Proteasome Activation is Mediated via a Functional Switch of the Rpt6 C-terminal Tail Following Chaperone-dependent Assembly.

scientific article published on 9 October 2015

Proteasome Activation is Mediated via a Functional Switch of the Rpt6 C-terminal Tail Following Chaperone-dependent Assembly. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/SREP14909
P932PMC publication ID4598862
P698PubMed publication ID26449534

P2093author name stringSoyeon Park
Vladyslava Sokolova
George Polovin
Frances Li
P2860cites workIncreased proteasome activity in human embryonic stem cells is regulated by PSMD11Q24298544
Assembly pathway of the Mammalian proteasome base subcomplex is mediated by multiple specific chaperonesQ24316277
ATP binding by proteasomal ATPases regulates cellular assembly and substrate-induced functions of the 26 S proteasomeQ36579541
Conformational dynamics of the Rpt6 ATPase in proteasome assembly and Rpn14 bindingQ36896600
Insights into the molecular architecture of the 26S proteasomeQ37274386
Structural biology of the proteasomeQ38081952
Stable incorporation of ATPase subunits into 19 S regulatory particle of human proteasome requires nucleotide binding and C-terminal tailsQ38466156
Heterohexameric ring arrangement of the eukaryotic proteasomal ATPases: implications for proteasome structure and assembly.Q40836221
Molecular model of the human 26S proteasomeQ41613713
ATP binds to proteasomal ATPases in pairs with distinct functional effects, implying an ordered reaction cycleQ42156125
Characterization of the proteasome using native gel electrophoresisQ46794661
Purification of proteasomes, proteasome subcomplexes, and proteasome-associated proteins from budding yeastQ81786895
Proteasome assembly from 15S precursors involves major conformational changes and recycling of the Pba1-Pba2 chaperoneQ86573364
Chaperone-mediated pathway of proteasome regulatory particle assemblyQ24321620
Mechanism of gate opening in the 20S proteasome by the proteasomal ATPasesQ24564109
Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S proteasomeQ24567788
Docking of the proteasomal ATPases' carboxyl termini in the 20S proteasome's alpha ring opens the gate for substrate entryQ24674433
A gated channel into the proteasome core particleQ27627907
Structural Insights into the Regulatory Particle of the Proteasome from Methanocaldococcus jannaschiiQ27655690
The proteasomal subunit Rpn6 is a molecular clamp holding the core and regulatory subcomplexes togetherQ27676340
Reconfiguration of the proteasome during chaperone-mediated assemblyQ27677979
Dual functions of the Hsm3 protein in chaperoning and scaffolding regulatory particle subunits during the proteasome assemblyQ27678263
Structural basis for proteasome formation controlled by an assembly chaperone nas2Q27689676
Structure of 20S proteasome from yeast at 2.4 A resolutionQ27735081
UCSF Chimera--a visualization system for exploratory research and analysisQ27860666
Hexameric assembly of the proteasomal ATPases is templated through their C terminiQ27931123
An inducible chaperone adapts proteasome assembly to stressQ27933155
Multiple proteasome-interacting proteins assist the assembly of the yeast 19S regulatory particleQ27936642
Structural defects in the regulatory particle-core particle interface of the proteasome induce a novel proteasome stress responseQ27938348
Hsm3/S5b participates in the assembly pathway of the 19S regulatory particle of the proteasomeQ27938858
Multiple assembly chaperones govern biogenesis of the proteasome regulatory particle baseQ27939675
Epitope tagging of yeast genes using a PCR-based strategy: more tags and improved practical routinesQ28131620
An asymmetric interface between the regulatory and core particles of the proteasomeQ28251784
Complete subunit architecture of the proteasome regulatory particleQ28257212
Conformational switching of the 26S proteasome enables substrate degradationQ28292908
The C Terminus of Rpt3, an ATPase Subunit of PA700 (19 S) Regulatory Complex, Is Essential for 26 S Proteasome Assembly but Not for ActivationQ28295352
Recognition and processing of ubiquitin-protein conjugates by the proteasomeQ29547616
The yeast polyubiquitin gene is essential for resistance to high temperatures, starvation, and other stressesQ29616169
Structure of the 26S proteasome from Schizosaccharomyces pombe at subnanometer resolutionQ30497623
Near-atomic resolution structural model of the yeast 26S proteasome.Q30524942
The 1.9 A structure of a proteasome-11S activator complex and implications for proteasome-PAN/PA700 interactions.Q33987362
ATP binding to PAN or the 26S ATPases causes association with the 20S proteasome, gate opening, and translocation of unfolded proteins.Q33991996
ATP binding and ATP hydrolysis play distinct roles in the function of 26S proteasomeQ33999948
Structure of the 26S proteasome with ATP-γS bound provides insights into the mechanism of nucleotide-dependent substrate translocationQ34339520
C termini of proteasomal ATPases play nonequivalent roles in cellular assembly of mammalian 26 S proteasomeQ35128239
Maturation of the proteasome core particle induces an affinity switch that controls regulatory particle associationQ35234644
Loss of Rpt5 protein interactions with the core particle and Nas2 protein causes the formation of faulty proteasomes that are inhibited by Ecm29 protein.Q35378632
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P407language of work or nameEnglishQ1860
P921main subjectmolecular chaperonesQ422496
P304page(s)14909
P577publication date2015-10-09
P1433published inScientific ReportsQ2261792
P1476titleProteasome Activation is Mediated via a Functional Switch of the Rpt6 C-terminal Tail Following Chaperone-dependent Assembly.
P478volume5

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cites work (P2860)
Q41676470A proteomic atlas of insulin signalling reveals tissue-specific mechanisms of longevity assurance.
Q98303578AMPK controls the axonal regenerative ability of dorsal root ganglia sensory neurons after spinal cord injury
Q61450205An Allosteric Interaction Network Promotes Conformation State-Dependent Eviction of the Nas6 Assembly Chaperone from Nascent 26S Proteasomes
Q35862786Gates, Channels, and Switches: Elements of the Proteasome Machine
Q42320401Nucleotide-dependent switch in proteasome assembly mediated by the Nas6 chaperone
Q33853086Phosphorylation of the 19S regulatory particle ATPase subunit, Rpt6, modifies susceptibility to proteotoxic stress and protein aggregation.
Q37581070Precise assembly and regulation of 26S proteasome and correlation between proteasome dysfunction and neurodegenerative diseases
Q39352782Proteasome Structure and Assembly
Q90673658Regulation of proteasome assembly and activity in health and disease
Q48092080Sophisticated lessons from simple organisms: appreciating the value of curiosity-driven research
Q92127278The Proteasome and Its Network: Engineering for Adaptability
Q95650650The proteasome as a druggable target with multiple therapeutic potentialities: Cutting and non-cutting edges
Q38945828The ubiquitin-proteasome system and chromosome 17 in cerebellar granule cells and medulloblastoma subgroups
Q91983592Two alternative mechanisms regulate the onset of chaperone-mediated assembly of the proteasomal ATPases
Q90365039Ubiquitin-dependent switch during assembly of the proteasomal ATPases mediated by Not4 ubiquitin ligase

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