A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes

scientific article

A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/SJ.EMBOJ.7601338
P3181OpenCitations bibliographic resource ID3626776
P932PMC publication ID1589993
P698PubMed publication ID16990800
P5875ResearchGate publication ID6803358

P50authorShigeo MurataQ55186538
P2093author name stringJun Hamazaki
Keiji Tanaka
Shun-Ichiro Iemura
Tohru Natsume
Hideki Yashiroda
P2860cites workIdentification of two proteins, S14 and UIP1, that interact with UCH37Q24290789
The ubiquitin-proteasome proteolytic pathway: destruction for the sake of constructionQ24292709
A heterodimeric complex that promotes the assembly of mammalian 20S proteasomesQ24292874
Molecular cloning and characterization of the complementary DNA of an M(r) 110,000 antigen expressed by human gastric carcinoma cells and upregulated by gamma-interferonQ24313931
Structure and functions of the 20S and 26S proteasomesQ24328777
Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysisQ27860815
A comprehensive two-hybrid analysis to explore the yeast protein interactomeQ27861093
Multiple associated proteins regulate proteasome structure and functionQ27931244
Proteasomal proteomics: identification of nucleotide-sensitive proteasome-interacting proteins by mass spectrometric analysis of affinity-purified proteasomesQ27931576
An integrated mass spectrometry-based proteomic approach: quantitative analysis of tandem affinity-purified in vivo cross-linked protein complexes (QTAX) to decipher the 26 S proteasome-interacting network.Q27933467
Multiubiquitin chain receptors define a layer of substrate selectivity in the ubiquitin-proteasome systemQ27935666
A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and eIF3.Q27936509
Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasomeQ27937927
A cryptic protease couples deubiquitination and degradation by the proteasomeQ27938068
Complementary roles for Rpn11 and Ubp6 in deubiquitination and proteolysis by the proteasomeQ27939996
Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuliQ28116145
Homodimer of two F-box proteins betaTrCP1 or betaTrCP2 binds to IkappaBalpha for signal-dependent ubiquitinationQ28143145
Editing of ubiquitin conjugates by an isopeptidase in the 26S proteasomeQ28303702
Impairment of starvation-induced and constitutive autophagy in Atg7-deficient miceQ28588080
The proteasome: paradigm of a self-compartmentalizing proteaseQ29615187
Functional cloning of ARM-1, an adhesion-regulating molecule upregulated in metastatic tumor cellsQ30891488
Abnormally high expression of proteasomes in human leukemic cellsQ33790428
ATP binding to PAN or the 26S ATPases causes association with the 20S proteasome, gate opening, and translocation of unfolded proteins.Q33991996
Adhesion properties of adhesion-regulating molecule 1 protein on endothelial cellsQ34409988
Adrm1, a putative cell adhesion regulating protein, is a novel proteasome-associated factor.Q34543753
The regulatory complex of Drosophila melanogaster 26S proteasomes. Subunit composition and localization of a deubiquitylating enzymeQ36342543
Ornithine decarboxylase is degraded by the 26S proteasome without ubiquitinationQ41589996
CHIP is a chaperone-dependent E3 ligase that ubiquitylates unfolded proteinQ41776375
Xoom is maternally stored and functions as a transmembrane protein for gastrulation movement in Xenopus embryosQ43517073
Influence of proline residues on protein conformationQ47638868
Loss of Usp14 results in reduced levels of ubiquitin in ataxia miceQ48763744
Uch2/Uch37 is the major deubiquitinating enzyme associated with the 26S proteasome in fission yeast.Q52561129
Identification of a novel tumor-associated Mr 110,000 gene product in human gastric carcinoma cells that is immunologically related to carcinoembryonic antigenQ68003950
KEKE motifs. Proposed roles in protein-protein association and presentation of peptides by MHC class I receptorsQ72067211
Identification of a 26S proteasome-associated UCH in fission yeastQ73937075
A direct nanoflow liquid chromatography-tandem mass spectrometry system for interaction proteomicsQ78287803
P433issue19
P407language of work or nameEnglishQ1860
P921main subjectendopeptidase activator activityQ21108542
Proteasome 26S subunit, non-ATPase 4Q21111228
Adhesion regulating molecule 1Q21111230
P304page(s)4524-4536
P577publication date2006-09-21
P1433published inThe EMBO JournalQ1278554
P1476titleA novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes
P478volume25

Reverse relations

cites work (P2860)
Q35806570A High Affinity hRpn2-Derived Peptide That Displaces Human Rpn13 from Proteasome in 293T Cells
Q24294383A Protein Interaction Network for Ecm29 Links the 26 S Proteasome to Molecular Motors and Endosomal Components
Q37435436A bis-benzylidine piperidone targeting proteasome ubiquitin receptor RPN13/ADRM1 as a therapy for cancer
Q33691600A global census of fission yeast deubiquitinating enzyme localization and interaction networks reveals distinct compartmentalization profiles and overlapping functions in endocytosis and polarity
Q37148352A proteasome assembly defect in rpn3 mutants is associated with Rpn11 instability and increased sensitivity to stress
Q53038879ADRM1 gene amplification is a candidate driver for metastatic gastric cancers.
Q38866440ADRM1-amplified metastasis gene in gastric cancer
Q92376431Acute unfolding of a single protein immediately stimulates recruitment of ubiquitin protein ligase E3C (UBE3C) to 26S proteasomes
Q37210700Affinity purification strategy to capture human endogenous proteasome complexes diversity and to identify proteasome-interacting proteins.
Q36656050Amplification Target ADRM1: Role as an Oncogene and Therapeutic Target for Ovarian Cancer.
Q90239219An Extended Conformation for K48 Ubiquitin Chains Revealed by the hRpn2:Rpn13:K48-Diubiquitin Structure
Q24599005An emerging model for BAP1's role in regulating cell cycle progression
Q24316277Assembly pathway of the Mammalian proteasome base subcomplex is mediated by multiple specific chaperones
Q24329078Association of C-terminal ubiquitin hydrolase BRCA1-associated protein 1 with cell cycle regulator host cell factor 1
Q28238443Autoregulation of the 26S proteasome by in situ ubiquitination
Q43240834Binding of SGTA to Rpn13 selectively modulates protein quality control
Q63384377Breaking the chains: deubiquitylating enzyme specificity begets function
Q81323469Cell biology: two hands for degradation
Q28477341Characterisation of the Trichinella spiralis deubiquitinating enzyme, TsUCH37, an evolutionarily conserved proteasome interaction partner
Q42614153Characterization and tissue expression of channel catfish (Ictalurus punctatus Rafinesque, 1818) ubiquitin carboxyl-terminal hydrolase L5 (UCHL5) cDNA.
Q37076872Characterization of Dynamic UbR-Proteasome Subcomplexes by In vivo Cross-linking (X) Assisted Bimolecular Tandem Affinity Purification (XBAP) and Label-free Quantitation
Q39145596Characterization of the testis-specific proteasome subunit α4s in mammals
Q36572619Compensatory increase in USP14 activity accompanies impaired proteasomal proteolysis during aging
Q28257212Complete subunit architecture of the proteasome regulatory particle
Q46147511Comprehensive analysis of 20q13 genes in ovarian cancer identifies ADRM1 as amplification target
Q28292908Conformational switching of the 26S proteasome enables substrate degradation
Q37734102Conservation and developmental expression of ubiquitin isopeptidases in Schistosoma mansoni
Q57063488Covalent Rpn13-Binding Inhibitors for the Treatment of Ovarian Cancer
Q27675008Crystal structure of the catalytic domain of UCHL5, a proteasome-associated human deubiquitinating enzyme, reveals an unproductive form of the enzyme
Q53749111Detection of the first gross CDC73 germline deletion in an HPT-JT syndrome family.
Q36502572Deubiquitinating enzyme BAP1 is involved in the formation and maintenance of the diapause embryos of Artemia
Q57163862Discovering proteasomal deubiquitinating enzyme inhibitors for cancer therapy: lessons from rational design, nature and old drug reposition
Q24323042Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex
Q64074440Dynamic Regulation of Proteasome Expression
Q92972669Dynamic Regulation of the 26S Proteasome: From Synthesis to Degradation
Q41291592Early and consistent overexpression of ADRM1 in ovarian high-grade serous carcinoma.
Q38237803Emerging mechanistic insights into AAA complexes regulating proteasomal degradation
Q29616735Enhancement of proteasome activity by a small-molecule inhibitor of USP14
Q37719492Entropic stabilization of a deubiquitinase provides conformational plasticity and slow unfolding kinetics beneficial for functioning on the proteasome
Q90736751Estrogen Receptors and Ubiquitin Proteasome System: Mutual Regulation
Q88888766Exploring the autoinhibitory domain of the electrogenic Na+ /HCO3- transporter NBCe1-B, from residues 28 to 62
Q55056162Expression and clinical significance of UCH37 in human esophageal squamous cell carcinoma.
Q26996345Functions of the 19S complex in proteasomal degradation
Q35862786Gates, Channels, and Switches: Elements of the Proteasome Machine
Q43179672Genetic evidence linking age-dependent attenuation of the 26S proteasome with the aging process
Q39904574High-content functional screen to identify proteins that correct F508del-CFTR function
Q64247702Identification of differentially expressed proteins in the injured lung from zinc chloride smoke inhalation based on proteomics analysis
Q34398136Inherent asymmetry in the 26S proteasome is defined by the ubiquitin receptor RPN13
Q39571518Knockdown of ovarian cancer amplification target ADRM1 leads to downregulation of GIPC1 and upregulation of RECK.
Q27671821Length of the active-site crossover loop defines the substrate specificity of ubiquitin C-terminal hydrolases for ubiquitin chains
Q28256624Localization of the proteasomal ubiquitin receptors Rpn10 and Rpn13 by electron cryomicroscopy
Q34478411MTMDAT-HADDOCK: high-throughput, protein complex structure modeling based on limited proteolysis and mass spectrometry
Q36455723Mapping the structural topology of the yeast 19S proteasomal regulatory particle using chemical cross-linking and probabilistic modeling
Q41375336Mechanism of UCH-L5 activation and inhibition by DEUBAD domains in RPN13 and INO80G.
Q27683490Mechanism of the Rpn13-induced activation of Uch37
Q47292178Meddling with Fate: The Proteasomal Deubiquitinating Enzymes
Q28259014Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach
Q34928594Molecular mechanisms of proteasome assembly
Q57804762Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1
Q37566975Multitasking with ubiquitin through multivalent interactions
Q35721961Muscle Segment Homeobox Genes Direct Embryonic Diapause by Limiting Inflammation in the Uterus
Q89982710NRF3-POMP-20S proteasome assembly axis promotes cancer development via ubiquitin-independent proteolysis of p53 and Rb
Q28586356PAC1 gene knockout reveals an essential role of chaperone-mediated 20S proteasome biogenesis and latent 20S proteasomes in cellular homeostasis
Q50562538Performance of ZDOCK and IRAD in CAPRI rounds 28-34.
Q91902748Perturbation of ubiquitin homeostasis promotes macrophage oxidative defenses
Q39614537Phospho-ΔNp63α/Rpn13-dependent regulation of LKB1 degradation modulates autophagy in cancer cells
Q34438764Phosphorylated TP63 Induces Transcription of RPN13, Leading to NOS2 Protein Degradation
Q37401250Polyubiquitin binding and disassembly by deubiquitinating enzymes
Q38741389Polyubiquitin-Photoactivatable Crosslinking Reagents for Mapping Ubiquitin Interactome Identify Rpn1 as a Proteasome Ubiquitin-Associating Subunit
Q27650664Proteasome subunit Rpn13 is a novel ubiquitin receptor
Q47161331Proteasome-associated deubiquitinases and cancer
Q37431978Proteomics reveals a physical and functional link between hepatocyte nuclear factor 4alpha and transcription factor IID.
Q37912201Proteomics to study the diversity and dynamics of proteasome complexes: from fundamentals to the clinic.
Q30818805Purification, crystallization and preliminary X-ray data collection of the N-terminal domain of the 26S proteasome regulatory subunit p27 and its complex with the ATPase domain of Rpt5 from Mus musculus
Q29547616Recognition and processing of ubiquitin-protein conjugates by the proteasome
Q37406494Reconstitution of the 26S proteasome reveals functional asymmetries in its AAA+ unfoldase
Q35723276Redundant Roles of Rpn10 and Rpn13 in Recognition of Ubiquitinated Proteins and Cellular Homeostasis.
Q24645701Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes
Q36283686Regulation of E2 promoter binding factor 1 (E2F1) transcriptional activity through a deubiquitinating enzyme, UCH37.
Q30496086Regulation of NF-kappaB activity and inducible nitric oxide synthase by regulatory particle non-ATPase subunit 13 (Rpn13).
Q38120938Regulation of proteolysis by human deubiquitinating enzymes
Q28505259Regulators of the proteasome pathway, Uch37 and Rpn13, play distinct roles in mouse development
Q24305134Relative structural and functional roles of multiple deubiquitylating proteins associated with mammalian 26S proteasome
Q28259286Rpn1 and Rpn2 coordinate ubiquitin processing factors at proteasome
Q36176652Rpn10-mediated degradation of ubiquitinated proteins is essential for mouse development
Q27936724Rpn13p and Rpn14p are involved in the recognition of ubiquitinated Gcn4p by the 26S proteasome
Q35898247Sirt1-deficiency causes defective protein quality control
Q34419828Slipping up: partial substrate degradation by ATP-dependent proteases
Q57804600Specific modification of aged proteasomes revealed by tag-exchangeable knock-in mice
Q27677566Stabilization of an Unusual Salt Bridge in Ubiquitin by the Extra C-Terminal Domain of the Proteasome-Associated Deubiquitinase UCH37 as a Mechanism of Its Exo Specificity
Q35163646Structural basis for the activation and inhibition of the UCH37 deubiquitylase
Q38081952Structural biology of the proteasome
Q27674550Structural characterization of human Uch37
Q38557562Structural disorder and its role in proteasomal degradation
Q37396451Structural insights into proteasome activation by the 19S regulatory particle
Q52322457Structure and Function of the 26S Proteasome.
Q51035419Structure and energetics of pairwise interactions between proteasome subunits RPN2, RPN13, and ubiquitin clarify a substrate recruitment mechanism.
Q27691353Structure characterization of the 26S proteasome
Q90207565Structure of E3 ligase E6AP with a proteasome-binding site provided by substrate receptor hRpn10
Q27661655Structure of Proteasome Ubiquitin Receptor hRpn13 and Its Activation by the Scaffolding Protein hRpn2
Q61727849Structure of hRpn10 Bound to UBQLN2 UBL Illustrates Basis for Complementarity between Shuttle Factors and Substrates at the Proteasome
Q33862782Structure of the Rpn13-Rpn2 complex provides insights for Rpn13 and Uch37 as anticancer targets
Q27657027Structure of the S5a:K48-Linked Diubiquitin Complex and Its Interactions with Rpn13
Q42382149Structures of Rpn1 T1:Rad23 and hRpn13:hPLIC2 Reveal Distinct Binding Mechanisms between Substrate Receptors and Shuttle Factors of the Proteasome
Q38959150Systematic characterization of deubiquitylating enzymes for roles in maintaining genome integrity
Q34496129The BAP1/ASXL2 Histone H2A Deubiquitinase Complex Regulates Cell Proliferation and Is Disrupted in Cancer
Q35199357The E3 ubiquitin ligase parkin is recruited to the 26 S proteasome via the proteasomal ubiquitin receptor Rpn13
Q36884720The Proteasome Ubiquitin Receptor hRpn13 and Its Interacting Deubiquitinating Enzyme Uch37 Are Required for Proper Cell Cycle Progression
Q39213276The Ubiquitin Receptor ADRM1 Modulates HAP40-Induced Proteasome Activity.
Q38122985The complexity of recognition of ubiquitinated substrates by the 26S proteasome
Q26738549The life cycle of the 26S proteasome: from birth, through regulation and function, and onto its death
Q37467606The lysine 48 and lysine 63 ubiquitin conjugates are processed differently by the 26 s proteasome
Q92932075The proteasome 19S cap and its ubiquitin receptors provide a versatile recognition platform for substrates
Q95650650The proteasome as a druggable target with multiple therapeutic potentialities: Cutting and non-cutting edges
Q36472495The proteasome: overview of structure and functions
Q36844591The spatial and temporal organization of ubiquitin networks
Q57301712Transcriptional regulation of the 26S proteasome by Nrf1
Q47328929UCHL5 expression associates with improved survival in lymph-node-positive rectal cancer
Q37642658Ubiquitin C-terminal hydrolase37 regulates Tcf7 DNA binding for the activation of Wnt signalling
Q37239897Ubiquitin carboxyl-terminal hydrolase-L5 promotes TGFβ-1 signaling by de-ubiquitinating and stabilizing Smad2/Smad3 in pulmonary fibrosis
Q42821759Ubiquitin chain trimming recycles the substrate binding sites of the 26 S proteasome and promotes degradation of lysine 48-linked polyubiquitin conjugates
Q27650666Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction
Q29614829Ubiquitin-binding domains - from structures to functions
Q36685213Ubiquitinated proteins activate the proteasomal ATPases by binding to Usp14 or Uch37 homologs
Q41915219Ubiquitinated proteins activate the proteasome by binding to Usp14/Ubp6, which causes 20S gate opening
Q98564449Unveiling the immunomodulatory properties of Haemonchus contortus adhesion regulating molecule 1 interacting with goat T cells
Q34680335VWA domain of S5a restricts the ability to bind ubiquitin and Ubl to the 26S proteasome
Q33739902Viable mouse gene ablations that robustly alter brain Aβ levels are rare
Q39447209hRpn13, a newly identified component of the 19S particle, regulates proliferation, differentiation, and function in the human osteoblast-like cell line MG63. [corrected].
Q24321826hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the deubiquitinating enzyme, UCH37
Q48279984pyDock scoring for the new modeling challenges in docking: Protein-peptide, homo-multimers, and domain-domain interactions

Search more.