Structural biology of the proteasome

scientific article published on 13 February 2013

Structural biology of the proteasome is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1146/ANNUREV-BIOPHYS-083012-130417
P932PMC publication ID4878838
P698PubMed publication ID23414347

P2093author name stringChristopher P Hill
Erik Kish-Trier
P2860cites workAn unstructured initiation site is required for efficient proteasome-mediated degradationQ45018402
RPN-6 determines C. elegans longevity under proteotoxic stress conditionsQ46942610
Chaperone-assisted assembly of the proteasome core particleQ47838223
A conserved processing mechanism regulates the activity of transcription factors Cubitus interruptus and NF-κBQ57851826
Quantitative dynamics and binding studies of the 20S proteasome by NMRQ59082478
Specificity of the ubiquitin isopeptidase in the PA700 regulatory complex of 26 S proteasomesQ73836181
ATP-induced structural transitions in PAN, the proteasome-regulatory ATPase complex in ArchaeaQ80441084
A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomesQ24304237
The crystal structure of the human Mov34 MPN domain reveals a metal-free dimerQ24309182
hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the deubiquitinating enzyme, UCH37Q24321826
Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14Q24537053
Mechanism of gate opening in the 20S proteasome by the proteasomal ATPasesQ24564109
Docking of the proteasomal ATPases' carboxyl termini in the 20S proteasome's alpha ring opens the gate for substrate entryQ24674433
Structural basis for the activation of 20S proteasomes by 11S regulatorsQ27628418
The structure of the mammalian 20S proteasome at 2.75 A resolutionQ27638997
DNA-repair protein hHR23a alters its protein structure upon binding proteasomal subunit S5aQ27642353
Crystal structures of the Rhodococcus proteasome with and without its pro-peptides: implications for the role of the pro-peptide in proteasome assemblyQ27642721
Structure of the oncoprotein gankyrin in complex with S6 ATPase of the 26S proteasomeQ27643792
Interactions of PAN's C-termini with archaeal 20S proteasome and implications for the eukaryotic proteasome–ATPase interactionsQ27646619
Crystal structure of a chaperone complex that contributes to the assembly of yeast 20S proteasomesQ27649865
Proteasome subunit Rpn13 is a novel ubiquitin receptorQ27650664
Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interactionQ27650666
Structural basis for specific cleavage of Lys 63-linked polyubiquitin chainsQ27651870
Structure and activity of the N-terminal substrate recognition domains in proteasomal ATPasesQ27655687
Structural Insights into the Regulatory Particle of the Proteasome from Methanocaldococcus jannaschiiQ27655690
Structure of the S5a:K48-Linked Diubiquitin Complex and Its Interactions with Rpn13Q27657027
Inhibitors selective for mycobacterial versus human proteasomesQ27657451
Structural Insights on the Mycobacterium tuberculosis Proteasomal ATPase MpaQ27657813
Running in Reverse: The Structural Basis for Translocation Polarity in Hexameric HelicasesQ27658029
Structural Models for Interactions between the 20S Proteasome and Its PAN/19S ActivatorsQ27658058
Structures of asymmetric ClpX hexamers reveal nucleotide-dependent motions in a AAA+ protein-unfolding machineQ27658178
Structure of a Blm10 Complex Reveals Common Mechanisms for Proteasome Binding and Gate OpeningQ27660222
Crystal Structure of Yeast Rpn14, a Chaperone of the 19 S Regulatory Particle of the ProteasomeQ27660259
Dynamic regulation of archaeal proteasome gate opening as studied by TROSY NMRQ27660397
Structural basis for the assembly and gate closure mechanisms of the Mycobacterium tuberculosis 20S proteasomeQ27661499
Structure of Proteasome Ubiquitin Receptor hRpn13 and Its Activation by the Scaffolding Protein hRpn2Q27661655
Structure of Rpn10 and Its Interactions with Polyubiquitin Chains and the Proteasome Subunit Rpn12Q27664179
Binding-induced folding of prokaryotic ubiquitin-like protein on the Mycobacterium proteasomal ATPase targets substrates for degradationQ27665108
Structural and functional characterization of Rpn12 identifies residues required for Rpn10 proteasome incorporationQ27671597
Structure of a Proteasome Pba1-Pba2 Complex: IMPLICATIONS FOR PROTEASOME ASSEMBLY, ACTIVATION, AND BIOLOGICAL FUNCTIONQ27671782
Structural characterization of human Uch37Q27674550
The proteasomal subunit Rpn6 is a molecular clamp holding the core and regulatory subcomplexes togetherQ27676340
Structural Basis for Specific Recognition of Rpt1p, an ATPase Subunit of 26 S Proteasome, by Proteasome-dedicated Chaperone Hsm3pQ27677277
Immuno- and constitutive proteasome crystal structures reveal differences in substrate and inhibitor specificityQ27677313
The structure of the 26S proteasome subunit Rpn2 reveals its PC repeat domain as a closed toroid of two concentric α-helical ringsQ27677964
Dual functions of the Hsm3 protein in chaperoning and scaffolding regulatory particle subunits during the proteasome assemblyQ27678263
Crystal structure of the 20S proteasome from the archaeon T. acidophilum at 3.4 A resolutionQ27730197
Structure of 20S proteasome from yeast at 2.4 A resolutionQ27735081
Structure of the proteasome activator REGalpha (PA28alpha)Q27748362
Proteasome subunit Rpn1 binds ubiquitin-like protein domainsQ27930136
An atomic model AAA-ATPase/20S core particle sub-complex of the 26S proteasomeQ37407311
Proteasome activatorsQ37826501
The role of the proteasome in the generation of MHC class I ligands and immune responsesQ37851052
Proteasome activator 200: the heat is on...Q37851267
Inhibitors for the immuno- and constitutive proteasome: current and future trends in drug developmentQ38019864
Mechanism of DNA translocation in a replicative hexameric helicaseQ38311331
TROSY-based NMR evidence for a novel class of 20S proteasome inhibitorsQ39973916
Ubiquitin-independent degradation of cell-cycle inhibitors by the REGgamma proteasomeQ40115986
Ubiquitin- and ATP-independent proteolytic turnover of p21 by the REGgamma-proteasome pathwayQ40115992
Heterohexameric ring arrangement of the eukaryotic proteasomal ATPases: implications for proteasome structure and assembly.Q40836221
Mechanism of substrate unfolding and translocation by the regulatory particle of the proteasome from Methanocaldococcus jannaschiiQ41297845
Molecular model of the human 26S proteasomeQ41613713
Solution NMR spectroscopy of supra-molecular systems, why bother? A methyl-TROSY viewQ41616060
Identification of the Cdc48•20S proteasome as an ancient AAA+ proteolytic machine.Q41953180
ATP binds to proteasomal ATPases in pairs with distinct functional effects, implying an ordered reaction cycleQ42156125
Proteasome substrate degradation requires association plus extended peptideQ42208073
ATP-dependent steps in the binding of ubiquitin conjugates to the 26S proteasome that commit to degradationQ42600957
Isolation of mammalian 26S proteasomes and p97/VCP complexes using the ubiquitin-like domain from HHR23B reveals novel proteasome-associated proteinsQ42930872
The proteasome antechamber maintains substrates in an unfolded stateQ44216424
ATP hydrolysis by the proteasome regulatory complex PAN serves multiple functions in protein degradationQ44283109
Multiple associated proteins regulate proteasome structure and functionQ27931244
Blm10 protein promotes proteasomal substrate turnover by an active gating mechanismQ27931319
Proteasomal proteomics: identification of nucleotide-sensitive proteasome-interacting proteins by mass spectrometric analysis of affinity-purified proteasomesQ27931576
Deubiquitinating enzyme Ubp6 functions noncatalytically to delay proteasomal degradation.Q27932109
Substrate selection by the proteasome during degradation of protein complexesQ27932156
A multimeric assembly factor controls the formation of alternative 20S proteasomesQ27933912
A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and eIF3.Q27936509
The HEAT repeat protein Blm10 regulates the yeast proteasome by capping the core particleQ27938094
An asymmetric interface between the regulatory and core particles of the proteasomeQ28251784
Localization of the proteasomal ubiquitin receptors Rpn10 and Rpn13 by electron cryomicroscopyQ28256624
Complete subunit architecture of the proteasome regulatory particleQ28257212
Molecular architecture of the 26S proteasome holocomplex determined by an integrative approachQ28259014
Rpn1 and Rpn2 coordinate ubiquitin processing factors at proteasomeQ28259286
Editing of ubiquitin conjugates by an isopeptidase in the 26S proteasomeQ28303702
Recognition and processing of ubiquitin-protein conjugates by the proteasomeQ29547616
Enhancement of proteasome activity by a small-molecule inhibitor of USP14Q29616735
Evolutionary relationships and structural mechanisms of AAA+ proteinsQ29617454
Structure of the 26S proteasome from Schizosaccharomyces pombe at subnanometer resolutionQ30497623
Near-atomic resolution structural model of the yeast 26S proteasome.Q30524942
Components of the ubiquitin-proteasome pathway compete for surfaces on Rad23 family proteinsQ33317408
Taking a bite: proteasomal protein processingQ33958918
The 1.9 A structure of a proteasome-11S activator complex and implications for proteasome-PAN/PA700 interactions.Q33987362
Proteasome assembly triggers a switch required for active-site maturation.Q33997684
Conformational constraints in protein degradation by the 20S proteasomeQ34058982
Defining the geometry of the two-component proteasome degronQ34161503
Structure of the Blm10-20 S proteasome complex by cryo-electron microscopy. Insights into the mechanism of activation of mature yeast proteasomes.Q34307472
Proteasome from Thermoplasma acidophilum: a threonine proteaseQ34309062
Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1.Q34556881
A conserved 20S proteasome assembly factor requires a C-terminal HbYX motif for proteasomal precursor bindingQ34928089
Molecular mechanisms of proteasome assemblyQ34928594
Mobilizing the proteolytic machine: cell biological roles of proteasome activators and inhibitorsQ36010873
The pore of activated 20S proteasomes has an ordered 7-fold symmetric conformationQ36065854
Assembly manual for the proteasome regulatory particle: the first draftQ36200349
Endoproteolytic activity of the proteasomeQ36450745
P921main subjectstructural biologyQ908902
P304page(s)29-49
P577publication date2013-02-13
P1433published inAnnual Review of BiophysicsQ4034062
P1476titleStructural biology of the proteasome
P478volume42

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