USP7 inhibitor P22077 inhibits neuroblastoma growth via inducing p53-mediated apoptosis

scientific article published on 17 October 2013

USP7 inhibitor P22077 inhibits neuroblastoma growth via inducing p53-mediated apoptosis is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1009141938
P356DOI10.1038/CDDIS.2013.400
P932PMC publication ID3920959
P698PubMed publication ID24136231
P5875ResearchGate publication ID258055930

P50authorEugene S KimQ90707464
Jed G NuchternQ125346872
P2093author name stringY Zhao
H Zhang
J Cheng
J Yang
Y Yu
Y Rojas
R H Patel
J Dou
I T Ma
J M Shohet
S A Vasudevan
Y-H Fan
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p53 and human cancer: the first ten thousand mutations.Q33767112
Inactivation of HAUSP in vivo modulates p53 functionQ33802926
The Mdm2-p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressorQ34030117
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p53 post-translational modification: deregulated in tumorigenesisQ34300569
Conformational stabilization of ubiquitin yields potent and selective inhibitors of USP7.Q34487783
The requirement for evasion of programmed cell death in neuroblastomas with MYCN amplificationQ35184984
The p53 signal transduction pathway is intact in human neuroblastoma despite cytoplasmic localization.Q35773674
Promoting apoptosis as a strategy for cancer drug discoveryQ36292878
A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistanceQ36338365
The p53 pathway in hematopoiesis: lessons from mouse models, implications for humansQ36509629
Deubiquitinating enzymes as novel anticancer targetsQ36536984
Immunology and immunotherapy of neuroblastomaQ36856798
The genetic landscape of high-risk neuroblastomaQ36929803
TAK1 inhibitor 5Z-7-oxozeaenol sensitizes neuroblastoma to chemotherapyQ37185105
Tumor suppressive functions of p53Q37412688
Tumour suppression by p53: a role for the DNA damage response?Q37591937
Reactivation of p53: from peptides to small molecules.Q37818922
Genetically engineered murine models--contribution to our understanding of the genetics, molecular pathology and therapeutic targeting of neuroblastomaQ37940719
Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymesQ39437160
Effect of MDM2 and vascular endothelial growth factor inhibition on tumor angiogenesis and metastasis in neuroblastomaQ39560187
Nutlin-3a is a potential therapeutic for ewing sarcomaQ39628701
Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cellsQ39813804
Hyperubiquitylation of wild-type p53 contributes to cytoplasmic sequestration in neuroblastomaQ40155261
Functional characterization of a new p53 mutant generated by homozygous deletion in a neuroblastoma cell lineQ40175009
Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cellsQ40410781
SUMO-1 modification of Mdm2 prevents its self-ubiquitination and increases Mdm2 ability to ubiquitinate p53.Q40868752
Mdm2 association with p53 targets its ubiquitinationQ42824389
MDM2 inhibition sensitizes neuroblastoma to chemotherapy-induced apoptotic cell deathQ45862563
Long-term complications in survivors of advanced stage neuroblastoma.Q50474808
A developmental model of neuroblastoma: differentiating stroma-poor tumors' progress along an extra-adrenal chromaffin lineage.Q52199250
NeuroblastomaQ54265665
Recent advances in neuroblastomaQ56637924
Low frequency of the p53 gene mutations in neuroblastomaQ72496549
The loss of mdm2 induces p53-mediated apoptosisQ73673966
Preclinical models of pediatric solid tumors (neuroblastoma) and their use in drug discoveryQ84970191
P921main subjectapoptotic processQ14599311
neuroblastomaQ938205
P304page(s)e867
P577publication date2013-10-17
P1433published inCell Death and DiseaseQ2197222
P1476titleUSP7 inhibitor P22077 inhibits neuroblastoma growth via inducing p53-mediated apoptosis
P478volume4

Reverse relations

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