Inhibition of 19S proteasome-associated deubiquitinases by metal-containing compounds

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Inhibition of 19S proteasome-associated deubiquitinases by metal-containing compounds is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.18632/ONCOSCIENCE.167
P932PMC publication ID4468331
P698PubMed publication ID26097878
P5875ResearchGate publication ID280032444

P2093author name stringJinbao Liu
Hongbiao Huang
Ningning Liu
Q. Ping Dou
P2860cites workThe ubiquitin-proteasome proteolytic pathway: destruction for the sake of constructionQ24292709
Relative structural and functional roles of multiple deubiquitylating proteins associated with mammalian 26S proteasomeQ24305134
The ubiquitin-specific protease USP28 is required for MYC stabilityQ24308568
Suppression of cancer cell growth by promoting cyclin D1 degradationQ24317660
Deubiquitination of Dishevelled by Usp14 is required for Wnt signalingQ24318750
Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient miceQ24616207
Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymesQ24645701
The thioxotriazole copper(II) complex A0 induces endoplasmic reticulum stress and paraptotic death in human cancer cellsQ24651419
Functions of the 19S complex in proteasomal degradationQ26996345
Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interactionQ27650666
Structure of Proteasome Ubiquitin Receptor hRpn13 and Its Activation by the Scaffolding Protein hRpn2Q27661655
Deubiquitinating enzyme Ubp6 functions noncatalytically to delay proteasomal degradation.Q27932109
A cryptic protease couples deubiquitination and degradation by the proteasomeQ27938068
Breaking the chains: structure and function of the deubiquitinasesQ28131738
Identification of the familial cylindromatosis tumour-suppressor geneQ28145560
Gold compounds as therapeutic agents for human diseasesQ28243207
Auranofin displays anticancer activity against ovarian cancer cells through FOXO3 activation independent of p53Q28245322
The history of gold therapy for tuberculosisQ28249467
MiR-4782-3p inhibited non-small cell lung cancer growth via USP14.Q51110014
Cu(II) binding to monomeric, oligomeric, and fibrillar forms of the Alzheimer's disease amyloid-beta peptide.Q53293533
Sanggenon C decreases tumor cell viability associated with proteasome inhibitionQ95811372
The JAMM motif of human deubiquitinase Poh1 is essential for cell viabilityQ28284132
The 19 S proteasomal subunit POH1 contributes to the regulation of c-Jun ubiquitination, stability, and subcellular localizationQ28304241
A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14Q28359750
Over-expression of deubiquitinating enzyme USP14 in lung adenocarcinoma promotes proliferation through the accumulation of β-cateninQ28385613
A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistanceQ28395203
Antiviral activity of a small molecule deubiquitinase inhibitor occurs via induction of the unfolded protein responseQ28481001
Enhancement of proteasome activity by a small-molecule inhibitor of USP14Q29616735
The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathwayQ29616746
The 26S proteasome: a molecular machine designed for controlled proteolysisQ29619692
A mutation linked to retinitis pigmentosa in HPRP31 causes protein instability and impairs its interactions with spliceosomal snRNPs.Q30375617
Regulation of NF-kappaB activity and inducible nitric oxide synthase by regulatory particle non-ATPase subunit 13 (Rpn13).Q30496086
Gold(III) compounds as new family of anticancer drugs.Q31150569
Organic copper complexes as a new class of proteasome inhibitors and apoptosis inducers in human cancer cellsQ33199028
Copper-triggered aggregation of ubiquitinQ33503629
A novel proteasome inhibitor suppresses tumor growth via targeting both 19S proteasome deubiquitinases and 20S proteolytic peptidasesQ33729793
Effect of ubiquitin carboxy-terminal hydrolase 37 on apoptotic in A549 cellsQ33810416
A small-molecule inhibitor of deubiquitinating enzyme USP14 inhibits Dengue virus replicationQ34150998
A novel copper complex induces paraptosis in colon cancer cells via the activation of ER stress signallingQ34169479
Clinically used antirheumatic agent auranofin is a proteasomal deubiquitinase inhibitor and inhibits tumor growthQ34221890
Auranofin induces lethal oxidative and endoplasmic reticulum stress and exerts potent preclinical activity against chronic lymphocytic leukemiaQ34231446
MCP-induced protein 1 deubiquitinates TRAF proteins and negatively regulates JNK and NF-kappaB signalingQ34420804
The deubiquitinating enzyme UCH37 interacts with Smads and regulates TGF-beta signallingQ34435000
Ubiquitin C-terminal Hydrolase 37, a novel predictor for hepatocellular carcinoma recurrence, promotes cell migration and invasion via interacting and deubiquitinating PRP19.Q34503527
Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1.Q34556881
Ubiquitin-aldehyde: a general inhibitor of ubiquitin-recycling processesQ34607942
Anti-rheumatic agent auranofin induced apoptosis in chronic myeloid leukemia cells resistant to imatinib through both Bcr/Abl-dependent and -independent mechanismsQ34619261
KEAP1-dependent synthetic lethality induced by AKT and TXNRD1 inhibitors in lung cancerQ34793532
Trimming of Ubiquitin Chains by Proteasome-associated Deubiquitinating EnzymesQ34994389
Gold(III)-dithiocarbamato peptidomimetics in the forefront of the targeted anticancer therapy: preclinical studies against human breast neoplasia.Q35083349
USP14 inhibitor IU1 prevents ventilator-induced lung injury in rats.Q35242436
Iminophosphorane-organogold(III) complexes induce cell death through mitochondrial ROS productionQ35446994
Ubiquitin homeostasis is critical for synaptic development and functionQ35659611
A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistanceQ36338365
Usp14 deficiency increases tau phosphorylation without altering tau degradation or causing tau-dependent deficitsQ36354014
Copper in medicine: homeostasis, chelation therapy and antitumor drug designQ36412904
Dithiocarbamate-based coordination compounds as potent proteasome inhibitors in human cancer cellsQ36837031
1,10-Phenanthroline promotes copper complexes into tumor cells and induces apoptosis by inhibiting the proteasome activity.Q36869057
Overexpression of USP14 protease reduces I-κB protein levels and increases cytokine release in lung epithelial cellsQ36890519
Gold complexes as prospective metal-based anticancer drugsQ36977891
Copper: an essential metal in biologyQ37031388
The tumor proteasome as a novel target for gold(III) complexes: implications for breast cancer therapyQ37175850
Shikonin exerts antitumor activity via proteasome inhibition and cell death induction in vitro and in vivo.Q37254808
Inhibition of p38 MAPK sensitizes tumour cells to cisplatin-induced apoptosis mediated by reactive oxygen species and JNK.Q37342850
USP7 inhibitor P22077 inhibits neuroblastoma growth via inducing p53-mediated apoptosisQ37577477
Gambogic acid induces apoptosis in imatinib-resistant chronic myeloid leukemia cells via inducing proteasome inhibition and caspase-dependent Bcr-Abl downregulationQ37610733
Structural biology of the proteasomeQ38081952
Regulation of TRAIL-receptor expression by the ubiquitin-proteasome system.Q38260461
A novel copper(I) complex induces ER-stress-mediated apoptosis and sensitizes B-acute lymphoblastic leukemia cells to chemotherapeutic agentsQ38979471
The 19S Deubiquitinase inhibitor b-AP15 is enriched in cells and elicits rapid commitment to cell death.Q39006249
Different affinity of nuclear factor-kappa B proteins to DNA modified by antitumor cisplatin and its clinically ineffective trans isomer.Q39034883
Proapoptotic effects of the novel proteasome inhibitor b-AP15 on multiple myeloma cells and natural killer cellsQ39051768
Deubiquitinase inhibition of 19S regulatory particles by 4-arylidene curcumin analog AC17 causes NF-κB inhibition and p53 reactivation in human lung cancer cells.Q39148869
A novel inhibitor of proteasome deubiquitinating activity renders tumor cells sensitive to TRAIL-mediated apoptosis by natural killer cells and T cells.Q39149515
Deubiquitinases as potential anti-cancer targets for gold(III) complexesQ39158500
Ubiquitin C-terminal hydrolase-L5 is required for high glucose-induced transforming growth factor-β receptor I expression and hypertrophy in mesangial cellsQ39180071
The small molecule inhibitor PR-619 of deubiquitinating enzymes affects the microtubule network and causes protein aggregate formation in neural cells: implications for neurodegenerative diseasesQ39352352
Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymesQ39437160
Inhibition of proteasome deubiquitinating activity as a new cancer therapyQ39447379
Deubiquitinase inhibition by small-molecule WP1130 triggers aggresome formation and tumor cell apoptosis.Q39636568
Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survivalQ39761203
Auranofin, an immunosuppressive drug, inhibits MHC class I and MHC class II pathways of antigen presentation in dendritic cellsQ39992342
Inhibition of the proteasome activity by gallium(III) complexes contributes to their anti prostate tumor effectsQ40073607
Gold(III) compounds as anticancer agents: relevance of gold-protein interactions for their mechanism of actionQ40136607
Clioquinol, a therapeutic agent for Alzheimer's disease, has proteasome-inhibitory, androgen receptor-suppressing, apoptosis-inducing, and antitumor activities in human prostate cancer cells and xenograftsQ40169646
Antiproliferative and apoptotic effects of two new gold(III) methylsarcosinedithiocarbamate derivatives on human acute myeloid leukemia cells in vitro.Q40177156
A novel anticancer gold(III) dithiocarbamate compound inhibits the activity of a purified 20S proteasome and 26S proteasome in human breast cancer cell cultures and xenografts.Q40213112
Non-apoptotic programmed cell death induced by a copper(II) complex in human fibrosarcoma cells.Q40274015
Gold(III) dithiocarbamate derivatives for the treatment of cancer: solution chemistry, DNA binding, and hemolytic propertiesQ40310092
UCH-L1 aggresome formation in response to proteasome impairment indicates a role in inclusion formation in Parkinson's diseaseQ40540062
The essential 26S proteasome subunit Rpn11 confers multidrug resistance to mammalian cellsQ40674587
Gambogic acid is a tissue-specific proteasome inhibitor in vitro and in vivoQ43675946
Gold dithiocarbamate derivatives as potential antineoplastic agents: design, spectroscopic properties, and in vitro antitumor activity.Q46372854
[History of gold--with danish contribution to tuberculosis and rheumatoid arthritis].Q46529108
Effects of zinc pyrithione and copper pyrithione on microbial community function and structure in sediments.Q47737159
New uses for old drugs. Auranofin, a clinically established antiarthritic metallodrug, exhibits potent antimalarial effects in vitro: Mechanistic and pharmacological implicationsQ47861024
Disulfiram, a clinically used anti-alcoholism drug and copper-binding agent, induces apoptotic cell death in breast cancer cultures and xenografts via inhibition of the proteasome activityQ48381026
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)457-66
P577publication date2015-05-31
P1433published inOncoscienceQ27725796
P1476titleInhibition of 19S proteasome-associated deubiquitinases by metal-containing compounds
P478volume2

Reverse relations

cites work (P2860)
Q64087483Auranofin Releasing Antibacterial and Antibiofilm Polyurethane Intravascular Catheter Coatings
Q91944789Autophagy Induced by Proteasomal DUB Inhibitor NiPT Restricts NiPT-Mediated Cancer Cell Death
Q47446573Cadmium pyrithione suppresses tumor growth in vitro and in vivo through inhibition of proteasomal deubiquitinase.
Q30238915Colorectal Carcinoma: A General Overview and Future Perspectives in Colorectal Cancer
Q58921478Deubiquitinases as Anticancer Targets of Gold Complexes
Q92724049Gold as a Possible Alternative to Platinum-Based Chemotherapy for Colon Cancer Treatment
Q48138003Gold compounds as cysteine protease inhibitors: perspectives for pharmaceutical application as antiparasitic agents
Q47098444Metal-based proteasomal deubiquitinase inhibitors as potential anticancer agents
Q38796911Novel antitumor adamantane-azole gold(I) complexes as potential inhibitors of thioredoxin reductase.
Q37517626The emerging role of deubiquitinating enzymes in genomic integrity, diseases, and therapeutics
Q36771950Two clinical drugs deubiquitinase inhibitor auranofin and aldehyde dehydrogenase inhibitor disulfiram trigger synergistic anti-tumor effects in vitro and in vivo

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