Structural insights into proteasome activation by the 19S regulatory particle

scientific article published on 14 May 2013

Structural insights into proteasome activation by the 19S regulatory particle is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1021/BI400417A
P932PMC publication ID3864829
P698PubMed publication ID23672618

P2093author name stringAaron Ehlinger
Kylie J Walters
P2860cites workMPN+, a putative catalytic motif found in a subset of MPN domain proteins from eukaryotes and prokaryotes, is critical for Rpn11 functionQ21284393
Interaction of hHR23 with S5a. The ubiquitin-like domain of hHR23 mediates interaction with S5a subunit of 26 S proteasomeQ22010540
Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulationQ24290515
A heterodimeric complex that promotes the assembly of mammalian 20S proteasomesQ24292874
Rad23 ubiquitin-associated domains (UBA) inhibit 26 S proteasome-catalyzed proteolysis by sequestering lysine 48-linked polyubiquitin chainsQ24298011
Mass spectrometric characterization of the affinity-purified human 26S proteasome complexQ24298353
A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomesQ24304237
Ubiquitin receptor proteins hHR23a and hPLIC2 interactQ24314369
Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chainsQ24316967
hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the deubiquitinating enzyme, UCH37Q24321826
PA200, a nuclear proteasome activator involved in DNA repairQ24536971
Glycine-alanine repeats impair proper substrate unfolding by the proteasomeQ24543904
Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?Q24617857
Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradationQ24643067
Docking of the proteasomal ATPases' carboxyl termini in the 20S proteasome's alpha ring opens the gate for substrate entryQ24674433
Applied techniques for mining natural proteasome inhibitorsQ27026146
A gated channel into the proteasome core particleQ27627907
Structural basis for the activation of 20S proteasomes by 11S regulatorsQ27628418
Crystal structures of the HslVU peptidase-ATPase complex reveal an ATP-dependent proteolysis mechanismQ27630654
Structural studies of the interaction between ubiquitin family proteins and proteasome subunit S5aQ27637621
DNA-repair protein hHR23a alters its protein structure upon binding proteasomal subunit S5aQ27642353
Structural basis for the recognition between the regulatory particles Nas6 and Rpt3 of the yeast 26S proteasomeQ27645374
Interactions of PAN's C-termini with archaeal 20S proteasome and implications for the eukaryotic proteasome–ATPase interactionsQ27646619
Affinity Makes the Difference: Nonselective Interaction of the UBA Domain of Ubiquilin-1 with Monomeric Ubiquitin and Polyubiquitin ChainsQ27649753
Proteasome subunit Rpn13 is a novel ubiquitin receptorQ27650664
Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interactionQ27650666
Structure and activity of the N-terminal substrate recognition domains in proteasomal ATPasesQ27655687
Structural Insights into the Regulatory Particle of the Proteasome from Methanocaldococcus jannaschiiQ27655690
Structure of the S5a:K48-Linked Diubiquitin Complex and Its Interactions with Rpn13Q27657027
Structure of a Blm10 Complex Reveals Common Mechanisms for Proteasome Binding and Gate OpeningQ27660222
Dynamic regulation of archaeal proteasome gate opening as studied by TROSY NMRQ27660397
Structure of Proteasome Ubiquitin Receptor hRpn13 and Its Activation by the Scaffolding Protein hRpn2Q27661655
Structure of a Proteasome Pba1-Pba2 Complex: IMPLICATIONS FOR PROTEASOME ASSEMBLY, ACTIVATION, AND BIOLOGICAL FUNCTIONQ27671782
The proteasomal subunit Rpn6 is a molecular clamp holding the core and regulatory subcomplexes togetherQ27676340
Structural Basis for Specific Recognition of Rpt1p, an ATPase Subunit of 26 S Proteasome, by Proteasome-dedicated Chaperone Hsm3pQ27677277
Nucleotide Binding and Conformational Switching in the Hexameric Ring of a AAA+ MachineQ27677748
The structure of the 26S proteasome subunit Rpn2 reveals its PC repeat domain as a closed toroid of two concentric α-helical ringsQ27677964
Reconfiguration of the proteasome during chaperone-mediated assemblyQ27677979
Dual functions of the Hsm3 protein in chaperoning and scaffolding regulatory particle subunits during the proteasome assemblyQ27678263
Order of the proteasomal ATPases and eukaryotic proteasome assemblyQ27687728
Crystal structure of the 20S proteasome from the archaeon T. acidophilum at 3.4 A resolutionQ27730197
Structure of 20S proteasome from yeast at 2.4 A resolutionQ27735081
Structure of the proteasome activator REGalpha (PA28alpha)Q27748362
RING domain E3 ubiquitin ligasesQ27860546
The ubiquitin systemQ27860803
A comprehensive two-hybrid analysis to explore the yeast protein interactomeQ27861093
Proteasome subunit Rpn1 binds ubiquitin-like protein domainsQ27930136
N-myristoylation of the Rpt2 subunit regulates intracellular localization of the yeast 26S proteasomeQ27930576
Hexameric assembly of the proteasomal ATPases is templated through their C terminiQ27931123
Multiple associated proteins regulate proteasome structure and functionQ27931244
Blm10 protein promotes proteasomal substrate turnover by an active gating mechanismQ27931319
Proteasomal proteomics: identification of nucleotide-sensitive proteasome-interacting proteins by mass spectrometric analysis of affinity-purified proteasomesQ27931576
Identification of ubiquitin-like protein-binding subunits of the 26S proteasomeQ27931789
Deubiquitinating enzyme Ubp6 functions noncatalytically to delay proteasomal degradation.Q27932109
Analysis of polyubiquitin conjugates reveals that the Rpn10 substrate receptor contributes to the turnover of multiple proteasome targetsQ27932507
Proteasomes can degrade a significant proportion of cellular proteins independent of ubiquitinationQ27932737
A genomic screen identifies Dsk2p and Rad23p as essential components of ER-associated degradationQ27934931
Structure of the 26S proteasome with ATP-γS bound provides insights into the mechanism of nucleotide-dependent substrate translocationQ34339520
Phosphorylated TP63 Induces Transcription of RPN13, Leading to NOS2 Protein DegradationQ34438764
Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasomeQ34501396
Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1.Q34556881
Polyubiquitin linkage profiles in three models of proteolytic stress suggest the etiology of Alzheimer diseaseQ34695804
A conserved 20S proteasome assembly factor requires a C-terminal HbYX motif for proteasomal precursor bindingQ34928089
Dependence of proteasome processing rate on substrate unfoldingQ34978877
A conserved F box regulatory complex controls proteasome activity in DrosophilaQ35025085
C termini of proteasomal ATPases play nonequivalent roles in cellular assembly of mammalian 26 S proteasomeQ35128239
Proteasomal degradation from internal sites favors partial proteolysis via remote domain stabilizationQ35420913
Identification of an activation region in the proteasome activator REGalphaQ35972023
Functional asymmetries of proteasome translocase poreQ36002883
The pore of activated 20S proteasomes has an ordered 7-fold symmetric conformationQ36065854
Rpn10-mediated degradation of ubiquitinated proteins is essential for mouse developmentQ36176652
Taking it step by step: mechanistic insights from structural studies of ubiquitin/ubiquitin-like protein modification pathwaysQ36327733
Proteasome allostery as a population shift between interchanging conformersQ36483667
Bipartite determinants mediate an evolutionarily conserved interaction between Cdc48 and the 20S peptidaseQ36653627
Conformational dynamics of the Rpt6 ATPase in proteasome assembly and Rpn14 bindingQ36896600
ClpX(P) generates mechanical force to unfold and translocate its protein substratesQ36938901
Synthetic lethality of rpn11-1 rpn10Δ is linked to altered proteasome assembly and activityQ37088436
Targeting proteins for destruction by the ubiquitin system: implications for human pathobiologyQ37286190
Multitasking with ubiquitin through multivalent interactionsQ37566975
Proteasome activatorsQ37826501
Proteasome activator 200: the heat is on...Q37851267
Novel proteasome inhibitors to overcome bortezomib resistanceQ37878771
Assembly and function of the proteasomeQ37986626
The ubiquitin system, an immense realmQ38015892
Structural biology of the proteasomeQ38081952
A role for the proteasome regulator PA28alpha in antigen presentationQ38357921
Nuclear magnetic resonance studies of the denaturation of ubiquitinQ39163834
Structure and recognition of polyubiquitin chains of different lengths and linkageQ39553217
Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomibQ40431708
Binding of polyubiquitin chains to ubiquitin-associated (UBA) domains of HHR23A.Q40488188
The central unit within the 19S regulatory particle of the proteasomeQ40817421
Heterohexameric ring arrangement of the eukaryotic proteasomal ATPases: implications for proteasome structure and assembly.Q40836221
Yeast UBL-UBA proteins have partially redundant functions in cell cycle control.Q41044924
Physical and functional interactions of monoubiquitylated transactivators with the proteasomeQ41176671
Mechanism of substrate unfolding and translocation by the regulatory particle of the proteasome from Methanocaldococcus jannaschiiQ41297845
Molecular model of the human 26S proteasomeQ41613713
Avid interactions underlie the Lys63-linked polyubiquitin binding specificities observed for UBA domainsQ41869345
Ubiquitinated proteins activate the proteasome by binding to Usp14/Ubp6, which causes 20S gate openingQ41915219
Identification of the Cdc48•20S proteasome as an ancient AAA+ proteolytic machine.Q41953180
ATP binds to proteasomal ATPases in pairs with distinct functional effects, implying an ordered reaction cycleQ42156125
ATP-dependent steps in the binding of ubiquitin conjugates to the 26S proteasome that commit to degradationQ42600957
Solution conformation of Lys63-linked di-ubiquitin chain provides clues to functional diversity of polyubiquitin signalingQ42614287
Participation of the proteasomal lid subunit Rpn11 in mitochondrial morphology and function is mapped to a distinct C-terminal domainQ42806283
Together, Rpn10 and Dsk2 can serve as a polyubiquitin chain-length sensorQ42936102
The proteasome antechamber maintains substrates in an unfolded stateQ44216424
Co- and post-translational modifications of the 26S proteasome in yeastQ44786896
Purification and characterization of a protein inhibitor of the 20S proteasome (macropain)Q44981964
An unstructured initiation site is required for efficient proteasome-mediated degradationQ45018402
Structural determinants for selective recognition of a Lys48-linked polyubiquitin chain by a UBA domainQ46539684
Loops in the central channel of ClpA chaperone mediate protein binding, unfolding, and translocationQ46576864
Diverse polyubiquitin interaction properties of ubiquitin-associated domainsQ46592679
Identification, purification, and characterization of a high molecular weight, ATP-dependent activator (PA700) of the 20 S proteasome.Q47379441
Identification, purification, and characterization of a protein activator (PA28) of the 20 S proteasome (macropain)Q68127933
Coordinated dual cleavages induced by the proteasome regulator PA28 lead to dominant MHC ligandsQ71254579
What curves alpha-solenoids? Evidence for an alpha-helical toroid structure of Rpn1 and Rpn2 proteins of the 26 S proteasomeQ77070509
Structure of S5a bound to monoubiquitin provides a model for polyubiquitin recognitionQ81643532
UBL/UBA ubiquitin receptor proteins bind a common tetraubiquitin chainQ82233807
UBA domains of DNA damage-inducible proteins interact with ubiquitinQ27935487
Multiubiquitin chain receptors define a layer of substrate selectivity in the ubiquitin-proteasome systemQ27935666
A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and eIF3.Q27936509
Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasomeQ27937927
A cryptic protease couples deubiquitination and degradation by the proteasomeQ27938068
The HEAT repeat protein Blm10 regulates the yeast proteasome by capping the core particleQ27938094
The catalytic activity of Ubp6 enhances maturation of the proteasomal regulatory particleQ27938889
The active sites of the eukaryotic 20 S proteasome and their involvement in subunit precursor processingQ27939678
Purification of an 11 S regulator of the multicatalytic proteaseQ28202111
An asymmetric interface between the regulatory and core particles of the proteasomeQ28251784
Incorporation of the Rpn12 subunit couples completion of proteasome regulatory particle lid assembly to lid-base joiningQ28256050
Complete subunit architecture of the proteasome regulatory particleQ28257212
Molecular architecture of the 26S proteasome holocomplex determined by an integrative approachQ28259014
Rpn1 and Rpn2 coordinate ubiquitin processing factors at proteasomeQ28259286
Dissection of the assembly pathway of the proteasome lid in Saccharomyces cerevisiaeQ28282533
Differential roles of the COOH termini of AAA subunits of PA700 (19 S regulator) in asymmetric assembly and activation of the 26 S proteasomeQ28294192
Analysis of the human protein interactome and comparison with yeast, worm and fly interaction datasetsQ28299231
Editing of ubiquitin conjugates by an isopeptidase in the 26S proteasomeQ28303702
Regulators of the proteasome pathway, Uch37 and Rpn13, play distinct roles in mouse developmentQ28505259
Phosphorylation of Rpt6 regulates synaptic strength in hippocampal neuronsQ28579831
Developmental defects and male sterility in mice lacking the ubiquitin-like DNA repair gene mHR23BQ28594975
Recognition and processing of ubiquitin-protein conjugates by the proteasomeQ29547616
Proteins containing the UBA domain are able to bind to multi-ubiquitin chainsQ29614360
Rad23 links DNA repair to the ubiquitin/proteasome pathwayQ29614361
A 26 S protease subunit that binds ubiquitin conjugatesQ29614362
Ubiquitin-binding domains - from structures to functionsQ29614829
Nonproteolytic functions of ubiquitin in cell signalingQ29617294
OB(oligonucleotide/oligosaccharide binding)-fold: common structural and functional solution for non-homologous sequencesQ29620102
Regulation of NF-kappaB activity and inducible nitric oxide synthase by regulatory particle non-ATPase subunit 13 (Rpn13).Q30496086
Structure of the 26S proteasome from Schizosaccharomyces pombe at subnanometer resolutionQ30497623
Near-atomic resolution structural model of the yeast 26S proteasome.Q30524942
Substrate specificity of the human proteasomeQ30783959
Rad23 escapes degradation because it lacks a proteasome initiation regionQ33801171
A proteasomal ATPase subunit recognizes the polyubiquitin degradation signalQ33958676
The 1.9 A structure of a proteasome-11S activator complex and implications for proteasome-PAN/PA700 interactions.Q33987362
Synchrotron protein footprinting supports substrate translocation by ClpA via ATP-induced movements of the D2 loopQ34089946
The substrate translocation channel of the proteasomeQ34214137
Twists and turns in ubiquitin-like protein conjugation cascadesQ34225698
Ubiquitin-binding proteins: decoders of ubiquitin-mediated cellular functionsQ34266494
Proteasome from Thermoplasma acidophilum: a threonine proteaseQ34309062
ATP-dependent incorporation of 20S protease into the 26S complex that degrades proteins conjugated to ubiquitinQ34310551
P433issue21
P407language of work or nameEnglishQ1860
P304page(s)3618-3628
P577publication date2013-05-14
P1433published inBiochemistryQ764876
P1476titleStructural insights into proteasome activation by the 19S regulatory particle
P478volume52

Reverse relations

cites work (P2860)
Q35806570A High Affinity hRpn2-Derived Peptide That Displaces Human Rpn13 from Proteasome in 293T Cells
Q90239219An Extended Conformation for K48 Ubiquitin Chains Revealed by the hRpn2:Rpn13:K48-Diubiquitin Structure
Q47561562Break Breast Cancer Addiction by CRISPR/Cas9 Genome Editing
Q94540572Cooperativity in Proteasome Core Particle Maturation
Q92369782Exercise training prevents the perivascular adipose tissue-induced aortic dysfunction with metabolic syndrome
Q36293871FV-162 is a novel, orally bioavailable, irreversible proteasome inhibitor with improved pharmacokinetics displaying preclinical efficacy with continuous daily dosing.
Q90350628M1-linked ubiquitination by LUBEL is required for inflammatory responses to oral infection in Drosophila
Q93049085Methods to Discover and Evaluate Proteasome Small Molecule Stimulators
Q50932512Multiple functions of insulin-degrading enzyme: a metabolic crosslight?
Q36723224Myosin VI Contains a Compact Structural Motif that Binds to Ubiquitin Chains
Q92157489Proteasome Activation as a New Therapeutic Approach To Target Proteotoxic Disorders
Q26859368Regulation of cardiac proteasomes by ubiquitination, SUMOylation, and beyond
Q37712428Reversible phosphorylation of the 26S proteasome.
Q33846508Sequential actions of the AAA-ATPase valosin-containing protein (VCP)/p97 and the proteasome 19 S regulatory particle in sterol-accelerated, endoplasmic reticulum (ER)-associated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
Q36833345Site-specific proteasome phosphorylation controls cell proliferation and tumorigenesis
Q90207565Structure of E3 ligase E6AP with a proteasome-binding site provided by substrate receptor hRpn10
Q61727849Structure of hRpn10 Bound to UBQLN2 UBL Illustrates Basis for Complementarity between Shuttle Factors and Substrates at the Proteasome
Q33862782Structure of the Rpn13-Rpn2 complex provides insights for Rpn13 and Uch37 as anticancer targets
Q36884720The Proteasome Ubiquitin Receptor hRpn13 and Its Interacting Deubiquitinating Enzyme Uch37 Are Required for Proper Cell Cycle Progression
Q35218996The prenyltransferase UBIAD1 is the target of geranylgeraniol in degradation of HMG CoA reductase
Q38855545ZPAC is required for normal spermatogenesis in mice
Q40898427ahg12 is a dominant proteasome mutant that affects multiple regulatory systems for germination of Arabidopsis.