Ubiquitin-specific protease 7 is a drug-able target that promotes hepatocellular carcinoma and chemoresistance

scientific article published on 28 January 2020

Ubiquitin-specific protease 7 is a drug-able target that promotes hepatocellular carcinoma and chemoresistance is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1186/S12935-020-1109-2
P932PMC publication ID6986148
P698PubMed publication ID32002017

P50authorJinxia LiuQ88253958
P2093author name stringWei Zhang
Feng Jiang
Shiqing Zhang
Yihui Fan
Runzhou Ni
Jingxin Zhang
Wenkai Ni
Cuihua Lu
Lishuai Qu
Mingbing Xiao
Saiyan Bian
Chenzhou Xu
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The ubiquitin-specific protease USP28 is required for MYC stabilityQ24308568
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Structure of USP7 catalytic domain and three Ubl-domains reveals a connector α-helix with regulatory roleQ27704874
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OTUD7B controls non-canonical NF-κB activation through deubiquitination of TRAF3Q28513798
Methylation of histone H3 Lys 4 in coding regions of active genesQ29614680
Deubiquitination of Tip60 by USP7 determines the activity of the p53-dependent apoptotic pathwayQ30415089
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HAUSP deubiquitinates and stabilizes N-Myc in neuroblastomaQ37387937
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USP7 inhibitor P22077 inhibits neuroblastoma growth via inducing p53-mediated apoptosisQ37577477
CDDO-Me reveals USP7 as a novel target in ovarian cancer cellsQ37718344
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USP7 promotes cell proliferation through the stabilization of Ki-67 protein in non-small cell lung cancer cellsQ39426487
Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cellsQ39813804
Prospero-related homeobox 1 drives angiogenesis of hepatocellular carcinoma through selectively activating IL-8 expressionQ40147252
MicroRNA-205 regulates ubiquitin specific peptidase 7 protein expression in hepatocellular carcinoma cellsQ40780673
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Targeting HAUSP in both p53 wildtype and p53-mutant tumors.Q52332504
Ubiquitin-specific protease 7 accelerates p14(ARF) degradation by deubiquitinating thyroid hormone receptor-interacting protein 12 and promotes hepatocellular carcinoma progression.Q53225430
Clinical Significance of Ubiquitin Specific Protease 7 (USP7) in Predicting Prognosis of Hepatocellular Carcinoma and its Functional Mechanisms.Q54957789
Destabilizing NEK2 overcomes resistance to proteasome inhibition in multiple myeloma.Q54977194
Systemic Therapy for Hepatocellular Carcinoma: Latest AdvancesQ58093758
Role of autophagy in tumorigenesis, metastasis, targeted therapy and drug resistance of hepatocellular carcinomaQ58699656
Emerging insights into HAUSP (USP7) in physiology, cancer and other diseasesQ59357734
Polycomb- and Methylation-Independent Roles of EZH2 as a Transcription ActivatorQ60918251
Genome-scale CRISPR-Cas9 screen identifies druggable dependencies in wild-type Ewing sarcomaQ61570969
USP7 Cooperates with NOTCH1 to Drive the Oncogenic Transcriptional Program in T-Cell LeukemiaQ61816131
Ubiquitin-specific protease 7 sustains DNA damage response and promotes cervical carcinogenesisQ64389021
Ubiquitin-based anticancer therapy: carpet bombing with proteasome inhibitors vs surgical strikes with E1, E2, E3, or DUB inhibitorsQ84174712
Blockade of deubiquitinase USP7 overcomes bortezomib resistance by suppressing NF-κB signaling pathway in multiple myelomaQ90339903
Ubiquitin‑specific protease 7 promotes osteosarcoma cell metastasis by inducing epithelial‑mesenchymal transitionQ90443572
Cancer statistics, 2019Q90941571
Targeting the overexpressed USP7 inhibits esophageal squamous cell carcinoma cell growth by inducing NOXA-mediated apoptosisQ91292445
P921main subjecthepatocellular carcinomaQ1148337
P304page(s)28
P577publication date2020-01-28
P1433published inCancer Cell InternationalQ1829859
P1476titleUbiquitin-specific protease 7 is a drug-able target that promotes hepatocellular carcinoma and chemoresistance
P478volume20