Maturation of the proteasome core particle induces an affinity switch that controls regulatory particle association

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Maturation of the proteasome core particle induces an affinity switch that controls regulatory particle association is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2015NatCo...6.6384W
P6179Dimensions Publication ID1020117054
P356DOI10.1038/NCOMMS7384
P932PMC publication ID4380239
P698PubMed publication ID25812915
P5875ResearchGate publication ID273632688

P50authorJeroen RoelofsQ73074113
P2093author name stringEric J Deeds
Michael A Rowland
Alex Ondracek
Prashant S Wani
P2860cites workA heterodimeric complex that promotes the assembly of mammalian 20S proteasomesQ24292874
Chaperone-mediated pathway of proteasome regulatory particle assemblyQ24321620
Docking of the proteasomal ATPases' carboxyl termini in the 20S proteasome's alpha ring opens the gate for substrate entryQ24674433
Crystal structure of a chaperone complex that contributes to the assembly of yeast 20S proteasomesQ27649865
Structure of a Blm10 Complex Reveals Common Mechanisms for Proteasome Binding and Gate OpeningQ27660222
Structure of a Proteasome Pba1-Pba2 Complex: IMPLICATIONS FOR PROTEASOME ASSEMBLY, ACTIVATION, AND BIOLOGICAL FUNCTIONQ27671782
Reconfiguration of the proteasome during chaperone-mediated assemblyQ27677979
Conformational dynamics of the Rpt6 ATPase in proteasome assembly and Rpn14 bindingQ36896600
Some assembly required: dedicated chaperones in eukaryotic proteasome biogenesisQ37116375
The proteasome-associated protein Ecm29 inhibits proteasomal ATPase activity and in vivo protein degradation by the proteasomeQ37226121
PACemakers of proteasome core particle assembly.Q37266780
Reconstitution of the 26S proteasome reveals functional asymmetries in its AAA+ unfoldaseQ37406494
Catalytic mechanism and assembly of the proteasome.Q37407654
Proteasomes associated with the Blm10 activator protein antagonize mitochondrial fission through degradation of the fission protein Dnm1.Q37727657
Structural biology of the proteasomeQ38081952
Assembly of the 20S proteasome.Q38090856
The mechanism for molecular assembly of the proteasomeQ38154406
A tetrahedral transition state at the active sites of the 20S proteasome is coupled to opening of the alpha-ring channelQ42177637
Characterization of the proteasome using native gel electrophoresisQ46794661
Stability of the proteasome can be regulated allosterically through engagement of its proteolytic active sites.Q46891027
Pba3-Pba4 heterodimer acts as a molecular matchmaker in proteasome α-ring formation.Q53509643
Dual functions of the Hsm3 protein in chaperoning and scaffolding regulatory particle subunits during the proteasome assemblyQ27678263
Differential global structural changes in the core particle of yeast and mouse proteasome induced by ligand bindingQ27684495
Structural basis for proteasome formation controlled by an assembly chaperone nas2Q27689676
Global analysis of protein expression in yeastQ27860658
Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiaeQ27861085
Blm3 is part of nascent proteasomes and is involved in a late stage of nuclear proteasome assemblyQ27930761
The C-terminal extension of the beta7 subunit and activator complexes stabilize nascent 20 S proteasomes and promote their maturationQ27930979
Hexameric assembly of the proteasomal ATPases is templated through their C terminiQ27931123
Multiple associated proteins regulate proteasome structure and functionQ27931244
Ump1p is required for proper maturation of the 20S proteasome and becomes its substrate upon completion of the assembly.Q27931305
Blm10 protein promotes proteasomal substrate turnover by an active gating mechanismQ27931319
Acetylation-mediated proteasomal degradation of core histones during DNA repair and spermatogenesisQ27933881
A multimeric assembly factor controls the formation of alternative 20S proteasomesQ27933912
20 S proteasomes are imported as precursor complexes into the nucleus of yeastQ27934865
beta-Subunit appendages promote 20S proteasome assembly by overcoming an Ump1-dependent checkpointQ27935938
20S proteasome assembly is orchestrated by two distinct pairs of chaperones in yeast and in mammals.Q27936515
Blm10 facilitates nuclear import of proteasome core particlesQ27936817
The HEAT repeat protein Blm10 regulates the yeast proteasome by capping the core particleQ27938094
Three new dominant drug resistance cassettes for gene disruption in Saccharomyces cerevisiaeQ28131610
Empirical statistical model to estimate the accuracy of peptide identifications made by MS/MS and database searchQ28211385
An asymmetric interface between the regulatory and core particles of the proteasomeQ28251784
Complete subunit architecture of the proteasome regulatory particleQ28257212
Molecular architecture of the 26S proteasome holocomplex determined by an integrative approachQ28259014
Differential roles of the COOH termini of AAA subunits of PA700 (19 S regulator) in asymmetric assembly and activation of the 26 S proteasomeQ28294192
Regulation of proteasome activity in health and diseaseQ28392708
Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiaeQ29546523
Near-atomic resolution structural model of the yeast 26S proteasome.Q30524942
Computer-based analysis of the binding steps in protein complex formationQ33708315
A conserved 20S proteasome assembly factor requires a C-terminal HbYX motif for proteasomal precursor bindingQ34928089
Molecular mechanisms of proteasome assemblyQ34928594
Loss of Rpt5 protein interactions with the core particle and Nas2 protein causes the formation of faulty proteasomes that are inhibited by Ecm29 protein.Q35378632
Optimizing ring assembly reveals the strength of weak interactionsQ35787075
Stochastic dynamics of macromolecular-assembly networks.Q36494123
Functional and biochemical characterization of the 20S proteasome in a yeast temperature-sensitive mutant, rpt6-1.Q36835578
P407language of work or nameEnglishQ1860
P304page(s)6384
P577publication date2015-03-16
P1433published inNature CommunicationsQ573880
P1476titleMaturation of the proteasome core particle induces an affinity switch that controls regulatory particle association
P478volume6

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cites work (P2860)
Q33788930A widespread family of serine/threonine protein phosphatases shares a common regulatory switch with proteasomal proteases.
Q61450205An Allosteric Interaction Network Promotes Conformation State-Dependent Eviction of the Nas6 Assembly Chaperone from Nascent 26S Proteasomes
Q94540572Cooperativity in Proteasome Core Particle Maturation
Q36489345Distinct Elements in the Proteasomal β5 Subunit Propeptide Required for Autocatalytic Processing and Proteasome Assembly
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Q91643887Native Gel Approaches in Studying Proteasome Assembly and Chaperones
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Q40451741Proteasome Activation is Mediated via a Functional Switch of the Rpt6 C-terminal Tail Following Chaperone-dependent Assembly.
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Q47247682Structural insights on the dynamics of proteasome formation
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Q38950512UPS Activation in the Battle Against Aging and Aggregation-Related Diseases: An Extended Review