Breaking the chains: deubiquitylating enzyme specificity begets function

scientific article published on 01 June 2019

Breaking the chains: deubiquitylating enzyme specificity begets function is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1111977419
P356DOI10.1038/S41580-019-0099-1
P698PubMed publication ID30733604

P50authorDavid KomanderQ28050888
Michael J. ClagueQ37834266
P2093author name stringSylvie Urbé
P2860cites workRecruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene inductionQ22001513
Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65Q24292901
The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesisQ24293633
OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitinQ24294696
The mechanism of linkage-specific ubiquitin chain elongation by a single-subunit E2Q24294888
Ubiquitin-specific protease-like 1 (USPL1) is a SUMO isopeptidase with essential, non-catalytic functionsQ24295247
Regulation of cell cycle progression and gene expression by H2A deubiquitinationQ24296401
Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1Q24296739
OTULIN restricts Met1-linked ubiquitination to control innate immune signalingQ24296844
OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysisQ24297538
SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosisQ24298626
RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signalingQ24298746
The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagyQ24298748
Human USP3 is a chromatin modifier required for S phase progression and genome stabilityQ24299488
De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signallingQ24299573
A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomesQ24304237
Relative structural and functional roles of multiple deubiquitylating proteins associated with mammalian 26S proteasomeQ24305134
Solution structure of the Ubp-M BUZ domain, a highly specific protein module that recognizes the C-terminal tail of free ubiquitinQ24306397
Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes.Q52347232
A family of unconventional deubiquitinases with modular chain specificity determinants.Q52373689
Uch2/Uch37 is the major deubiquitinating enzyme associated with the 26S proteasome in fission yeastQ52561129
ZUFSP Deubiquitylates K63-Linked Polyubiquitin Chains to Promote Genome Stability.Q52632783
Deubiquitylases USP5 and USP13 are recruited to and regulate heat-induced stress granules through their deubiquitylating activitiesQ52641849
Pseudo-DUBs as allosteric activators and molecular scaffolds of protein complexesQ52803388
Structural Basis for the Activation and Inhibition of the UCH37 Deubiquitylase.Q54618551
Dual role of USP30 in controlling basal pexophagy and mitophagy.Q55518582
The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate ImmunityQ57334872
OTULIN limits cell death and inflammation by deubiquitinating LUBACQ58215556
Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topologyQ58215681
Active site alanine mutations convert deubiquitinases into high-affinity ubiquitin-binding proteinsQ58375318
Expansion of DUB functionality generated by alternative isoforms - USP35, a case studyQ63979689
The Differential Modulation of USP Activity by Internal Regulatory Domains, Interactors and Eight Ubiquitin Chain TypesQ64166837
L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damageQ64389662
Proteolysis: from the lysosome to ubiquitin and the proteasomeQ81354981
Ubiquitin-specific protease 2 as a tool for quantification of total ubiquitin levels in biological specimensQ83212169
Suppression of LUBAC-mediated linear ubiquitination by a specific interaction between LUBAC and the deubiquitinases CYLD and OTULINQ87160378
CHMP1B is a target of USP8/UBPY regulated by ubiquitin during endocytosisQ89196972
Cezanne/OTUD7B is a cell cycle-regulated deubiquitinase that antagonizes the degradation of APC/C substratesQ89421745
Epidithiodiketopiperazines Inhibit Protein Degradation by Targeting Proteasome Deubiquitinase Rpn11Q91145771
Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockadeQ91737916
The ubiquitin isopeptidase UBPY regulates endosomal ubiquitin dynamics and is essential for receptor down-regulationQ24306674
Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUBQ24309403
Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysisQ24310659
USP22, an hSAGA subunit and potential cancer stem cell marker, reverses the polycomb-catalyzed ubiquitylation of histone H2AQ24311562
The ER-resident ubiquitin-specific protease 19 participates in the UPR and rescues ERAD substratesQ24313484
USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondriaQ24316174
Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chainsQ24316967
Isoform-specific localization of the deubiquitinase USP33 to the Golgi apparatusQ24317741
The structure of the CYLD USP domain explains its specificity for Lys63-linked polyubiquitin and reveals a B box moduleQ24319910
Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complexQ24323042
UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exitQ24324253
USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110Q24329195
Mutations in STAMBP, encoding a deubiquitinating enzyme, cause microcephaly-capillary malformation syndromeQ24337654
A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulationQ24337802
The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradationQ24337922
Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase CezanneQ24338586
Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient miceQ24616207
USP7 counteracts SCFbetaTrCP- but not APCCdh1-mediated proteolysis of ClaspinQ24652867
AMSH is an endosome-associated ubiquitin isopeptidaseQ24676880
Ubiquitin modificationsQ26751380
Role of Deubiquitinating Enzymes in DNA RepairQ26773800
The role of ubiquitylation in immune defence and pathogen evasionQ26860775
Structure of the A20 OTU domain and mechanistic insights into deubiquitinationQ27648895
Structural basis for specific cleavage of Lys 63-linked polyubiquitin chainsQ27651870
Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activationQ27654230
K11-linked polyubiquitination in cell cycle control revealed by a K11 linkage-specific antibodyQ27663589
Engineered diubiquitin synthesis reveals Lys29-isopeptide specificity of an OTU deubiquitinaseQ27664221
Length of the active-site crossover loop defines the substrate specificity of ubiquitin C-terminal hydrolases for ubiquitin chainsQ27671821
Mechanism of USP7/HAUSP activation by its C-terminal ubiquitin-like domain and allosteric regulation by GMP-synthetaseQ27674789
OTUB1 Co-opts Lys48-Linked Ubiquitin Recognition to Suppress E2 Enzyme FunctionQ27677192
The mechanism of OTUB1-mediated inhibition of ubiquitinationQ27677504
Crystal structure of the proteasomal deubiquitylation module Rpn8-Rpn11Q27681666
Molecular Basis and Regulation of OTULIN-LUBAC InteractionQ27683237
Insights into the Mechanism of Deubiquitination by JAMM Deubiquitinases from Cocrystal Structures of the Enzyme with the Substrate and ProductQ27683606
Structure of the Rpn11-Rpn8 dimer reveals mechanisms of substrate deubiquitination during proteasomal degradationQ27688973
Binding of OTULIN to the PUB domain of HOIP controls NF-κB signalingQ27690030
Cullin-RING ubiquitin E3 ligase regulation by the COP9 signalosomeQ27704406
Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase CezanneQ27728466
UBP43 (USP18) Specifically Removes ISG15 from Conjugated ProteinsQ27863712
A conserved deubiquitinating enzyme controls cell growth by regulating RNA polymerase I stability.Q27931751
MINDY-1 Is a Member of an Evolutionarily Conserved and Structurally Distinct New Family of Deubiquitinating Enzymes.Q27934744
Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasomeQ27937927
A cryptic protease couples deubiquitination and degradation by the proteasomeQ27938068
The ubiquitin binding domain ZnF UBP recognizes the C-terminal diglycine motif of unanchored ubiquitinQ27939113
CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune SignalingQ28117541
A BRISC-SHMT complex deubiquitinates IFNAR1 and regulates interferon responsesQ28118033
The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and AutoimmunityQ28118489
Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domainQ28119149
Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory diseaseQ28119173
Breaking the chains: structure and function of the deubiquitinasesQ28131738
Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chainQ28142613
Identification of the familial cylindromatosis tumour-suppressor geneQ28145560
CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family membersQ28201693
Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaBQ28201706
The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitinationQ28201717
The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutationQ28207617
The ubiquitin codeQ28265104
Conformational switching of the 26S proteasome enables substrate degradationQ28292908
Editing of ubiquitin conjugates by an isopeptidase in the 26S proteasomeQ28303702
Systematic survey of deubiquitinase localization identifies USP21 as a regulator of centrosome- and microtubule-associated functionsQ28575853
Mechanism and regulation of the Lys6-selective deubiquitinase USP30.Q47748385
Structural basis for specific cleavage of Lys6-linked polyubiquitin chains by USP30.Q47748414
Dual regulation of Fbw7 function and oncogenic transformation by Usp28.Q47831783
Receptor oligomerization guides pathway choice between proteasomal and autophagic degradation.Q48144486
Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-κB and restricts bacterial proliferationQ48178189
Discovery and characterization of highly potent and selective allosteric USP7 inhibitorsQ48188572
Human BRCA1-BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resectionQ48219281
Deubiquitylating enzymes and drug discovery: emerging opportunities.Q48265884
The K48-K63 Branched Ubiquitin Chain Regulates NF-κB SignalingQ48964297
USP48 restrains resection by site-specific cleavage of the BRCA1 ubiquitin mark from H2A.Q49185754
K63 ubiquitylation triggers proteasomal degradation by seeding branched ubiquitin chainsQ49596652
Building and decoding ubiquitin chains for mitophagyQ49864965
OTUD4 Is a Phospho-Activated K63 Deubiquitinase that Regulates MyD88-Dependent Signaling.Q50209863
HOIP deficiency causes embryonic lethality by aberrant TNFR1-mediated endothelial cell deathQ50630569
RNF8- and Ube2S-Dependent Ubiquitin Lysine 11-Linkage Modification in Response to DNA DamageQ50635296
A20 and CYLD do not share significant overlapping functions during B cell development and activationQ50783685
Recognition of Client Proteins by the Proteasome.Q51096331
LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesisQ52309452
Targeting HAUSP in both p53 wildtype and p53-mutant tumorsQ52332504
Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome StabilityQ52342572
Quantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis.Q34622632
USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkinQ34815182
Ubiquitin acetylation inhibits polyubiquitin chain elongationQ35084540
Impaired regulation of NF-kappaB and increased susceptibility to colitis-associated tumorigenesis in CYLD-deficient miceQ35099711
Recurrent gain-of-function USP8 mutations in Cushing's diseaseQ35146226
Screening of DUB activity and specificity by MALDI-TOF mass spectrometryQ35232335
Protein standard absolute quantification (PSAQ) method for the measurement of cellular ubiquitin poolsQ35381570
Substrate degradation by the proteasome: a single-molecule kinetic analysisQ35670301
Ubiquitin-specific protease 14 modulates degradation of cellular prion proteinQ35710420
Cross-species DNA copy number analyses identifies multiple 1q21-q23 subtype-specific driver genes for breast cancerQ35816299
Deubiquitinating enzymes regulate PARK2-mediated mitophagyQ35853250
Rpn1 provides adjacent receptor sites for substrate binding and deubiquitination by the proteasomeQ35935216
Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaksQ36095690
Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responsesQ36229402
A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistanceQ36338365
Atomic structure of the 26S proteasome lid reveals the mechanism of deubiquitinase inhibition.Q36568548
Prion-mediated neurodegeneration is associated with early impairment of the ubiquitin-proteasome systemQ36578308
Endocytosis: the DUB versionQ36601432
USP14 deubiquitinates proteasome-bound substrates that are ubiquitinated at multiple sitesQ36834923
Structural basis for histone H2B deubiquitination by the SAGA DUB module.Q36892380
The SAGA Deubiquitination Module Promotes DNA Repair and Class Switch Recombination through ATM and DNAPK-Mediated γH2AX Formation.Q36955793
Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chainsQ37191956
Lysine 63-linked polyubiquitination is required for EGF receptor degradationQ37203860
The ubiquitin specific protease USP34 promotes ubiquitin signaling at DNA double-strand breaksQ37224708
HAUSP deubiquitinates and stabilizes N-Myc in neuroblastomaQ37387937
A role for the Cajal-body-associated SUMO isopeptidase USPL1 in snRNA transcription mediated by RNA polymerase II.Q37608722
Ubiquitin: Same Molecule, Different Degradation PathwaysQ37812727
Selectivity of the ubiquitin-binding modulesQ38008504
Governance of Endocytic Trafficking and Signaling by Reversible UbiquitylationQ38043227
Deubiquitylases from genes to organismQ38125278
A20 in inflammation and autoimmunityQ38163677
Writing and reading H2B monoubiquitylationQ38177592
USP19 deubiquitinating enzyme supports cell proliferation by stabilizing KPC1, a ubiquitin ligase for p27Kip1Q28583199
Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signalingQ28588278
Regulation of T cell development by the deubiquitinating enzyme CYLDQ28588773
USP51 deubiquitylates H2AK13,15ub and regulates DNA damage responseQ28596573
A single MIU motif of MINDY-1 recognizes K48-linked polyubiquitin chainsQ28910344
53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin markQ29465773
The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responsesQ29616349
Enhancement of proteasome activity by a small-molecule inhibitor of USP14Q29616735
The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathwayQ29616746
PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activityQ29617292
p53 ubiquitination: Mdm2 and beyondQ29619502
Activation of the endosome-associated ubiquitin isopeptidase AMSH by STAM, a component of the multivesicular body-sorting machineryQ30159944
Near-atomic resolution structural model of the yeast 26S proteasome.Q30524942
Enhanced protein degradation by branched ubiquitin chains.Q33637926
Specificity of the BRISC deubiquitinating enzyme is not due to selective binding to Lys63-linked polyubiquitinQ33796008
Stabilization of the transcription factor Foxp3 by the deubiquitinase USP7 increases Treg-cell-suppressive capacity.Q34049065
Generation and physiological roles of linear ubiquitin chainsQ34197025
Germline BAP1 mutation predisposes to uveal melanoma, lung adenocarcinoma, meningioma, and other cancersQ34218657
The BAP1/ASXL2 Histone H2A Deubiquitinase Complex Regulates Cell Proliferation and Is Disrupted in CancerQ34496129
The demographics of the ubiquitin systemQ38439051
Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activityQ38576138
The X-linked deubiquitinase USP9X is an integral component of centrosomeQ38700147
Evaluation and Design of Genome-Wide CRISPR/SpCas9 Knockout Screens.Q38706202
SPATA2 promotes CYLD activity and regulates TNF-induced NF-κB signaling and cell death.Q38755803
SPATA2 links CYLD to the TNF-α receptor signaling complex and modulates the receptor signaling outcomesQ38764224
BAP1/ASXL1 recruitment and activation for H2A deubiquitination.Q38806099
LUBAC-Recruited CYLD and A20 Regulate Gene Activation and Cell Death by Exerting Opposing Effects on Linear Ubiquitin in Signaling ComplexesQ38811648
A mechanism for the suppression of homologous recombination in G1 cellsQ38813207
The increasing complexity of the ubiquitin codeQ38845500
USP30 deubiquitylates mitochondrial Parkin substrates and restricts apoptotic cell deathQ38903534
Systematic characterization of deubiquitylating enzymes for roles in maintaining genome integrityQ38959150
Integration of cellular ubiquitin and membrane traffic systems: focus on deubiquitylasesQ39074161
Mechanisms of Deubiquitinase Specificity and Regulation.Q39302629
Molecular Basis for K63-Linked Ubiquitination Processes in Double-Strand DNA Break Repair: A Focus on Kinetics and Dynamics.Q39355026
SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC SignalingQ39426341
Regulation of homologous recombination by RNF20-dependent H2B ubiquitination.Q39583815
Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survivalQ39761203
The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML networkQ39948774
The deubiquitinating enzyme ataxin-3, a polyglutamine disease protein, edits Lys63 linkages in mixed linkage ubiquitin chains.Q39965496
Rapid turnover of the histone-ubiquitin conjugate, protein A24Q40499161
Quantitative Proteomic Atlas of Ubiquitination and Acetylation in the DNA Damage Response.Q40861699
SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling ComplexesQ41001480
Deubiquitinase-based analysis of ubiquitin chain architecture using Ubiquitin Chain Restriction (UbiCRest).Q41015604
Dimerization and ubiquitin mediated recruitment of A20, a complex deubiquitinating enzyme.Q41112588
Mechanism of UCH-L5 activation and inhibition by DEUBAD domains in RPN13 and INO80G.Q41375336
Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.Q41546924
Mutations in the deubiquitinase gene USP8 cause Cushing's diseaseQ41716700
Global, quantitative and dynamic mapping of protein subcellular localizationQ41783695
Phosphorylation and linear ubiquitin direct A20 inhibition of inflammationQ41791638
Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage.Q41792409
Regulation of mitochondrial morphology by USP30, a deubiquitinating enzyme present in the mitochondrial outer membraneQ42070422
The deubiquitinase activity of A20 is dispensable for NF-κB signaling.Q42076015
Synthesis of Isomeric Phosphoubiquitin Chains Reveals that Phosphorylation Controls Deubiquitinase Activity and Specificity.Q42264412
Deubiquitinating enzyme CYLD regulates the peripheral development and naive phenotype maintenance of B cellsQ42510282
A common ancestry for BAP1 and Uch37 regulatorsQ42650941
Regulation of ubiquitin chain initiation to control the timing of substrate degradation.Q42778545
An AAA Motor-Driven Mechanical Switch in Rpn11 Controls Deubiquitination at the 26S ProteasomeQ43891282
Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle and Protein Quality ControlQ46325087
USP7 small-molecule inhibitors interfere with ubiquitin bindingQ46429336
Zinc-finger UBPs: regulators of deubiquitylationQ46728959
Structures of CYLD USP with Met1- or Lys63-linked diubiquitin reveal mechanisms for dual specificity.Q47073950
Meddling with Fate: The Proteasomal Deubiquitinating EnzymesQ47292178
PICKLES: the database of pooled in-vitro CRISPR knockout library essentiality screens.Q47595090
Structure-Guided Development of a Potent and Selective Non-covalent Active-Site Inhibitor of USP7.Q47619828
Computational correction of copy number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells.Q47627028
Molecular basis of USP7 inhibition by selective small-molecule inhibitorsQ47633676
P2507corrigendum / erratumPublisher Correction: Breaking the chains: deubiquitylating enzyme specificity begets functionQ63384374
P433issue6
P304page(s)338-352
P577publication date2019-06-01
P1433published inNature Reviews Molecular Cell BiologyQ1573120
P1476titleBreaking the chains: deubiquitylating enzyme specificity begets function
P478volume20

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cites work (P2860)
Q90040846A new gene inventory of the ubiquitin and ubiquitin-like conjugation pathways in Giardia intestinalis
Q89675763ALIX- and ESCRT-III-dependent sorting of tetraspanins to exosomes
Q107563258Biochemical characterization of protease activity of Nsp3 from SARS-CoV-2 and its inhibition by nanobodies
Q90482784CDK4/6 inhibition blocks cancer metastasis through a USP51-ZEB1-dependent deubiquitination mechanism
Q90363481Cellular Functions of OCT-3/4 Regulated by Ubiquitination in Proliferating Cells
Q89676635Comparison of Cross-Regulation by Different OTUB1:E2 Complexes
Q90293202Comprehensive Landscape of Active Deubiquitinating Enzymes Profiled by Advanced Chemoproteomics
Q100311434Control of craniofacial and brain development by Cullin3-RING ubiquitin ligases: Lessons from human disease genetics
Q104581362Crosstalk between Ubiquitination and Other Post-translational Protein Modifications in Plant Immunity
Q90088711Deubiquitinases: Pro-oncogenic Activity and Therapeutic Targeting in Blood Malignancies
Q91576425Deubiquitinating enzymes (DUBs): DoUBle-edged swords in CNS autoimmunity
Q89940813Development of a DUB-selective fluorogenic substrate
Q90575977Dissenting degradation: Deubiquitinases in cell cycle and cancer
Q92131201Dual role of a GTPase conformational switch for membrane fusion by mitofusin ubiquitylation
Q92972669Dynamic Regulation of the 26S Proteasome: From Synthesis to Degradation
Q92105561Enzymatic Logic of Ubiquitin Chain Assembly
Q100762265Equilibrium between nascent and parental MCM proteins protects replicating genomes
Q101166887High-throughput matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry-based deubiquitylating enzyme assay for drug discovery
Q96127623Insights into catalysis and regulation of non-canonical ubiquitination and deubiquitination by bacterial deamidase effectors
Q132730853Key roles of ubiquitination in regulating critical regulators of cancer stem cell functionality
Q94547397Mitochondrial Quality Control Governed by Ubiquitin
Q64915831Mitofusins: Disease Gatekeepers and Hubs in Mitochondrial Quality Control by E3 Ligases.
Q83227308Negative regulation of autophagy by UBA6-BIRC6-mediated ubiquitination of LC3
Q90776305OTULIN protects the liver against cell death, inflammation, fibrosis, and cancer
Q92641626Oxygen-dependent asparagine hydroxylation of the ubiquitin-associated (UBA) domain in Cezanne regulates ubiquitin binding
Q100946558Quality control of the mitochondrial proteome
Q92542607Recent Developments in Cell Permeable Deubiquitinating Enzyme Activity-Based Probes
Q90505741Small molecules that target the ubiquitin system
Q90180949Strategy for Development of Site-Specific Ubiquitin Antibodies
Q96303690The Beginning of the End: Initial Steps in the Degradation of Plasma Membrane Proteins
Q64064610The Deubiquitylase USP4 Interacts with the Water Channel AQP2 to Modulate Its Apical Membrane Accumulation and Cellular Abundance
Q93196147The deubiquitylase USP2 maintains ErbB2 abundance via counteracting endocytic degradation and represents a therapeutic target in ErbB2-positive breast cancer
Q64288182The role of ubiquitin-specific peptidases in cancer progression
Q90627210UBP12 and UBP13 negatively regulate the activity of the ubiquitin-dependent peptidases DA1, DAR1 and DAR2
Q90162112UL36 Encoded by Marek's Disease Virus Exhibits Linkage-Specific Deubiquitinase Activity
Q90029108USP16 counteracts mono-ubiquitination of RPS27a and promotes maturation of the 40S ribosomal subunit
Q99616615USP29 enhances chemotherapy-induced stemness in non-small cell lung cancer via stabilizing Snail1 in response to oxidative stress
Q93188561USP44 suppresses pancreatic cancer progression and overcomes gemcitabine resistance by deubiquitinating FBP1
Q104111361Ubiquitin-dependent and -independent functions of OTULIN in cell fate control and beyond
Q92038158Ubiquitin-specific protease 8 (USP8/UBPy): a prototypic multidomain deubiquitinating enzyme with pleiotropic functions
Q91940275Writing and erasing MYC ubiquitination and SUMOylation

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