The substrate translocation channel of the proteasome

scientific article

The substrate translocation channel of the proteasome is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/S0300-9084(01)01242-1
P698PubMed publication ID11295493

P2093author name stringHuber R
Köhler A
Moroder L
Glickman MH
Bajorek M
Finley D
Groll M
Rubin DM
P2860cites workAnalysis of mammalian 20S proteasome biogenesis: the maturation of beta-subunits is an ordered two-step mechanism involving autocatalysisQ24561722
Molecular mechanisms for the conversion of zymogens to active proteolytic enzymesQ24673104
A gated channel into the proteasome core particleQ27627907
Structural basis for the activation of 20S proteasomes by 11S regulatorsQ27628418
Crystal structure of the 20S proteasome from the archaeon T. acidophilum at 3.4 A resolutionQ27730197
Structure of 20S proteasome from yeast at 2.4 A resolutionQ27735081
Autocatalytic subunit processing couples active site formation in the 20S proteasome to completion of assemblyQ27931608
Identification of the yeast 20S proteasome catalytic centers and subunit interactions required for active-site formationQ27932645
A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and eIF3.Q27936509
Active site mutants in the six regulatory particle ATPases reveal multiple roles for ATP in the proteasomeQ27937064
In vivo half-life of a protein is a function of its amino-terminal residueQ28287702
The 26S proteasome: a molecular machine designed for controlled proteolysisQ29619692
The catalytic sites of 20S proteasomes and their role in subunit maturation: a mutational and crystallographic studyQ30779094
Proteasomes and other self-compartmentalizing proteases in prokaryotesQ33542295
The proteasomeQ33689946
The proteasome, a novel protease regulated by multiple mechanismsQ33700949
Structure and mechanism of ATP-dependent proteasesQ33745046
The proteasome activator 11 S REG (PA28) and class I antigen presentationQ33796158
Contribution of proteasomal beta-subunits to the cleavage of peptide substrates analyzed with yeast mutantsQ34753108
Conformational constraints for protein self-cleavage in the proteasomeQ47923187
Proteasome active sites allosterically regulate each other, suggesting a cyclical bite-chew mechanism for protein breakdownQ73075592
Evidence for the existence of a non-catalytic modifier site of peptide hydrolysis by the 20 S proteasomeQ73778113
P433issue3-4
P407language of work or nameEnglishQ1860
P304page(s)325-332
P577publication date2001-03-01
P1433published inBiochimieQ2904035
P1476titleThe substrate translocation channel of the proteasome.
P478volume83

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cites work (P2860)
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Q34299042ASK1 negatively regulates the 26 S proteasome
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Q35209250Archaeal proteasomes: potential in metabolic engineering
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Q55401911Cationic porphyrins are tunable gatekeepers of the 20S proteasome.
Q41107536Copper(II) ions affect the gating dynamics of the 20S proteasome: a molecular and in cell study
Q37711312Effects of ethanol on the proteasome interacting proteins
Q47137426Electrostatic Map Of Proteasome α-Rings Encodes The Design of Allosteric Porphyrin-Based Inhibitors Able To Affect 20S Conformation By Cooperative Binding.
Q38355943Hepatitis B virus HBx peptide 116-138 and proteasome activator PA28 compete for binding to the proteasome alpha4/MC6 subunit.
Q28487088Identification of substrates of the Mycobacterium tuberculosis proteasome
Q44082373Increased degradation of oxidized proteins in yeast defective in 26 S proteasome assembly
Q44517886Inhibition of proteasome activity by selected amino acids
Q93160103Intracellular Peptides in Cell Biology and Pharmacology
Q81274554New uses for old copper-binding drugs: converting the pro-angiogenic copper to a specific cancer cell death inducer
Q28259006Parkin interacts with the proteasome subunit alpha4
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Q92063917Proteostasis Failure in Neurodegenerative Diseases: Focus on Oxidative Stress
Q47916219Rapid degradation of solid-phase bound peptides by the 20S proteasome
Q37396451Structural insights into proteasome activation by the 19S regulatory particle
Q42114358Structure of the human 26S proteasome: subunit radial displacements open the gate into the proteolytic core
Q33958918Taking a bite: proteasomal protein processing
Q45258108The ClpP double ring tetradecameric protease exhibits plastic ring-ring interactions, and the N termini of its subunits form flexible loops that are essential for ClpXP and ClpAP complex formation
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Q35226259The asymmetry in the mature amino-terminus of ClpP facilitates a local symmetry match in ClpAP and ClpXP complexes
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Q26749321The ubiquitin proteasomal system: a potential target for the management of Alzheimer's disease
Q35836872The ubiquitin-proteasome system as a prospective molecular target for cancer treatment and prevention

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