An asymmetric interface between the regulatory and core particles of the proteasome

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An asymmetric interface between the regulatory and core particles of the proteasome is …
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scholarly articleQ13442814

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P356DOI10.1038/NSMB.2147
P8608Fatcat IDrelease_qmbeoqooyjfeligktfq6mwaf4m
P3181OpenCitations bibliographic resource ID762109
P932PMC publication ID3210322
P698PubMed publication ID22037170
P5875ResearchGate publication ID51756509

P50authorMin Jae LeeQ56433592
Steven P. GygiQ88679013
Fiona E McAllisterQ116878152
P2093author name stringGeng Tian
Daniel Finley
Christopher P Hill
Soyeon Park
Bettina Huck
P2860cites workProduction of multimeric forms of CD4 through a sugar-based cross-linking strategy.Q55241735
Purification of proteasomes, proteasome subcomplexes, and proteasome-associated proteins from budding yeastQ81786895
Assembly pathway of the Mammalian proteasome base subcomplex is mediated by multiple specific chaperonesQ24316277
Chaperone-mediated pathway of proteasome regulatory particle assemblyQ24321620
Mechanism of gate opening in the 20S proteasome by the proteasomal ATPasesQ24564109
Docking of the proteasomal ATPases' carboxyl termini in the 20S proteasome's alpha ring opens the gate for substrate entryQ24674433
The structures of HsIU and the ATP-dependent protease HsIU-HsIVQ27621563
A gated channel into the proteasome core particleQ27627907
Structural basis for the activation of 20S proteasomes by 11S regulatorsQ27628418
Crystal structures of the HslVU peptidase-ATPase complex reveal an ATP-dependent proteolysis mechanismQ27630654
Nucleotide-dependent conformational changes in a protease-associated ATPase HsIUQ27636245
Interactions of PAN's C-termini with archaeal 20S proteasome and implications for the eukaryotic proteasome–ATPase interactionsQ27646619
Improved structures of full-length p97, an AAA ATPase: implications for mechanisms of nucleotide-dependent conformational changeQ27650550
Structure and activity of the N-terminal substrate recognition domains in proteasomal ATPasesQ27655687
Structural Insights into the Regulatory Particle of the Proteasome from Methanocaldococcus jannaschiiQ27655690
Running in Reverse: The Structural Basis for Translocation Polarity in Hexameric HelicasesQ27658029
Structural Models for Interactions between the 20S Proteasome and Its PAN/19S ActivatorsQ27658058
Structures of asymmetric ClpX hexamers reveal nucleotide-dependent motions in a AAA+ protein-unfolding machineQ27658178
Structure of 20S proteasome from yeast at 2.4 A resolutionQ27735081
Hexameric assembly of the proteasomal ATPases is templated through their C terminiQ27931123
Multiple associated proteins regulate proteasome structure and functionQ27931244
The axial channel of the proteasome core particle is gated by the Rpt2 ATPase and controls both substrate entry and product releaseQ27933726
A multimeric assembly factor controls the formation of alternative 20S proteasomesQ27933912
A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and eIF3.Q27936509
Multiple proteasome-interacting proteins assist the assembly of the yeast 19S regulatory particleQ27936642
The HEAT repeat protein Blm10 regulates the yeast proteasome by capping the core particleQ27938094
Multiple assembly chaperones govern biogenesis of the proteasome regulatory particle baseQ27939675
A versatile toolbox for PCR-based tagging of yeast genes: new fluorescent proteins, more markers and promoter substitution cassettesQ28131622
Structural and functional characterization of interaction between hepatitis B virus X protein and the proteasome complexQ28140767
Quaternary structure of the ATPase complex of human 26S proteasomes determined by chemical cross-linkingQ28189874
Targeting proteins for degradationQ28261886
Differential roles of the COOH termini of AAA subunits of PA700 (19 S regulator) in asymmetric assembly and activation of the 26 S proteasomeQ28294192
The C Terminus of Rpt3, an ATPase Subunit of PA700 (19 S) Regulatory Complex, Is Essential for 26 S Proteasome Assembly but Not for ActivationQ28295352
Recognition and processing of ubiquitin-protein conjugates by the proteasomeQ29547616
The yeast polyubiquitin gene is essential for resistance to high temperatures, starvation, and other stressesQ29616169
Global unfolding of a substrate protein by the Hsp100 chaperone ClpA.Q30322959
Single-molecule protein unfolding and translocation by an ATP-fueled proteolytic machine.Q30473723
Structure of the 26S proteasome from Schizosaccharomyces pombe at subnanometer resolutionQ30497623
A protein-protein interaction map of the Caenorhabditis elegans 26S proteasomeQ33757687
The 1.9 A structure of a proteasome-11S activator complex and implications for proteasome-PAN/PA700 interactions.Q33987362
ATP binding to PAN or the 26S ATPases causes association with the 20S proteasome, gate opening, and translocation of unfolded proteins.Q33991996
AAA+ proteases: ATP-fueled machines of protein destructionQ34176192
Assembly manual for the proteasome regulatory particle: the first draftQ36200349
Proteasomes: machines for all reasonsQ36826333
ClpX(P) generates mechanical force to unfold and translocate its protein substratesQ36938901
Insights into the structural dynamics of the Hsp110-Hsp70 interaction reveal the mechanism for nucleotide exchange activityQ36954881
Insights into the molecular architecture of the 26S proteasomeQ37274386
Subcomplexes of PA700, the 19 S regulator of the 26 S proteasome, reveal relative roles of AAA subunits in 26 S proteasome assembly and activation and ATPase activityQ37375673
Mechanism of DNA translocation in a replicative hexameric helicaseQ38311331
Yeast cycloheximide-resistant crl mutants are proteasome mutants defective in protein degradationQ38615074
Heterohexameric ring arrangement of the eukaryotic proteasomal ATPases: implications for proteasome structure and assembly.Q40836221
Structure of the human 26S proteasome: subunit radial displacements open the gate into the proteolytic coreQ42114358
ATP binds to proteasomal ATPases in pairs with distinct functional effects, implying an ordered reaction cycleQ42156125
Proteasome disassembly and downregulation is correlated with viability during stationary phaseQ42166737
Pore loops of the AAA+ ClpX machine grip substrates to drive translocation and unfoldingQ43218186
Assembly of the 26S proteasome is regulated by phosphorylation of the p45/Rpt6 ATPase subunitQ43516889
Protein unfolding by a AAA+ protease is dependent on ATP-hydrolysis rates and substrate energy landscapes.Q46788602
Characterization of the proteasome using native gel electrophoresisQ46794661
Stability of the proteasome can be regulated allosterically through engagement of its proteolytic active sites.Q46891027
Subunit-subunit interactions in the human 26S proteasomeQ47983972
26S proteasome structure revealed by three-dimensional electron microscopyQ48941878
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectProteasome regulatory particle lid subunit RPN11 YFR004WQ27547318
Proteasome regulatory particle base subunit RPT2 YDL007WQ27547381
Proteasome regulatory particle base subunit RPT5 YOR117WQ27547446
Proteasome regulatory particle base subunit RPT6 YGL048CQ27550471
Proteasome regulatory particle base subunit RPT1 YKL145WQ27550511
Proteasome regulatory particle base subunit RPT3 YDR394WQ27551622
Proteasome regulatory particle base subunit RPT4 YOR259CQ27552216
structural biologyQ908902
P304page(s)1259-1267
P577publication date2011-10-30
P1433published inNature Structural & Molecular BiologyQ1071739
P1476titleAn asymmetric interface between the regulatory and core particles of the proteasome
P478volume18

Reverse relations

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