| scholarly article | Q13442814 |
| P2093 | author name string | Alfred L Goldberg | |
| David M Smith | |||
| Galit Kafri | |||
| Hugo Fraga | |||
| Christian Reis | |||
| P2860 | cites work | The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction | Q24292709 |
| Mechanism of gate opening in the 20S proteasome by the proteasomal ATPases | Q24564109 | ||
| Docking of the proteasomal ATPases' carboxyl termini in the 20S proteasome's alpha ring opens the gate for substrate entry | Q24674433 | ||
| The structures of HsIU and the ATP-dependent protease HsIU-HsIV | Q27621563 | ||
| Crystal structure of T7 gene 4 ring helicase indicates a mechanism for sequential hydrolysis of nucleotides | Q27625337 | ||
| Crystal and solution structures of an HslUV protease-chaperone complex | Q27628834 | ||
| Interactions of PAN's C-termini with archaeal 20S proteasome and implications for the eukaryotic proteasome–ATPase interactions | Q27646619 | ||
| Structure and activity of the N-terminal substrate recognition domains in proteasomal ATPases | Q27655687 | ||
| Structural Insights into the Regulatory Particle of the Proteasome from Methanocaldococcus jannaschii | Q27655690 | ||
| Structures of asymmetric ClpX hexamers reveal nucleotide-dependent motions in a AAA+ protein-unfolding machine | Q27658178 | ||
| Crystal structure of the 20S proteasome from the archaeon T. acidophilum at 3.4 A resolution | Q27730197 | ||
| Structure of 20S proteasome from yeast at 2.4 A resolution | Q27735081 | ||
| Hexameric assembly of the proteasomal ATPases is templated through their C termini | Q27931123 | ||
| Multiple associated proteins regulate proteasome structure and function | Q27931244 | ||
| Analysis of the AAA sensor-2 motif in the C-terminal ATPase domain of Hsp104 with a site-specific fluorescent probe of nucleotide binding | Q27931784 | ||
| Substrate binding to the molecular chaperone Hsp104 and its regulation by nucleotides | Q27932701 | ||
| An intersubunit signaling network coordinates ATP hydrolysis by m-AAA proteases | Q27940248 | ||
| AAA+ superfamily ATPases: common structure--diverse function | Q28208908 | ||
| Analysis of nucleotide binding to P97 reveals the properties of a tandem AAA hexameric ATPase | Q28577671 | ||
| Structure of the 26S proteasome from Schizosaccharomyces pombe at subnanometer resolution | Q30497623 | ||
| ATP binding to PAN or the 26S ATPases causes association with the 20S proteasome, gate opening, and translocation of unfolded proteins. | Q33991996 | ||
| Proteasomes and their associated ATPases: a destructive combination | Q33998676 | ||
| ATP binding and ATP hydrolysis play distinct roles in the function of 26S proteasome | Q33999948 | ||
| Nobel committee tags ubiquitin for distinction | Q34391316 | ||
| AAA proteins | Q35035247 | ||
| Fluorescence polarization assay to quantify protein-protein interactions | Q35738254 | ||
| Insights into the molecular architecture of the 26S proteasome | Q37274386 | ||
| Heterohexameric ring arrangement of the eukaryotic proteasomal ATPases: implications for proteasome structure and assembly. | Q40836221 | ||
| Mechanism of substrate unfolding and translocation by the regulatory particle of the proteasome from Methanocaldococcus jannaschii | Q41297845 | ||
| ATP-binding sites in brain p97/VCP (valosin-containing protein), a multifunctional AAA ATPase | Q41882364 | ||
| Structure of the human 26S proteasome: subunit radial displacements open the gate into the proteolytic core | Q42114358 | ||
| Asymmetric nucleotide transactions of the HslUV protease. | Q42262524 | ||
| Isolation of mammalian 26S proteasomes and p97/VCP complexes using the ubiquitin-like domain from HHR23B reveals novel proteasome-associated proteins | Q42930872 | ||
| Mechanism of homotropic control to coordinate hydrolysis in a hexameric AAA+ ring ATPase | Q44272346 | ||
| ATP hydrolysis by the proteasome regulatory complex PAN serves multiple functions in protein degradation | Q44283109 | ||
| Asymmetric interactions of ATP with the AAA+ ClpX6 unfoldase: allosteric control of a protein machine. | Q46576860 | ||
| Rebuilt AAA + motors reveal operating principles for ATP-fuelled machines | Q46764297 | ||
| Stability of the proteasome can be regulated allosterically through engagement of its proteolytic active sites. | Q46891027 | ||
| 26S proteasome structure revealed by three-dimensional electron microscopy | Q48941878 | ||
| Binding of nucleotides to the ATP-dependent protease La from Escherichia coli | Q68195827 | ||
| PAN, the proteasome-activating nucleotidase from archaebacteria, is a protein-unfolding molecular chaperone | Q73135763 | ||
| ATP-induced structural transitions in PAN, the proteasome-regulatory ATPase complex in Archaea | Q80441084 | ||
| Pyrophosphate and tripolyphosphate affect firefly luciferase luminescence because they act as substrates and not as allosteric effectors | Q80715690 | ||
| P433 | issue | 4 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 526-538 | |
| P577 | publication date | 2011-02-01 | |
| P1433 | published in | Cell | Q655814 |
| P1476 | title | ATP binds to proteasomal ATPases in pairs with distinct functional effects, implying an ordered reaction cycle | |
| P478 | volume | 144 |
| Q36910805 | A chemical proteomics approach to profiling the ATP-binding proteome of Mycobacterium tuberculosis |
| Q39414304 | AAA-ATPases in Protein Degradation. |
| Q36579541 | ATP binding by proteasomal ATPases regulates cellular assembly and substrate-induced functions of the 26 S proteasome |
| Q40433246 | ATP binding to neighbouring subunits and intersubunit allosteric coupling underlie proteasomal ATPase function. |
| Q61450205 | An Allosteric Interaction Network Promotes Conformation State-Dependent Eviction of the Nas6 Assembly Chaperone from Nascent 26S Proteasomes |
| Q41729079 | An assay for 26S proteasome activity based on fluorescence anisotropy measurements of dye-labeled protein substrates |
| Q28251784 | An asymmetric interface between the regulatory and core particles of the proteasome |
| Q48211716 | Aortic dysfunction in metabolic syndrome mediated by perivascular adipose tissue TNFα and NOX2 dependent pathway |
| Q37606188 | Archaeal proteasomes and sampylation |
| Q33674570 | Architecture and assembly of the archaeal Cdc48*20S proteasome |
| Q24310079 | Arresting a Torsin ATPase reshapes the endoplasmic reticulum |
| Q27931319 | Blm10 protein promotes proteasomal substrate turnover by an active gating mechanism |
| Q35128239 | C termini of proteasomal ATPases play nonequivalent roles in cellular assembly of mammalian 26 S proteasome |
| Q24296821 | Cancer vulnerabilities unveiled by genomic loss |
| Q83409476 | Cell biology: Destruction deconstructed |
| Q42420204 | Chance, destiny, and the inner workings of ClpXP. |
| Q27004511 | Chemical and biological approaches for adapting proteostasis to ameliorate protein misfolding and aggregation diseases: progress and prognosis |
| Q34221890 | Clinically used antirheumatic agent auranofin is a proteasomal deubiquitinase inhibitor and inhibits tumor growth |
| Q34198403 | ClpXP, an ATP-powered unfolding and protein-degradation machine |
| Q35886561 | Coarse-Grained Simulations of Topology-Dependent Mechanisms of Protein Unfolding and Translocation Mediated by ClpY ATPase Nanomachines |
| Q34662342 | Combination therapy targeting ectopic ATP synthase and 26S proteasome induces ER stress in breast cancer cells |
| Q34837495 | Computer simulation of assembly and co-operativity of hexameric AAA ATPases |
| Q55394341 | Conformational switching in the coiled-coil domains of a proteasomal ATPase regulates substrate processing. |
| Q28085237 | Cooperation of Hsp70 and Hsp100 chaperone machines in protein disaggregation |
| Q41876436 | Coordinated gripping of substrate by subunits of a AAA+ proteolytic machine |
| Q58766350 | Could a Common Mechanism of Protein Degradation Impairment Underlie Many Neurodegenerative Diseases? |
| Q59060928 | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome |
| Q60952470 | Cryo-EM structures of the archaeal PAN-proteasome reveal an around-the-ring ATPase cycle |
| Q24567788 | Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S proteasome |
| Q36536393 | Design principles of a universal protein degradation machine |
| Q90450055 | Development of high throughput screening methods for inhibitors of ClpC1P1P2 from Mycobacteria tuberculosis |
| Q34297167 | Differentiation of the DnaA-oriC subcomplex for DNA unwinding in a replication initiation complex. |
| Q34452213 | Divergent tissue and sex effects of rapamycin on the proteasome-chaperone network of old mice. |
| Q27678263 | Dual functions of the Hsm3 protein in chaperoning and scaffolding regulatory particle subunits during the proteasome assembly |
| Q92972669 | Dynamic Regulation of the 26S Proteasome: From Synthesis to Degradation |
| Q38237803 | Emerging mechanistic insights into AAA complexes regulating proteasomal degradation |
| Q90691676 | Expanded Coverage of the 26S Proteasome Conformational Landscape Reveals Mechanisms of Peptidase Gating |
| Q36002883 | Functional asymmetries of proteasome translocase pore |
| Q26996345 | Functions of the 19S complex in proteasomal degradation |
| Q37116324 | Gambogic acid moderates cardiac responses to chronic hypoxia likely by acting on the proteasome and NF-κB pathway |
| Q37285392 | Gambogic acid suppresses pressure overload cardiac hypertrophy in rats |
| Q33354004 | Genetic analyses of the Arabidopsis 26S proteasome regulatory particle reveal its importance during light stress and a specific role for the N-terminus of RPT2 in development |
| Q39010593 | High-resolution cryo-EM structure of the proteasome in complex with ADP-AlFx |
| Q54948646 | Identification of modules of hepatic encephalopathy based on protein-protein network and gene expression data. |
| Q37217467 | Immuno- and constitutive proteasomes do not differ in their abilities to degrade ubiquitinated proteins |
| Q27678078 | Insights into dynein motor domain function from a 3.3-Å crystal structure |
| Q35558711 | Keeping proteasomes under control--a role for phosphorylation in the nucleus |
| Q27682707 | Lassomycin, a Ribosomally Synthesized Cyclic Peptide, Kills Mycobacterium tuberculosis by Targeting the ATP-Dependent Protease ClpC1P1P2 |
| Q34994607 | Loose binding of the DF axis with the A3B3 complex stimulates the initial activity of Enterococcus hirae V1-ATPase |
| Q37625067 | Marching to the beat of the ring: polypeptide translocation by AAA+ proteases. |
| Q64987744 | Measurement of the Multiple Activities of 26S Proteasomes. |
| Q90089209 | Mechanism of the allosteric activation of the ClpP protease machinery by substrates and active-site inhibitors |
| Q47102245 | Mechanistic insight into the assembly of the HerA-NurA helicase-nuclease DNA end resection complex |
| Q38660358 | Mechanistic insights into bacterial AAA+ proteases and protein-remodelling machines |
| Q34308388 | Mechanochemical basis of protein degradation by a double-ring AAA+ machine |
| Q38772212 | Mini review: ATP-dependent proteases in bacteria |
| Q27693890 | Molecular architecture and assembly of the eukaryotic proteasome |
| Q28259014 | Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach |
| Q42320499 | Mutant Analysis Reveals Allosteric Regulation of ClpB Disaggregase |
| Q39605561 | Mycobacterium tuberculosis proteasomal ATPase Mpa has a β-grasp domain that hinders docking with the proteasome core protease. |
| Q39997925 | NADH binds and stabilizes the 26S proteasomes independent of ATP. |
| Q36442058 | New approaches for dissecting protease functions to improve probe development and drug discovery |
| Q27677748 | Nucleotide Binding and Conformational Switching in the Hexameric Ring of a AAA+ Machine |
| Q36675188 | Open-gate mutants of the mammalian proteasome show enhanced ubiquitin-conjugate degradation |
| Q38648242 | Origin and Functional Evolution of the Cdc48/p97/VCP AAA+ Protein Unfolding and Remodeling Machine |
| Q90618691 | PSMC2 is Up-regulated in Pancreatic Cancer and Promotes Cancer Cell Proliferation and Inhibits Apoptosis |
| Q37702385 | PSMC2 is up-regulated in osteosarcoma and regulates osteosarcoma cell proliferation, apoptosis and migration |
| Q34433523 | PilT2 enhances the speed of gonococcal type IV pilus retraction and of twitching motility |
| Q37606186 | Prokaryotic proteasomes: nanocompartments of degradation |
| Q40451741 | Proteasome Activation is Mediated via a Functional Switch of the Rpt6 C-terminal Tail Following Chaperone-dependent Assembly. |
| Q28244689 | Proteasome function is required for platelet production |
| Q35601400 | Proteasome functional insufficiency in cardiac pathogenesis |
| Q35792807 | Proteasomes and protein conjugation across domains of life |
| Q36207938 | Protein oligomerization monitored by fluorescence fluctuation spectroscopy: self-assembly of rubisco activase |
| Q89766695 | Proteins containing ubiquitin-like (Ubl) domains not only bind to 26S proteasomes but also induce their activation |
| Q99584387 | Proteolytic systems of archaea: slicing, dicing, and mincing in the extreme |
| Q26738716 | Recent advances in the structural biology of the 26S proteasome |
| Q27677979 | Reconfiguration of the proteasome during chaperone-mediated assembly |
| Q37406494 | Reconstitution of the 26S proteasome reveals functional asymmetries in its AAA+ unfoldase |
| Q35257872 | Regulated protein turnover: snapshots of the proteasome in action |
| Q41456400 | Regulation of ribulose-1,5-bisphosphate carboxylase/oxygenase (rubisco) activase: product inhibition, cooperativity, and magnesium activation |
| Q27000202 | Regulation of the proteasome by ATP: implications for ischemic myocardial injury and donor heart preservation |
| Q36833345 | Site-specific proteasome phosphorylation controls cell proliferation and tumorigenesis |
| Q38466156 | Stable incorporation of ATPase subunits into 19 S regulatory particle of human proteasome requires nucleotide binding and C-terminal tails |
| Q90646210 | Stepping up protein degradation |
| Q42030136 | Stochastic but highly coordinated protein unfolding and translocation by the ClpXP proteolytic machine. |
| Q96110646 | Structural basis for distinct operational modes and protease activation in AAA+ protease Lon |
| Q38081952 | Structural biology of the proteasome |
| Q35865605 | Structural characterization of the interaction of Ubp6 with the 26S proteasome |
| Q37396451 | Structural insights into proteasome activation by the 19S regulatory particle |
| Q52322457 | Structure and Function of the 26S Proteasome. |
| Q34339520 | Structure of the 26S proteasome with ATP-γS bound provides insights into the mechanism of nucleotide-dependent substrate translocation |
| Q37102327 | Structure of the human 26S proteasome at a resolution of 3.9 Å. |
| Q89932777 | Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate |
| Q35670301 | Substrate degradation by the proteasome: a single-molecule kinetic analysis |
| Q35582160 | Subunit asymmetry and roles of conformational switching in the hexameric AAA+ ring of ClpX |
| Q38601568 | Targeting tumor suppressor genes for cancer therapy |
| Q34506149 | Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling |
| Q47161924 | The AAA ATPase Vps4 binds ESCRT-III substrates through a repeating array of dipeptide-binding pockets. |
| Q37213960 | The ATP costs and time required to degrade ubiquitinated proteins by the 26 S proteasome. |
| Q39318404 | The Logic of the 26S Proteasome |
| Q89292786 | The Methanosarcina mazei MM2060 Gene Encodes a Bifunctional Kinase/Decarboxylase Enzyme Involved in Cobamide Biosynthesis |
| Q38288328 | The Proteasomal ATPases Use a Slow but Highly Processive Strategy to Unfold Proteins |
| Q42628250 | The RPT2 subunit of the 26S proteasome directs complex assembly, histone dynamics, and gametophyte and sporophyte development in Arabidopsis |
| Q42508594 | The deubiquitinating enzyme Usp14 allosterically inhibits multiple proteasomal activities and ubiquitin-independent proteolysis |
| Q28482991 | The hetero-hexameric nature of a chloroplast AAA+ FtsH protease contributes to its thermodynamic stability |
| Q28513793 | The p97/VCP ATPase is critical in muscle atrophy and the accelerated degradation of muscle proteins |
| Q37226121 | The proteasome-associated protein Ecm29 inhibits proteasomal ATPase activity and in vivo protein degradation by the proteasome |
| Q26748001 | The recognition of ubiquitinated proteins by the proteasome |
| Q36268060 | The ubiquitin-proteasome system of Saccharomyces cerevisiae |
| Q37593375 | Time-resolved neutron scattering provides new insight into protein substrate processing by a AAA+ unfoldase |
| Q93379935 | UBL domain of Usp14 and other proteins stimulates proteasome activities and protein degradation in cells |
| Q30789737 | Unfolding the mechanism of the AAA+ unfoldase VAT by a combined cryo-EM, solution NMR study |
| Q36435295 | cAMP-induced phosphorylation of 26S proteasomes on Rpn6/PSMD11 enhances their activity and the degradation of misfolded proteins. |
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