Gates, Channels, and Switches: Elements of the Proteasome Machine

scientific article published on 28 November 2015

Gates, Channels, and Switches: Elements of the Proteasome Machine is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.TIBS.2015.10.009
P932PMC publication ID4706478
P698PubMed publication ID26643069

P2093author name stringXiang Chen
Daniel Finley
Kylie J Walters
P2860cites workIn vitro assembly and recognition of Lys-63 polyubiquitin chainsQ43615489
ATP-dependent proteases degrade their substrates by processively unraveling them from the degradation signalQ43681662
ATP hydrolysis by the proteasome regulatory complex PAN serves multiple functions in protein degradationQ44283109
An unstructured initiation site is required for efficient proteasome-mediated degradationQ45018402
The size of the proteasomal substrate determines whether its degradation will be mediated by mono- or polyubiquitylationQ46223379
Ubiquitin ligase Hul5 is required for fragment-specific substrate degradation in endoplasmic reticulum-associated degradationQ46626985
RPN-6 determines C. elegans longevity under proteotoxic stress conditionsQ46942610
Proteasomes. A molecular census of 26S proteasomes in intact neuronsQ48364209
Interaction of NUB1 with the proteasome subunit S5a.Q50336228
The N-terminal unstructured domain of yeast ODC functions as a transplantable and replaceable ubiquitin-independent degron.Q52607726
FAT10 and NUB1L bind to the VWA domain of Rpn10 and Rpn1 to enable proteasome-mediated proteolysis.Q53178691
A ubiquitin stress response induces altered proteasome composition.Q55043910
A conserved processing mechanism regulates the activity of transcription factors Cubitus interruptus and NF-κBQ57851826
Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topologyQ58215681
A series of ubiquitin binding factors connects CDC48/p97 to substrate multiubiquitylation and proteasomal targetingQ81277350
Structure of S5a bound to monoubiquitin provides a model for polyubiquitin recognitionQ81643532
Modification by single ubiquitin moieties rather than polyubiquitination is sufficient for proteasomal processing of the p105 NF-κB precursorQ82863691
Structural plasticity allows UCH37 to be primed by RPN13 or locked down by INO80GQ86881857
Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interactionQ27650666
Structure and activity of the N-terminal substrate recognition domains in proteasomal ATPasesQ27655687
Structural Insights into the Regulatory Particle of the Proteasome from Methanocaldococcus jannaschiiQ27655690
Structure of the S5a:K48-Linked Diubiquitin Complex and Its Interactions with Rpn13Q27657027
Structure of Proteasome Ubiquitin Receptor hRpn13 and Its Activation by the Scaffolding Protein hRpn2Q27661655
The proteasomal subunit Rpn6 is a molecular clamp holding the core and regulatory subcomplexes togetherQ27676340
Reconfiguration of the proteasome during chaperone-mediated assemblyQ27677979
Crystal structure of the proteasomal deubiquitylation module Rpn8-Rpn11Q27681666
Formation of an intricate helical bundle dictates the assembly of the 26S proteasome lidQ27685325
Structure of the Rpn11-Rpn8 dimer reveals mechanisms of substrate deubiquitination during proteasomal degradationQ27688973
Molecular architecture and assembly of the eukaryotic proteasomeQ27693890
Structure of 20S proteasome from yeast at 2.4 A resolutionQ27735081
Proteasome subunit Rpn1 binds ubiquitin-like protein domainsQ27930136
Mobilization of processed, membrane-tethered SPT23 transcription factor by CDC48(UFD1/NPL4), a ubiquitin-selective chaperoneQ27930650
Multiple associated proteins regulate proteasome structure and functionQ27931244
Blm10 protein promotes proteasomal substrate turnover by an active gating mechanismQ27931319
Multiple interactions of rad23 suggest a mechanism for ubiquitylated substrate delivery important in proteolysisQ27931879
Deubiquitinating enzyme Ubp6 functions noncatalytically to delay proteasomal degradation.Q27932109
Ubiquitin chains are remodeled at the proteasome by opposing ubiquitin ligase and deubiquitinating activities.Q27933653
RPN4 is a ligand, substrate, and transcriptional regulator of the 26S proteasome: a negative feedback circuitQ27933746
Acetylation-mediated proteasomal degradation of core histones during DNA repair and spermatogenesisQ27933881
UBA domains of DNA damage-inducible proteins interact with ubiquitinQ27935487
A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and eIF3.Q27936509
Active site mutants in the six regulatory particle ATPases reveal multiple roles for ATP in the proteasomeQ27937064
Lysine 63-linked polyubiquitin chain may serve as a targeting signal for the 26S proteasomeQ27937521
Activation of a membrane-bound transcription factor by regulated ubiquitin/proteasome-dependent processing.Q27937925
Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasomeQ27937927
A cryptic protease couples deubiquitination and degradation by the proteasomeQ27938068
Structural defects in the regulatory particle-core particle interface of the proteasome induce a novel proteasome stress responseQ27938348
Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type I IFN productionQ28114794
Regulation of CD8+ T cell development by thymus-specific proteasomesQ28116400
Hybrid proteasomes. Induction by interferon-gamma and contribution to ATP-dependent proteolysisQ28143710
Autoregulation of the 26S proteasome by in situ ubiquitinationQ28238443
Interaction of hHR23 with S5a. The ubiquitin-like domain of hHR23 mediates interaction with S5a subunit of 26 S proteasomeQ22010540
Autoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugatesQ24297402
Increased proteasome activity in human embryonic stem cells is regulated by PSMD11Q24298544
The SRC-3/AIB1 coactivator is degraded in a ubiquitin- and ATP-independent manner by the REGgamma proteasomeQ24302180
A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomesQ24304237
Mechanism of ubiquitin-chain formation by the human anaphase-promoting complexQ24313604
hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the deubiquitinating enzyme, UCH37Q24321826
Proteasome activator PA28gamma-dependent nuclear retention and degradation of hepatitis C virus core proteinQ24322067
Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complexQ24323042
UBLCP1 is a 26S proteasome phosphatase that regulates nuclear proteasome activityQ24338712
Ubiquitin-associated (UBA) domains in Rad23 bind ubiquitin and promote inhibition of multi-ubiquitin chain assemblyQ24522596
Recognition of the polyubiquitin proteolytic signalQ24530006
Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S proteasomeQ24567788
Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementiaQ24600027
Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?Q24617857
Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradationQ24643067
Docking of the proteasomal ATPases' carboxyl termini in the 20S proteasome's alpha ring opens the gate for substrate entryQ24674433
mTORC1 signaling activates NRF1 to increase cellular proteasome levelsQ27012468
Specific SKN-1/Nrf stress responses to perturbations in translation elongation and proteasome activityQ27339698
A gated channel into the proteasome core particleQ27627907
Structural basis for the activation of 20S proteasomes by 11S regulatorsQ27628418
Structural studies of the interaction between ubiquitin family proteins and proteasome subunit S5aQ27637621
Proteasome subunit Rpn13 is a novel ubiquitin receptorQ27650664
Regulation of the 26S proteasome complex during oxidative stressQ35120069
Structural basis for the activation and inhibition of the UCH37 deubiquitylaseQ35163646
Loss of Rpt5 protein interactions with the core particle and Nas2 protein causes the formation of faulty proteasomes that are inhibited by Ecm29 protein.Q35378632
A three-part signal governs differential processing of Gli1 and Gli3 proteins by the proteasomeQ35604264
Substrate degradation by the proteasome: a single-molecule kinetic analysisQ35670301
N-Terminal Coiled-Coil Structure of ATPase Subunits of 26S Proteasome Is Crucial for Proteasome FunctionQ35712222
Redundant Roles of Rpn10 and Rpn13 in Recognition of Ubiquitinated Proteins and Cellular Homeostasis.Q35723276
APC/C-mediated multiple monoubiquitylation provides an alternative degradation signal for cyclin B1Q35754866
Structural characterization of the interaction of Ubp6 with the 26S proteasomeQ35865605
Functional asymmetries of proteasome translocase poreQ36002883
Ubp6 deubiquitinase controls conformational dynamics and substrate degradation of the 26S proteasome.Q36029605
Identification and proteomic analysis of distinct UBE3A/E6AP protein complexes.Q36210923
Development of proteasome inhibitors as research tools and cancer drugsQ36389262
The ATP costs and time required to degrade ubiquitinated proteins by the 26 S proteasome.Q37213960
The proteasome-associated protein Ecm29 inhibits proteasomal ATPase activity and in vivo protein degradation by the proteasomeQ37226121
The E3 ubiquitin ligase UBE3C enhances proteasome processivity by ubiquitinating partially proteolyzed substrates.Q37348923
Reconstitution of the 26S proteasome reveals functional asymmetries in its AAA+ unfoldaseQ37406494
The lysine 48 and lysine 63 ubiquitin conjugates are processed differently by the 26 s proteasomeQ37467606
Marching to the beat of the ring: polypeptide translocation by AAA+ proteases.Q37625067
The intrinsically disordered Sem1 protein functions as a molecular tether during proteasome lid biogenesis.Q37626715
Proteasomes associated with the Blm10 activator protein antagonize mitochondrial fission through degradation of the fission protein Dnm1.Q37727657
Assembly and function of the proteasomeQ37986626
Inhibitors for the immuno- and constitutive proteasome: current and future trends in drug developmentQ38019864
Atypical ubiquitylation - the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages.Q38028343
FAT10ylation as a signal for proteasomal degradationQ38075383
Structural biology of the proteasomeQ38081952
Assembly of the 20S proteasome.Q38090856
The mechanism for molecular assembly of the proteasomeQ38154406
The unique functions of tissue-specific proteasomesQ38167099
Catching a DUB in the act: novel ubiquitin-based active site directed probesQ38280690
Structural disorder and its role in proteasomal degradationQ38557562
Reversible 26S proteasome disassembly upon mitochondrial stress.Q38992225
Ubiquitin-independent degradation of cell-cycle inhibitors by the REGgamma proteasomeQ40115986
Ubiquitin- and ATP-independent proteolytic turnover of p21 by the REGgamma-proteasome pathwayQ40115992
Proteasome Activation is Mediated via a Functional Switch of the Rpt6 C-terminal Tail Following Chaperone-dependent Assembly.Q40451741
Mechanism of UCH-L5 activation and inhibition by DEUBAD domains in RPN13 and INO80G.Q41375336
Localization of the regulatory particle subunit Sem1 in the 26S proteasomeQ41611000
Molecular model of the human 26S proteasomeQ41613713
Coordinated gripping of substrate by subunits of a AAA+ proteolytic machineQ41876436
Ubiquitinated proteins activate the proteasome by binding to Usp14/Ubp6, which causes 20S gate openingQ41915219
Identification of the Cdc48•20S proteasome as an ancient AAA+ proteolytic machine.Q41953180
Sequence composition of disordered regions fine-tunes protein half-lifeQ42010327
Hul5 HECT ubiquitin ligase plays a major role in the ubiquitylation and turnover of cytosolic misfolded proteinsQ42069478
An ALS disease mutation in Cdc48/p97 impairs 20S proteasome binding and proteolytic communicationQ42269965
Dissection of Axial-Pore Loop Function during Unfolding and Translocation by a AAA+ Proteolytic MachineQ42530780
ATP-dependent steps in the binding of ubiquitin conjugates to the 26S proteasome that commit to degradationQ42600957
The ubiquitin ligase Hul5 promotes proteasomal processivityQ42924551
Together, Rpn10 and Dsk2 can serve as a polyubiquitin chain-length sensorQ42936102
Dss1 is a 26S proteasome ubiquitin receptorQ43006495
Proteasome-mediated processing of Nrf1 is essential for coordinate induction of all proteasome subunits and p97Q28243388
An asymmetric interface between the regulatory and core particles of the proteasomeQ28251784
Complete subunit architecture of the proteasome regulatory particleQ28257212
Molecular architecture of the 26S proteasome holocomplex determined by an integrative approachQ28259014
Control of p97 function by cofactor bindingQ28266780
Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cellsQ28279454
Conformational switching of the 26S proteasome enables substrate degradationQ28292908
Proteasomal Degradation Is Transcriptionally Controlled by TCF11 via an ERAD-Dependent Feedback LoopQ28295179
Editing of ubiquitin conjugates by an isopeptidase in the 26S proteasomeQ28303702
p97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibitionQ28306282
Evolution of proteasome regulators in eukaryotesQ28334391
Regulation of proteasome activity in health and diseaseQ28392708
Phosphorylation of Rpt6 regulates synaptic strength in hippocampal neuronsQ28579831
Autophagic Degradation of the 26S Proteasome Is Mediated by the Dual ATG8/Ubiquitin Receptor RPN10 in ArabidopsisQ28830597
Recognition and processing of ubiquitin-protein conjugates by the proteasomeQ29547616
A 26 S protease subunit that binds ubiquitin conjugatesQ29614362
Enhancement of proteasome activity by a small-molecule inhibitor of USP14Q29616735
The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa BQ29618194
Global unfolding of a substrate protein by the Hsp100 chaperone ClpA.Q30322959
Near-atomic resolution structural model of the yeast 26S proteasome.Q30524942
Enhanced protein degradation by branched ubiquitin chains.Q33637926
Rad23 escapes degradation because it lacks a proteasome initiation regionQ33801171
PA28αβ: the enigmatic magic ring of the proteasome?Q33912635
Productive RUPture: activation of transcription factors by proteasomal processing.Q33983417
Delivery of ubiquitinated substrates to protein-unfolding machinesQ33989072
Proteasome regulation by ADP-ribosylationQ34036523
Defining the geometry of the two-component proteasome degronQ34161503
AAA+ proteases: ATP-fueled machines of protein destructionQ34176192
Structure of the 26S proteasome with ATP-γS bound provides insights into the mechanism of nucleotide-dependent substrate translocationQ34339520
Intrinsically disordered segments affect protein half-life in the cell and during evolutionQ34438593
Pri sORF peptides induce selective proteasome-mediated protein processingQ34494721
Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1.Q34556881
Ubiquitin-aldehyde: a general inhibitor of ubiquitin-recycling processesQ34607942
Proteasomal degradation of Sfp1 contributes to the repression of ribosome biogenesis during starvation and is mediated by the proteasome activator Blm10.Q34611628
Ubiquitin depletion as a key mediator of toxicity by translational inhibitorsQ34986792
P433issue1
P1104number of pages17
P304page(s)77-93
P577publication date2015-11-28
P1433published inTrends in Biochemical SciencesQ1565711
P1476titleGates, Channels, and Switches: Elements of the Proteasome Machine
P478volume41

Reverse relations

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