Inhibition of Proteasome Activity Induces Formation of Alternative Proteasome Complexes

scientific article published on 18 April 2016

Inhibition of Proteasome Activity Induces Formation of Alternative Proteasome Complexes is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M116.717652
P932PMC publication ID4933230
P698PubMed publication ID27129254

P50authorOliver EickelbergQ18026479
Olivier CouxQ42432056
P2093author name stringDietrich Trümbach
Silke Meiners
Claire Abeza
Vanessa Welk
Vera Kleene
P2860cites workIncreased proteasome activity in human embryonic stem cells is regulated by PSMD11Q24298544
The SRC-3/AIB1 coactivator is degraded in a ubiquitin- and ATP-independent manner by the REGgamma proteasomeQ24302180
Proteasome activator PA28 gamma regulates p53 by enhancing its MDM2-mediated degradationQ24319027
PA200, a nuclear proteasome activator involved in DNA repairQ24536971
A gated channel into the proteasome core particleQ27627907
Differential global structural changes in the core particle of yeast and mouse proteasome induced by ligand bindingQ27684495
Signal integration in the endoplasmic reticulum unfolded protein responseQ27860577
Acetylation-mediated proteasomal degradation of core histones during DNA repair and spermatogenesisQ27933881
Rpn6p, a proteasome subunit from Saccharomyces cerevisiae, is essential for the assembly and activity of the 26 S proteasomeQ27939823
Hybrid proteasomes. Induction by interferon-gamma and contribution to ATP-dependent proteolysisQ28143710
Global quantification of mammalian gene expression controlQ28238103
Proteasome-mediated processing of Nrf1 is essential for coordinate induction of all proteasome subunits and p97Q28243388
Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cellsQ28279454
Proteasomal Degradation Is Transcriptionally Controlled by TCF11 via an ERAD-Dependent Feedback LoopQ28295179
Evolution of proteasome regulators in eukaryotesQ28334391
Regulation of proteasome activity in health and diseaseQ28392708
Differential expression regulation of the alpha and beta subunits of the PA28 proteasome activator in mature dendritic cellsQ28509272
Recognition and processing of ubiquitin-protein conjugates by the proteasomeQ29547616
MatInspector and beyond: promoter analysis based on transcription factor binding sitesQ29616314
United States Food and Drug Administration approval summary: bortezomib for the treatment of progressive multiple myeloma after one prior therapyQ33371230
U.s. Food and Drug Administration approval: carfilzomib for the treatment of multiple myelomaQ33408443
Molecular and cellular roles of PI31 (PSMF1) protein in regulation of proteasome functionQ33792867
The ubiquitin-proteasome system as a drug target in cerebrovascular disease: therapeutic potential of proteasome inhibitorsQ33892755
Comparative analysis of REG{gamma} expression in mouse and human tissuesQ34042286
Proteasomes in apoptosis: villains or guardians?Q34158571
Molecular dissection of the 11S REG (PA28) proteasome activatorsQ34214167
REGγ modulates p53 activity by regulating its cellular localizationQ34329586
High yield bacterial expression and purification of active recombinant PA28alphabeta complex.Q54413667
Coordinated dual cleavages induced by the proteasome regulator PA28 lead to dominant MHC ligandsQ71254579
Growth retardation in mice lacking the proteasome activator PA28gammaQ73297649
Characterization of recombinant REGalpha, REGbeta, and REGgamma proteasome activatorsQ73770368
Proteasomes and proteasome activator 200 kDa (PA200) accumulate on chromatin in response to ionizing radiationQ80379217
Purification and characterization of proteasomes from Saccharomyces cerevisiaeQ81132246
Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signalingQ34506149
The axial channel of the 20S proteasome opens upon binding of the PA200 activatorQ34555139
Proteasome activator PA200 is required for normal spermatogenesisQ34563112
Deciphering preferential interactions within supramolecular protein complexes: the proteasome caseQ35093980
Global organization and function of mammalian cytosolic proteasome pools: Implications for PA28 and 19S regulatory complexesQ35190938
Regulation of immunoproteasome function in the lungQ35623348
Compromising the 19S proteasome complex protects cells from reduced flux through the proteasomeQ36002378
Mobilizing the proteolytic machine: cell biological roles of proteasome activators and inhibitorsQ36010873
Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunitsQ36150369
Aging perturbs 26S proteasome assembly in Drosophila melanogasterQ36212686
cAMP-induced phosphorylation of 26S proteasomes on Rpn6/PSMD11 enhances their activity and the degradation of misfolded proteins.Q36435295
Proteasome allostery as a population shift between interchanging conformersQ36483667
Role for proteasome activator PA200 and postglutamyl proteasome activity in genomic stability.Q36945044
The REGγ proteasome regulates hepatic lipid metabolism through inhibition of autophagyQ37269271
The proteasome activator PA200 regulates tumor cell responsiveness to glutamine and resistance to ionizing radiation.Q37603650
Building on bortezomib: second-generation proteasome inhibitors as anti-cancer therapyQ37684185
Proteasome activatorsQ37826501
Proteasome activator 200: the heat is on...Q37851267
Structural biology of the proteasomeQ38081952
Regulation of the proteasome: evaluating the lung proteasome as a new therapeutic targetQ38179456
Analysis of Drosophila 26 S proteasome using RNA interferenceQ38294064
A role for the proteasome regulator PA28alpha in antigen presentationQ38357921
Mammalian proteasome subtypes: Their diversity in structure and functionQ38685306
Reversible 26S proteasome disassembly upon mitochondrial stress.Q38992225
Label-free quantitative proteomics reveals the dynamics of proteasome complexes composition and stoichiometry in a wide range of human cell lines.Q38997541
Acute cigarette smoke exposure impairs proteasome function in the lungQ39282499
A novel role for PA28gamma-proteasome in nuclear speckle organization and SR protein traffickingQ40015705
Ubiquitin-independent degradation of cell-cycle inhibitors by the REGgamma proteasomeQ40115986
Ubiquitin- and ATP-independent proteolytic turnover of p21 by the REGgamma-proteasome pathwayQ40115992
Inhibition of proteasome activity induces concerted expression of proteasome genes and de novo formation of Mammalian proteasomesQ40658264
Effect of histamine on proliferation of normal human adult lung fibroblastsQ41131152
A tetrahedral transition state at the active sites of the 20S proteasome is coupled to opening of the alpha-ring channelQ42177637
Regulation of 26S Proteasome Activity in Pulmonary FibrosisQ42480163
Genetic evidence linking age-dependent attenuation of the 26S proteasome with the aging processQ43179672
Alveolar macrophage/peripheral blood monocyte-derived factors modulate proliferation of primary lines of human lung fibroblastsQ44256518
Stability of the proteasome can be regulated allosterically through engagement of its proteolytic active sites.Q46891027
Nontoxic proteasome inhibition activates a protective antioxidant defense response in endothelial cells.Q52932265
P4510describes a project that usesImageJQ1659584
P433issue25
P407language of work or nameEnglishQ1860
P304page(s)13147-13159
P577publication date2016-04-18
P1433published inJournal of Biological ChemistryQ867727
P1476titleInhibition of Proteasome Activity Induces Formation of Alternative Proteasome Complexes
P478volume291

Reverse relations

cites work (P2860)
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Q56753804PIP30/FAM192A is a novel regulator of the nuclear proteasome activator PA28γ
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