | 2006-06-21 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: a two-site interaction model for the Nrf2-Keap1 complex | |
| P478 | volume | 281 |
| Q55461978 | 2-Deoxy-D-glucose and 6-aminonicotinamide-mediated Nrf2 down regulation leads to radiosensitization of malignant cells via abrogation of GSH-mediated defense |
| Q90451937 | A Naturally-Occurring Dominant-Negative Inhibitor of Keap1 Competitively against Its Negative Regulation of Nrf2 |
| Q58701423 | A catalogue of somatic NRF2 gain-of-function mutations in cancer |
| Q39710585 | A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62. |
| Q37336872 | ALS-FTLD associated mutations of SQSTM1 impact on Keap1-Nrf2 signalling |
| Q38742679 | Absolute Amounts and Status of the Nrf2-Keap1-Cul3 Complex within Cells |
| Q28579883 | Actinfilin is a Cul3 substrate adaptor, linking GluR6 kainate receptor subunits to the ubiquitin-proteasome pathway |
| Q33707203 | Activation of NRF2 by nitrosative agents and H2O2 involves KEAP1 disulfide formation |
| Q38298598 | Activation of Nrf2-regulated glutathione pathway genes by ischemic preconditioning |
| Q55392669 | Activation of p62/SQSTM1-Keap1-Nuclear Factor Erythroid 2-Related Factor 2 Pathway in Cancer. |
| Q41592607 | Activation of the Nrf2/ARE signaling pathway by probucol contributes to inhibiting inflammation and neuronal apoptosis after spinal cord injury |
| Q24336527 | Adaptor protein self-assembly drives the control of a cullin-RING ubiquitin ligase |
| Q38207006 | Aging, immunosenescence and membrane rafts: the lipid connection |
| Q35200121 | Altered behavioral development in Nrf2 knockout mice following early postnatal exposure to valproic acid. |
| Q36994823 | Analysis of dimerization of BTB-IVR domains of Keap1 and its interaction with Cul3, by molecular modeling |
| Q26800229 | Antioxidant responses and cellular adjustments to oxidative stress |
| Q28386384 | Arsenic‐Mediated Activation of the Nrf2‐Keap1 Antioxidant Pathway |
| Q28391506 | Basic principles and emerging concepts in the redox control of transcription factors |
| Q28277430 | Bood POZ containing gene type 2 is a human counterpart of yeast Btb3p and promotes the degradation of terminal deoxynucleotidyltransferase |
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| Q33967276 | CR6-interacting factor 1 (CRIF1) regulates NF-E2-related factor 2 (NRF2) protein stability by proteasome-mediated degradation |
| Q37071189 | Cell signaling pathways involved in drug-mediated fetal hemoglobin induction: Strategies to treat sickle cell disease |
| Q37217435 | Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity. |
| Q28384232 | Cellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disorders |
| Q37359358 | Characterization of RhoBTB-dependent Cul3 ubiquitin ligase complexes--evidence for an autoregulatory mechanism |
| Q36851342 | Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1-NRF2 pathway, and not the BACH1-NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling comp |
| Q36539849 | Chemical and biological mechanisms of phytochemical activation of Nrf2 and importance in disease prevention |
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| Q92950658 | Conformational Dynamics of the HIV-Vif Protein Complex |
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| Q45921478 | Cross-talk between transcription factors AhR and Nrf2: lessons for cancer chemoprevention from dioxin. |
| Q37398830 | Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1. |
| Q21203558 | Cullin-RING ubiquitin ligases: global regulation and activation cycles |
| Q28118714 | Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection |
| Q24629359 | Cysteine-based regulation of the CUL3 adaptor protein Keap1 |
| Q37811619 | Cytochrome P450-mediated pulmonary metabolism of carcinogens: regulation and cross-talk in lung carcinogenesis |
| Q54380424 | Development of an efficient E. coli expression and purification system for a catalytically active, human Cullin3-RINGBox1 protein complex and elucidation of its quaternary structure with Keap1. |
| Q28306504 | Dietary Diacetylene Falcarindiol Induces Phase 2 Drug-Metabolizing Enzymes and Blocks Carbon Tetrachloride-Induced Hepatotoxicity in Mice through Suppression of Lipid Peroxidation |
| Q28075814 | Dietary Phytochemicals in Neuroimmunoaging: A New Therapeutic Possibility for Humans? |
| Q27647812 | Different Electrostatic Potentials Define ETGE and DLG Motifs as Hinge and Latch in Oxidative Stress Response |
| Q24646029 | Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response |
| Q28085561 | Discovery of direct inhibitors of Keap1-Nrf2 protein-protein interaction as potential therapeutic and preventive agents |
| Q28821830 | Dual NRF2 paralogs in Coho salmon and their antioxidant response element targets |
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| Q37119963 | Dual roles of Nrf2 in cancer |
| Q53821856 | Effects of mulberry leaves on production performance and the potential modulation of antioxidative status in laying hens |
| Q38869922 | Emerging role of NRF2 in chemoresistance by regulating drug-metabolizing enzymes and efflux transporters. |
| Q28396785 | Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection |
| Q39472400 | Enhanced sensitivity of A549 cells to the cytotoxic action of anticancer drugs via suppression of Nrf2 by procyanidins from Cinnamomi Cortex extract |
| Q36211986 | Epigallocatechin-3-Gallate Reduces Cytotoxic Effects Caused by Dental Monomers: A Hypothesis. |
| Q90478608 | Fibroblast Growth Factor 1 Ameliorates Diabetes-Induced Liver Injury by Reducing Cellular Stress and Restoring Autophagy |
| Q64292797 | Fruit-Derived Polyphenol Supplementation for Athlete Recovery and Performance |
| Q90212257 | Genome-Wide CRISPR Screen Reveals Autophagy Disruption as the Convergence Mechanism That Regulates the NRF2 Transcription Factor |
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| Q42702448 | Grape seed proanthocyanidins ameliorates cadmium-induced renal injury and oxidative stress in experimental rats through the up-regulation of nuclear related factor 2 and antioxidant responsive elements |
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| Q47106243 | Hydralazine induces stress resistance and extends C. elegans lifespan by activating the NRF2/SKN-1 signalling pathway. |
| Q35905381 | Hypertension-causing Mutations in Cullin3 Protein Impair RhoA Protein Ubiquitination and Augment the Association with Substrate Adaptors. |
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| Q92689773 | JNK Phosphorylates The Neh6 Domain Of Nrf2 And Downregulates Cytoprotective Genes In Acetaminophen-Induced Liver Injury |
| Q49834826 | KEAP1 and Done? Targeting the NRF2 Pathway with Sulforaphane |
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| Q39579939 | KPNA6 (Importin α7)-Mediated Nuclear Import of Keap1 Represses the Nrf2-Dependent Antioxidant Response |
| Q39523928 | Keap1 Mutations and Nrf2 Pathway Activation in Epithelial Ovarian Cancer |
| Q33734064 | Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains |
| Q30497261 | Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals |
| Q38920601 | Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants. |
| Q57753359 | Keap1-MCM3 interaction is a potential coordinator of molecular machineries of antioxidant response and genomic DNA replication in metazoa |
| Q38022427 | Keap1: One stone kills three birds Nrf2, IKKβ and Bcl-2/Bcl-xL |
| Q47279133 | Kelch-like ECH-associated protein 1 (KEAP1) differentially regulates nuclear factor erythroid-2-related factors 1 and 2 (NRF1 and NRF2). |
| Q35555898 | Kinetic analyses of Keap1-Nrf2 interaction and determination of the minimal Nrf2 peptide sequence required for Keap1 binding using surface plasmon resonance |
| Q27681060 | Kinetic, Thermodynamic, and Structural Characterizations of the Association between Nrf2-DLGex Degron and Keap1 |
| Q38955183 | MDA-7/IL-24 inhibits Nrf2-mediated antioxidant response through activation of p38 pathway and inhibition of ERK pathway involved in cancer cell apoptosis |
| Q28817936 | Macrophage Migration Inhibitory Factor as an Emerging Drug Target to Regulate Antioxidant Response Element System |
| Q34387857 | Mechanism of Cullin3 E3 Ubiquitin Ligase Dimerization |
| Q28482975 | Mechanism of chemical activation of Nrf2 |
| Q33763536 | Mechanisms and functions of Nrf2 signaling in Drosophila |
| Q28394732 | Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease |
| Q37865512 | Mechanisms of induction of cytosolic and microsomal glutathione transferase (GST) genes by xenobiotics and pro-inflammatory agents |
| Q39405227 | Metabolic switching and cell fate decisions: implications for pluripotency, reprogramming and development |
| Q53290445 | Molecular cross-talk between the NRF2/KEAP1 signaling pathway, autophagy, and apoptosis |
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| Q44138968 | Molecular evolution of Keap1. Two Keap1 molecules with distinctive intervening region structures are conserved among fish |
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| Q90244978 | NF-κB and Keap1 Interaction Represses Nrf2-Mediated Antioxidant Response in Rabbit Hemorrhagic Disease Virus Infection |
| Q106513210 | NFE2L2 binds KEAP1:NEDD8-CUL3:RBX1 |
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| Q88582817 | NRF2 and the Hallmarks of Cancer |
| Q55287213 | NRF2 regulates the glutamine transporter Slc38a3 (SNAT3) in kidney in response to metabolic acidosis. |
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| Q35763004 | Nrf2b, novel zebrafish paralog of oxidant-responsive transcription factor NF-E2-related factor 2 (NRF2). |
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| Q36745578 | Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination |
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