| scholarly article | Q13442814 |
| P356 | DOI | 10.1016/J.YEXCR.2020.112300 |
| P698 | PubMed publication ID | 32986984 |
| P50 | author | Anthony J. Asmar | Q42319805 |
| P2093 | author name string | David B Beck | |
| Achim Werner | |||
| P2860 | cites work | Characterization of Mayven, a novel actin-binding protein predominantly expressed in brain | Q22010235 |
| Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells | Q22010574 | ||
| TAK1 is a ubiquitin-dependent kinase of MKK and IKK | Q24291454 | ||
| Gigaxonin interacts with tubulin folding cofactor B and controls its degradation through the ubiquitin-proteasome pathway | Q24296695 | ||
| CUL9 mediates the functions of the 3M complex and ubiquitylates survivin to maintain genome integrity. | Q24296919 | ||
| Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling | Q24298930 | ||
| Ubiquitin-dependent regulation of COPII coat size and function | Q24305964 | ||
| The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses | Q24306576 | ||
| KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron | Q24307394 | ||
| A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells | Q24307672 | ||
| Identification of KLHL41 Mutations Implicates BTB-Kelch-Mediated Ubiquitination as an Alternate Pathway to Myofibrillar Disruption in Nemaline Myopathy | Q24309236 | ||
| Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex | Q24313604 | ||
| Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation | Q24314520 | ||
| Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation | Q24315943 | ||
| Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement | Q24318748 | ||
| Adaptor protein self-assembly drives the control of a cullin-RING ubiquitin ligase | Q24336527 | ||
| The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis | Q24336860 | ||
| Gigaxonin-controlled degradation of MAP1B light chain is critical to neuronal survival | Q24338406 | ||
| BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase | Q24558689 | ||
| Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex | Q24559743 | ||
| Biological insights from 108 schizophrenia-associated genetic loci | Q24561833 | ||
| Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2 | Q24563807 | ||
| LZTR1 is a regulator of RAS ubiquitination and signaling | Q93160063 | ||
| The ubiquitin ligase adaptor SPOP in cancer | Q93175108 | ||
| De novo variants in CUL3 are associated with global developmental delays with or without infantile spasms | Q93270527 | ||
| Posing the APC/C E3 Ubiquitin Ligase to Orchestrate Cell Division | Q93348582 | ||
| The development, patterning and evolution of neural crest cell differentiation into cartilage and bone | Q94953921 | ||
| The mutational constraint spectrum quantified from variation in 141,456 humans | Q95933932 | ||
| KCTD13 is a major driver of mirrored neuroanatomical phenotypes of the 16p11.2 copy number variant | Q36004324 | ||
| Deconjugation of Nedd8 from Cul1 Is Directly Regulated by Skp1-F-box and Substrate, and the COP9 Signalosome Inhibits Deneddylated SCF by a Noncatalytic Mechanism | Q36216079 | ||
| Ubiquitylation and cell signaling | Q36251951 | ||
| The genetic basis of a craniofacial disease provides insight into COPII coat assembly. | Q36487336 | ||
| Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism | Q36642707 | ||
| The Colossus of Ubiquitylation: Decrypting a Cellular Code | Q36660304 | ||
| Rate of de novo mutations and the importance of father's age to disease risk | Q24632353 | ||
| Microduplications of 16p11.2 are associated with schizophrenia | Q24634151 | ||
| Mutations in a BTB-Kelch protein, KLHL7, cause autosomal-dominant retinitis pigmentosa | Q24647358 | ||
| The RASopathies: developmental syndromes of Ras/MAPK pathway dysregulation | Q24655603 | ||
| Sequence and structural analysis of BTB domain proteins | Q24812693 | ||
| Building the Neuronal Microtubule Cytoskeleton | Q26801526 | ||
| Analysis of protein-coding genetic variation in 60,706 humans | Q26831376 | ||
| Building and remodelling Cullin-RING E3 ubiquitin ligases | Q27027816 | ||
| Different Electrostatic Potentials Define ETGE and DLG Motifs as Hinge and Latch in Oxidative Stress Response | Q27647812 | ||
| Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases | Q27657740 | ||
| The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation | Q27675805 | ||
| Structural Basis for Cul3 Protein Assembly with the BTB-Kelch Family of E3 Ubiquitin Ligases | Q27675990 | ||
| Kelch proteins: emerging roles in skeletal muscle development and diseases. | Q27687474 | ||
| CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP proteins to spatially restrict TIAM1-RAC1 signaling | Q27697991 | ||
| Structural Insights into KCTD Protein Assembly and Cullin3 Recognition | Q27702091 | ||
| Cullin-RING ubiquitin E3 ligase regulation by the COP9 signalosome | Q27704406 | ||
| RING domain E3 ubiquitin ligases | Q27860546 | ||
| Mechanisms underlying ubiquitination | Q27860656 | ||
| A role for Saccharomyces cerevisiae Cul8 ubiquitin ligase in proper anaphase progression | Q27931729 | ||
| Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation | Q28115944 | ||
| Function and regulation of cullin-RING ubiquitin ligases | Q28131707 | ||
| Synaptic, transcriptional and chromatin genes disrupted in autism | Q28250800 | ||
| Association between microdeletion and microduplication at 16p11.2 and autism | Q28264205 | ||
| The ubiquitin code | Q28265104 | ||
| Non-invasive genetic diagnosis of male infertility using spermatozoal RNA: KLHL10 mutations in oligozoospermic patients impair homodimerization | Q28268874 | ||
| Positional cloning of a gene involved in the pathogenesis of Treacher Collins syndrome. The Treacher Collins Syndrome Collaborative Group | Q28273395 | ||
| Mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with aggressive outbursts, seizures, relative macrocephaly, central obesity, hypogonadism, pes cavus, and tremor | Q28284058 | ||
| Mutation in CUL4B, which encodes a member of cullin-RING ubiquitin ligase complex, causes X-linked mental retardation | Q28286574 | ||
| The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation | Q28302850 | ||
| The gene encoding gigaxonin, a new member of the cytoskeletal BTB/kelch repeat family, is mutated in giant axonal neuropathy | Q28506382 | ||
| Haploinsufficiency of kelch-like protein homolog 10 causes infertility in male mice | Q28509955 | ||
| Interactions between CAP70 and actinfilin are important for integrity of actin cytoskeleton structures in neurons | Q28570199 | ||
| Actinfilin is a Cul3 substrate adaptor, linking GluR6 kainate receptor subunits to the ubiquitin-proteasome pathway | Q28579883 | ||
| Giant axonal neuropathy-associated gigaxonin mutations impair intermediate filament protein degradation | Q36793478 | ||
| Cand1 promotes assembly of new SCF complexes through dynamic exchange of F box proteins | Q36850952 | ||
| Shared genetic contribution to Ischaemic Stroke and Alzheimer's Disease | Q36895476 | ||
| Structural and kinetic analysis of the COP9-Signalosome activation and the cullin-RING ubiquitin ligase deneddylation cycle | Q36932100 | ||
| REN(KCTD11) is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma | Q36987393 | ||
| Structural Basis for a Reciprocal Regulation between SCF and CSN | Q36988986 | ||
| Mutations in KLHL40 are a frequent cause of severe autosomal-recessive nemaline myopathy | Q37010363 | ||
| Higher-order oligomerization promotes localization of SPOP to liquid nuclear speckles | Q37011857 | ||
| The origins of medulloblastoma subtypes | Q37014819 | ||
| Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation | Q37101488 | ||
| Gigaxonin controls vimentin organization through a tubulin chaperone-independent pathway | Q37147147 | ||
| The emerging family of CULLIN3-RING ubiquitin ligases (CRL3s): cellular functions and disease implications. | Q37163747 | ||
| Mechanisms and function of substrate recruitment by F-box proteins. | Q37307464 | ||
| Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase | Q37482039 | ||
| Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution | Q37830775 | ||
| Mechanisms Regulating Protein Localization. | Q38546818 | ||
| Glycosylation of KEAP1 links nutrient sensing to redox stress signaling. | Q38664878 | ||
| Degradation of the Intermediate Filament Family by Gigaxonin | Q38700422 | ||
| The increasing complexity of the ubiquitin code | Q38845500 | ||
| CAND1 exchange factor promotes Keap1 integration into cullin 3-RING ubiquitin ligase during adipogenesis | Q38848466 | ||
| Bacurd1/Kctd13 and Bacurd2/Tnfaip1 are interacting partners to Rnd proteins which influence the long-term positioning and dendritic maturation of cerebral cortical neurons. | Q38952332 | ||
| Biomolecular condensates: organizers of cellular biochemistry | Q39146409 | ||
| Pathogenic variants in KCTD7 perturb neuronal K+ fluxes and glutamine transport. | Q39289781 | ||
| Ubiquitin-Dependent Regulation of Stem Cell Biology. | Q39320843 | ||
| Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation | Q39750898 | ||
| A dominant-negative form of the E3 ubiquitin ligase Cullin-1 disrupts the correct allocation of cell fate in the neural crest lineage | Q40333381 | ||
| BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. | Q40633677 | ||
| Spatiotemporal 16p11.2 protein network implicates cortical late mid-fetal brain development and KCTD13-Cul3-RhoA pathway in psychiatric diseases | Q42164701 | ||
| Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases | Q42694183 | ||
| Cytoskeletal regulation by the Nedd8 ubiquitin-like protein modification pathway | Q43888176 | ||
| Xenopus BTBD6 and its Drosophila homologue lute are required for neuronal development | Q43980915 | ||
| Ubiquitylation at the crossroads of development and disease. | Q44379396 | ||
| Trade-off and flexibility in the dynamic regulation of the cullin-RING ubiquitin ligase repertoire. | Q46004261 | ||
| The whole-genome landscape of medulloblastoma subtypes | Q46567834 | ||
| Kctd13 deletion reduces synaptic transmission via increased RhoA. | Q47035966 | ||
| The BTB protein MEL-26 is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase. | Q47069071 | ||
| A Krebs Cycle Component Limits Caspase Activation Rate through Mitochondrial Surface Restriction of CRL Activation | Q47071529 | ||
| Hedgehog antagonist REN(KCTD11) regulates proliferation and apoptosis of developing granule cell progenitors | Q28589954 | ||
| A SPOPL/Cullin-3 ubiquitin ligase complex regulates endocytic trafficking by targeting EPS15 at endosomes | Q28834146 | ||
| Stabilizing mutations of KLHL24 ubiquitin ligase cause loss of keratin 14 and human skin fragility | Q28975757 | ||
| Cell-fate determination by ubiquitin-dependent regulation of translation | Q28975777 | ||
| Regulation of the CUL3 Ubiquitin Ligase by a Calcium-Dependent Co-adaptor | Q28975781 | ||
| Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations | Q29030218 | ||
| A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein | Q29547884 | ||
| The role of the Rho GTPases in neuronal development | Q29616295 | ||
| Building ubiquitin chains: E2 enzymes at work | Q29619578 | ||
| Process elongation of oligodendrocytes is promoted by the Kelch-related actin-binding protein Mayven | Q30160315 | ||
| Intermediate filament aggregates cause mitochondrial dysmotility and increase energy demands in giant axonal neuropathy | Q30826535 | ||
| A ubiquitin ligase complex regulates caspase activation during sperm differentiation in Drosophila | Q33299579 | ||
| A feedback loop mediated by degradation of an inhibitor is required to initiate neuronal differentiation | Q33594150 | ||
| ATP5H/KCTD2 locus is associated with Alzheimer's disease risk. | Q33652534 | ||
| Identification and characterization of KCASH2 and KCASH3, 2 novel Cullin3 adaptors suppressing histone deacetylase and Hedgehog activity in medulloblastoma. | Q33864635 | ||
| Whole exome sequencing reveals inherited and de novo variants in autism spectrum disorder: a trio study from Saudi families | Q33916084 | ||
| Roles of Wnt proteins in neural development and maintenance | Q33941597 | ||
| Next-generation sequencing identifies rare variants associated with Noonan syndrome | Q34025431 | ||
| Giant axonal neuropathy (GAN): case report and two novel mutations in the gigaxonin gene | Q34125035 | ||
| Mutations in genes encoding subunits of RNA polymerases I and III cause Treacher Collins syndrome. | Q34153403 | ||
| Genetics of craniofacial development and malformation | Q34271559 | ||
| A compound heterozygous missense mutation and a large deletion in the KCTD7 gene presenting as an opsoclonus-myoclonus ataxia-like syndrome | Q34277615 | ||
| A homozygous mutation in KCTD7 links neuronal ceroid lipofuscinosis to the ubiquitin-proteasome system. | Q34285108 | ||
| Dominant mutations in KBTBD13, a member of the BTB/Kelch family, cause nemaline myopathy with cores | Q34381793 | ||
| Dynamics of Cullin-RING Ubiquitin Ligase Network Revealed by Systematic Quantitative Proteomics | Q34433677 | ||
| Identification of mutations in CUL7 in 3-M syndrome | Q34448386 | ||
| Cranio-lenticulo-sutural dysplasia is caused by a SEC23A mutation leading to abnormal endoplasmic-reticulum-to-Golgi trafficking | Q34566704 | ||
| Structural assembly of cullin-RING ubiquitin ligase complexes | Q34762436 | ||
| Sensory-motor deficits and neurofilament disorganization in gigaxonin-null mice | Q34980848 | ||
| Establishing neural crest identity: a gene regulatory recipe | Q34999153 | ||
| Tcof1/Treacle is required for neural crest cell formation and proliferation deficiencies that cause craniofacial abnormalities | Q35011856 | ||
| PDZ-RhoGEF ubiquitination by Cullin3-KLHL20 controls neurotrophin-induced neurite outgrowth | Q35047461 | ||
| When ubiquitin meets ubiquitin receptors: a signalling connection | Q35141760 | ||
| Copy number variants and infantile spasms: evidence for abnormalities in ventral forebrain development and pathways of synaptic function | Q35591685 | ||
| Bacurd2 is a novel interacting partner to Rnd2 which controls radial migration within the developing mammalian cerebral cortex | Q35610329 | ||
| SCF ubiquitin ligases in the maintenance of genome stability | Q35754115 | ||
| Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities | Q35754537 | ||
| Caspase Activity and a Specific Cytochrome C Are Required for Sperm Differentiation in Drosophila | Q47071601 | ||
| Large-scale discovery of novel genetic causes of developmental disorders | Q47073693 | ||
| Secretory COPII coat component Sec23a is essential for craniofacial chondrocyte maturation | Q47073852 | ||
| Cullin 3-Based Ubiquitin Ligases as Master Regulators of Mammalian Cell Differentiation. | Q47284253 | ||
| Ubiquitin signaling and autophagy | Q47349935 | ||
| Composition and Regulation of the Cellular Repertoire of SCF Ubiquitin Ligases | Q47380507 | ||
| Functional analysis of Cullin 3 E3 ligases in tumorigenesis. | Q47413250 | ||
| Liquid phase condensation in cell physiology and disease | Q47649585 | ||
| Process elongation of oligodendrocytes is promoted by the Kelch-related protein MRP2/KLHL1. | Q48260498 | ||
| KCTD2, an adaptor of Cullin3 E3 ubiquitin ligase, suppresses gliomagenesis by destabilizing c-Myc | Q48369262 | ||
| Enc1 expression in the chick telencephalon at intermediate and late stages of development. | Q48435489 | ||
| MAPK and PI3K Signaling: at the Crossroads of Neural Crest Development. | Q49905672 | ||
| PARC and CUL7 form atypical cullin RING ligase complexes | Q50336204 | ||
| Targeting of protein ubiquitination by BTB–Cullin 3–Roc1 ubiquitin ligases | Q50337002 | ||
| Autosomal recessive Noonan syndrome associated with biallelic LZTR1 variants | Q50422342 | ||
| Cand1-Mediated Adaptive Exchange Mechanism Enables Variation in F-Box Protein Expression. | Q52729296 | ||
| ENC1 Modulates the Aggregation and Neurotoxicity of Mutant Huntingtin Through p62 Under ER Stress | Q53253751 | ||
| Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: a two-site interaction model for the Nrf2-Keap1 complex | Q53616483 | ||
| Rare variants in SOS2 and LZTR1 are associated with Noonan syndrome | Q54283112 | ||
| A novel mutation in the GAN gene causes an intermediate form of giant axonal neuropathy in an Arab-Israeli family. | Q55056967 | ||
| Multisite dependency of an E3 ligase controls monoubiquitylation-dependent cell fate decisions | Q56535619 | ||
| Cancer Mutations of the Tumor Suppressor SPOP Disrupt the Formation of Active, Phase-Separated Compartments | Q57029699 | ||
| KCTD7 deficiency defines a distinct neurodegenerative disorder with a conserved autophagy-lysosome defect | Q57180375 | ||
| Principles of Ubiquitin-Dependent Signaling | Q57183203 | ||
| Correction: A Genome-Wide Investigation of SNPs and CNVs in Schizophrenia | Q57323037 | ||
| Dimerization quality control ensures neuronal development and survival | Q59957053 | ||
| Breaking the chains: deubiquitylating enzyme specificity begets function | Q63384377 | ||
| Dominant Noonan syndrome-causing LZTR1 mutations specifically affect the kelch domain substrate-recognition surface and enhance RAS-MAPK signaling | Q64042419 | ||
| Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction | Q64104255 | ||
| SPOP Promotes Nanog Destruction to Suppress Stem Cell Traits and Prostate Cancer Progression. | Q64947175 | ||
| Intermediate filament aggregation in fibroblasts of giant axonal neuropathy patients is aggravated in non dividing cells and by microtubule destabilization | Q73199659 | ||
| BTB/POZ domain proteins are putative substrate adaptors for cullin 3 ubiquitin ligases | Q79120285 | ||
| Heterogeneity and specialized functions of translation machinery: from genes to organisms | Q88562596 | ||
| Two novel mutations in the GAN gene causing giant axonal neuropathy | Q89017640 | ||
| Harnessing the Power of Proteolysis for Targeted Protein Inactivation | Q89467856 | ||
| NEDD8 nucleates a multivalent cullin-RING-UBE2D ubiquitin ligation assembly | Q89686909 | ||
| Sonic Hedgehog repression underlies gigaxonin mutation-induced motor deficits in giant axonal neuropathy | Q90020755 | ||
| Cullin 3, a cellular scripter of the non-proteolytic ubiquitin code | Q90758988 | ||
| CUL3 Deficiency Causes Social Deficits and Anxiety-like Behaviors by Impairing Excitation-Inhibition Balance through the Promotion of Cap-Dependent Translation | Q91522928 | ||
| PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling | Q92040867 | ||
| Enzymatic Logic of Ubiquitin Chain Assembly | Q92105561 | ||
| LZTR1 facilitates polyubiquitination and degradation of RAS-GTPases | Q92134766 | ||
| RIT1 oncoproteins escape LZTR1-mediated proteolysis | Q92370778 | ||
| Assembly and Regulation of CRL Ubiquitin Ligases | Q92390116 | ||
| De Novo Missense Variants in FBXW11 Cause Diverse Developmental Phenotypes Including Brain, Eye, and Digit Anomalies | Q92550947 | ||
| Gigaxonin glycosylation regulates intermediate filament turnover and may impact giant axonal neuropathy etiology or treatment | Q92682038 | ||
| Proteolysis-Targeting Chimeras as Therapeutics and Tools for Biological Discovery | Q92755207 | ||
| PIKES Analysis Reveals Response to Degraders and Key Regulatory Mechanisms of the CRL4 Network | Q92886985 | ||
| Behavioral, circuitry, and molecular aberrations by region-specific deficiency of the high-risk autism gene Cul3 | Q92914169 | ||
| Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination | Q93160013 | ||
| P304 | page(s) | 112300 | |
| P577 | publication date | 2020-09-25 | |
| P1433 | published in | Experimental Cell Research | Q1524289 |
| P1476 | title | Control of craniofacial and brain development by Cullin3-RING ubiquitin ligases: Lessons from human disease genetics |
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