Mechanism of DNA translocation in a replicative hexameric helicase

scientific article published on July 2006

Mechanism of DNA translocation in a replicative hexameric helicase is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1045376961
P356DOI10.1038/NATURE04943
P698PubMed publication ID16855583
P5875ResearchGate publication ID6929468

P50authorLeemor Joshua-TorQ25358110
P2093author name stringEric J Enemark
P2860cites workInteractions of bacteriophage T7 DNA primase/helicase protein with single-stranded and double-stranded DNAsQ38314172
Biochemical and electron microscopic image analysis of the hexameric E1 helicase.Q38328578
Chaperone proteins abrogate inhibition of the human papillomavirus (HPV) E1 replicative helicase by the HPV E2 proteinQ39681443
Simian virus 40 T-antigen DNA helicase is a hexamer which forms a binary complex during bidirectional unwinding from the viral origin of DNA replicationQ40063919
Recruitment and loading of the E1 initiator protein: an ATP-dependent process catalysed by a transcription factorQ42662203
DnaB drives DNA branch migration and dislodges proteins while encircling two DNA strands.Q44199583
Asymmetric interactions of hexameric bacteriophage T7 DNA helicase with the 5'- and 3'-tails of the forked DNA substrate.Q44224411
Backbone tracking by the SF2 helicase NPH-II.Q44898061
Mechanisms of conformational change for a replicative hexameric helicase of SV40 large tumor antigenQ45082909
Mechanochemistry of t7 DNA helicase.Q46540594
Assembly of a double hexameric helicaseQ46802326
Crystal structure of T7 gene 4 ring helicase indicates a mechanism for sequential hydrolysis of nucleotidesQ27625337
Crystal structures of two intermediates in the assembly of the papillomavirus replication initiation complexQ27638318
Structure of the replicative helicase of the oncoprotein SV40 large tumour antigenQ27641342
Solution structure of the origin DNA-binding domain of SV40 T-antigenQ27734074
Raster3D Version 2.0. A program for photorealistic molecular graphicsQ27860485
An extensively modified version of MolScript that includes greatly enhanced coloring capabilitiesQ27860594
Likelihood-enhanced fast translation functionsQ27860634
DNA replication in eukaryotic cellsQ28131747
DNA-induced switch from independent to sequential dTTP hydrolysis in the bacteriophage T7 DNA helicaseQ28292888
Clamp loaders and sliding clampsQ31048743
The papillomavirus E1 protein forms a DNA-dependent hexameric complex with ATPase and DNA helicase activitiesQ33783679
Sequential and ordered assembly of E1 initiator complexes on the papillomavirus origin of DNA replication generates progressive structural changes related to meltingQ34325784
Bacteriophage T7 helicase/primase proteins form rings around single-stranded DNA that suggest a general structure for hexameric helicasesQ34387475
Replicative helicase loaders: ring breakers and ring makersQ35195270
Induction of structural changes in the bovine papillomavirus type 1 origin of replication by the viral E1 and E2 proteinsQ35750818
Binding and unwinding: SF3 viral helicasesQ36046459
Bovine papilloma virus (BPV)-encoded E1 protein contains multiple activities required for BPV DNA replicationQ36068854
The E1 protein of bovine papilloma virus 1 is an ATP-dependent DNA helicaseQ36336279
The X-ray structure of the papillomavirus helicase in complex with its molecular matchmaker E2.Q37480430
P433issue7100
P407language of work or nameEnglishQ1860
P304page(s)270-275
P577publication date2006-07-01
P1433published inNatureQ180445
P1476titleMechanism of DNA translocation in a replicative hexameric helicase
P478volume442

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cites work (P2860)
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Q37603329Structural biology of MCM helicases
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Q37626173Structure of eukaryotic CMG helicase at a replication fork and implications to replisome architecture and origin initiation
Q27701671Structure of the eukaryotic MCM complex at 3.8 Å
Q27310160Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation
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Q45325699Structure of the large terminase from a hyperthermophilic virus reveals a unique mechanism for oligomerization and ATP hydrolysis
Q48373223Structure of the mitochondrial inner membrane AAA+ protease YME1 gives insight into substrate processing.
Q35222255Structure of the origin-binding domain of simian virus 40 large T antigen bound to DNA.
Q91809478Structure-based mechanism for activation of the AAA+ GTPase McrB by the endonuclease McrC
Q40339706Structure-based mutational analysis of the bovine papillomavirus E1 helicase domain identifies residues involved in the nonspecific DNA binding activity required for double trimer formation
Q61908508Structures and operating principles of the replisome
Q27658178Structures of asymmetric ClpX hexamers reveal nucleotide-dependent motions in a AAA+ protein-unfolding machine
Q33564505Study of SV40 large T antigen nucleotide specificity for DNA unwinding
Q37404660Substrate interactions and promiscuity in a viral DNA packaging motor
Q57477239Substrate-engaged 26 proteasome structures reveal mechanisms for ATP-hydrolysis-driven translocation
Q58024045Substrate-engaged 26S proteasome structures reveal mechanisms for ATP-hydrolysis–driven translocation
Q41881445Subunit organization of Mcm2-7 and the unequal role of active sites in ATP hydrolysis and viability.
Q36769543Switching from single-stranded to double-stranded DNA limits the unwinding processivity of ring-shaped T7 DNA helicase
Q47161924The AAA ATPase Vps4 binds ESCRT-III substrates through a repeating array of dipeptide-binding pockets.
Q35680285The Cell Cycle Timing of Human Papillomavirus DNA Replication
Q27643659The Crystal Structure of the SV40 T-Antigen Origin Binding Domain in Complex with DNA
Q37262962The E1 proteins
Q27677343The Elongator subcomplex Elp456 is a hexameric RecA-like ATPase
Q50190654The Eukaryotic CMG Helicase at the Replication Fork: Emerging Architecture Reveals an Unexpected Mechanism
Q26752772The Eukaryotic Replisome Goes Under the Microscope
Q52656083The Macromolecular Machines that Duplicate the Escherichia coli Chromosome as Targets for Drug Discovery.
Q37451513The Mcm complex: unwinding the mechanism of a replicative helicase.
Q27655502The Mechanism of ATP-Dependent Primer-Template Recognition by a Clamp Loader Complex
Q27680464The Oligomeric State of the Active Vps4 AAA ATPase
Q35070043The PS1 hairpin of Mcm3 is essential for viability and for DNA unwinding in vitro
Q42777752The RNA-mediated, asymmetric ring regulatory mechanism of the transcription termination Rho helicase decrypted by time-resolved nucleotide analog interference probing (trNAIP).
Q35826233The amino acid linker between the endonuclease and helicase domains of adeno-associated virus type 5 Rep plays a critical role in DNA-dependent oligomerization
Q60921857The conformational changes coupling ATP hydrolysis and translocation in a bacterial DnaB helicase
Q27653133The crystal structure of a replicative hexameric helicase DnaC and its complex with single-stranded DNA
Q27646527The crystal structure of the Thermus aquaticus DnaB helicase monomer
Q30444766The domain structure of Helicobacter pylori DnaB helicase: the N-terminal domain can be dispensable for helicase activity whereas the extreme C-terminal region is essential for its function
Q33699332The effects of oligomerization on Saccharomyces cerevisiae Mcm4/6/7 function
Q37028396The eukaryotic CMG helicase pumpjack and integration into the replisome
Q38805624The excluded DNA strand is SEW important for hexameric helicase unwinding
Q27673737The hexameric helicase DnaB adopts a nonplanar conformation during translocation.
Q40176009The hexameric structure of the human mitochondrial replicative helicase Twinkle.
Q47384276The human papillomavirus DNA helicase E1 binds, stimulates, and confers processivity to cellular DNA polymerase epsilon
Q34311575The interdomain linker of AAV-2 Rep68 is an integral part of its oligomerization domain: role of a conserved SF3 helicase residue in oligomerization
Q53435989The interplay of DNA binding, ATP hydrolysis and helicase activities of the archaeal MCM helicase.
Q64056520The mechanism of DNA unwinding by the eukaryotic replicative helicase
Q27002267The minichromosome maintenance replicative helicase
Q91386860The molecular principles governing the activity and functional diversity of AAA+ proteins
Q37833811The nuts and bolts of ring-translocase structure and mechanism
Q34623947The proteasome under the microscope: the regulatory particle in focus
Q48146728The ring-shaped hexameric helicases that function at DNA replication forks
Q36669669The role of ATP-dependent machines in regulating genome topology
Q28306649The structural basis for MCM2-7 helicase activation by GINS and Cdc45.
Q34546716The structure of SV40 large T hexameric helicase in complex with AT-rich origin DNA.
Q36620720Translocation and stability of replicative DNA helicases upon encountering DNA-protein cross-links
Q60206134Transmembrane signaling by asymmetry
Q92877860Two-Step Activation Mechanism of the ClpB Disaggregase for Sequential Substrate Threading by the Main ATPase Motor
Q36506000Two-subunit DNA escort mechanism and inactive subunit bypass in an ultra-fast ring ATPase
Q30789737Unfolding the mechanism of the AAA+ unfoldase VAT by a combined cryo-EM, solution NMR study
Q36644928Viral enzymes

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