Validation of Babesia proteasome as a drug target

scholarly article published by Anthony J. O'Donoghue in 2018

Validation of Babesia proteasome as a drug target is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.IJPDDR.2018.08.001
P932PMC publication ID6092455
P698PubMed publication ID30103207

P50authorMarie JaloveckáQ56798590
Anthony J. O'DonoghueQ56916758
Daniel SojkaQ95093330
P2093author name stringLars Eckmann
Ondrej Hajdusek
David Hartmann
Yukiko Miyamoto
P2860cites workLarge-scale phylogenomic analyses reveal that two enigmatic protist lineages, telonemia and centroheliozoa, are related to photosynthetic chromalveolatesQ23380247
Babesia divergens, a bovine blood parasite of veterinary and zoonotic importanceQ24681513
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Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sicknessQ28817181
Mitochondrial Genome Sequences and Structures Aid in the Resolution of Piroplasmida phylogenyQ28821648
The 26S proteasome: a molecular machine designed for controlled proteolysisQ29619692
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Velcade: U.S. FDA approval for the treatment of multiple myeloma progressing on prior therapyQ33357936
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A common red algal origin of the apicomplexan, dinoflagellate, and heterokont plastidsQ33934728
Pharmacokinetics, pharmacodynamics, metabolism, distribution, and excretion of carfilzomib in rats.Q53233409
First case of human babesiosis in Germany - Clinical presentation and molecular characterisation of the pathogenQ56773866
Isolation of Babesia divergens from carrier cattle blood using in vitro cultureQ79964336
Assembly, structure, and function of the 26S proteasome.Q33988314
Validation of the proteasome as a therapeutic target in Plasmodium using an epoxyketone inhibitor with parasite-specific toxicityQ34473136
Transfusion-transmitted Babesia spp.: bull's-eye on Babesia microtiQ34491565
Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasomeQ34501396
Babesiosis: similar to malaria but differentQ34571537
A fluorescent broad-spectrum proteasome inhibitor for labeling proteasomes in vitro and in vivoQ34582794
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Structure- and function-based design of Plasmodium-selective proteasome inhibitorsQ36584903
Acquisition of exogenous haem is essential for tick reproductionQ36768068
Limitations of SLLVY-AMC in calpain and proteasome measurementsQ37218606
Proteasome inhibitors: an expanding army attacking a unique targetQ37979388
Babesia: a world emerging.Q38032685
Bovine babesiosis in the 21st century: advances in biology and functional genomicsQ38052243
Structural biology of the proteasomeQ38081952
Human babesiosis in Europe: what clinicians need to knowQ38150686
Phylogeny and evolution of apicoplasts and apicomplexan parasitesQ38275826
The cryo-EM structure of the Plasmodium falciparum 20S proteasome and its use in the fight against malaria.Q38861425
Targeting proteasomes in infectious organisms to combat diseaseQ39103077
Severe human Babesia divergens infection in NorwayQ39287339
Nonproteasomal targets of the proteasome inhibitors bortezomib and carfilzomib: a link to clinical adverse eventsQ39583670
Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian ToxicityQ40139788
Clinical and Molecular Evidence of Atovaquone and Azithromycin Resistance in Relapsed Babesia microti infection associated with Rituximab and Chronic Lymphocytic Leukemia.Q40199750
Babesiosis in splenectomized adults. Review of 22 reported casesQ40211486
Case records of the Massachusetts General Hospital. Case 17-2007. A 25-year-old woman with relapsing fevers and recent onset of dyspnea.Q40448654
A global map of genetic diversity in Babesia microti reveals strong population structure and identifies variants associated with clinical relapseQ40559129
Babesiosis in patients with AIDS: a chronic infection presenting as fever of unknown originQ40669200
Fatal babesiosis in man, Finland, 2004.Q42053973
Evaluation of the proteasome inhibitor MLN9708 in preclinical models of human cancerQ43160211
Emergence of resistance to azithromycin-atovaquone in immunocompromised patients with Babesia microti infectionQ43202835
Evaluation of the in vitro growth-inhibitory effect of epoxomicin on Babesia parasitesQ43246722
Babesiosis and infection with human immunodeficiency virus (HIV)Q44624807
Babesiosis and HIV.Q44786718
Expressed sequence tag (EST) analysis of the erythrocytic stages of Babesia bovisQ44890427
A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis.Q45969598
Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasomeQ46119731
Persistent and relapsing babesiosis in immunocompromised patientsQ46817889
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectpharmacologyQ128406
parasitologyQ180502
P304page(s)394-402
P577publication date2018-08-07
P1433published inInternational Journal for Parasitology: Drugs and Drug ResistanceQ20181953
P1476titleValidation of Babesia proteasome as a drug target
P478volume8